CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1)

Gene

• Entrez ID: 79094
• Gene name: ChaC glutathione specific gamma-glutamylcyclotransferase 1
• Gene symbol: CHAC1
• Synonyms (NCBI Gene): -
• Chromosome: 15
• Chromosome location: 15q15.1
• Summary: This gene encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signa

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017672	hsa-miR-335-5p	Microarray	18185580
MIRT072103	hsa-miR-548at-5p	PAR-CLIP	20371350
MIRT072097	hsa-miR-561-3p	PAR-CLIP	20371350
MIRT548843	hsa-miR-5692a	PAR-CLIP	20371350
MIRT548842	hsa-miR-224-5p	PAR-CLIP	20371350
MIRT072095	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT072104	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT072105	hsa-miR-5697	PAR-CLIP	20371350
MIRT072094	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT140198	hsa-miR-6733-3p	PAR-CLIP	20371350
MIRT548841	hsa-miR-4302	PAR-CLIP	20371350
MIRT072102	hsa-miR-4697-3p	PAR-CLIP	20371350
MIRT072099	hsa-miR-1297	PAR-CLIP	20371350
MIRT072092	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT072093	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT072101	hsa-miR-4465	PAR-CLIP	20371350
MIRT072096	hsa-miR-498	PAR-CLIP	20371350
MIRT072103	hsa-miR-548at-5p	PAR-CLIP	21572407
MIRT072097	hsa-miR-561-3p	PAR-CLIP	21572407
MIRT548843	hsa-miR-5692a	PAR-CLIP	21572407
MIRT548842	hsa-miR-224-5p	PAR-CLIP	21572407
MIRT140196	hsa-miR-6165	PAR-CLIP	21572407
MIRT072095	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT072104	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT072105	hsa-miR-5697	PAR-CLIP	21572407
MIRT072094	hsa-miR-95-5p	PAR-CLIP	21572407
MIRT140198	hsa-miR-6733-3p	PAR-CLIP	21572407
MIRT548841	hsa-miR-4302	PAR-CLIP	21572407
MIRT140189	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT072102	hsa-miR-4697-3p	PAR-CLIP	21572407
MIRT072099	hsa-miR-1297	PAR-CLIP	21572407
MIRT072092	hsa-miR-26a-5p	PAR-CLIP	21572407
MIRT072093	hsa-miR-26b-5p	PAR-CLIP	21572407
MIRT072101	hsa-miR-4465	PAR-CLIP	21572407
MIRT072096	hsa-miR-498	PAR-CLIP	21572407
MIRT072103	hsa-miR-548at-5p	PAR-CLIP	21572407
MIRT072097	hsa-miR-561-3p	PAR-CLIP	21572407
MIRT548843	hsa-miR-5692a	PAR-CLIP	21572407
MIRT548842	hsa-miR-224-5p	PAR-CLIP	21572407
MIRT072095	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT072104	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT072105	hsa-miR-5697	PAR-CLIP	21572407
MIRT072094	hsa-miR-95-5p	PAR-CLIP	21572407
MIRT140198	hsa-miR-6733-3p	PAR-CLIP	21572407
MIRT548841	hsa-miR-4302	PAR-CLIP	21572407
MIRT072102	hsa-miR-4697-3p	PAR-CLIP	21572407
MIRT072099	hsa-miR-1297	PAR-CLIP	21572407
MIRT072092	hsa-miR-26a-5p	PAR-CLIP	21572407
MIRT072093	hsa-miR-26b-5p	PAR-CLIP	21572407
MIRT072101	hsa-miR-4465	PAR-CLIP	21572407
MIRT072096	hsa-miR-498	PAR-CLIP	21572407
MIRT114962	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT114925	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT114923	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT114924	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT114927	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT114929	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT114931	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT249859	hsa-miR-503-5p	PAR-CLIP	23592263
MIRT249860	hsa-miR-646	PAR-CLIP	23592263
MIRT249845	hsa-miR-383-3p	PAR-CLIP	23592263
MIRT114951	hsa-miR-6742-3p	PAR-CLIP	23592263
MIRT114955	hsa-miR-6776-5p	PAR-CLIP	23592263
MIRT114932	hsa-miR-661	PAR-CLIP	23592263
MIRT494244	hsa-miR-193b-5p	PAR-CLIP	23592263
MIRT114928	hsa-miR-363-5p	PAR-CLIP	23592263
MIRT114952	hsa-miR-6745	PAR-CLIP	23592263
MIRT114953	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT114954	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT114935	hsa-miR-1293	PAR-CLIP	23592263
MIRT114942	hsa-miR-4483	PAR-CLIP	23592263
MIRT494243	hsa-miR-3650	PAR-CLIP	23592263
MIRT114930	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT114936	hsa-miR-3151-5p	PAR-CLIP	23592263
MIRT114939	hsa-miR-4447	PAR-CLIP	23592263
MIRT114940	hsa-miR-4472	PAR-CLIP	23592263
MIRT114950	hsa-miR-6742-5p	PAR-CLIP	23592263
MIRT114943	hsa-miR-4524a-5p	PAR-CLIP	23592263
MIRT114946	hsa-miR-4524b-5p	PAR-CLIP	23592263
MIRT114937	hsa-miR-3170	PAR-CLIP	23592263
MIRT114965	hsa-miR-6855-5p	PAR-CLIP	23592263
MIRT114957	hsa-miR-6796-5p	PAR-CLIP	23592263
MIRT114933	hsa-miR-374b-3p	PAR-CLIP	23592263
MIRT494242	hsa-miR-3154	PAR-CLIP	23592263
MIRT494241	hsa-miR-4446-3p	PAR-CLIP	23592263
MIRT494240	hsa-miR-6784-5p	PAR-CLIP	23592263
MIRT494239	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT494238	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT494237	hsa-miR-4784	PAR-CLIP	23592263
MIRT494236	hsa-miR-4434	PAR-CLIP	23592263
MIRT494235	hsa-miR-4516	PAR-CLIP	23592263
MIRT494234	hsa-miR-5703	PAR-CLIP	23592263
MIRT494233	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT494232	hsa-miR-7154-3p	PAR-CLIP	23592263
MIRT494231	hsa-miR-765	PAR-CLIP	23592263
MIRT494230	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT494229	hsa-miR-4743-5p	PAR-CLIP	23592263
MIRT494228	hsa-miR-4492	PAR-CLIP	23592263
MIRT494227	hsa-miR-4498	PAR-CLIP	23592263
MIRT494225	hsa-miR-5001-5p	PAR-CLIP	23592263
MIRT494226	hsa-miR-762	PAR-CLIP	23592263
MIRT114969	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT281064	hsa-miR-4311	PAR-CLIP	23592263
MIRT479296	hsa-miR-7109-3p	PAR-CLIP	23592263
MIRT140195	hsa-miR-4524b-3p	PAR-CLIP	23592263
MIRT140199	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT140203	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT140178	hsa-miR-940	PAR-CLIP	23592263
MIRT140182	hsa-miR-1324	PAR-CLIP	23592263
MIRT140187	hsa-miR-4514	PAR-CLIP	23592263
MIRT140188	hsa-miR-4692	PAR-CLIP	23592263
MIRT140176	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT140185	hsa-miR-4251	PAR-CLIP	23592263
MIRT140202	hsa-miR-6868-5p	PAR-CLIP	23592263
MIRT140201	hsa-miR-6857-3p	PAR-CLIP	23592263
MIRT479295	hsa-miR-539-5p	PAR-CLIP	23592263
MIRT140183	hsa-miR-3166	PAR-CLIP	23592263
MIRT140190	hsa-miR-4740-5p	PAR-CLIP	23592263
MIRT140181	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT140192	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT140184	hsa-miR-3199	PAR-CLIP	23592263
MIRT140205	hsa-miR-8052	PAR-CLIP	23592263
MIRT479294	hsa-miR-132-3p	PAR-CLIP	23592263
MIRT479293	hsa-miR-212-3p	PAR-CLIP	23592263
MIRT405966	hsa-miR-144-3p	PAR-CLIP	23592263
MIRT479292	hsa-miR-4463	PAR-CLIP	23592263
MIRT479290	hsa-miR-6871-5p	PAR-CLIP	23592263
MIRT479291	hsa-miR-4494	PAR-CLIP	23592263
MIRT479289	hsa-miR-204-3p	PAR-CLIP	23592263
MIRT479288	hsa-miR-4646-5p	PAR-CLIP	23592263
MIRT249872	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT479287	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT479286	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT369094	hsa-miR-656-5p	PAR-CLIP	23592263
MIRT405967	hsa-miR-194-5p	PAR-CLIP	23592263
MIRT369102	hsa-miR-6501-5p	PAR-CLIP	23592263
MIRT479285	hsa-miR-1202	PAR-CLIP	23592263
MIRT479284	hsa-miR-3972	PAR-CLIP	23592263
MIRT369101	hsa-miR-5006-5p	PAR-CLIP	23592263
MIRT479283	hsa-miR-1302	PAR-CLIP	23592263
MIRT479282	hsa-miR-4298	PAR-CLIP	23592263
MIRT072092	hsa-miR-26a-5p	HITS-CLIP	22473208
MIRT072093	hsa-miR-26b-5p	HITS-CLIP	22473208
MIRT114923	hsa-miR-15a-5p	PAR-CLIP	26701625
MIRT114923	hsa-miR-15a-5p	PAR-CLIP	26701625
MIRT114923	hsa-miR-15a-5p	PAR-CLIP	26701625
MIRT114925	hsa-miR-15b-5p	PAR-CLIP	26701625
MIRT114925	hsa-miR-15b-5p	PAR-CLIP	26701625
MIRT114925	hsa-miR-15b-5p	PAR-CLIP	26701625
MIRT114924	hsa-miR-16-5p	PAR-CLIP	26701625
MIRT114924	hsa-miR-16-5p	PAR-CLIP	26701625
MIRT114924	hsa-miR-16-5p	PAR-CLIP	26701625
MIRT494244	hsa-miR-193b-5p	PAR-CLIP	26701625
MIRT114927	hsa-miR-195-5p	PAR-CLIP	26701625
MIRT114927	hsa-miR-195-5p	PAR-CLIP	26701625
MIRT114927	hsa-miR-195-5p	PAR-CLIP	26701625
MIRT114936	hsa-miR-3151-5p	PAR-CLIP	26701625
MIRT114937	hsa-miR-3170	PAR-CLIP	26701625
MIRT114933	hsa-miR-374b-3p	PAR-CLIP	26701625
MIRT114933	hsa-miR-374b-3p	PAR-CLIP	26701625
MIRT114933	hsa-miR-374b-3p	PAR-CLIP	26701625
MIRT249845	hsa-miR-383-3p	PAR-CLIP	26701625
MIRT249845	hsa-miR-383-3p	PAR-CLIP	26701625
MIRT249845	hsa-miR-383-3p	PAR-CLIP	26701625
MIRT114929	hsa-miR-424-5p	PAR-CLIP	26701625
MIRT114929	hsa-miR-424-5p	PAR-CLIP	26701625
MIRT114929	hsa-miR-424-5p	PAR-CLIP	26701625
MIRT114939	hsa-miR-4447	PAR-CLIP	26701625
MIRT114940	hsa-miR-4472	PAR-CLIP	26701625
MIRT114943	hsa-miR-4524a-5p	PAR-CLIP	26701625
MIRT114943	hsa-miR-4524a-5p	PAR-CLIP	26701625
MIRT114943	hsa-miR-4524a-5p	PAR-CLIP	26701625
MIRT114946	hsa-miR-4524b-5p	PAR-CLIP	26701625
MIRT114946	hsa-miR-4524b-5p	PAR-CLIP	26701625
MIRT114946	hsa-miR-4524b-5p	PAR-CLIP	26701625
MIRT114930	hsa-miR-491-5p	PAR-CLIP	26701625
MIRT114931	hsa-miR-497-5p	PAR-CLIP	26701625
MIRT114931	hsa-miR-497-5p	PAR-CLIP	26701625
MIRT114931	hsa-miR-497-5p	PAR-CLIP	26701625
MIRT249859	hsa-miR-503-5p	PAR-CLIP	26701625
MIRT249859	hsa-miR-503-5p	PAR-CLIP	26701625
MIRT249859	hsa-miR-503-5p	PAR-CLIP	26701625
MIRT249860	hsa-miR-646	PAR-CLIP	26701625
MIRT249860	hsa-miR-646	PAR-CLIP	26701625
MIRT249860	hsa-miR-646	PAR-CLIP	26701625
MIRT114950	hsa-miR-6742-5p	PAR-CLIP	26701625
MIRT114957	hsa-miR-6796-5p	PAR-CLIP	26701625
MIRT114962	hsa-miR-6838-5p	PAR-CLIP	26701625
MIRT114962	hsa-miR-6838-5p	PAR-CLIP	26701625
MIRT114962	hsa-miR-6838-5p	PAR-CLIP	26701625
MIRT114965	hsa-miR-6855-5p	PAR-CLIP	26701625
MIRT072103	hsa-miR-548at-5p	PAR-CLIP	20371350
MIRT072097	hsa-miR-561-3p	PAR-CLIP	20371350
MIRT548843	hsa-miR-5692a	PAR-CLIP	20371350
MIRT548842	hsa-miR-224-5p	PAR-CLIP	20371350
MIRT072095	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT072104	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT072105	hsa-miR-5697	PAR-CLIP	20371350
MIRT072094	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT140198	hsa-miR-6733-3p	PAR-CLIP	20371350
MIRT548841	hsa-miR-4302	PAR-CLIP	20371350
MIRT072102	hsa-miR-4697-3p	PAR-CLIP	20371350
MIRT072099	hsa-miR-1297	PAR-CLIP	20371350
MIRT072092	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT072093	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT072101	hsa-miR-4465	PAR-CLIP	20371350
MIRT072096	hsa-miR-498	PAR-CLIP	20371350
MIRT072103	hsa-miR-548at-5p	PAR-CLIP	21572407
MIRT072097	hsa-miR-561-3p	PAR-CLIP	21572407
MIRT548843	hsa-miR-5692a	PAR-CLIP	21572407
MIRT548842	hsa-miR-224-5p	PAR-CLIP	21572407
MIRT140196	hsa-miR-6165	PAR-CLIP	21572407
MIRT072095	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT072104	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT072105	hsa-miR-5697	PAR-CLIP	21572407
MIRT072094	hsa-miR-95-5p	PAR-CLIP	21572407
MIRT140198	hsa-miR-6733-3p	PAR-CLIP	21572407
MIRT548841	hsa-miR-4302	PAR-CLIP	21572407
MIRT140189	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT072102	hsa-miR-4697-3p	PAR-CLIP	21572407
MIRT072099	hsa-miR-1297	PAR-CLIP	21572407
MIRT072092	hsa-miR-26a-5p	PAR-CLIP	21572407
MIRT072093	hsa-miR-26b-5p	PAR-CLIP	21572407
MIRT072101	hsa-miR-4465	PAR-CLIP	21572407
MIRT072096	hsa-miR-498	PAR-CLIP	21572407
MIRT072103	hsa-miR-548at-5p	PAR-CLIP	21572407
MIRT072097	hsa-miR-561-3p	PAR-CLIP	21572407
MIRT548843	hsa-miR-5692a	PAR-CLIP	21572407
MIRT548842	hsa-miR-224-5p	PAR-CLIP	21572407
MIRT072095	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT072104	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT072105	hsa-miR-5697	PAR-CLIP	21572407
MIRT072094	hsa-miR-95-5p	PAR-CLIP	21572407
MIRT140198	hsa-miR-6733-3p	PAR-CLIP	21572407
MIRT548841	hsa-miR-4302	PAR-CLIP	21572407
MIRT072102	hsa-miR-4697-3p	PAR-CLIP	21572407
MIRT072099	hsa-miR-1297	PAR-CLIP	21572407
MIRT072092	hsa-miR-26a-5p	PAR-CLIP	21572407
MIRT072093	hsa-miR-26b-5p	PAR-CLIP	21572407
MIRT072101	hsa-miR-4465	PAR-CLIP	21572407
MIRT072096	hsa-miR-498	PAR-CLIP	21572407
MIRT114962	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT114925	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT114923	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT114924	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT114927	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT114929	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT114931	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT249859	hsa-miR-503-5p	PAR-CLIP	23592263
MIRT249860	hsa-miR-646	PAR-CLIP	23592263
MIRT249845	hsa-miR-383-3p	PAR-CLIP	23592263
MIRT114951	hsa-miR-6742-3p	PAR-CLIP	23592263
MIRT114955	hsa-miR-6776-5p	PAR-CLIP	23592263
MIRT114932	hsa-miR-661	PAR-CLIP	23592263
MIRT494244	hsa-miR-193b-5p	PAR-CLIP	23592263
MIRT114928	hsa-miR-363-5p	PAR-CLIP	23592263
MIRT114952	hsa-miR-6745	PAR-CLIP	23592263
MIRT114953	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT114954	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT114935	hsa-miR-1293	PAR-CLIP	23592263
MIRT114942	hsa-miR-4483	PAR-CLIP	23592263
MIRT494243	hsa-miR-3650	PAR-CLIP	23592263
MIRT114930	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT114936	hsa-miR-3151-5p	PAR-CLIP	23592263
MIRT114939	hsa-miR-4447	PAR-CLIP	23592263
MIRT114940	hsa-miR-4472	PAR-CLIP	23592263
MIRT114950	hsa-miR-6742-5p	PAR-CLIP	23592263
MIRT114943	hsa-miR-4524a-5p	PAR-CLIP	23592263
MIRT114946	hsa-miR-4524b-5p	PAR-CLIP	23592263
MIRT114937	hsa-miR-3170	PAR-CLIP	23592263
MIRT114965	hsa-miR-6855-5p	PAR-CLIP	23592263
MIRT114957	hsa-miR-6796-5p	PAR-CLIP	23592263
MIRT114933	hsa-miR-374b-3p	PAR-CLIP	23592263
MIRT494242	hsa-miR-3154	PAR-CLIP	23592263
MIRT494241	hsa-miR-4446-3p	PAR-CLIP	23592263
MIRT494240	hsa-miR-6784-5p	PAR-CLIP	23592263
MIRT494239	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT494238	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT494237	hsa-miR-4784	PAR-CLIP	23592263
MIRT494236	hsa-miR-4434	PAR-CLIP	23592263
MIRT494235	hsa-miR-4516	PAR-CLIP	23592263
MIRT494234	hsa-miR-5703	PAR-CLIP	23592263
MIRT494233	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT494232	hsa-miR-7154-3p	PAR-CLIP	23592263
MIRT494231	hsa-miR-765	PAR-CLIP	23592263
MIRT494230	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT494229	hsa-miR-4743-5p	PAR-CLIP	23592263
MIRT494228	hsa-miR-4492	PAR-CLIP	23592263
MIRT494227	hsa-miR-4498	PAR-CLIP	23592263
MIRT494225	hsa-miR-5001-5p	PAR-CLIP	23592263
MIRT494226	hsa-miR-762	PAR-CLIP	23592263
MIRT114969	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT281064	hsa-miR-4311	PAR-CLIP	23592263
MIRT479296	hsa-miR-7109-3p	PAR-CLIP	23592263
MIRT140195	hsa-miR-4524b-3p	PAR-CLIP	23592263
MIRT140199	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT140203	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT140178	hsa-miR-940	PAR-CLIP	23592263
MIRT140182	hsa-miR-1324	PAR-CLIP	23592263
MIRT140187	hsa-miR-4514	PAR-CLIP	23592263
MIRT140188	hsa-miR-4692	PAR-CLIP	23592263
MIRT140176	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT140185	hsa-miR-4251	PAR-CLIP	23592263
MIRT140202	hsa-miR-6868-5p	PAR-CLIP	23592263
MIRT140201	hsa-miR-6857-3p	PAR-CLIP	23592263
MIRT479295	hsa-miR-539-5p	PAR-CLIP	23592263
MIRT140183	hsa-miR-3166	PAR-CLIP	23592263
MIRT140190	hsa-miR-4740-5p	PAR-CLIP	23592263
MIRT140181	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT140192	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT140184	hsa-miR-3199	PAR-CLIP	23592263
MIRT140205	hsa-miR-8052	PAR-CLIP	23592263
MIRT479294	hsa-miR-132-3p	PAR-CLIP	23592263
MIRT479293	hsa-miR-212-3p	PAR-CLIP	23592263
MIRT405966	hsa-miR-144-3p	PAR-CLIP	23592263
MIRT479292	hsa-miR-4463	PAR-CLIP	23592263
MIRT479290	hsa-miR-6871-5p	PAR-CLIP	23592263
MIRT479291	hsa-miR-4494	PAR-CLIP	23592263
MIRT479289	hsa-miR-204-3p	PAR-CLIP	23592263
MIRT479288	hsa-miR-4646-5p	PAR-CLIP	23592263
MIRT249872	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT479287	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT479286	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT369094	hsa-miR-656-5p	PAR-CLIP	23592263
MIRT405967	hsa-miR-194-5p	PAR-CLIP	23592263
MIRT369102	hsa-miR-6501-5p	PAR-CLIP	23592263
MIRT479285	hsa-miR-1202	PAR-CLIP	23592263
MIRT479284	hsa-miR-3972	PAR-CLIP	23592263
MIRT369101	hsa-miR-5006-5p	PAR-CLIP	23592263
MIRT479283	hsa-miR-1302	PAR-CLIP	23592263
MIRT479282	hsa-miR-4298	PAR-CLIP	23592263
MIRT888401	hsa-miR-1205	CLIP-seq
MIRT888402	hsa-miR-122	CLIP-seq
MIRT888403	hsa-miR-1245	CLIP-seq
MIRT888404	hsa-miR-142-3p	CLIP-seq
MIRT888405	hsa-miR-15a	CLIP-seq
MIRT888406	hsa-miR-15b	CLIP-seq
MIRT888407	hsa-miR-16	CLIP-seq
MIRT888408	hsa-miR-1915	CLIP-seq
MIRT888409	hsa-miR-195	CLIP-seq
MIRT888410	hsa-miR-1972	CLIP-seq
MIRT888411	hsa-miR-198	CLIP-seq
MIRT888412	hsa-miR-214	CLIP-seq
MIRT888413	hsa-miR-224	CLIP-seq
MIRT888414	hsa-miR-24	CLIP-seq
MIRT888415	hsa-miR-26a	CLIP-seq
MIRT888416	hsa-miR-26b	CLIP-seq
MIRT888417	hsa-miR-296-5p	CLIP-seq
MIRT888418	hsa-miR-3120-5p	CLIP-seq
MIRT888419	hsa-miR-3126-5p	CLIP-seq
MIRT888420	hsa-miR-3136-3p	CLIP-seq
MIRT888421	hsa-miR-3151	CLIP-seq
MIRT888422	hsa-miR-3155	CLIP-seq
MIRT888423	hsa-miR-3155b	CLIP-seq
MIRT888424	hsa-miR-3619-5p	CLIP-seq
MIRT888425	hsa-miR-3657	CLIP-seq
MIRT888426	hsa-miR-3677-5p	CLIP-seq
MIRT888427	hsa-miR-3918	CLIP-seq
MIRT888428	hsa-miR-424	CLIP-seq
MIRT888429	hsa-miR-4290	CLIP-seq
MIRT888430	hsa-miR-4291	CLIP-seq
MIRT888431	hsa-miR-431	CLIP-seq
MIRT888432	hsa-miR-4417	CLIP-seq
MIRT888433	hsa-miR-4433	CLIP-seq
MIRT888434	hsa-miR-4436b-3p	CLIP-seq
MIRT888435	hsa-miR-4437	CLIP-seq
MIRT888436	hsa-miR-4481	CLIP-seq
MIRT888437	hsa-miR-4524	CLIP-seq
MIRT888438	hsa-miR-4669	CLIP-seq
MIRT888439	hsa-miR-4674	CLIP-seq
MIRT888440	hsa-miR-4685-5p	CLIP-seq
MIRT888441	hsa-miR-4686	CLIP-seq
MIRT888442	hsa-miR-4726-3p	CLIP-seq
MIRT888443	hsa-miR-4745-5p	CLIP-seq
MIRT888444	hsa-miR-4768-3p	CLIP-seq
MIRT888445	hsa-miR-484	CLIP-seq
MIRT888446	hsa-miR-497	CLIP-seq
MIRT888447	hsa-miR-503	CLIP-seq
MIRT888448	hsa-miR-539	CLIP-seq
MIRT888449	hsa-miR-555	CLIP-seq
MIRT888450	hsa-miR-556-5p	CLIP-seq
MIRT888451	hsa-miR-558	CLIP-seq
MIRT888452	hsa-miR-570	CLIP-seq
MIRT888453	hsa-miR-581	CLIP-seq
MIRT888454	hsa-miR-625	CLIP-seq
MIRT888455	hsa-miR-663b	CLIP-seq
MIRT888456	hsa-miR-761	CLIP-seq
MIRT888457	hsa-miR-767-3p	CLIP-seq
MIRT888458	hsa-miR-922	CLIP-seq
MIRT888459	hsa-miR-1276	CLIP-seq
MIRT888460	hsa-miR-132	CLIP-seq
MIRT888461	hsa-miR-144	CLIP-seq
MIRT888405	hsa-miR-15a	CLIP-seq
MIRT888406	hsa-miR-15b	CLIP-seq
MIRT888407	hsa-miR-16	CLIP-seq
MIRT888462	hsa-miR-194	CLIP-seq
MIRT888409	hsa-miR-195	CLIP-seq
MIRT888463	hsa-miR-2110	CLIP-seq
MIRT888464	hsa-miR-212	CLIP-seq
MIRT888465	hsa-miR-2861	CLIP-seq
MIRT888466	hsa-miR-3115	CLIP-seq
MIRT888420	hsa-miR-3136-3p	CLIP-seq
MIRT888421	hsa-miR-3151	CLIP-seq
MIRT888467	hsa-miR-3165	CLIP-seq
MIRT888468	hsa-miR-3194-3p	CLIP-seq
MIRT888469	hsa-miR-326	CLIP-seq
MIRT888470	hsa-miR-330-5p	CLIP-seq
MIRT888426	hsa-miR-3677-5p	CLIP-seq
MIRT888427	hsa-miR-3918	CLIP-seq
MIRT888428	hsa-miR-424	CLIP-seq
MIRT888471	hsa-miR-4267	CLIP-seq
MIRT888472	hsa-miR-4271	CLIP-seq
MIRT888473	hsa-miR-4456	CLIP-seq
MIRT888474	hsa-miR-4471	CLIP-seq
MIRT888475	hsa-miR-4512	CLIP-seq
MIRT888437	hsa-miR-4524	CLIP-seq
MIRT888476	hsa-miR-4667-5p	CLIP-seq
MIRT888440	hsa-miR-4685-5p	CLIP-seq
MIRT888477	hsa-miR-4700-5p	CLIP-seq
MIRT888478	hsa-miR-4711-5p	CLIP-seq
MIRT888479	hsa-miR-4725-3p	CLIP-seq
MIRT888446	hsa-miR-497	CLIP-seq
MIRT888447	hsa-miR-503	CLIP-seq
MIRT888448	hsa-miR-539	CLIP-seq
MIRT888449	hsa-miR-555	CLIP-seq
MIRT888480	hsa-miR-582-3p	CLIP-seq
MIRT888481	hsa-miR-583	CLIP-seq
MIRT888455	hsa-miR-663b	CLIP-seq
MIRT888482	hsa-miR-766	CLIP-seq
MIRT888457	hsa-miR-767-3p	CLIP-seq
MIRT888463	hsa-miR-2110	CLIP-seq
MIRT888412	hsa-miR-214	CLIP-seq
MIRT888467	hsa-miR-3165	CLIP-seq
MIRT888424	hsa-miR-3619-5p	CLIP-seq
MIRT888472	hsa-miR-4271	CLIP-seq
MIRT888430	hsa-miR-4291	CLIP-seq
MIRT888473	hsa-miR-4456	CLIP-seq
MIRT888474	hsa-miR-4471	CLIP-seq
MIRT888440	hsa-miR-4685-5p	CLIP-seq
MIRT888479	hsa-miR-4725-3p	CLIP-seq
MIRT1963385	hsa-miR-4743	CLIP-seq
MIRT888450	hsa-miR-556-5p	CLIP-seq
MIRT888480	hsa-miR-582-3p	CLIP-seq
MIRT888456	hsa-miR-761	CLIP-seq
MIRT888458	hsa-miR-922	CLIP-seq
MIRT888412	hsa-miR-214	CLIP-seq
MIRT888424	hsa-miR-3619-5p	CLIP-seq
MIRT888430	hsa-miR-4291	CLIP-seq
MIRT888440	hsa-miR-4685-5p	CLIP-seq
MIRT888456	hsa-miR-761	CLIP-seq
MIRT888458	hsa-miR-922	CLIP-seq
MIRT888411	hsa-miR-198	CLIP-seq
MIRT888463	hsa-miR-2110	CLIP-seq
MIRT888412	hsa-miR-214	CLIP-seq
MIRT888467	hsa-miR-3165	CLIP-seq
MIRT888424	hsa-miR-3619-5p	CLIP-seq
MIRT888425	hsa-miR-3657	CLIP-seq
MIRT888472	hsa-miR-4271	CLIP-seq
MIRT888429	hsa-miR-4290	CLIP-seq
MIRT888430	hsa-miR-4291	CLIP-seq
MIRT888434	hsa-miR-4436b-3p	CLIP-seq
MIRT888473	hsa-miR-4456	CLIP-seq
MIRT888474	hsa-miR-4471	CLIP-seq
MIRT2199804	hsa-miR-4645-5p	CLIP-seq
MIRT888438	hsa-miR-4669	CLIP-seq
MIRT2199805	hsa-miR-4673	CLIP-seq
MIRT888440	hsa-miR-4685-5p	CLIP-seq
MIRT888479	hsa-miR-4725-3p	CLIP-seq
MIRT888480	hsa-miR-582-3p	CLIP-seq
MIRT888456	hsa-miR-761	CLIP-seq
MIRT888482	hsa-miR-766	CLIP-seq
MIRT888458	hsa-miR-922	CLIP-seq
MIRT888405	hsa-miR-15a	CLIP-seq
MIRT888406	hsa-miR-15b	CLIP-seq
MIRT888407	hsa-miR-16	CLIP-seq
MIRT888409	hsa-miR-195	CLIP-seq
MIRT888421	hsa-miR-3151	CLIP-seq
MIRT888428	hsa-miR-424	CLIP-seq
MIRT888437	hsa-miR-4524	CLIP-seq
MIRT888446	hsa-miR-497	CLIP-seq
MIRT888447	hsa-miR-503	CLIP-seq
MIRT888454	hsa-miR-625	CLIP-seq
MIRT2502434	hsa-miR-1909	CLIP-seq
MIRT888410	hsa-miR-1972	CLIP-seq
MIRT888411	hsa-miR-198	CLIP-seq
MIRT888463	hsa-miR-2110	CLIP-seq
MIRT888412	hsa-miR-214	CLIP-seq
MIRT888414	hsa-miR-24	CLIP-seq
MIRT888419	hsa-miR-3126-5p	CLIP-seq
MIRT888422	hsa-miR-3155	CLIP-seq
MIRT888423	hsa-miR-3155b	CLIP-seq
MIRT888467	hsa-miR-3165	CLIP-seq
MIRT888468	hsa-miR-3194-3p	CLIP-seq
MIRT888469	hsa-miR-326	CLIP-seq
MIRT888470	hsa-miR-330-5p	CLIP-seq
MIRT888424	hsa-miR-3619-5p	CLIP-seq
MIRT888425	hsa-miR-3657	CLIP-seq
MIRT2502435	hsa-miR-3663-3p	CLIP-seq
MIRT888471	hsa-miR-4267	CLIP-seq
MIRT888472	hsa-miR-4271	CLIP-seq
MIRT2502436	hsa-miR-4283	CLIP-seq
MIRT888430	hsa-miR-4291	CLIP-seq
MIRT888435	hsa-miR-4437	CLIP-seq
MIRT888473	hsa-miR-4456	CLIP-seq
MIRT888474	hsa-miR-4471	CLIP-seq
MIRT2199804	hsa-miR-4645-5p	CLIP-seq
MIRT888476	hsa-miR-4667-5p	CLIP-seq
MIRT888438	hsa-miR-4669	CLIP-seq
MIRT2199805	hsa-miR-4673	CLIP-seq
MIRT2502437	hsa-miR-4690-3p	CLIP-seq
MIRT888477	hsa-miR-4700-5p	CLIP-seq
MIRT888478	hsa-miR-4711-5p	CLIP-seq
MIRT888479	hsa-miR-4725-3p	CLIP-seq
MIRT888445	hsa-miR-484	CLIP-seq
MIRT888449	hsa-miR-555	CLIP-seq
MIRT888452	hsa-miR-570	CLIP-seq
MIRT888480	hsa-miR-582-3p	CLIP-seq
MIRT888456	hsa-miR-761	CLIP-seq
MIRT888482	hsa-miR-766	CLIP-seq
MIRT888457	hsa-miR-767-3p	CLIP-seq
MIRT888458	hsa-miR-922	CLIP-seq
MIRT888410	hsa-miR-1972	CLIP-seq
MIRT888411	hsa-miR-198	CLIP-seq
MIRT888463	hsa-miR-2110	CLIP-seq
MIRT888412	hsa-miR-214	CLIP-seq
MIRT888414	hsa-miR-24	CLIP-seq
MIRT888419	hsa-miR-3126-5p	CLIP-seq
MIRT888422	hsa-miR-3155	CLIP-seq
MIRT888423	hsa-miR-3155b	CLIP-seq
MIRT888467	hsa-miR-3165	CLIP-seq
MIRT888468	hsa-miR-3194-3p	CLIP-seq
MIRT888469	hsa-miR-326	CLIP-seq
MIRT888470	hsa-miR-330-5p	CLIP-seq
MIRT888424	hsa-miR-3619-5p	CLIP-seq
MIRT888425	hsa-miR-3657	CLIP-seq
MIRT888471	hsa-miR-4267	CLIP-seq
MIRT888472	hsa-miR-4271	CLIP-seq
MIRT888430	hsa-miR-4291	CLIP-seq
MIRT888473	hsa-miR-4456	CLIP-seq
MIRT888474	hsa-miR-4471	CLIP-seq
MIRT2199804	hsa-miR-4645-5p	CLIP-seq
MIRT888476	hsa-miR-4667-5p	CLIP-seq
MIRT888438	hsa-miR-4669	CLIP-seq
MIRT2199805	hsa-miR-4673	CLIP-seq
MIRT888477	hsa-miR-4700-5p	CLIP-seq
MIRT888478	hsa-miR-4711-5p	CLIP-seq
MIRT888479	hsa-miR-4725-3p	CLIP-seq
MIRT1963385	hsa-miR-4743	CLIP-seq
MIRT888445	hsa-miR-484	CLIP-seq
MIRT888449	hsa-miR-555	CLIP-seq
MIRT888452	hsa-miR-570	CLIP-seq
MIRT888480	hsa-miR-582-3p	CLIP-seq
MIRT888456	hsa-miR-761	CLIP-seq
MIRT888482	hsa-miR-766	CLIP-seq
MIRT888457	hsa-miR-767-3p	CLIP-seq
MIRT888458	hsa-miR-922	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ATF4	Activation	21737788

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003839	Function	Gamma-glutamylcyclotransferase activity	TAS
GO:0005112	Function	Notch binding	IEA
GO:0005112	Function	Notch binding	ISS
GO:0005515	Function	Protein binding	IPI	16189514
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005802	Component	Trans-Golgi network	IEA
GO:0005802	Component	Trans-Golgi network	ISS
GO:0005829	Component	Cytosol	IDA	19109178
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006750	Process	Glutathione biosynthetic process	TAS
GO:0006751	Process	Glutathione catabolic process	IBA
GO:0006751	Process	Glutathione catabolic process	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0006986	Process	Response to unfolded protein	IEA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0010955	Process	Negative regulation of protein processing	IMP	22445366
GO:0016829	Function	Lyase activity	IEA
GO:0022008	Process	Neurogenesis	IEA
GO:0022008	Process	Neurogenesis	ISS
GO:0045746	Process	Negative regulation of Notch signaling pathway	IMP	22445366
GO:0061771	Process	Response to caloric restriction	IEA
GO:0061928	Function	Glutathione specific gamma-glutamylcyclotransferase activity	IBA
GO:0061928	Function	Glutathione specific gamma-glutamylcyclotransferase activity	IDA	27913623
GO:0061928	Function	Glutathione specific gamma-glutamylcyclotransferase activity	IEA
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	19109178

Other IDs

• MIM: 614587
• HGNC: 28680
• e!Ensembl: ENSG00000128965

Protein

• UniProt ID: Q9BUX1
• Protein name: Glutathione-specific gamma-glutamylcyclotransferase 1 (Gamma-GCG 1) (EC 4.3.2.7) (Blocks Notch protein) (Botch) (Cation transport regulator-like protein 1)
• Protein function: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623). Glutathione depletion is an important factor for apoptosis initiati
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04752	ChaC	33 → 208	ChaC-like protein	Family

• Sequence:

  MKQESAAPNTPPTSQSPTPSAQFPRNDGDPQALWIFGYGSLVWRPDFAYSDSRVGFVRGY
  SRRFWQGDTFHRGSDKMPGRVVTLLEDHEGCTWGVAYQVQGEQVSKALKYLNVREAVLGG
  YDTKEVTFYPQDAPDQPLKALAYVATPQNPGYLGPAPEEAIATQILACRGFSGHNLEYLL
  RLADFMQLCGPQAQDEHLAAIVDAVGTMLPCFCPTEQALALV

• Sequence length: 222

Pathways

KEGG:

Glutathione metabolism
Metabolic pathways

Reactome:

Glutathione synthesis and recycling

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	22108517, 29091014		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	22108517, 29091014, 37643511, 39214479	Associate	★☆☆☆☆ Found in Text Mining only
Burkitt Lymphoma	Burkitt`s Lymphoma	BEFREE	31537387		★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	39273406	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	33728749	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	22108517		★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic Fibrosis	BEFREE	30555487		★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic fibrosis	Pubtator	30555487	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	29316219		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	29316219	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	27986595, 29316219		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	27986595		★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Hereditary breast and ovarian cancer syndrome	Pubtator	22108517	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	39595659	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	22108517, 29091014		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	22108517		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	23342279, 29091014, 31161335		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	22108517		★☆☆☆☆ Found in Text Mining only
Melanoma Cutaneous Malignant	Melanoma	Pubtator	35232428	Associate	★☆☆☆☆ Found in Text Mining only
Mucositis	Mucositis	Pubtator	40037075	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29109091, 29632819		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	28686580		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	28686580	Associate	★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	22108517		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	22108517	Associate	★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	Pubtator	35983595	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	23342279		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	34284774, 35023280	Associate	★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal Melanoma	BEFREE	31161335		★☆☆☆☆ Found in Text Mining only