Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	79446
Gene name	WD repeat domain 25
Gene symbol	WDR25
Synonyms (NCBI Gene)	C14orf67
Chromosome	14
Chromosome location	14q32.2
Summary	This gene encodes a protein containing 7 WD repeats. WD repeats are approximately 30 to 40-amino acid domains containing several conserved residues, typically having a Tryptophan-Aspartic acid dipeptide (WD) at the C-terminal end. WD domains are involved

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029702	hsa-miR-26b-5p	Microarray	19088304
MIRT051963	hsa-let-7b-5p	CLASH	23622248
MIRT1489910	hsa-miR-1912	CLIP-seq
MIRT1489911	hsa-miR-3130-5p	CLIP-seq
MIRT1489912	hsa-miR-4482	CLIP-seq
MIRT1489913	hsa-miR-711	CLIP-seq
MIRT2147703	hsa-miR-4286	CLIP-seq
MIRT2147704	hsa-miR-4649-3p	CLIP-seq
MIRT2661690	hsa-miR-1200	CLIP-seq
MIRT2661691	hsa-miR-1224-5p	CLIP-seq
MIRT2661692	hsa-miR-1245b-3p	CLIP-seq
MIRT2661693	hsa-miR-1263	CLIP-seq
MIRT2661694	hsa-miR-1289	CLIP-seq
MIRT2661695	hsa-miR-1827	CLIP-seq
MIRT1489910	hsa-miR-1912	CLIP-seq
MIRT2661696	hsa-miR-24	CLIP-seq
MIRT2661697	hsa-miR-2467-5p	CLIP-seq
MIRT1489911	hsa-miR-3130-5p	CLIP-seq
MIRT2661698	hsa-miR-3183	CLIP-seq
MIRT2661699	hsa-miR-3188	CLIP-seq
MIRT2661700	hsa-miR-335	CLIP-seq
MIRT2661701	hsa-miR-3915	CLIP-seq
MIRT2661702	hsa-miR-3928	CLIP-seq
MIRT2661703	hsa-miR-3975	CLIP-seq
MIRT2147703	hsa-miR-4286	CLIP-seq
MIRT2661704	hsa-miR-4324	CLIP-seq
MIRT2661705	hsa-miR-4326	CLIP-seq
MIRT2661706	hsa-miR-4470	CLIP-seq
MIRT1489912	hsa-miR-4482	CLIP-seq
MIRT2661707	hsa-miR-4496	CLIP-seq
MIRT2147704	hsa-miR-4649-3p	CLIP-seq
MIRT2661708	hsa-miR-4689	CLIP-seq
MIRT2661709	hsa-miR-4713-5p	CLIP-seq
MIRT2661710	hsa-miR-4723-3p	CLIP-seq
MIRT2661711	hsa-miR-4738-3p	CLIP-seq
MIRT2661712	hsa-miR-4780	CLIP-seq
MIRT2661713	hsa-miR-483-3p	CLIP-seq
MIRT2661714	hsa-miR-485-5p	CLIP-seq
MIRT2661715	hsa-miR-499a-5p	CLIP-seq
MIRT2661716	hsa-miR-544b	CLIP-seq
MIRT1489913	hsa-miR-711	CLIP-seq
MIRT2661690	hsa-miR-1200	CLIP-seq
MIRT2661691	hsa-miR-1224-5p	CLIP-seq
MIRT2661692	hsa-miR-1245b-3p	CLIP-seq
MIRT2661693	hsa-miR-1263	CLIP-seq
MIRT2661694	hsa-miR-1289	CLIP-seq
MIRT2661695	hsa-miR-1827	CLIP-seq
MIRT1489910	hsa-miR-1912	CLIP-seq
MIRT2661696	hsa-miR-24	CLIP-seq
MIRT2661697	hsa-miR-2467-5p	CLIP-seq
MIRT1489911	hsa-miR-3130-5p	CLIP-seq
MIRT2661698	hsa-miR-3183	CLIP-seq
MIRT2661699	hsa-miR-3188	CLIP-seq
MIRT2661701	hsa-miR-3915	CLIP-seq
MIRT2661702	hsa-miR-3928	CLIP-seq
MIRT2661703	hsa-miR-3975	CLIP-seq
MIRT2147703	hsa-miR-4286	CLIP-seq
MIRT2661704	hsa-miR-4324	CLIP-seq
MIRT2661705	hsa-miR-4326	CLIP-seq
MIRT2661706	hsa-miR-4470	CLIP-seq
MIRT1489912	hsa-miR-4482	CLIP-seq
MIRT2661707	hsa-miR-4496	CLIP-seq
MIRT2147704	hsa-miR-4649-3p	CLIP-seq
MIRT2661708	hsa-miR-4689	CLIP-seq
MIRT2661709	hsa-miR-4713-5p	CLIP-seq
MIRT2661710	hsa-miR-4723-3p	CLIP-seq
MIRT2661711	hsa-miR-4738-3p	CLIP-seq
MIRT2661712	hsa-miR-4780	CLIP-seq
MIRT2661713	hsa-miR-483-3p	CLIP-seq
MIRT2661714	hsa-miR-485-5p	CLIP-seq
MIRT2661715	hsa-miR-499a-5p	CLIP-seq
MIRT2661716	hsa-miR-544b	CLIP-seq
MIRT1489913	hsa-miR-711	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 32296183, 33961781

MIM	HGNC	e!Ensembl
618059	21064	ENSG00000176473

Q64LD2

Protein name

WD repeat-containing protein 25

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	236 → 277	WD domain, G-beta repeat	Repeat
PF00400	WD40	462 → 501	WD domain, G-beta repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Expressed in heart, muscle, testis, ovary, uterus and prostate. {ECO:0000269|PubMed:15587985}.

Sequence

MTARTLSLMASLVAYDDSDSEAETEHAGSFNATGQQKDTSGVARPPGQDFASGTLDVPKA
GAQPTKHGSCEDPGGYRLPLAQLGRSDWGSCPSQRLQWPGKEPQVTFPIKEPSCSSLWTS
HVPASHMPLAAARFKQVKLSRNFPKSSFHAQSESETVGKNGSSFQKKKCEDCVVPYTPRR
LRQRQALSTETGKGKDVEPQGPPAGRAPAPLYVGPGVSEFIQPYLNSHYKETTVPRKVLF
HLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARW
APCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKA
WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN
QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE
CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDM
KIWH

Sequence length

544

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
EOSINOPHILIC ESOPHAGITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Long QT syndrome	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Coronary Artery Disease	Coronary artery disease	Pubtator	26305337	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	26305337	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

WDR25 (WD repeat domain 25)