BRCC3 (BRCA1/BRCA2-containing complex subunit 3)

Gene

• Entrez ID: 79184
• Gene name: BRCA1/BRCA2-containing complex subunit 3
• Gene symbol: BRCC3
• Synonyms (NCBI Gene): BRCC36, C6.1A, CXorf53
• Chromosome: X
• Chromosome location: Xq28
• Summary: This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049186	hsa-miR-92a-3p	CLASH	23622248
MIRT041195	hsa-miR-193b-3p	CLASH	23622248
MIRT524738	hsa-miR-3121-5p	HITS-CLIP	21572407
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509212	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT509210	hsa-miR-567	HITS-CLIP	21572407
MIRT509209	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT509208	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509206	hsa-miR-297	HITS-CLIP	21572407
MIRT541942	hsa-miR-4743-3p	HITS-CLIP	21572407
MIRT541941	hsa-miR-4652-3p	HITS-CLIP	21572407
MIRT509211	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT660164	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT660163	hsa-miR-596	HITS-CLIP	23824327
MIRT660162	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT660161	hsa-miR-4742-5p	HITS-CLIP	23824327
MIRT660160	hsa-miR-4269	HITS-CLIP	23824327
MIRT660159	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT660158	hsa-miR-4514	HITS-CLIP	23824327
MIRT660157	hsa-miR-4692	HITS-CLIP	23824327
MIRT660156	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT660155	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT660154	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT660153	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT660152	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT660151	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT660150	hsa-miR-7977	HITS-CLIP	23824327
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT524738	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT524738	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT524738	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT509209	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT541943	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509212	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT524738	hsa-miR-3121-5p	PAR-CLIP	21572407
MIRT509210	hsa-miR-567	PAR-CLIP	21572407
MIRT509209	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509206	hsa-miR-297	PAR-CLIP	21572407
MIRT541942	hsa-miR-4743-3p	PAR-CLIP	21572407
MIRT541941	hsa-miR-4652-3p	PAR-CLIP	21572407
MIRT550785	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509211	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT541943	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509212	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT509210	hsa-miR-567	PAR-CLIP	21572407
MIRT509209	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509206	hsa-miR-297	PAR-CLIP	21572407
MIRT509211	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT541943	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509212	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT509210	hsa-miR-567	PAR-CLIP	21572407
MIRT509209	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509206	hsa-miR-297	PAR-CLIP	21572407
MIRT541942	hsa-miR-4743-3p	PAR-CLIP	21572407
MIRT541941	hsa-miR-4652-3p	PAR-CLIP	21572407
MIRT509211	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT524738	hsa-miR-3121-5p	PAR-CLIP	23446348
MIRT509212	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT509210	hsa-miR-567	PAR-CLIP	23446348
MIRT509209	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509206	hsa-miR-297	PAR-CLIP	23446348
MIRT509211	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT509210	hsa-miR-567	PAR-CLIP	23446348
MIRT509206	hsa-miR-297	PAR-CLIP	23446348
MIRT509212	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT509211	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT509210	hsa-miR-567	PAR-CLIP	23446348
MIRT509209	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509206	hsa-miR-297	PAR-CLIP	23446348
MIRT445918	hsa-miR-3184-3p	PAR-CLIP	22100165
MIRT445917	hsa-miR-1264	PAR-CLIP	22100165
MIRT445916	hsa-miR-208a-5p	PAR-CLIP	22100165
MIRT445915	hsa-miR-208b-5p	PAR-CLIP	22100165
MIRT445914	hsa-miR-7705	PAR-CLIP	22100165
MIRT445913	hsa-miR-4635	PAR-CLIP	22100165
MIRT445912	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT445911	hsa-miR-573	PAR-CLIP	22100165
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	27418678
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	27418678
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	27418678
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	27418678
MIRT509209	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT509209	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	27418678
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	27418678
MIRT509212	hsa-miR-511-3p	HITS-CLIP	27418678
MIRT509212	hsa-miR-511-3p	HITS-CLIP	27418678
MIRT509211	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT509211	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT509208	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT509208	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT524738	hsa-miR-3121-5p	HITS-CLIP	21572407
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509212	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT509210	hsa-miR-567	HITS-CLIP	21572407
MIRT509209	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT509208	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509206	hsa-miR-297	HITS-CLIP	21572407
MIRT541942	hsa-miR-4743-3p	HITS-CLIP	21572407
MIRT541941	hsa-miR-4652-3p	HITS-CLIP	21572407
MIRT509211	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT660164	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT660163	hsa-miR-596	HITS-CLIP	23824327
MIRT660162	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT660161	hsa-miR-4742-5p	HITS-CLIP	23824327
MIRT660160	hsa-miR-4269	HITS-CLIP	23824327
MIRT660159	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT660158	hsa-miR-4514	HITS-CLIP	23824327
MIRT660157	hsa-miR-4692	HITS-CLIP	23824327
MIRT660156	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT660155	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT660154	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT660153	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT660152	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT660151	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT660150	hsa-miR-7977	HITS-CLIP	23824327
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT524738	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT524738	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT524738	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT509209	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT541943	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509212	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT524738	hsa-miR-3121-5p	PAR-CLIP	21572407
MIRT509210	hsa-miR-567	PAR-CLIP	21572407
MIRT509209	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509206	hsa-miR-297	PAR-CLIP	21572407
MIRT541942	hsa-miR-4743-3p	PAR-CLIP	21572407
MIRT541941	hsa-miR-4652-3p	PAR-CLIP	21572407
MIRT550785	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509211	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT541943	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509212	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT509210	hsa-miR-567	PAR-CLIP	21572407
MIRT509209	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509206	hsa-miR-297	PAR-CLIP	21572407
MIRT509211	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT541943	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509212	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT509210	hsa-miR-567	PAR-CLIP	21572407
MIRT509209	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509206	hsa-miR-297	PAR-CLIP	21572407
MIRT541942	hsa-miR-4743-3p	PAR-CLIP	21572407
MIRT541941	hsa-miR-4652-3p	PAR-CLIP	21572407
MIRT509211	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT524738	hsa-miR-3121-5p	PAR-CLIP	23446348
MIRT509212	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT509210	hsa-miR-567	PAR-CLIP	23446348
MIRT509209	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509206	hsa-miR-297	PAR-CLIP	23446348
MIRT509211	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT509210	hsa-miR-567	PAR-CLIP	23446348
MIRT509206	hsa-miR-297	PAR-CLIP	23446348
MIRT509212	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT509211	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT509210	hsa-miR-567	PAR-CLIP	23446348
MIRT509209	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509206	hsa-miR-297	PAR-CLIP	23446348
MIRT445918	hsa-miR-3184-3p	PAR-CLIP	22100165
MIRT445917	hsa-miR-1264	PAR-CLIP	22100165
MIRT445916	hsa-miR-208a-5p	PAR-CLIP	22100165
MIRT445915	hsa-miR-208b-5p	PAR-CLIP	22100165
MIRT445914	hsa-miR-7705	PAR-CLIP	22100165
MIRT445913	hsa-miR-4635	PAR-CLIP	22100165
MIRT445912	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT445911	hsa-miR-573	PAR-CLIP	22100165
MIRT755767	hsa-miR-4796-5p	Luciferase reporter assay, Western blotting, qRT-PCR, in vitro cullelar assays, GFP reporter assay	37460775
MIRT824103	hsa-miR-181a	CLIP-seq
MIRT824104	hsa-miR-181b	CLIP-seq
MIRT824105	hsa-miR-181c	CLIP-seq
MIRT824106	hsa-miR-181d	CLIP-seq
MIRT824107	hsa-miR-3908	CLIP-seq
MIRT824108	hsa-miR-4262	CLIP-seq
MIRT824109	hsa-miR-4276	CLIP-seq
MIRT824110	hsa-miR-4307	CLIP-seq
MIRT824111	hsa-miR-4326	CLIP-seq
MIRT824112	hsa-miR-4421	CLIP-seq
MIRT824113	hsa-miR-4711-3p	CLIP-seq
MIRT824114	hsa-miR-4718	CLIP-seq
MIRT824115	hsa-miR-4727-5p	CLIP-seq
MIRT824116	hsa-miR-4769-3p	CLIP-seq
MIRT824117	hsa-miR-494	CLIP-seq
MIRT824118	hsa-miR-545	CLIP-seq
MIRT824119	hsa-miR-568	CLIP-seq
MIRT824120	hsa-miR-101	CLIP-seq
MIRT824121	hsa-miR-105	CLIP-seq
MIRT824122	hsa-miR-1243	CLIP-seq
MIRT824123	hsa-miR-144	CLIP-seq
MIRT824124	hsa-miR-145	CLIP-seq
MIRT824125	hsa-miR-21	CLIP-seq
MIRT824126	hsa-miR-218	CLIP-seq
MIRT824127	hsa-miR-3150a-5p	CLIP-seq
MIRT824128	hsa-miR-3150b-5p	CLIP-seq
MIRT824129	hsa-miR-3180-5p	CLIP-seq
MIRT824130	hsa-miR-3201	CLIP-seq
MIRT824131	hsa-miR-3672	CLIP-seq
MIRT824132	hsa-miR-3940-5p	CLIP-seq
MIRT824133	hsa-miR-410	CLIP-seq
MIRT824134	hsa-miR-4260	CLIP-seq
MIRT824135	hsa-miR-4283	CLIP-seq
MIRT824136	hsa-miR-4424	CLIP-seq
MIRT824137	hsa-miR-4463	CLIP-seq
MIRT824138	hsa-miR-4489	CLIP-seq
MIRT824139	hsa-miR-4501	CLIP-seq
MIRT824140	hsa-miR-4507	CLIP-seq
MIRT824141	hsa-miR-4720-3p	CLIP-seq
MIRT824142	hsa-miR-4789-5p	CLIP-seq
MIRT824143	hsa-miR-4791	CLIP-seq
MIRT824144	hsa-miR-4804-3p	CLIP-seq
MIRT824145	hsa-miR-485-3p	CLIP-seq
MIRT824146	hsa-miR-487a	CLIP-seq
MIRT824147	hsa-miR-513a-3p	CLIP-seq
MIRT824148	hsa-miR-590-3p	CLIP-seq
MIRT824149	hsa-miR-590-5p	CLIP-seq
MIRT824150	hsa-miR-591	CLIP-seq
MIRT824151	hsa-miR-636	CLIP-seq
MIRT1943622	hsa-miR-1	CLIP-seq
MIRT1943623	hsa-miR-1299	CLIP-seq
MIRT1943624	hsa-miR-136	CLIP-seq
MIRT1943625	hsa-miR-193a-5p	CLIP-seq
MIRT1943626	hsa-miR-206	CLIP-seq
MIRT1943627	hsa-miR-219-2-3p	CLIP-seq
MIRT1943628	hsa-miR-2964a-3p	CLIP-seq
MIRT1943629	hsa-miR-302f	CLIP-seq
MIRT1943630	hsa-miR-3140-3p	CLIP-seq
MIRT1943631	hsa-miR-323b-3p	CLIP-seq
MIRT1943632	hsa-miR-326	CLIP-seq
MIRT1943633	hsa-miR-330-5p	CLIP-seq
MIRT1943634	hsa-miR-3673	CLIP-seq
MIRT1943635	hsa-miR-383	CLIP-seq
MIRT824110	hsa-miR-4307	CLIP-seq
MIRT824111	hsa-miR-4326	CLIP-seq
MIRT1943636	hsa-miR-4452	CLIP-seq
MIRT1943637	hsa-miR-4464	CLIP-seq
MIRT1943638	hsa-miR-4641	CLIP-seq
MIRT1943639	hsa-miR-4691-5p	CLIP-seq
MIRT824113	hsa-miR-4711-3p	CLIP-seq
MIRT824115	hsa-miR-4727-5p	CLIP-seq
MIRT1943640	hsa-miR-4731-5p	CLIP-seq
MIRT1943641	hsa-miR-4748	CLIP-seq
MIRT1943642	hsa-miR-4768-5p	CLIP-seq
MIRT824116	hsa-miR-4769-3p	CLIP-seq
MIRT1943643	hsa-miR-4772-5p	CLIP-seq
MIRT1943644	hsa-miR-5096	CLIP-seq
MIRT1943645	hsa-miR-511	CLIP-seq
MIRT1943646	hsa-miR-520d-5p	CLIP-seq
MIRT1943647	hsa-miR-524-5p	CLIP-seq
MIRT1943648	hsa-miR-579	CLIP-seq
MIRT1943649	hsa-miR-613	CLIP-seq
MIRT1943650	hsa-miR-664	CLIP-seq
MIRT1943651	hsa-miR-875-3p	CLIP-seq
MIRT2182295	hsa-miR-1238	CLIP-seq
MIRT824124	hsa-miR-145	CLIP-seq
MIRT2182296	hsa-miR-1976	CLIP-seq
MIRT2182297	hsa-miR-3124-3p	CLIP-seq
MIRT824129	hsa-miR-3180-5p	CLIP-seq
MIRT2182298	hsa-miR-3650	CLIP-seq
MIRT2182299	hsa-miR-369-3p	CLIP-seq
MIRT2182300	hsa-miR-371-5p	CLIP-seq
MIRT824134	hsa-miR-4260	CLIP-seq
MIRT824135	hsa-miR-4283	CLIP-seq
MIRT824138	hsa-miR-4489	CLIP-seq
MIRT2182301	hsa-miR-4760-3p	CLIP-seq
MIRT1943642	hsa-miR-4768-5p	CLIP-seq
MIRT1943646	hsa-miR-520d-5p	CLIP-seq
MIRT1943647	hsa-miR-524-5p	CLIP-seq
MIRT2182302	hsa-miR-3115	CLIP-seq
MIRT2384870	hsa-miR-323-5p	CLIP-seq
MIRT2182298	hsa-miR-3650	CLIP-seq
MIRT2384871	hsa-miR-876-3p	CLIP-seq
MIRT824134	hsa-miR-4260	CLIP-seq
MIRT824135	hsa-miR-4283	CLIP-seq
MIRT824138	hsa-miR-4489	CLIP-seq
MIRT1943646	hsa-miR-520d-5p	CLIP-seq
MIRT1943647	hsa-miR-524-5p	CLIP-seq
MIRT2485948	hsa-let-7a	CLIP-seq
MIRT2485949	hsa-let-7b	CLIP-seq
MIRT2485950	hsa-let-7c	CLIP-seq
MIRT2485951	hsa-let-7d	CLIP-seq
MIRT2485952	hsa-let-7e	CLIP-seq
MIRT2485953	hsa-let-7f	CLIP-seq
MIRT2485954	hsa-let-7g	CLIP-seq
MIRT2485955	hsa-let-7i	CLIP-seq
MIRT2485956	hsa-miR-125a-5p	CLIP-seq
MIRT2485957	hsa-miR-125b	CLIP-seq
MIRT2485958	hsa-miR-1294	CLIP-seq
MIRT2485959	hsa-miR-129-5p	CLIP-seq
MIRT2485960	hsa-miR-1305	CLIP-seq
MIRT2485961	hsa-miR-1914	CLIP-seq
MIRT2485962	hsa-miR-197	CLIP-seq
MIRT2182296	hsa-miR-1976	CLIP-seq
MIRT2485963	hsa-miR-202	CLIP-seq
MIRT2485964	hsa-miR-23a	CLIP-seq
MIRT2485965	hsa-miR-23b	CLIP-seq
MIRT2485966	hsa-miR-23c	CLIP-seq
MIRT2485967	hsa-miR-3119	CLIP-seq
MIRT2485968	hsa-miR-3140-5p	CLIP-seq
MIRT824131	hsa-miR-3672	CLIP-seq
MIRT2485969	hsa-miR-3674	CLIP-seq
MIRT2182299	hsa-miR-369-3p	CLIP-seq
MIRT2485970	hsa-miR-375	CLIP-seq
MIRT2485971	hsa-miR-3924	CLIP-seq
MIRT2485972	hsa-miR-3973	CLIP-seq
MIRT824133	hsa-miR-410	CLIP-seq
MIRT2485973	hsa-miR-421	CLIP-seq
MIRT2485974	hsa-miR-4263	CLIP-seq
MIRT2485975	hsa-miR-4279	CLIP-seq
MIRT2485976	hsa-miR-4316	CLIP-seq
MIRT2485977	hsa-miR-4319	CLIP-seq
MIRT824136	hsa-miR-4424	CLIP-seq
MIRT2485978	hsa-miR-4426	CLIP-seq
MIRT2485979	hsa-miR-4458	CLIP-seq
MIRT824137	hsa-miR-4463	CLIP-seq
MIRT2485980	hsa-miR-4474-3p	CLIP-seq
MIRT2485981	hsa-miR-4500	CLIP-seq
MIRT1943638	hsa-miR-4641	CLIP-seq
MIRT2485982	hsa-miR-4647	CLIP-seq
MIRT2485983	hsa-miR-4662b	CLIP-seq
MIRT2485984	hsa-miR-4699-5p	CLIP-seq
MIRT2485985	hsa-miR-4709-5p	CLIP-seq
MIRT2485986	hsa-miR-4732-5p	CLIP-seq
MIRT2485987	hsa-miR-4735-5p	CLIP-seq
MIRT824142	hsa-miR-4789-5p	CLIP-seq
MIRT824145	hsa-miR-485-3p	CLIP-seq
MIRT824146	hsa-miR-487a	CLIP-seq
MIRT824117	hsa-miR-494	CLIP-seq
MIRT1943645	hsa-miR-511	CLIP-seq
MIRT824147	hsa-miR-513a-3p	CLIP-seq
MIRT2485988	hsa-miR-520g	CLIP-seq
MIRT2485989	hsa-miR-520h	CLIP-seq
MIRT2485990	hsa-miR-544b	CLIP-seq
MIRT2485991	hsa-miR-548ae	CLIP-seq
MIRT2485992	hsa-miR-548aj	CLIP-seq
MIRT2485993	hsa-miR-548am	CLIP-seq
MIRT2485994	hsa-miR-548x	CLIP-seq
MIRT2485995	hsa-miR-576-3p	CLIP-seq
MIRT2485996	hsa-miR-576-5p	CLIP-seq
MIRT2485997	hsa-miR-578	CLIP-seq
MIRT824148	hsa-miR-590-3p	CLIP-seq
MIRT2485998	hsa-miR-607	CLIP-seq
MIRT2485999	hsa-miR-643	CLIP-seq
MIRT1943650	hsa-miR-664	CLIP-seq
MIRT2486000	hsa-miR-98	CLIP-seq
MIRT2485948	hsa-let-7a	CLIP-seq
MIRT2485949	hsa-let-7b	CLIP-seq
MIRT2485950	hsa-let-7c	CLIP-seq
MIRT2485951	hsa-let-7d	CLIP-seq
MIRT2485952	hsa-let-7e	CLIP-seq
MIRT2485953	hsa-let-7f	CLIP-seq
MIRT2485954	hsa-let-7g	CLIP-seq
MIRT2485955	hsa-let-7i	CLIP-seq
MIRT2485956	hsa-miR-125a-5p	CLIP-seq
MIRT2485957	hsa-miR-125b	CLIP-seq
MIRT2485959	hsa-miR-129-5p	CLIP-seq
MIRT2485960	hsa-miR-1305	CLIP-seq
MIRT2485961	hsa-miR-1914	CLIP-seq
MIRT2485962	hsa-miR-197	CLIP-seq
MIRT2182296	hsa-miR-1976	CLIP-seq
MIRT2485963	hsa-miR-202	CLIP-seq
MIRT2485964	hsa-miR-23a	CLIP-seq
MIRT2485965	hsa-miR-23b	CLIP-seq
MIRT2485966	hsa-miR-23c	CLIP-seq
MIRT2485967	hsa-miR-3119	CLIP-seq
MIRT2485968	hsa-miR-3140-5p	CLIP-seq
MIRT824131	hsa-miR-3672	CLIP-seq
MIRT2485969	hsa-miR-3674	CLIP-seq
MIRT2182299	hsa-miR-369-3p	CLIP-seq
MIRT2485970	hsa-miR-375	CLIP-seq
MIRT2485971	hsa-miR-3924	CLIP-seq
MIRT2485972	hsa-miR-3973	CLIP-seq
MIRT824133	hsa-miR-410	CLIP-seq
MIRT2485975	hsa-miR-4279	CLIP-seq
MIRT2485977	hsa-miR-4319	CLIP-seq
MIRT824136	hsa-miR-4424	CLIP-seq
MIRT2485978	hsa-miR-4426	CLIP-seq
MIRT2485979	hsa-miR-4458	CLIP-seq
MIRT824137	hsa-miR-4463	CLIP-seq
MIRT2485980	hsa-miR-4474-3p	CLIP-seq
MIRT2485981	hsa-miR-4500	CLIP-seq
MIRT2485982	hsa-miR-4647	CLIP-seq
MIRT2485983	hsa-miR-4662b	CLIP-seq
MIRT2485984	hsa-miR-4699-5p	CLIP-seq
MIRT2485986	hsa-miR-4732-5p	CLIP-seq
MIRT824142	hsa-miR-4789-5p	CLIP-seq
MIRT824117	hsa-miR-494	CLIP-seq
MIRT1943645	hsa-miR-511	CLIP-seq
MIRT824147	hsa-miR-513a-3p	CLIP-seq
MIRT2485988	hsa-miR-520g	CLIP-seq
MIRT2485989	hsa-miR-520h	CLIP-seq
MIRT2485990	hsa-miR-544b	CLIP-seq
MIRT2485991	hsa-miR-548ae	CLIP-seq
MIRT2485992	hsa-miR-548aj	CLIP-seq
MIRT2485993	hsa-miR-548am	CLIP-seq
MIRT2485994	hsa-miR-548x	CLIP-seq
MIRT2485995	hsa-miR-576-3p	CLIP-seq
MIRT2485997	hsa-miR-578	CLIP-seq
MIRT824148	hsa-miR-590-3p	CLIP-seq
MIRT2485998	hsa-miR-607	CLIP-seq
MIRT1943650	hsa-miR-664	CLIP-seq
MIRT2486000	hsa-miR-98	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	IDA	14636569
GO:0000152	Component	Nuclear ubiquitin ligase complex	IDA	14636569
GO:0000922	Component	Spindle pole	IEA
GO:0004843	Function	Cysteine-type deubiquitinase activity	IEA
GO:0005515	Function	Protein binding	IPI	14636569, 18077395, 19202061, 19261748, 19261749, 19615732, 32296183, 33961781, 37398436
GO:0005634	Component	Nucleus	IDA	14636569, 19202061
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	20656689
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	24075985
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006282	Process	Regulation of DNA repair	NAS	20656689
GO:0006302	Process	Double-strand break repair	IBA
GO:0006302	Process	Double-strand break repair	IMP	17525341, 19261746, 19261748
GO:0006325	Process	Chromatin organization	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0007095	Process	Mitotic G2 DNA damage checkpoint signaling	IMP	17525341, 19261746, 19261748
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IBA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IMP	17525341, 19214193, 19261746
GO:0010165	Process	Response to X-ray	IDA	14636569
GO:0010212	Process	Response to ionizing radiation	IMP	17525341, 19261746, 19261748
GO:0016579	Process	Protein deubiquitination	TAS
GO:0016787	Function	Hydrolase activity	IEA
GO:0030234	Function	Enzyme regulator activity	IDA	14636569
GO:0031593	Function	Polyubiquitin modification-dependent protein binding	IBA
GO:0031593	Function	Polyubiquitin modification-dependent protein binding	IDA	19261749
GO:0044546	Process	NLRP3 inflammasome complex assembly	IDA	35114687, 35254907
GO:0044818	Process	Mitotic G2/M transition checkpoint	NAS	22369660
GO:0045739	Process	Positive regulation of DNA repair	IMP	17525341, 19261746, 19261748
GO:0046872	Function	Metal ion binding	IEA
GO:0051301	Process	Cell division	IEA
GO:0061578	Function	K63-linked deubiquitinase activity	IDA	19202061, 28943315
GO:0061578	Function	K63-linked deubiquitinase activity	TAS
GO:0070531	Component	BRCA1-A complex	IBA
GO:0070531	Component	BRCA1-A complex	IDA	17525341, 19202061, 19261746, 19261748, 19261749
GO:0070531	Component	BRCA1-A complex	IEA
GO:0070531	Component	BRCA1-A complex	NAS	20656689
GO:0070536	Process	Protein K63-linked deubiquitination	IDA	17525341, 19214193
GO:0070536	Process	Protein K63-linked deubiquitination	IEA
GO:0070536	Process	Protein K63-linked deubiquitination	IMP	24075985
GO:0070552	Component	BRISC complex	IBA
GO:0070552	Component	BRISC complex	IDA	19214193, 24075985
GO:0070552	Component	BRISC complex	IEA
GO:0071479	Process	Cellular response to ionizing radiation	IMP	14636569
GO:0140492	Function	Metal-dependent deubiquitinase activity	IEA
GO:0140492	Function	Metal-dependent deubiquitinase activity	IMP	19261746
GO:0140861	Process	DNA repair-dependent chromatin remodeling	IMP	19202061, 19261746
GO:1900227	Process	Positive regulation of NLRP3 inflammasome complex assembly	IDA	28943315
GO:1900227	Process	Positive regulation of NLRP3 inflammasome complex assembly	ISS
GO:2000001	Process	Regulation of DNA damage checkpoint	NAS	14636569

Other IDs

• MIM: 300617
• HGNC: 24185
• e!Ensembl: ENSG00000185515

Protein

• UniProt ID: P46736
• Protein name: Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36)
• Protein function: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains (PubMed:19214193, PubMed:2065
• PDB: 6H3C, 6R8F, 8PVY, 8PY2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01398	JAB	7 → 148	JAB1/Mov34/MPN/PAD-1 ubiquitin protease	Family
  PF18110	BRCC36_C	228 → 308	BRCC36 C-terminal helical domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Aberrantly expressed in the vast majority of breast tumors. {ECO:0000269|PubMed:16707425}.
• Sequence:

  MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMR
  TVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGW
  YHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQK
  SSESLHGPRDFWSSSQHISIEGQKEEERYERIEIPIHIVPHVTIGKVCLESAVELPKILC
  QEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQE
  LQQEKEELMQELSSLE

• Sequence length: 316

Pathways

KEGG:

Homologous recombination
NOD-like receptor signaling pathway

Reactome:

Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Hereditary cancer-predisposing syndrome	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOYAMOYA ANGIOPATHY, SHORT STATURE, FACIAL DYSMORPHISM, HYPERGONADOTROPIC HYPOGONADISM SYNDROME	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOYAMOYA ANGIOPATHY-SHORT STATURE-FACIAL DYSMORPHISM-HYPERGONADOTROPIC HYPOGONADISM SYNDROME	—	Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOYAMOYA DISEASE	—	Disgenet, GenCC Disgenet, GenCC	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOYAMOYA DISEASE 4 WITH SHORT STATURE, HYPERGONADOTROPIC HYPOGONADISM, AND FACIAL DYSMORPHISM	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	16707425, 30272359		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	14636569, 26024915, 34309165	Associate	★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	30272359		★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	30272359		★☆☆☆☆ Found in Text Mining only
Dry Eye Syndromes	Dry Eye Syndromes	BEFREE	28238526		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	25337721		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	25337721		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	25337721		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	37681916	Associate	★☆☆☆☆ Found in Text Mining only
Leiomyoma	Leiomyoma	Pubtator	21685710	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	16707425, 30272359		★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	30272359		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	14636569, 16707425, 26024915		★☆☆☆☆ Found in Text Mining only
Moyamoya angiopathy-short stature-facial dysmorphism-hypergonadotropic hypogonadism syndrome	Moyamoya disease-Short Stature-Facial Dysmorphism-Hypergonadotropic Hypogonadism Syndrome	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Moyamoya Disease	Moyamoya Disease	BEFREE	21596366, 25093848, 26691666, 27128593		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Moyamoya Disease	Moyamoya Disease	GENOMICS_ENGLAND_DG	21596366		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Moyamoya Disease	Moyamoya disease	Pubtator	25093848	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Moyamoya disease 1	Moyamoya disease	BEFREE	25093848, 27128593		★☆☆☆☆ Found in Text Mining only
MOYAMOYA DISEASE 4 WITH SHORT STATURE, HYPERGONADOTROPIC HYPOGONADISM, AND FACIAL DYSMORPHISM	Moyamoya disease-Short Stature-Facial Dysmorphism-Hypergonadotropic Hypogonadism Syndrome	ORPHANET_DG	21596366		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	26001790, 31576005		★☆☆☆☆ Found in Text Mining only
Myelodysplastic-Myeloproliferative Diseases	Myelodysplastic-Myeloproliferative Diseases	BEFREE	26001790		★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	26024915		★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	26024915	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	26001790		★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	BEFREE	30834083		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	31787240		★☆☆☆☆ Found in Text Mining only
Testicular Germ Cell Tumor	Testicular germ cell tumor	Pubtator	17167184	Associate	★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	26848770		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	26848770	Associate	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	30272359	Stimulate	★☆☆☆☆ Found in Text Mining only
Vascular Diseases	Vascular Diseases	BEFREE	21596366		★☆☆☆☆ Found in Text Mining only