Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	7918
Gene name	G-patch domain and ankyrin repeats 1
Gene symbol	GPANK1
Synonyms (NCBI Gene)	ANKRD59BAT4D6S54EG5GPATCH10
Chromosome	6
Chromosome location	6p21.33
Summary	This gene is located in a cluster of HLA-B-associated transcripts, which is included in the human major histocompatability complex III region. This gene encodes a protein which is thought to play a role in immunity. Multiple alternatively spliced variants

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Show/Hide all (224)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024275	hsa-miR-215-5p	Microarray	19074876
MIRT1028157	hsa-miR-2861	CLIP-seq
MIRT1028158	hsa-miR-3161	CLIP-seq
MIRT1028159	hsa-miR-3187-3p	CLIP-seq
MIRT1028160	hsa-miR-3667-3p	CLIP-seq
MIRT1028161	hsa-miR-3677-3p	CLIP-seq
MIRT1028162	hsa-miR-3926	CLIP-seq
MIRT1028163	hsa-miR-4297	CLIP-seq
MIRT1028164	hsa-miR-4434	CLIP-seq
MIRT1028165	hsa-miR-4435	CLIP-seq
MIRT1028166	hsa-miR-4453	CLIP-seq
MIRT1028167	hsa-miR-4516	CLIP-seq
MIRT1028168	hsa-miR-4522	CLIP-seq
MIRT1028169	hsa-miR-4531	CLIP-seq
MIRT1028170	hsa-miR-4538	CLIP-seq
MIRT1028171	hsa-miR-4690-3p	CLIP-seq
MIRT1028172	hsa-miR-4701-5p	CLIP-seq
MIRT1028173	hsa-miR-4802-3p	CLIP-seq
MIRT1028174	hsa-miR-548s	CLIP-seq
MIRT1028175	hsa-miR-588	CLIP-seq
MIRT1028176	hsa-miR-1182	CLIP-seq
MIRT1028177	hsa-miR-15a	CLIP-seq
MIRT1028178	hsa-miR-15b	CLIP-seq
MIRT1028179	hsa-miR-16	CLIP-seq
MIRT1028180	hsa-miR-1827	CLIP-seq
MIRT1028181	hsa-miR-188-5p	CLIP-seq
MIRT1028182	hsa-miR-195	CLIP-seq
MIRT1028183	hsa-miR-214	CLIP-seq
MIRT1028184	hsa-miR-25	CLIP-seq
MIRT1028185	hsa-miR-3136-3p	CLIP-seq
MIRT1028186	hsa-miR-3150a-3p	CLIP-seq
MIRT1028187	hsa-miR-3175	CLIP-seq
MIRT1028188	hsa-miR-32	CLIP-seq
MIRT1028189	hsa-miR-3545-3p	CLIP-seq
MIRT1028190	hsa-miR-3619-5p	CLIP-seq
MIRT1028191	hsa-miR-363	CLIP-seq
MIRT1028192	hsa-miR-367	CLIP-seq
MIRT1028193	hsa-miR-3929	CLIP-seq
MIRT1028194	hsa-miR-424	CLIP-seq
MIRT1028195	hsa-miR-4253	CLIP-seq
MIRT1028196	hsa-miR-4257	CLIP-seq
MIRT1028197	hsa-miR-4271	CLIP-seq
MIRT1028198	hsa-miR-4291	CLIP-seq
MIRT1028199	hsa-miR-4325	CLIP-seq
MIRT1028200	hsa-miR-4419b	CLIP-seq
MIRT1028201	hsa-miR-4478	CLIP-seq
MIRT1028202	hsa-miR-4494	CLIP-seq
MIRT1028203	hsa-miR-4537	CLIP-seq
MIRT1028204	hsa-miR-4649-3p	CLIP-seq
MIRT1028205	hsa-miR-4667-5p	CLIP-seq
MIRT1028206	hsa-miR-4700-5p	CLIP-seq
MIRT1028207	hsa-miR-4710	CLIP-seq
MIRT1028208	hsa-miR-4722-5p	CLIP-seq
MIRT1028209	hsa-miR-4725-3p	CLIP-seq
MIRT1028210	hsa-miR-4726-3p	CLIP-seq
MIRT1028211	hsa-miR-4768-3p	CLIP-seq
MIRT1028212	hsa-miR-4771	CLIP-seq
MIRT1028213	hsa-miR-4780	CLIP-seq
MIRT1028214	hsa-miR-4792	CLIP-seq
MIRT1028215	hsa-miR-485-5p	CLIP-seq
MIRT1028216	hsa-miR-486-3p	CLIP-seq
MIRT1028217	hsa-miR-497	CLIP-seq
MIRT1028218	hsa-miR-499a-5p	CLIP-seq
MIRT1028219	hsa-miR-508-5p	CLIP-seq
MIRT1028220	hsa-miR-623	CLIP-seq
MIRT1028221	hsa-miR-761	CLIP-seq
MIRT1028222	hsa-miR-766	CLIP-seq
MIRT1028223	hsa-miR-922	CLIP-seq
MIRT1028224	hsa-miR-92a	CLIP-seq
MIRT1028225	hsa-miR-92b	CLIP-seq
MIRT1028226	hsa-miR-939	CLIP-seq
MIRT1028227	hsa-miR-940	CLIP-seq
MIRT2005000	hsa-miR-4307	CLIP-seq
MIRT2237691	hsa-miR-1268	CLIP-seq
MIRT2237692	hsa-miR-1268b	CLIP-seq
MIRT2237693	hsa-miR-1285	CLIP-seq
MIRT1028180	hsa-miR-1827	CLIP-seq
MIRT1028181	hsa-miR-188-5p	CLIP-seq
MIRT1028184	hsa-miR-25	CLIP-seq
MIRT1028186	hsa-miR-3150a-3p	CLIP-seq
MIRT2237694	hsa-miR-3151	CLIP-seq
MIRT1028187	hsa-miR-3175	CLIP-seq
MIRT2237695	hsa-miR-3187-5p	CLIP-seq
MIRT1028188	hsa-miR-32	CLIP-seq
MIRT1028191	hsa-miR-363	CLIP-seq
MIRT1028192	hsa-miR-367	CLIP-seq
MIRT1028193	hsa-miR-3929	CLIP-seq
MIRT1028195	hsa-miR-4253	CLIP-seq
MIRT1028199	hsa-miR-4325	CLIP-seq
MIRT1028200	hsa-miR-4419b	CLIP-seq
MIRT2237696	hsa-miR-4476	CLIP-seq
MIRT1028201	hsa-miR-4478	CLIP-seq
MIRT1028203	hsa-miR-4537	CLIP-seq
MIRT1028204	hsa-miR-4649-3p	CLIP-seq
MIRT1028205	hsa-miR-4667-5p	CLIP-seq
MIRT1028206	hsa-miR-4700-5p	CLIP-seq
MIRT1028207	hsa-miR-4710	CLIP-seq
MIRT1028208	hsa-miR-4722-5p	CLIP-seq
MIRT1028211	hsa-miR-4768-3p	CLIP-seq
MIRT1028214	hsa-miR-4792	CLIP-seq
MIRT1028215	hsa-miR-485-5p	CLIP-seq
MIRT1028216	hsa-miR-486-3p	CLIP-seq
MIRT1028218	hsa-miR-499a-5p	CLIP-seq
MIRT1028219	hsa-miR-508-5p	CLIP-seq
MIRT2237697	hsa-miR-541	CLIP-seq
MIRT2237698	hsa-miR-612	CLIP-seq
MIRT2237699	hsa-miR-654-5p	CLIP-seq
MIRT2237700	hsa-miR-661	CLIP-seq
MIRT1028222	hsa-miR-766	CLIP-seq
MIRT1028224	hsa-miR-92a	CLIP-seq
MIRT1028225	hsa-miR-92b	CLIP-seq
MIRT1028226	hsa-miR-939	CLIP-seq
MIRT1028227	hsa-miR-940	CLIP-seq
MIRT2237691	hsa-miR-1268	CLIP-seq
MIRT2237692	hsa-miR-1268b	CLIP-seq
MIRT1028180	hsa-miR-1827	CLIP-seq
MIRT1028186	hsa-miR-3150a-3p	CLIP-seq
MIRT1028187	hsa-miR-3175	CLIP-seq
MIRT1028162	hsa-miR-3926	CLIP-seq
MIRT1028193	hsa-miR-3929	CLIP-seq
MIRT1028195	hsa-miR-4253	CLIP-seq
MIRT1028200	hsa-miR-4419b	CLIP-seq
MIRT1028164	hsa-miR-4434	CLIP-seq
MIRT1028201	hsa-miR-4478	CLIP-seq
MIRT2450527	hsa-miR-4486	CLIP-seq
MIRT1028167	hsa-miR-4516	CLIP-seq
MIRT1028169	hsa-miR-4531	CLIP-seq
MIRT1028204	hsa-miR-4649-3p	CLIP-seq
MIRT1028205	hsa-miR-4667-5p	CLIP-seq
MIRT2450528	hsa-miR-4684-5p	CLIP-seq
MIRT1028206	hsa-miR-4700-5p	CLIP-seq
MIRT1028208	hsa-miR-4722-5p	CLIP-seq
MIRT1028211	hsa-miR-4768-3p	CLIP-seq
MIRT1028173	hsa-miR-4802-3p	CLIP-seq
MIRT1028215	hsa-miR-485-5p	CLIP-seq
MIRT1028216	hsa-miR-486-3p	CLIP-seq
MIRT2450529	hsa-miR-548c-3p	CLIP-seq
MIRT1028174	hsa-miR-548s	CLIP-seq
MIRT2450530	hsa-miR-585	CLIP-seq
MIRT1028226	hsa-miR-939	CLIP-seq
MIRT1028227	hsa-miR-940	CLIP-seq
MIRT2237691	hsa-miR-1268	CLIP-seq
MIRT2237692	hsa-miR-1268b	CLIP-seq
MIRT2237693	hsa-miR-1285	CLIP-seq
MIRT1028180	hsa-miR-1827	CLIP-seq
MIRT1028181	hsa-miR-188-5p	CLIP-seq
MIRT2541703	hsa-miR-217	CLIP-seq
MIRT1028184	hsa-miR-25	CLIP-seq
MIRT1028186	hsa-miR-3150a-3p	CLIP-seq
MIRT2237694	hsa-miR-3151	CLIP-seq
MIRT1028187	hsa-miR-3175	CLIP-seq
MIRT2237695	hsa-miR-3187-5p	CLIP-seq
MIRT1028188	hsa-miR-32	CLIP-seq
MIRT2541704	hsa-miR-3613-3p	CLIP-seq
MIRT1028191	hsa-miR-363	CLIP-seq
MIRT1028192	hsa-miR-367	CLIP-seq
MIRT2541705	hsa-miR-371-5p	CLIP-seq
MIRT2541706	hsa-miR-371b-5p	CLIP-seq
MIRT1028162	hsa-miR-3926	CLIP-seq
MIRT1028193	hsa-miR-3929	CLIP-seq
MIRT1028195	hsa-miR-4253	CLIP-seq
MIRT1028199	hsa-miR-4325	CLIP-seq
MIRT1028200	hsa-miR-4419b	CLIP-seq
MIRT1028164	hsa-miR-4434	CLIP-seq
MIRT1028201	hsa-miR-4478	CLIP-seq
MIRT2450527	hsa-miR-4486	CLIP-seq
MIRT1028167	hsa-miR-4516	CLIP-seq
MIRT1028169	hsa-miR-4531	CLIP-seq
MIRT1028204	hsa-miR-4649-3p	CLIP-seq
MIRT1028205	hsa-miR-4667-5p	CLIP-seq
MIRT2450528	hsa-miR-4684-5p	CLIP-seq
MIRT1028206	hsa-miR-4700-5p	CLIP-seq
MIRT1028208	hsa-miR-4722-5p	CLIP-seq
MIRT2541707	hsa-miR-4738-3p	CLIP-seq
MIRT1028211	hsa-miR-4768-3p	CLIP-seq
MIRT1028213	hsa-miR-4780	CLIP-seq
MIRT1028173	hsa-miR-4802-3p	CLIP-seq
MIRT1028215	hsa-miR-485-5p	CLIP-seq
MIRT1028216	hsa-miR-486-3p	CLIP-seq
MIRT1028219	hsa-miR-508-5p	CLIP-seq
MIRT2237697	hsa-miR-541	CLIP-seq
MIRT2450529	hsa-miR-548c-3p	CLIP-seq
MIRT1028174	hsa-miR-548s	CLIP-seq
MIRT2450530	hsa-miR-585	CLIP-seq
MIRT2237698	hsa-miR-612	CLIP-seq
MIRT1028220	hsa-miR-623	CLIP-seq
MIRT2237699	hsa-miR-654-5p	CLIP-seq
MIRT2237700	hsa-miR-661	CLIP-seq
MIRT1028222	hsa-miR-766	CLIP-seq
MIRT1028224	hsa-miR-92a	CLIP-seq
MIRT1028225	hsa-miR-92b	CLIP-seq
MIRT1028226	hsa-miR-939	CLIP-seq
MIRT1028227	hsa-miR-940	CLIP-seq
MIRT2237691	hsa-miR-1268	CLIP-seq
MIRT2237692	hsa-miR-1268b	CLIP-seq
MIRT1028180	hsa-miR-1827	CLIP-seq
MIRT1028186	hsa-miR-3150a-3p	CLIP-seq
MIRT2237694	hsa-miR-3151	CLIP-seq
MIRT1028187	hsa-miR-3175	CLIP-seq
MIRT1028162	hsa-miR-3926	CLIP-seq
MIRT1028193	hsa-miR-3929	CLIP-seq
MIRT1028195	hsa-miR-4253	CLIP-seq
MIRT1028200	hsa-miR-4419b	CLIP-seq
MIRT1028164	hsa-miR-4434	CLIP-seq
MIRT1028201	hsa-miR-4478	CLIP-seq
MIRT2450527	hsa-miR-4486	CLIP-seq
MIRT1028167	hsa-miR-4516	CLIP-seq
MIRT1028169	hsa-miR-4531	CLIP-seq
MIRT1028204	hsa-miR-4649-3p	CLIP-seq
MIRT1028205	hsa-miR-4667-5p	CLIP-seq
MIRT2450528	hsa-miR-4684-5p	CLIP-seq
MIRT1028206	hsa-miR-4700-5p	CLIP-seq
MIRT1028208	hsa-miR-4722-5p	CLIP-seq
MIRT1028211	hsa-miR-4768-3p	CLIP-seq
MIRT1028173	hsa-miR-4802-3p	CLIP-seq
MIRT1028215	hsa-miR-485-5p	CLIP-seq
MIRT1028216	hsa-miR-486-3p	CLIP-seq
MIRT2237697	hsa-miR-541	CLIP-seq
MIRT2450529	hsa-miR-548c-3p	CLIP-seq
MIRT1028174	hsa-miR-548s	CLIP-seq
MIRT2450530	hsa-miR-585	CLIP-seq
MIRT2237699	hsa-miR-654-5p	CLIP-seq
MIRT1028226	hsa-miR-939	CLIP-seq
MIRT1028227	hsa-miR-940	CLIP-seq

Show/Hide all (2)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0005515	Function	Protein binding	IPI	21516116, 25416956, 28514442, 31515488, 32296183, 32814053, 33961781

MIM	HGNC	e!Ensembl
142610	13920	ENSG00000204438

O95872

Protein name

G patch domain and ankyrin repeat-containing protein 1 (Ankyrin repeat domain-containing protein 59) (G patch domain-containing protein 10) (HLA-B-associated transcript 4) (Protein G5)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13637	Ank_4	104 → 163		Repeat
PF01585	G-patch	255 → 299	G-patch domain	Family

Sequence

MSRPLLITFTPATDPSDLWKDGQQQPQPEKPESTLDGAAARAFYEALIGDESSAPDSQRS
QTEPARERKRKKRRIMKAPAAEAVAEGASGRHGQGRSLEAEDKMTHRILRAAQEGDLPEL
RRLLEPHEAGGAGGNINARDAFWWTPLMCAARAGQGAAVSYLLGRGAAWVGVCELSGRDA
AQLAEEAGFPEVARMVRESHGETRSPENRSPTPSLQYCENCDTHFQDSNHRTSTAHLLSL
SQGPQPPNLPLGVPISSPGFKLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGYRS
APQPRVTHFPAWDTRAVAGRERPPRVATLSWREERRREEKDRAWERDLRTYMNLEF

Sequence length

356

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTHYROIDISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MEMBRANOUS GLOMERULONEPHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Celiac Disease	Celiac disease	Pubtator	28282431	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	GWASDB_DG	17632545		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	GWASDB_DG	24871463		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Follicular	Lymphoma	BEFREE	21148756		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin	Non-Hodgkin lymphoma	BEFREE	21148756, 28282431		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin, Familial	Lymphoma	BEFREE	28282431		★★★★★ ★☆☆☆☆ Found in Text Mining only
Membranous glomerulonephritis	Membranous Glomerulonephritis	GWASCAT_DG	21323541		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myasthenia Gravis	Myasthenia Gravis	GWASDB_DG	23055271		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	GWASDB_DG	17804836, 19503088, 21156761		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma Kaposi	Sarcoma	Pubtator	25008864	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GPANK1 (G-patch domain and ankyrin repeats 1)