CERS4 (ceramide synthase 4)

Gene

• Entrez ID: 79603
• Gene name: Ceramide synthase 4
• Gene symbol: CERS4
• Synonyms (NCBI Gene): LASS4, Trh1
• Chromosome: 19
• Chromosome location: 19p13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021339	hsa-miR-9-5p	Microarray	17612493
MIRT712701	hsa-miR-512-3p	HITS-CLIP	19536157
MIRT712700	hsa-miR-4501	HITS-CLIP	19536157
MIRT712699	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT712698	hsa-miR-1909-5p	HITS-CLIP	19536157
MIRT712697	hsa-miR-1537-5p	HITS-CLIP	19536157
MIRT712696	hsa-miR-4718	HITS-CLIP	19536157
MIRT712695	hsa-miR-4999-5p	HITS-CLIP	19536157
MIRT712694	hsa-miR-630	HITS-CLIP	19536157
MIRT712693	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT708419	hsa-miR-660-5p	HITS-CLIP	19536157
MIRT708418	hsa-miR-500b-3p	HITS-CLIP	19536157
MIRT708417	hsa-miR-4704-3p	HITS-CLIP	19536157
MIRT708416	hsa-miR-153-5p	HITS-CLIP	19536157
MIRT708415	hsa-miR-6879-3p	HITS-CLIP	19536157
MIRT678983	hsa-miR-4740-3p	HITS-CLIP	23313552
MIRT642539	hsa-miR-4722-3p	HITS-CLIP	23313552
MIRT642538	hsa-miR-6727-3p	HITS-CLIP	23313552
MIRT678982	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT678980	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT678979	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT678978	hsa-miR-4666a-5p	HITS-CLIP	23313552
MIRT678977	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT678983	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT642539	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT642538	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT678982	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT642537	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT642536	hsa-miR-1976	HITS-CLIP	23824327
MIRT678981	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT678980	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT678979	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT678978	hsa-miR-4666a-5p	HITS-CLIP	23824327
MIRT642533	hsa-miR-4279	HITS-CLIP	23824327
MIRT678977	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT678983	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT642539	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT642538	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT678982	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT642537	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT642536	hsa-miR-1976	HITS-CLIP	23824327
MIRT678981	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT678980	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT678979	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT678978	hsa-miR-4666a-5p	HITS-CLIP	23824327
MIRT642533	hsa-miR-4279	HITS-CLIP	23824327
MIRT678977	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT642531	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT642530	hsa-miR-4770	HITS-CLIP	23824327
MIRT642529	hsa-miR-6088	HITS-CLIP	23824327
MIRT642528	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT661273	hsa-miR-1273f	HITS-CLIP	23824327
MIRT617212	hsa-miR-4313	HITS-CLIP	23824327
MIRT617210	hsa-miR-8055	HITS-CLIP	23824327
MIRT617209	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT642543	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT642542	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT642541	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT642540	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT642539	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT642538	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT642537	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT642536	hsa-miR-1976	HITS-CLIP	23824327
MIRT642535	hsa-miR-134-5p	HITS-CLIP	23824327
MIRT642534	hsa-miR-3118	HITS-CLIP	23824327
MIRT642533	hsa-miR-4279	HITS-CLIP	23824327
MIRT642532	hsa-miR-498	HITS-CLIP	23824327
MIRT642531	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT642530	hsa-miR-4770	HITS-CLIP	23824327
MIRT642529	hsa-miR-6088	HITS-CLIP	23824327
MIRT642528	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT617212	hsa-miR-4313	HITS-CLIP	23824327
MIRT617210	hsa-miR-8055	HITS-CLIP	23824327
MIRT617209	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT617213	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT617212	hsa-miR-4313	HITS-CLIP	23824327
MIRT617211	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT617210	hsa-miR-8055	HITS-CLIP	23824327
MIRT617209	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT494883	hsa-miR-362-5p	PAR-CLIP	23708386
MIRT494882	hsa-miR-500b-5p	PAR-CLIP	23708386
MIRT494881	hsa-miR-6841-3p	PAR-CLIP	23708386
MIRT494880	hsa-miR-1915-5p	PAR-CLIP	23708386
MIRT494879	hsa-miR-5189-3p	PAR-CLIP	23708386
MIRT494878	hsa-miR-502-5p	PAR-CLIP	23708386
MIRT494877	hsa-miR-192-3p	PAR-CLIP	23708386
MIRT494876	hsa-miR-3692-3p	PAR-CLIP	23708386
MIRT661273	hsa-miR-1273f	HITS-CLIP	27418678
MIRT617209	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT642531	hsa-miR-143-3p	HITS-CLIP	27418678
MIRT642528	hsa-miR-4708-5p	HITS-CLIP	27418678
MIRT642530	hsa-miR-4770	HITS-CLIP	27418678
MIRT642529	hsa-miR-6088	HITS-CLIP	27418678
MIRT617210	hsa-miR-8055	HITS-CLIP	27418678
MIRT712701	hsa-miR-512-3p	HITS-CLIP	19536157
MIRT712700	hsa-miR-4501	HITS-CLIP	19536157
MIRT712699	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT712698	hsa-miR-1909-5p	HITS-CLIP	19536157
MIRT712697	hsa-miR-1537-5p	HITS-CLIP	19536157
MIRT712696	hsa-miR-4718	HITS-CLIP	19536157
MIRT712695	hsa-miR-4999-5p	HITS-CLIP	19536157
MIRT712694	hsa-miR-630	HITS-CLIP	19536157
MIRT712693	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT708419	hsa-miR-660-5p	HITS-CLIP	19536157
MIRT708418	hsa-miR-500b-3p	HITS-CLIP	19536157
MIRT708417	hsa-miR-4704-3p	HITS-CLIP	19536157
MIRT708416	hsa-miR-153-5p	HITS-CLIP	19536157
MIRT708415	hsa-miR-6879-3p	HITS-CLIP	19536157
MIRT678983	hsa-miR-4740-3p	HITS-CLIP	23313552
MIRT642539	hsa-miR-4722-3p	HITS-CLIP	23313552
MIRT642538	hsa-miR-6727-3p	HITS-CLIP	23313552
MIRT678982	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT678980	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT678979	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT678978	hsa-miR-4666a-5p	HITS-CLIP	23313552
MIRT678977	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT678983	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT642539	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT642538	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT678982	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT642537	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT642536	hsa-miR-1976	HITS-CLIP	23824327
MIRT678981	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT678980	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT678979	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT678978	hsa-miR-4666a-5p	HITS-CLIP	23824327
MIRT642533	hsa-miR-4279	HITS-CLIP	23824327
MIRT678977	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT678983	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT642539	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT642538	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT678982	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT642537	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT642536	hsa-miR-1976	HITS-CLIP	23824327
MIRT678981	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT678980	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT678979	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT678978	hsa-miR-4666a-5p	HITS-CLIP	23824327
MIRT642533	hsa-miR-4279	HITS-CLIP	23824327
MIRT678977	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT642531	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT642530	hsa-miR-4770	HITS-CLIP	23824327
MIRT642529	hsa-miR-6088	HITS-CLIP	23824327
MIRT642528	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT661273	hsa-miR-1273f	HITS-CLIP	23824327
MIRT617212	hsa-miR-4313	HITS-CLIP	23824327
MIRT617210	hsa-miR-8055	HITS-CLIP	23824327
MIRT617209	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT642543	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT642542	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT642541	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT642540	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT642539	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT642538	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT642537	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT642536	hsa-miR-1976	HITS-CLIP	23824327
MIRT642535	hsa-miR-134-5p	HITS-CLIP	23824327
MIRT642534	hsa-miR-3118	HITS-CLIP	23824327
MIRT642533	hsa-miR-4279	HITS-CLIP	23824327
MIRT642532	hsa-miR-498	HITS-CLIP	23824327
MIRT642531	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT642530	hsa-miR-4770	HITS-CLIP	23824327
MIRT642529	hsa-miR-6088	HITS-CLIP	23824327
MIRT642528	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT617212	hsa-miR-4313	HITS-CLIP	23824327
MIRT617210	hsa-miR-8055	HITS-CLIP	23824327
MIRT617209	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT617213	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT617212	hsa-miR-4313	HITS-CLIP	23824327
MIRT617211	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT617210	hsa-miR-8055	HITS-CLIP	23824327
MIRT617209	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT494883	hsa-miR-362-5p	PAR-CLIP	23708386
MIRT494882	hsa-miR-500b-5p	PAR-CLIP	23708386
MIRT494881	hsa-miR-6841-3p	PAR-CLIP	23708386
MIRT494880	hsa-miR-1915-5p	PAR-CLIP	23708386
MIRT494879	hsa-miR-5189-3p	PAR-CLIP	23708386
MIRT494878	hsa-miR-502-5p	PAR-CLIP	23708386
MIRT494877	hsa-miR-192-3p	PAR-CLIP	23708386
MIRT494876	hsa-miR-3692-3p	PAR-CLIP	23708386
MIRT2465082	hsa-miR-1972	CLIP-seq
MIRT2465083	hsa-miR-361-3p	CLIP-seq
MIRT2465084	hsa-miR-3943	CLIP-seq
MIRT2465085	hsa-miR-4283	CLIP-seq
MIRT2465086	hsa-miR-4489	CLIP-seq
MIRT2465087	hsa-miR-4717-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006665	Process	Sphingolipid metabolic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030148	Process	Sphingolipid biosynthetic process	IEA
GO:0030148	Process	Sphingolipid biosynthetic process	TAS
GO:0046513	Process	Ceramide biosynthetic process	IBA
GO:0046513	Process	Ceramide biosynthetic process	IDA	17977534, 29632068
GO:0046513	Process	Ceramide biosynthetic process	IEA
GO:0046513	Process	Ceramide biosynthetic process	IEA
GO:0050291	Function	Sphingosine N-acyltransferase activity	IBA
GO:0050291	Function	Sphingosine N-acyltransferase activity	IDA	17977534, 29632068
GO:0050291	Function	Sphingosine N-acyltransferase activity	IEA
GO:0050291	Function	Sphingosine N-acyltransferase activity	TAS

Other IDs

• MIM: 615334
• HGNC: 23747
• e!Ensembl: ENSG00000090661

Protein

• UniProt ID: Q9HA82
• Protein name: Ceramide synthase 4 (CerS4) (EC 2.3.1.-) (LAG1 longevity assurance homolog 4) (Sphingosine N-acyltransferase CERS4) (EC 2.3.1.24)
• Protein function: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor. {ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:23530041, ECO:0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00046	Homeodomain	71 → 127	Homeodomain	Domain
  PF03798	TRAM_LAG1_CLN8	132 → 325	TLC domain	Domain

• Sequence:

  MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI
  GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR
  RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY
  WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD
  SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFF
  GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPL
  QLKNGAAGGPRPAPTDGPRSRVAGRLTNRHTTAT

• Sequence length: 394

Pathways

KEGG:

Sphingolipid metabolism
Metabolic pathways
Sphingolipid signaling pathway

Reactome:

Sphingolipid de novo biosynthesis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MACULAR TELANGIECTASIA TYPE 2	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	19905902		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	37885013	Stimulate	★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	37298446	Associate	★☆☆☆☆ Found in Text Mining only
Chronic Kidney Diseases	Kidney Disease	GWASCAT_DG	29545352		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	30272337		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37728516, 37758931	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms Hereditary Nonpolyposis	Lynch syndrome	Pubtator	37728516	Associate	★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	37298446	Associate	★☆☆☆☆ Found in Text Mining only
Dermatitis, Atopic	Dermatitis	BEFREE	27358008		★☆☆☆☆ Found in Text Mining only
Eczema	Eczema	BEFREE	27358008		★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	37728516	Associate	★☆☆☆☆ Found in Text Mining only
Heart Valve Diseases	Heart valve disease	Pubtator	37298446	Associate	★☆☆☆☆ Found in Text Mining only
Kidney Failure, Chronic	Kidney Failure	GWASCAT_DG	29545352		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	19905902		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	28789368		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	25451689, 25779024, 30272337		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	25779024		★☆☆☆☆ Found in Text Mining only
Rectal Carcinoma	Rectal Carcinoma	BEFREE	30272337		★☆☆☆☆ Found in Text Mining only