NOL12 (nucleolar protein 12)

Gene

• Entrez ID: 79159
• Gene name: Nucleolar protein 12
• Gene symbol: NOL12
• Synonyms (NCBI Gene): Nop25, dJ37E16.7
• Chromosome: 22
• Chromosome location: 22q13.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024790	hsa-miR-215-5p	Microarray	19074876
MIRT050280	hsa-miR-25-3p	CLASH	23622248
MIRT044142	hsa-miR-30e-5p	CLASH	23622248
MIRT042852	hsa-miR-324-3p	CLASH	23622248
MIRT1188468	hsa-miR-1184	CLIP-seq
MIRT1188469	hsa-miR-122	CLIP-seq
MIRT1188470	hsa-miR-1281	CLIP-seq
MIRT1188471	hsa-miR-1287	CLIP-seq
MIRT1188472	hsa-miR-1307	CLIP-seq
MIRT1188473	hsa-miR-130a	CLIP-seq
MIRT1188474	hsa-miR-130b	CLIP-seq
MIRT1188475	hsa-miR-15a	CLIP-seq
MIRT1188476	hsa-miR-15b	CLIP-seq
MIRT1188477	hsa-miR-16	CLIP-seq
MIRT1188478	hsa-miR-195	CLIP-seq
MIRT1188479	hsa-miR-200b	CLIP-seq
MIRT1188480	hsa-miR-200c	CLIP-seq
MIRT1188481	hsa-miR-2052	CLIP-seq
MIRT1188482	hsa-miR-214	CLIP-seq
MIRT1188483	hsa-miR-2278	CLIP-seq
MIRT1188484	hsa-miR-301a	CLIP-seq
MIRT1188485	hsa-miR-301b	CLIP-seq
MIRT1188486	hsa-miR-30a	CLIP-seq
MIRT1188487	hsa-miR-30b	CLIP-seq
MIRT1188488	hsa-miR-30c	CLIP-seq
MIRT1188489	hsa-miR-30d	CLIP-seq
MIRT1188490	hsa-miR-30e	CLIP-seq
MIRT1188491	hsa-miR-3135b	CLIP-seq
MIRT1188492	hsa-miR-361-3p	CLIP-seq
MIRT1188493	hsa-miR-3619-5p	CLIP-seq
MIRT1188494	hsa-miR-3622b-5p	CLIP-seq
MIRT1188495	hsa-miR-3652	CLIP-seq
MIRT1188496	hsa-miR-3661	CLIP-seq
MIRT1188497	hsa-miR-3663-5p	CLIP-seq
MIRT1188498	hsa-miR-3665	CLIP-seq
MIRT1188499	hsa-miR-3666	CLIP-seq
MIRT1188500	hsa-miR-374c	CLIP-seq
MIRT1188501	hsa-miR-3940-3p	CLIP-seq
MIRT1188502	hsa-miR-3942-3p	CLIP-seq
MIRT1188503	hsa-miR-424	CLIP-seq
MIRT1188504	hsa-miR-4253	CLIP-seq
MIRT1188505	hsa-miR-4284	CLIP-seq
MIRT1188506	hsa-miR-429	CLIP-seq
MIRT1188507	hsa-miR-4295	CLIP-seq
MIRT1188508	hsa-miR-4417	CLIP-seq
MIRT1188509	hsa-miR-4418	CLIP-seq
MIRT1188510	hsa-miR-4430	CLIP-seq
MIRT1188511	hsa-miR-4435	CLIP-seq
MIRT1188512	hsa-miR-4437	CLIP-seq
MIRT1188513	hsa-miR-4438	CLIP-seq
MIRT1188514	hsa-miR-4490	CLIP-seq
MIRT1188515	hsa-miR-4525	CLIP-seq
MIRT1188516	hsa-miR-454	CLIP-seq
MIRT1188517	hsa-miR-4638-5p	CLIP-seq
MIRT1188518	hsa-miR-4674	CLIP-seq
MIRT1188519	hsa-miR-4685-5p	CLIP-seq
MIRT1188520	hsa-miR-4695-3p	CLIP-seq
MIRT1188521	hsa-miR-4755-3p	CLIP-seq
MIRT1188522	hsa-miR-4761-3p	CLIP-seq
MIRT1188523	hsa-miR-4772-3p	CLIP-seq
MIRT1188524	hsa-miR-497	CLIP-seq
MIRT1188525	hsa-miR-509-3-5p	CLIP-seq
MIRT1188526	hsa-miR-5095	CLIP-seq
MIRT1188527	hsa-miR-509-5p	CLIP-seq
MIRT1188528	hsa-miR-516a-5p	CLIP-seq
MIRT1188529	hsa-miR-541	CLIP-seq
MIRT1188530	hsa-miR-580	CLIP-seq
MIRT1188531	hsa-miR-629	CLIP-seq
MIRT1188532	hsa-miR-631	CLIP-seq
MIRT1188533	hsa-miR-654-5p	CLIP-seq
MIRT1188534	hsa-miR-655	CLIP-seq
MIRT1188535	hsa-miR-760	CLIP-seq
MIRT1188536	hsa-miR-761	CLIP-seq
MIRT2054568	hsa-miR-1178	CLIP-seq
MIRT2054569	hsa-miR-1207-3p	CLIP-seq
MIRT1188470	hsa-miR-1281	CLIP-seq
MIRT2054570	hsa-miR-1297	CLIP-seq
MIRT1188483	hsa-miR-2278	CLIP-seq
MIRT2054571	hsa-miR-26a	CLIP-seq
MIRT2054572	hsa-miR-26b	CLIP-seq
MIRT2054573	hsa-miR-3074-5p	CLIP-seq
MIRT1188498	hsa-miR-3665	CLIP-seq
MIRT2054574	hsa-miR-370	CLIP-seq
MIRT2054575	hsa-miR-4326	CLIP-seq
MIRT2054576	hsa-miR-4465	CLIP-seq
MIRT1188519	hsa-miR-4685-5p	CLIP-seq
MIRT2054577	hsa-miR-512-5p	CLIP-seq
MIRT2054578	hsa-miR-668	CLIP-seq
MIRT2054579	hsa-miR-767-3p	CLIP-seq
MIRT1188468	hsa-miR-1184	CLIP-seq
MIRT2283705	hsa-miR-1258	CLIP-seq
MIRT1188470	hsa-miR-1281	CLIP-seq
MIRT2283706	hsa-miR-1289	CLIP-seq
MIRT2283707	hsa-miR-129-5p	CLIP-seq
MIRT1188472	hsa-miR-1307	CLIP-seq
MIRT2283708	hsa-miR-137	CLIP-seq
MIRT2283709	hsa-miR-146a	CLIP-seq
MIRT2283710	hsa-miR-146b-5p	CLIP-seq
MIRT2283711	hsa-miR-150	CLIP-seq
MIRT2283712	hsa-miR-25	CLIP-seq
MIRT2283713	hsa-miR-3187-3p	CLIP-seq
MIRT2283714	hsa-miR-3198	CLIP-seq
MIRT2283715	hsa-miR-32	CLIP-seq
MIRT2283716	hsa-miR-33a	CLIP-seq
MIRT2283717	hsa-miR-33b	CLIP-seq
MIRT2283718	hsa-miR-363	CLIP-seq
MIRT2283719	hsa-miR-367	CLIP-seq
MIRT2283720	hsa-miR-4270	CLIP-seq
MIRT1188505	hsa-miR-4284	CLIP-seq
MIRT2283721	hsa-miR-4294	CLIP-seq
MIRT2283722	hsa-miR-4309	CLIP-seq
MIRT1188509	hsa-miR-4418	CLIP-seq
MIRT2283723	hsa-miR-4441	CLIP-seq
MIRT2283724	hsa-miR-450b-5p	CLIP-seq
MIRT1188517	hsa-miR-4638-5p	CLIP-seq
MIRT2283725	hsa-miR-4661-3p	CLIP-seq
MIRT1188519	hsa-miR-4685-5p	CLIP-seq
MIRT1188520	hsa-miR-4695-3p	CLIP-seq
MIRT2283726	hsa-miR-4715-3p	CLIP-seq
MIRT2283727	hsa-miR-507	CLIP-seq
MIRT1188525	hsa-miR-509-3-5p	CLIP-seq
MIRT1188527	hsa-miR-509-5p	CLIP-seq
MIRT2283728	hsa-miR-557	CLIP-seq
MIRT2283729	hsa-miR-562	CLIP-seq
MIRT2283730	hsa-miR-651	CLIP-seq
MIRT2283731	hsa-miR-92a	CLIP-seq
MIRT2283732	hsa-miR-92b	CLIP-seq
MIRT1188468	hsa-miR-1184	CLIP-seq
MIRT2581862	hsa-miR-1228	CLIP-seq
MIRT1188470	hsa-miR-1281	CLIP-seq
MIRT2283707	hsa-miR-129-5p	CLIP-seq
MIRT2054570	hsa-miR-1297	CLIP-seq
MIRT1188472	hsa-miR-1307	CLIP-seq
MIRT2054571	hsa-miR-26a	CLIP-seq
MIRT2054572	hsa-miR-26b	CLIP-seq
MIRT2283716	hsa-miR-33a	CLIP-seq
MIRT2283717	hsa-miR-33b	CLIP-seq
MIRT1188505	hsa-miR-4284	CLIP-seq
MIRT1188509	hsa-miR-4418	CLIP-seq
MIRT2054576	hsa-miR-4465	CLIP-seq
MIRT2283724	hsa-miR-450b-5p	CLIP-seq
MIRT1188517	hsa-miR-4638-5p	CLIP-seq
MIRT1188519	hsa-miR-4685-5p	CLIP-seq
MIRT1188520	hsa-miR-4695-3p	CLIP-seq
MIRT2283726	hsa-miR-4715-3p	CLIP-seq
MIRT2581863	hsa-miR-4735-5p	CLIP-seq
MIRT2581864	hsa-miR-4775	CLIP-seq
MIRT2581865	hsa-miR-4794	CLIP-seq
MIRT2283727	hsa-miR-507	CLIP-seq
MIRT1188525	hsa-miR-509-3-5p	CLIP-seq
MIRT1188527	hsa-miR-509-5p	CLIP-seq
MIRT2283728	hsa-miR-557	CLIP-seq
MIRT2581866	hsa-miR-590-3p	CLIP-seq
MIRT1188468	hsa-miR-1184	CLIP-seq
MIRT2581862	hsa-miR-1228	CLIP-seq
MIRT1188470	hsa-miR-1281	CLIP-seq
MIRT2283707	hsa-miR-129-5p	CLIP-seq
MIRT2054570	hsa-miR-1297	CLIP-seq
MIRT1188472	hsa-miR-1307	CLIP-seq
MIRT2054571	hsa-miR-26a	CLIP-seq
MIRT2054572	hsa-miR-26b	CLIP-seq
MIRT2283716	hsa-miR-33a	CLIP-seq
MIRT2283717	hsa-miR-33b	CLIP-seq
MIRT1188505	hsa-miR-4284	CLIP-seq
MIRT1188509	hsa-miR-4418	CLIP-seq
MIRT2054576	hsa-miR-4465	CLIP-seq
MIRT2283724	hsa-miR-450b-5p	CLIP-seq
MIRT1188517	hsa-miR-4638-5p	CLIP-seq
MIRT1188519	hsa-miR-4685-5p	CLIP-seq
MIRT1188520	hsa-miR-4695-3p	CLIP-seq
MIRT2283726	hsa-miR-4715-3p	CLIP-seq
MIRT2581863	hsa-miR-4735-5p	CLIP-seq
MIRT2581864	hsa-miR-4775	CLIP-seq
MIRT2581865	hsa-miR-4794	CLIP-seq
MIRT2283727	hsa-miR-507	CLIP-seq
MIRT1188525	hsa-miR-509-3-5p	CLIP-seq
MIRT1188527	hsa-miR-509-5p	CLIP-seq
MIRT2283728	hsa-miR-557	CLIP-seq
MIRT2581866	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003697	Function	Single-stranded DNA binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	21044950, 25416956, 31515488, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0019843	Function	RRNA binding	IBA
GO:0019843	Function	RRNA binding	IEA
GO:0042802	Function	Identical protein binding	IPI	32296183

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9UGY1
• Protein name: Nucleolar protein 12
• Protein function: Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults (PubMed:29069457). Also plays
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09805	Nop25	5 → 148	Nucleolar protein 12 (25kDa)	Family

• Sequence:

  MGRNKKKKRDGDDRRPRLVLSFDEEKRREYLTGFHKRKVERKKAAIEEIKQRLKEEQRKL
  REERHQEYLKMLAEREEALEEADELDRLVTAKTESVQYDHPNHTVTVTTISDLDLSGARL
  LGLTPPEGGAGDRSEEEASSTEKPTKALPRKSRDPLLSQRISSLTASLHAHSRKKVKRKH
  PRRAQDSKKPPRAPRTSKAQRRRLTGKARHSGE

• Sequence length: 213

Pathways

Reactome:

Major pathway of rRNA processing in the nucleolus and cytosol

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATRIAL FIBRILLATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35693698	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	33229623	Associate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	35693698	Stimulate	★☆☆☆☆ Found in Text Mining only