Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	79622
Gene name	Small nuclear ribonucleoprotein U11/U12 subunit 25
Gene symbol	SNRNP25
Synonyms (NCBI Gene)	C16orf33
Chromosome	16
Chromosome location	16p13.3
Summary	Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes a

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Show/Hide all (182)

miRTarBase ID	miRNA	Experiments	Reference
MIRT713312	hsa-miR-665	HITS-CLIP	19536157
MIRT713311	hsa-miR-4677-3p	HITS-CLIP	19536157
MIRT713310	hsa-miR-3670	HITS-CLIP	19536157
MIRT713309	hsa-miR-4252	HITS-CLIP	19536157
MIRT713308	hsa-miR-6882-3p	HITS-CLIP	19536157
MIRT713312	hsa-miR-665	HITS-CLIP	19536157
MIRT713311	hsa-miR-4677-3p	HITS-CLIP	19536157
MIRT713310	hsa-miR-3670	HITS-CLIP	19536157
MIRT713309	hsa-miR-4252	HITS-CLIP	19536157
MIRT713308	hsa-miR-6882-3p	HITS-CLIP	19536157
MIRT713312	hsa-miR-665	HITS-CLIP	19536157
MIRT713311	hsa-miR-4677-3p	HITS-CLIP	19536157
MIRT713310	hsa-miR-3670	HITS-CLIP	19536157
MIRT713309	hsa-miR-4252	HITS-CLIP	19536157
MIRT713308	hsa-miR-6882-3p	HITS-CLIP	19536157
MIRT713312	hsa-miR-665	HITS-CLIP	19536157
MIRT713311	hsa-miR-4677-3p	HITS-CLIP	19536157
MIRT713310	hsa-miR-3670	HITS-CLIP	19536157
MIRT713309	hsa-miR-4252	HITS-CLIP	19536157
MIRT713308	hsa-miR-6882-3p	HITS-CLIP	19536157
MIRT713312	hsa-miR-665	HITS-CLIP	19536157
MIRT713311	hsa-miR-4677-3p	HITS-CLIP	19536157
MIRT713310	hsa-miR-3670	HITS-CLIP	19536157
MIRT713309	hsa-miR-4252	HITS-CLIP	19536157
MIRT713308	hsa-miR-6882-3p	HITS-CLIP	19536157
MIRT713312	hsa-miR-665	HITS-CLIP	19536157
MIRT713311	hsa-miR-4677-3p	HITS-CLIP	19536157
MIRT713310	hsa-miR-3670	HITS-CLIP	19536157
MIRT713309	hsa-miR-4252	HITS-CLIP	19536157
MIRT713308	hsa-miR-6882-3p	HITS-CLIP	19536157
MIRT1375871	hsa-miR-1200	CLIP-seq
MIRT1375872	hsa-miR-1238	CLIP-seq
MIRT1375873	hsa-miR-1266	CLIP-seq
MIRT1375874	hsa-miR-1321	CLIP-seq
MIRT1375875	hsa-miR-134	CLIP-seq
MIRT1375876	hsa-miR-193a-5p	CLIP-seq
MIRT1375877	hsa-miR-1972	CLIP-seq
MIRT1375878	hsa-miR-296-5p	CLIP-seq
MIRT1375879	hsa-miR-3074-5p	CLIP-seq
MIRT1375880	hsa-miR-3118	CLIP-seq
MIRT1375881	hsa-miR-3140-3p	CLIP-seq
MIRT1375882	hsa-miR-3148	CLIP-seq
MIRT1375883	hsa-miR-3153	CLIP-seq
MIRT1375884	hsa-miR-3162-5p	CLIP-seq
MIRT1375885	hsa-miR-3164	CLIP-seq
MIRT1375886	hsa-miR-3194-3p	CLIP-seq
MIRT1375887	hsa-miR-346	CLIP-seq
MIRT1375888	hsa-miR-3607-5p	CLIP-seq
MIRT1375889	hsa-miR-361-3p	CLIP-seq
MIRT1375890	hsa-miR-3616-3p	CLIP-seq
MIRT1375891	hsa-miR-3664-3p	CLIP-seq
MIRT1375892	hsa-miR-370	CLIP-seq
MIRT1375893	hsa-miR-4324	CLIP-seq
MIRT1375894	hsa-miR-4436b-3p	CLIP-seq
MIRT1375895	hsa-miR-4501	CLIP-seq
MIRT1375896	hsa-miR-4518	CLIP-seq
MIRT1375897	hsa-miR-4520b-3p	CLIP-seq
MIRT1375898	hsa-miR-4527	CLIP-seq
MIRT1375899	hsa-miR-4529-3p	CLIP-seq
MIRT1375900	hsa-miR-4535	CLIP-seq
MIRT1375901	hsa-miR-4540	CLIP-seq
MIRT1375902	hsa-miR-4640-5p	CLIP-seq
MIRT1375903	hsa-miR-4646-5p	CLIP-seq
MIRT1375904	hsa-miR-4650-5p	CLIP-seq
MIRT1375905	hsa-miR-4659a-5p	CLIP-seq
MIRT1375906	hsa-miR-4659b-5p	CLIP-seq
MIRT1375907	hsa-miR-4668-5p	CLIP-seq
MIRT1375908	hsa-miR-4721	CLIP-seq
MIRT1375909	hsa-miR-4726-3p	CLIP-seq
MIRT1375910	hsa-miR-4726-5p	CLIP-seq
MIRT1375911	hsa-miR-4727-5p	CLIP-seq
MIRT1375912	hsa-miR-4731-5p	CLIP-seq
MIRT1375913	hsa-miR-4739	CLIP-seq
MIRT1375914	hsa-miR-4755-3p	CLIP-seq
MIRT1375915	hsa-miR-4756-5p	CLIP-seq
MIRT1375916	hsa-miR-4761-3p	CLIP-seq
MIRT1375917	hsa-miR-4769-3p	CLIP-seq
MIRT1375918	hsa-miR-4776-5p	CLIP-seq
MIRT1375919	hsa-miR-4789-5p	CLIP-seq
MIRT1375920	hsa-miR-492	CLIP-seq
MIRT1375921	hsa-miR-544b	CLIP-seq
MIRT1375922	hsa-miR-554	CLIP-seq
MIRT1375923	hsa-miR-622	CLIP-seq
MIRT1375924	hsa-miR-660	CLIP-seq
MIRT1375925	hsa-miR-711	CLIP-seq
MIRT1375916	hsa-miR-4761-3p	CLIP-seq
MIRT1375873	hsa-miR-1266	CLIP-seq
MIRT1375874	hsa-miR-1321	CLIP-seq
MIRT1375877	hsa-miR-1972	CLIP-seq
MIRT1375884	hsa-miR-3162-5p	CLIP-seq
MIRT2335045	hsa-miR-3173-3p	CLIP-seq
MIRT1375891	hsa-miR-3664-3p	CLIP-seq
MIRT1375894	hsa-miR-4436b-3p	CLIP-seq
MIRT2335046	hsa-miR-4480	CLIP-seq
MIRT1375896	hsa-miR-4518	CLIP-seq
MIRT1375897	hsa-miR-4520b-3p	CLIP-seq
MIRT1375899	hsa-miR-4529-3p	CLIP-seq
MIRT1375900	hsa-miR-4535	CLIP-seq
MIRT1375904	hsa-miR-4650-5p	CLIP-seq
MIRT1375913	hsa-miR-4739	CLIP-seq
MIRT1375915	hsa-miR-4756-5p	CLIP-seq
MIRT1375916	hsa-miR-4761-3p	CLIP-seq
MIRT1375918	hsa-miR-4776-5p	CLIP-seq
MIRT2335047	hsa-miR-488	CLIP-seq
MIRT1375920	hsa-miR-492	CLIP-seq
MIRT1375923	hsa-miR-622	CLIP-seq
MIRT2629057	hsa-miR-1254	CLIP-seq
MIRT2629058	hsa-miR-151-5p	CLIP-seq
MIRT2629059	hsa-miR-151b	CLIP-seq
MIRT1375879	hsa-miR-3074-5p	CLIP-seq
MIRT2629060	hsa-miR-3116	CLIP-seq
MIRT2629061	hsa-miR-3131	CLIP-seq
MIRT2629062	hsa-miR-3147	CLIP-seq
MIRT1375882	hsa-miR-3148	CLIP-seq
MIRT1375883	hsa-miR-3153	CLIP-seq
MIRT2629063	hsa-miR-3157-5p	CLIP-seq
MIRT2629064	hsa-miR-342-5p	CLIP-seq
MIRT2629065	hsa-miR-3622a-5p	CLIP-seq
MIRT1375892	hsa-miR-370	CLIP-seq
MIRT2629066	hsa-miR-3945	CLIP-seq
MIRT2629067	hsa-miR-4253	CLIP-seq
MIRT2629068	hsa-miR-4316	CLIP-seq
MIRT2629069	hsa-miR-4425	CLIP-seq
MIRT2629070	hsa-miR-452	CLIP-seq
MIRT2629071	hsa-miR-4645-3p	CLIP-seq
MIRT1375903	hsa-miR-4646-5p	CLIP-seq
MIRT2629072	hsa-miR-4651	CLIP-seq
MIRT2629073	hsa-miR-4652-3p	CLIP-seq
MIRT2629074	hsa-miR-4664-5p	CLIP-seq
MIRT1375907	hsa-miR-4668-5p	CLIP-seq
MIRT2629075	hsa-miR-4676-3p	CLIP-seq
MIRT2629076	hsa-miR-4679	CLIP-seq
MIRT2629077	hsa-miR-4691-3p	CLIP-seq
MIRT2629078	hsa-miR-4693-5p	CLIP-seq
MIRT2629079	hsa-miR-4710	CLIP-seq
MIRT2629080	hsa-miR-4717-5p	CLIP-seq
MIRT1375912	hsa-miR-4731-5p	CLIP-seq
MIRT2629081	hsa-miR-4751	CLIP-seq
MIRT2629082	hsa-miR-583	CLIP-seq
MIRT2629083	hsa-miR-608	CLIP-seq
MIRT2629084	hsa-miR-611	CLIP-seq
MIRT1375924	hsa-miR-660	CLIP-seq
MIRT2629085	hsa-miR-661	CLIP-seq
MIRT1375925	hsa-miR-711	CLIP-seq
MIRT2629086	hsa-miR-935	CLIP-seq
MIRT2629057	hsa-miR-1254	CLIP-seq
MIRT2629058	hsa-miR-151-5p	CLIP-seq
MIRT2629059	hsa-miR-151b	CLIP-seq
MIRT1375879	hsa-miR-3074-5p	CLIP-seq
MIRT2629060	hsa-miR-3116	CLIP-seq
MIRT2629061	hsa-miR-3131	CLIP-seq
MIRT2629062	hsa-miR-3147	CLIP-seq
MIRT1375882	hsa-miR-3148	CLIP-seq
MIRT1375883	hsa-miR-3153	CLIP-seq
MIRT2629064	hsa-miR-342-5p	CLIP-seq
MIRT2629065	hsa-miR-3622a-5p	CLIP-seq
MIRT1375892	hsa-miR-370	CLIP-seq
MIRT2629066	hsa-miR-3945	CLIP-seq
MIRT2629067	hsa-miR-4253	CLIP-seq
MIRT2629068	hsa-miR-4316	CLIP-seq
MIRT2629069	hsa-miR-4425	CLIP-seq
MIRT2629070	hsa-miR-452	CLIP-seq
MIRT2629071	hsa-miR-4645-3p	CLIP-seq
MIRT1375903	hsa-miR-4646-5p	CLIP-seq
MIRT2629072	hsa-miR-4651	CLIP-seq
MIRT2629073	hsa-miR-4652-3p	CLIP-seq
MIRT2629074	hsa-miR-4664-5p	CLIP-seq
MIRT1375907	hsa-miR-4668-5p	CLIP-seq
MIRT2629075	hsa-miR-4676-3p	CLIP-seq
MIRT2629076	hsa-miR-4679	CLIP-seq
MIRT2629078	hsa-miR-4693-5p	CLIP-seq
MIRT2629079	hsa-miR-4710	CLIP-seq
MIRT2629080	hsa-miR-4717-5p	CLIP-seq
MIRT1375912	hsa-miR-4731-5p	CLIP-seq
MIRT2629081	hsa-miR-4751	CLIP-seq
MIRT2629082	hsa-miR-583	CLIP-seq
MIRT2629083	hsa-miR-608	CLIP-seq
MIRT2629084	hsa-miR-611	CLIP-seq
MIRT1375924	hsa-miR-660	CLIP-seq
MIRT2629085	hsa-miR-661	CLIP-seq
MIRT1375925	hsa-miR-711	CLIP-seq
MIRT2629086	hsa-miR-935	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	IDA	18559850
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005689	Component	U12-type spliceosomal complex	IBA
GO:0005689	Component	U12-type spliceosomal complex	IDA	15146077
GO:0005829	Component	Cytosol	IDA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IC	15146077
GO:0008380	Process	RNA splicing	IEA
GO:0045171	Component	Intercellular bridge	IDA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q9BV90

Protein name

U11/U12 small nuclear ribonucleoprotein 25 kDa protein (U11/U12 snRNP 25 kDa protein) (U11/U12-25K) (Minus-99 protein)

PDB

8R7N , 8Y6O , 9GBW , 9GBZ , 9GCM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18036	Ubiquitin_4	41 → 129	Ubiquitin-like domain	Domain

Sequence

MDVFQEGLAMVVQDPLLCDLPIQVTLEEVNSQIALEYGQAMTVRVCKMDGEVMPVVVVQS
ATVLDLKKAIQRYVQLKQEREGGIQHISWSYVWRTYHLTSAGEKLTEDRKKLRDYGIRNR
DEVSFIKKLRQK

Sequence length

132

Interactions

View interactions

	Reactome
			mRNA Splicing - Minor Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANCREATIC CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Neoplasms	Neoplasms	BEFREE	25300797		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	25300797, 26738504		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	25300797, 25418192	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SNRNP25 (small nuclear ribonucleoprotein U11/U12 subunit 25)