CORO7 (coronin 7)

Gene

• Entrez ID: 79585
• Gene name: Coronin 7
• Gene symbol: CORO7
• Synonyms (NCBI Gene): 0610011B16Rik, CRN7, POD1
• Chromosome: 16
• Chromosome location: 16p13.3
• Summary: This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has tw

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018155	hsa-miR-335-5p	Microarray	18185580
MIRT049245	hsa-miR-92a-3p	CLASH	23622248
MIRT696403	hsa-miR-606	HITS-CLIP	23313552
MIRT696402	hsa-miR-4781-3p	HITS-CLIP	23313552
MIRT696401	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT696400	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT696398	hsa-miR-4635	HITS-CLIP	23313552
MIRT696399	hsa-miR-4755-3p	HITS-CLIP	23313552
MIRT696397	hsa-miR-6131	HITS-CLIP	23313552
MIRT696396	hsa-miR-7158-3p	HITS-CLIP	23313552
MIRT696395	hsa-miR-203b-3p	HITS-CLIP	23313552
MIRT696394	hsa-miR-548s	HITS-CLIP	23313552
MIRT696393	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT696392	hsa-miR-588	HITS-CLIP	23313552
MIRT696391	hsa-miR-4435	HITS-CLIP	23313552
MIRT696390	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT484652	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT484651	hsa-miR-6865-3p	PAR-CLIP	23592263
MIRT484650	hsa-miR-3620-3p	PAR-CLIP	23592263
MIRT484649	hsa-miR-3151-3p	PAR-CLIP	23592263
MIRT484648	hsa-miR-3192-3p	PAR-CLIP	23592263
MIRT696403	hsa-miR-606	HITS-CLIP	23313552
MIRT696402	hsa-miR-4781-3p	HITS-CLIP	23313552
MIRT696401	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT696400	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT696398	hsa-miR-4635	HITS-CLIP	23313552
MIRT696399	hsa-miR-4755-3p	HITS-CLIP	23313552
MIRT696397	hsa-miR-6131	HITS-CLIP	23313552
MIRT696396	hsa-miR-7158-3p	HITS-CLIP	23313552
MIRT696395	hsa-miR-203b-3p	HITS-CLIP	23313552
MIRT696394	hsa-miR-548s	HITS-CLIP	23313552
MIRT696393	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT696392	hsa-miR-588	HITS-CLIP	23313552
MIRT696391	hsa-miR-4435	HITS-CLIP	23313552
MIRT696390	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT484652	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT484651	hsa-miR-6865-3p	PAR-CLIP	23592263
MIRT484650	hsa-miR-3620-3p	PAR-CLIP	23592263
MIRT484649	hsa-miR-3151-3p	PAR-CLIP	23592263
MIRT484648	hsa-miR-3192-3p	PAR-CLIP	23592263
MIRT904758	hsa-miR-125a-3p	CLIP-seq
MIRT904759	hsa-miR-1294	CLIP-seq
MIRT904760	hsa-miR-2114	CLIP-seq
MIRT904761	hsa-miR-3665	CLIP-seq
MIRT904762	hsa-miR-3689d	CLIP-seq
MIRT904763	hsa-miR-4466	CLIP-seq
MIRT904764	hsa-miR-4476	CLIP-seq
MIRT904765	hsa-miR-4488	CLIP-seq
MIRT904766	hsa-miR-4640-5p	CLIP-seq
MIRT904767	hsa-miR-4697-5p	CLIP-seq
MIRT904768	hsa-miR-4710	CLIP-seq
MIRT904769	hsa-miR-4726-5p	CLIP-seq
MIRT904770	hsa-miR-4736	CLIP-seq
MIRT904771	hsa-miR-4767	CLIP-seq
MIRT904772	hsa-miR-4795-5p	CLIP-seq
MIRT904773	hsa-miR-552	CLIP-seq
MIRT904774	hsa-miR-675	CLIP-seq
MIRT904775	hsa-miR-764	CLIP-seq
MIRT904776	hsa-miR-885-3p	CLIP-seq
MIRT1968323	hsa-miR-3130-3p	CLIP-seq
MIRT1968324	hsa-miR-3146	CLIP-seq
MIRT1968325	hsa-miR-331-3p	CLIP-seq
MIRT1968326	hsa-miR-3620	CLIP-seq
MIRT1968327	hsa-miR-4258	CLIP-seq
MIRT904768	hsa-miR-4710	CLIP-seq
MIRT1968328	hsa-miR-621	CLIP-seq
MIRT1968329	hsa-miR-628-5p	CLIP-seq
MIRT904759	hsa-miR-1294	CLIP-seq
MIRT2204144	hsa-miR-15a	CLIP-seq
MIRT2204145	hsa-miR-15b	CLIP-seq
MIRT2204146	hsa-miR-16	CLIP-seq
MIRT2204147	hsa-miR-195	CLIP-seq
MIRT904762	hsa-miR-3689d	CLIP-seq
MIRT2204148	hsa-miR-424	CLIP-seq
MIRT2204149	hsa-miR-4468	CLIP-seq
MIRT904765	hsa-miR-4488	CLIP-seq
MIRT904767	hsa-miR-4697-5p	CLIP-seq
MIRT904768	hsa-miR-4710	CLIP-seq
MIRT2204150	hsa-miR-497	CLIP-seq
MIRT904759	hsa-miR-1294	CLIP-seq
MIRT904762	hsa-miR-3689d	CLIP-seq
MIRT904765	hsa-miR-4488	CLIP-seq
MIRT904767	hsa-miR-4697-5p	CLIP-seq
MIRT904768	hsa-miR-4710	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0003779	Function	Actin binding	IDA	24768539
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	21130766, 24768539
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005794	Component	Golgi apparatus	ISS
GO:0005802	Component	Trans-Golgi network	IDA	24768539
GO:0005829	Component	Cytosol	IEA
GO:0006895	Process	Golgi to endosome transport	IMP	24768539
GO:0007015	Process	Actin filament organization	IEA
GO:0007015	Process	Actin filament organization	IEA
GO:0007030	Process	Golgi organization	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0016477	Process	Cell migration	IEA
GO:0030010	Process	Establishment of cell polarity	IEA
GO:0030041	Process	Actin filament polymerization	IMP	24768539
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0035332	Process	Positive regulation of hippo signaling	IMP	33162394

Other IDs

• MIM: 611668
• HGNC: 26161
• e!Ensembl: ENSG00000262246

Protein

• UniProt ID: P57737
• Protein name: Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog)
• Protein function: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08953	DUF1899	2 → 65	Domain of unknown function (DUF1899)	Domain
  PF00400	WD40	67 → 106	WD domain, G-beta repeat	Repeat
  PF00400	WD40	158 → 196	WD domain, G-beta repeat	Repeat
  PF16300	WD40_4	338 → 380		Repeat
  PF08953	DUF1899	468 → 532	Domain of unknown function (DUF1899)	Domain
  PF00400	WD40	584 → 623	WD domain, G-beta repeat	Repeat
  PF00400	WD40	629 → 665	WD domain, G-beta repeat	Repeat
  PF16300	WD40_4	808 → 852		Repeat

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine. {ECO:0000269|PubMed:21130766}.
• Sequence:

  MNRFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFNSDRPGVLGIVPL
  QGQGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGV
  VLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDG
  ALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREV
  KLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALSPV
  TQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDTAIVPIGYHVPRKAVEFHEDLFPDT
  AGCVPATDPHSWWAGDNQQVQKVSLNPACRPHPSFTSCLVPPAEPLPDTAQPAVMETPVG
  DADASEGFSSPPSSLTSPSTPSSLGPSLSSTSGIGTSPSLRSLQSLLGPSSKFRHAQGTV
  LHRDSHITNLKGLNLTTPGESDGFCANKLRVAVPLLSSGGQVAVLELRKPGRLPDTALPT
  LQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSL
  RFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGR
  VRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSERQLLLYEAEALAGG
  PLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFLECNSFTSPDPHK
  GLVLLPKTECDVREVELMRCLRLRQSSLEPVAFRLPRVRKEFFQDDVFPDTAVIWEPVLS
  AEAWLQGANGQPWLLSLQPPDMSPVSQAPREAPARRAPSSAQYLEEKSDQQKKEELLNAM
  VAKLGNREDPLPQDSFEGVDEDEWD

• Sequence length: 925

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute megakaryoblastic leukemia	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CUTANEOUS MELANOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mediastinal germ cell tumor	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations