CHCHD7 (coiled-coil-helix-coiled-coil-helix domain containing 7)

Gene

• Entrez ID: 79145
• Gene name: Coiled-coil-helix-coiled-coil-helix domain containing 7
• Gene symbol: CHCHD7
• Synonyms (NCBI Gene): COX23
• Chromosome: 8
• Chromosome location: 8q12.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023163	hsa-miR-124-3p	Microarray	18668037
MIRT643034	hsa-miR-4282	HITS-CLIP	23824327
MIRT643033	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT643032	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT643031	hsa-miR-302b-5p	HITS-CLIP	23824327
MIRT643030	hsa-miR-302d-5p	HITS-CLIP	23824327
MIRT643029	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT643034	hsa-miR-4282	HITS-CLIP	23824327
MIRT643033	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT643032	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT643031	hsa-miR-302b-5p	HITS-CLIP	23824327
MIRT643030	hsa-miR-302d-5p	HITS-CLIP	23824327
MIRT643029	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT172871	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT172872	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT172873	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT172880	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT643034	hsa-miR-4282	HITS-CLIP	23824327
MIRT643033	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT643032	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT643031	hsa-miR-302b-5p	HITS-CLIP	23824327
MIRT643030	hsa-miR-302d-5p	HITS-CLIP	23824327
MIRT643029	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT643034	hsa-miR-4282	HITS-CLIP	23824327
MIRT643033	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT643032	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT643031	hsa-miR-302b-5p	HITS-CLIP	23824327
MIRT643030	hsa-miR-302d-5p	HITS-CLIP	23824327
MIRT643029	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT888731	hsa-miR-1231	CLIP-seq
MIRT888732	hsa-miR-1262	CLIP-seq
MIRT888733	hsa-miR-3120-5p	CLIP-seq
MIRT888734	hsa-miR-3177-5p	CLIP-seq
MIRT888735	hsa-miR-3184	CLIP-seq
MIRT888736	hsa-miR-423-5p	CLIP-seq
MIRT888737	hsa-miR-4701-3p	CLIP-seq
MIRT888738	hsa-miR-4710	CLIP-seq
MIRT1963396	hsa-miR-513a-3p	CLIP-seq
MIRT2446981	hsa-miR-1224-3p	CLIP-seq
MIRT2446982	hsa-miR-1260	CLIP-seq
MIRT2446983	hsa-miR-1260b	CLIP-seq
MIRT2446984	hsa-miR-1280	CLIP-seq
MIRT2446985	hsa-miR-3622a-3p	CLIP-seq
MIRT2446986	hsa-miR-3622b-3p	CLIP-seq
MIRT2446987	hsa-miR-4324	CLIP-seq
MIRT2502487	hsa-miR-1178	CLIP-seq
MIRT2502488	hsa-miR-1245b-3p	CLIP-seq
MIRT2502489	hsa-miR-1290	CLIP-seq
MIRT2502490	hsa-miR-1297	CLIP-seq
MIRT2502491	hsa-miR-1298	CLIP-seq
MIRT2502492	hsa-miR-1305	CLIP-seq
MIRT2502493	hsa-miR-1323	CLIP-seq
MIRT2502494	hsa-miR-186	CLIP-seq
MIRT2502495	hsa-miR-205	CLIP-seq
MIRT2502496	hsa-miR-2116	CLIP-seq
MIRT2502497	hsa-miR-23a	CLIP-seq
MIRT2502498	hsa-miR-23b	CLIP-seq
MIRT2502499	hsa-miR-23c	CLIP-seq
MIRT2502500	hsa-miR-26a	CLIP-seq
MIRT2502501	hsa-miR-26b	CLIP-seq
MIRT2502502	hsa-miR-298	CLIP-seq
MIRT2502503	hsa-miR-3121-3p	CLIP-seq
MIRT2502504	hsa-miR-3124-3p	CLIP-seq
MIRT2502505	hsa-miR-3129-3p	CLIP-seq
MIRT2502506	hsa-miR-3130-5p	CLIP-seq
MIRT2502507	hsa-miR-3133	CLIP-seq
MIRT2502508	hsa-miR-3143	CLIP-seq
MIRT2502509	hsa-miR-3148	CLIP-seq
MIRT2502510	hsa-miR-3154	CLIP-seq
MIRT2502511	hsa-miR-3158-5p	CLIP-seq
MIRT2502512	hsa-miR-3189-3p	CLIP-seq
MIRT2502513	hsa-miR-3189-5p	CLIP-seq
MIRT2502514	hsa-miR-34b	CLIP-seq
MIRT2502515	hsa-miR-3682-5p	CLIP-seq
MIRT2502516	hsa-miR-3908	CLIP-seq
MIRT2502517	hsa-miR-3978	CLIP-seq
MIRT2502518	hsa-miR-4261	CLIP-seq
MIRT2502519	hsa-miR-4263	CLIP-seq
MIRT2502520	hsa-miR-4277	CLIP-seq
MIRT2502521	hsa-miR-4289	CLIP-seq
MIRT2502522	hsa-miR-4297	CLIP-seq
MIRT2502523	hsa-miR-4307	CLIP-seq
MIRT2502524	hsa-miR-4317	CLIP-seq
MIRT2502525	hsa-miR-4323	CLIP-seq
MIRT2502526	hsa-miR-4432	CLIP-seq
MIRT2502527	hsa-miR-4446-5p	CLIP-seq
MIRT2502528	hsa-miR-4465	CLIP-seq
MIRT2502529	hsa-miR-4475	CLIP-seq
MIRT2502530	hsa-miR-4477b	CLIP-seq
MIRT2502531	hsa-miR-4482	CLIP-seq
MIRT2502532	hsa-miR-4521	CLIP-seq
MIRT2502533	hsa-miR-4643	CLIP-seq
MIRT2502534	hsa-miR-4659a-3p	CLIP-seq
MIRT2502535	hsa-miR-4659b-3p	CLIP-seq
MIRT2502536	hsa-miR-466	CLIP-seq
MIRT2502537	hsa-miR-4677-5p	CLIP-seq
MIRT2502538	hsa-miR-4690-3p	CLIP-seq
MIRT2502539	hsa-miR-4709-3p	CLIP-seq
MIRT2502540	hsa-miR-4725-5p	CLIP-seq
MIRT2502541	hsa-miR-4729	CLIP-seq
MIRT2502542	hsa-miR-4755-5p	CLIP-seq
MIRT2502543	hsa-miR-4778-3p	CLIP-seq
MIRT2502544	hsa-miR-4789-3p	CLIP-seq
MIRT2502545	hsa-miR-4793-5p	CLIP-seq
MIRT2502546	hsa-miR-486-5p	CLIP-seq
MIRT2502547	hsa-miR-487a	CLIP-seq
MIRT2502548	hsa-miR-494	CLIP-seq
MIRT2502549	hsa-miR-498	CLIP-seq
MIRT2502550	hsa-miR-499-5p	CLIP-seq
MIRT2502551	hsa-miR-502-5p	CLIP-seq
MIRT2502552	hsa-miR-504	CLIP-seq
MIRT2502553	hsa-miR-511	CLIP-seq
MIRT1963396	hsa-miR-513a-3p	CLIP-seq
MIRT2502554	hsa-miR-526b	CLIP-seq
MIRT2502555	hsa-miR-543	CLIP-seq
MIRT2502556	hsa-miR-548ac	CLIP-seq
MIRT2502557	hsa-miR-548d-3p	CLIP-seq
MIRT2502558	hsa-miR-548o	CLIP-seq
MIRT2502559	hsa-miR-548z	CLIP-seq
MIRT2502560	hsa-miR-550b	CLIP-seq
MIRT2502561	hsa-miR-607	CLIP-seq
MIRT2502562	hsa-miR-616	CLIP-seq
MIRT2502563	hsa-miR-622	CLIP-seq
MIRT2502564	hsa-miR-633	CLIP-seq
MIRT2502565	hsa-miR-654-3p	CLIP-seq
MIRT2502566	hsa-miR-670	CLIP-seq
MIRT2502567	hsa-miR-885-5p	CLIP-seq
MIRT2502487	hsa-miR-1178	CLIP-seq
MIRT2502488	hsa-miR-1245b-3p	CLIP-seq
MIRT2502489	hsa-miR-1290	CLIP-seq
MIRT2502490	hsa-miR-1297	CLIP-seq
MIRT2502491	hsa-miR-1298	CLIP-seq
MIRT2502492	hsa-miR-1305	CLIP-seq
MIRT2502493	hsa-miR-1323	CLIP-seq
MIRT2502494	hsa-miR-186	CLIP-seq
MIRT2502495	hsa-miR-205	CLIP-seq
MIRT2502496	hsa-miR-2116	CLIP-seq
MIRT2502497	hsa-miR-23a	CLIP-seq
MIRT2502498	hsa-miR-23b	CLIP-seq
MIRT2502499	hsa-miR-23c	CLIP-seq
MIRT2502500	hsa-miR-26a	CLIP-seq
MIRT2502501	hsa-miR-26b	CLIP-seq
MIRT2502502	hsa-miR-298	CLIP-seq
MIRT2502503	hsa-miR-3121-3p	CLIP-seq
MIRT2502504	hsa-miR-3124-3p	CLIP-seq
MIRT2502505	hsa-miR-3129-3p	CLIP-seq
MIRT2502506	hsa-miR-3130-5p	CLIP-seq
MIRT2502507	hsa-miR-3133	CLIP-seq
MIRT2502508	hsa-miR-3143	CLIP-seq
MIRT2502509	hsa-miR-3148	CLIP-seq
MIRT2502510	hsa-miR-3154	CLIP-seq
MIRT2502511	hsa-miR-3158-5p	CLIP-seq
MIRT2502512	hsa-miR-3189-3p	CLIP-seq
MIRT2502513	hsa-miR-3189-5p	CLIP-seq
MIRT2502514	hsa-miR-34b	CLIP-seq
MIRT2502515	hsa-miR-3682-5p	CLIP-seq
MIRT2502516	hsa-miR-3908	CLIP-seq
MIRT2502517	hsa-miR-3978	CLIP-seq
MIRT2502518	hsa-miR-4261	CLIP-seq
MIRT2502519	hsa-miR-4263	CLIP-seq
MIRT2502520	hsa-miR-4277	CLIP-seq
MIRT2502521	hsa-miR-4289	CLIP-seq
MIRT2502522	hsa-miR-4297	CLIP-seq
MIRT2502523	hsa-miR-4307	CLIP-seq
MIRT2502524	hsa-miR-4317	CLIP-seq
MIRT2502525	hsa-miR-4323	CLIP-seq
MIRT2502526	hsa-miR-4432	CLIP-seq
MIRT2502527	hsa-miR-4446-5p	CLIP-seq
MIRT2502528	hsa-miR-4465	CLIP-seq
MIRT2502529	hsa-miR-4475	CLIP-seq
MIRT2502530	hsa-miR-4477b	CLIP-seq
MIRT2502531	hsa-miR-4482	CLIP-seq
MIRT2502532	hsa-miR-4521	CLIP-seq
MIRT2502533	hsa-miR-4643	CLIP-seq
MIRT2502534	hsa-miR-4659a-3p	CLIP-seq
MIRT2502535	hsa-miR-4659b-3p	CLIP-seq
MIRT2502536	hsa-miR-466	CLIP-seq
MIRT2502537	hsa-miR-4677-5p	CLIP-seq
MIRT2502538	hsa-miR-4690-3p	CLIP-seq
MIRT2678083	hsa-miR-4693-5p	CLIP-seq
MIRT2502539	hsa-miR-4709-3p	CLIP-seq
MIRT2502540	hsa-miR-4725-5p	CLIP-seq
MIRT2502542	hsa-miR-4755-5p	CLIP-seq
MIRT2502543	hsa-miR-4778-3p	CLIP-seq
MIRT2502544	hsa-miR-4789-3p	CLIP-seq
MIRT2502545	hsa-miR-4793-5p	CLIP-seq
MIRT2502546	hsa-miR-486-5p	CLIP-seq
MIRT2502547	hsa-miR-487a	CLIP-seq
MIRT2502548	hsa-miR-494	CLIP-seq
MIRT2502549	hsa-miR-498	CLIP-seq
MIRT2502550	hsa-miR-499-5p	CLIP-seq
MIRT2502551	hsa-miR-502-5p	CLIP-seq
MIRT2502552	hsa-miR-504	CLIP-seq
MIRT2502553	hsa-miR-511	CLIP-seq
MIRT1963396	hsa-miR-513a-3p	CLIP-seq
MIRT2502554	hsa-miR-526b	CLIP-seq
MIRT2502555	hsa-miR-543	CLIP-seq
MIRT2502558	hsa-miR-548o	CLIP-seq
MIRT2502560	hsa-miR-550b	CLIP-seq
MIRT2502561	hsa-miR-607	CLIP-seq
MIRT2502563	hsa-miR-622	CLIP-seq
MIRT2502566	hsa-miR-670	CLIP-seq
MIRT2502567	hsa-miR-885-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005758	Component	Mitochondrial intermembrane space	IEA
GO:0033108	Process	Mitochondrial respiratory chain complex assembly	IBA

Other IDs

• MIM: 611238
• HGNC: 28314
• e!Ensembl: ENSG00000170791

Protein

• UniProt ID: Q9BUK0
• Protein name: Coiled-coil-helix-coiled-coil-helix domain-containing protein 7
• PDB: 2LQT
• Sequence:

  MPSVTQRLRDPDINPCLSESDASTRCLDENNYDRERCSTYFLRYKNCRRFWNSIVMQRRK
  NGVKPFMPTAAERDEILRAVGNMPY

• Sequence length: 85

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CARCINOMA, BASAL CELL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CERVICAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CERVICAL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	24498085	Associate	★☆☆☆☆ Found in Text Mining only