WDR77 (WD repeat domain 77)

Gene

• Entrez ID: 79084
• Gene name: WD repeat domain 77
• Gene symbol: WDR77
• Synonyms (NCBI Gene): HKMT1069, MEP-50, MEP50, Nbla10071, p44, p44/Mep50
• Chromosome: 1
• Chromosome location: 1p13.2
• Summary: The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be inv

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT007024	hsa-miR-27a-3p	Luciferase reporter assay	21558443
MIRT007024	hsa-miR-27a-3p	Luciferase reporter assay	21558443
MIRT007024	hsa-miR-27a-3p	Luciferase reporter assay	21558443
MIRT047356	hsa-miR-34a-5p	CLASH	23622248
MIRT045318	hsa-miR-185-5p	CLASH	23622248
MIRT044590	hsa-miR-320a	CLASH	23622248
MIRT044590	hsa-miR-320a	CLASH	23622248
MIRT038875	hsa-miR-93-3p	CLASH	23622248
MIRT036545	hsa-miR-1225-5p	CLASH	23622248
MIRT696631	hsa-miR-6732-3p	HITS-CLIP	23313552
MIRT696630	hsa-miR-10a-5p	HITS-CLIP	23313552
MIRT696629	hsa-miR-10b-5p	HITS-CLIP	23313552
MIRT696628	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT696627	hsa-miR-339-5p	HITS-CLIP	23313552
MIRT696626	hsa-miR-4421	HITS-CLIP	23313552
MIRT696625	hsa-miR-5699-3p	HITS-CLIP	23313552
MIRT696624	hsa-miR-4794	HITS-CLIP	23313552
MIRT696623	hsa-miR-664a-5p	HITS-CLIP	23313552
MIRT696622	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT696621	hsa-miR-761	HITS-CLIP	23313552
MIRT651572	hsa-miR-6834-3p	HITS-CLIP	23824327
MIRT651571	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT651570	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT651569	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT651568	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT651567	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT545628	hsa-miR-552-3p	PAR-CLIP	21572407
MIRT545627	hsa-miR-7845-5p	PAR-CLIP	21572407
MIRT545626	hsa-miR-7705	PAR-CLIP	21572407
MIRT545625	hsa-miR-211-3p	PAR-CLIP	21572407
MIRT545624	hsa-miR-125a-3p	PAR-CLIP	21572407
MIRT545623	hsa-miR-513a-5p	PAR-CLIP	21572407
MIRT447964	hsa-miR-3609	PAR-CLIP	22100165
MIRT447963	hsa-miR-548ah-5p	PAR-CLIP	22100165
MIRT447962	hsa-miR-520g-3p	PAR-CLIP	22100165
MIRT447961	hsa-miR-520h	PAR-CLIP	22100165
MIRT447960	hsa-miR-186-3p	PAR-CLIP	22100165
MIRT447959	hsa-miR-150-5p	PAR-CLIP	22100165
MIRT447958	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT447957	hsa-miR-6778-3p	PAR-CLIP	22100165
MIRT447956	hsa-miR-1273e	PAR-CLIP	22100165
MIRT447964	hsa-miR-3609	PAR-CLIP	22100165
MIRT447963	hsa-miR-548ah-5p	PAR-CLIP	22100165
MIRT447962	hsa-miR-520g-3p	PAR-CLIP	22100165
MIRT447961	hsa-miR-520h	PAR-CLIP	22100165
MIRT447960	hsa-miR-186-3p	PAR-CLIP	22100165
MIRT447959	hsa-miR-150-5p	PAR-CLIP	22100165
MIRT447958	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT447957	hsa-miR-6778-3p	PAR-CLIP	22100165
MIRT447956	hsa-miR-1273e	PAR-CLIP	22100165
MIRT696631	hsa-miR-6732-3p	HITS-CLIP	23313552
MIRT696630	hsa-miR-10a-5p	HITS-CLIP	23313552
MIRT696629	hsa-miR-10b-5p	HITS-CLIP	23313552
MIRT696628	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT696627	hsa-miR-339-5p	HITS-CLIP	23313552
MIRT696626	hsa-miR-4421	HITS-CLIP	23313552
MIRT696625	hsa-miR-5699-3p	HITS-CLIP	23313552
MIRT696624	hsa-miR-4794	HITS-CLIP	23313552
MIRT696623	hsa-miR-664a-5p	HITS-CLIP	23313552
MIRT696622	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT696621	hsa-miR-761	HITS-CLIP	23313552
MIRT651572	hsa-miR-6834-3p	HITS-CLIP	23824327
MIRT651571	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT651570	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT651569	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT651568	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT651567	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT545628	hsa-miR-552-3p	PAR-CLIP	21572407
MIRT545627	hsa-miR-7845-5p	PAR-CLIP	21572407
MIRT545626	hsa-miR-7705	PAR-CLIP	21572407
MIRT545625	hsa-miR-211-3p	PAR-CLIP	21572407
MIRT545624	hsa-miR-125a-3p	PAR-CLIP	21572407
MIRT545623	hsa-miR-513a-5p	PAR-CLIP	21572407
MIRT447964	hsa-miR-3609	PAR-CLIP	22100165
MIRT447963	hsa-miR-548ah-5p	PAR-CLIP	22100165
MIRT447962	hsa-miR-520g-3p	PAR-CLIP	22100165
MIRT447961	hsa-miR-520h	PAR-CLIP	22100165
MIRT447960	hsa-miR-186-3p	PAR-CLIP	22100165
MIRT447959	hsa-miR-150-5p	PAR-CLIP	22100165
MIRT447958	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT447957	hsa-miR-6778-3p	PAR-CLIP	22100165
MIRT447956	hsa-miR-1273e	PAR-CLIP	22100165
MIRT447964	hsa-miR-3609	PAR-CLIP	22100165
MIRT447963	hsa-miR-548ah-5p	PAR-CLIP	22100165
MIRT447962	hsa-miR-520g-3p	PAR-CLIP	22100165
MIRT447961	hsa-miR-520h	PAR-CLIP	22100165
MIRT447960	hsa-miR-186-3p	PAR-CLIP	22100165
MIRT447959	hsa-miR-150-5p	PAR-CLIP	22100165
MIRT447958	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT447957	hsa-miR-6778-3p	PAR-CLIP	22100165
MIRT447956	hsa-miR-1273e	PAR-CLIP	22100165
MIRT1491536	hsa-miR-1207-5p	CLIP-seq
MIRT1491537	hsa-miR-1246	CLIP-seq
MIRT1491538	hsa-miR-1265	CLIP-seq
MIRT1491539	hsa-miR-1290	CLIP-seq
MIRT1491540	hsa-miR-1912	CLIP-seq
MIRT1491541	hsa-miR-1972	CLIP-seq
MIRT1491542	hsa-miR-200b	CLIP-seq
MIRT1491543	hsa-miR-200c	CLIP-seq
MIRT1491544	hsa-miR-2110	CLIP-seq
MIRT1491545	hsa-miR-217	CLIP-seq
MIRT1491546	hsa-miR-221	CLIP-seq
MIRT1491547	hsa-miR-222	CLIP-seq
MIRT1491548	hsa-miR-2392	CLIP-seq
MIRT1491549	hsa-miR-298	CLIP-seq
MIRT1491550	hsa-miR-3122	CLIP-seq
MIRT1491551	hsa-miR-3134	CLIP-seq
MIRT1491552	hsa-miR-3144-5p	CLIP-seq
MIRT1491553	hsa-miR-3155	CLIP-seq
MIRT1491554	hsa-miR-3155b	CLIP-seq
MIRT1491555	hsa-miR-3167	CLIP-seq
MIRT1491556	hsa-miR-3189-5p	CLIP-seq
MIRT1491557	hsa-miR-320e	CLIP-seq
MIRT1491558	hsa-miR-329	CLIP-seq
MIRT1491559	hsa-miR-335	CLIP-seq
MIRT1491560	hsa-miR-337-5p	CLIP-seq
MIRT1491561	hsa-miR-342-3p	CLIP-seq
MIRT1491562	hsa-miR-3616-3p	CLIP-seq
MIRT1491563	hsa-miR-362-3p	CLIP-seq
MIRT1491564	hsa-miR-3692	CLIP-seq
MIRT1491565	hsa-miR-376a	CLIP-seq
MIRT1491566	hsa-miR-376b	CLIP-seq
MIRT1491567	hsa-miR-3913-5p	CLIP-seq
MIRT1491568	hsa-miR-3914	CLIP-seq
MIRT1491569	hsa-miR-3929	CLIP-seq
MIRT1491570	hsa-miR-3941	CLIP-seq
MIRT1491571	hsa-miR-4271	CLIP-seq
MIRT1491572	hsa-miR-429	CLIP-seq
MIRT1491573	hsa-miR-4418	CLIP-seq
MIRT1491574	hsa-miR-4419b	CLIP-seq
MIRT1491575	hsa-miR-4436b-3p	CLIP-seq
MIRT1491576	hsa-miR-4457	CLIP-seq
MIRT1491577	hsa-miR-4469	CLIP-seq
MIRT1491578	hsa-miR-4478	CLIP-seq
MIRT1491579	hsa-miR-4485	CLIP-seq
MIRT1491580	hsa-miR-4494	CLIP-seq
MIRT1491581	hsa-miR-4650-5p	CLIP-seq
MIRT1491582	hsa-miR-4666-5p	CLIP-seq
MIRT1491583	hsa-miR-4667-5p	CLIP-seq
MIRT1491584	hsa-miR-4685-5p	CLIP-seq
MIRT1491585	hsa-miR-4700-3p	CLIP-seq
MIRT1491586	hsa-miR-4700-5p	CLIP-seq
MIRT1491587	hsa-miR-4725-3p	CLIP-seq
MIRT1491588	hsa-miR-4731-5p	CLIP-seq
MIRT1491589	hsa-miR-4747-5p	CLIP-seq
MIRT1491590	hsa-miR-4763-3p	CLIP-seq
MIRT1491591	hsa-miR-4796-5p	CLIP-seq
MIRT1491592	hsa-miR-484	CLIP-seq
MIRT1491593	hsa-miR-499a-5p	CLIP-seq
MIRT1491594	hsa-miR-509-3-5p	CLIP-seq
MIRT1491595	hsa-miR-509-5p	CLIP-seq
MIRT1491596	hsa-miR-513b	CLIP-seq
MIRT1491597	hsa-miR-603	CLIP-seq
MIRT1491598	hsa-miR-873	CLIP-seq
MIRT1491599	hsa-miR-876-5p	CLIP-seq
MIRT2148150	hsa-miR-1238	CLIP-seq
MIRT2148151	hsa-miR-1273d	CLIP-seq
MIRT2148152	hsa-miR-1275	CLIP-seq
MIRT2148153	hsa-miR-134	CLIP-seq
MIRT1491540	hsa-miR-1912	CLIP-seq
MIRT2148154	hsa-miR-1915	CLIP-seq
MIRT2148155	hsa-miR-3118	CLIP-seq
MIRT2148156	hsa-miR-3140-3p	CLIP-seq
MIRT1491553	hsa-miR-3155	CLIP-seq
MIRT1491554	hsa-miR-3155b	CLIP-seq
MIRT2148157	hsa-miR-3164	CLIP-seq
MIRT1491558	hsa-miR-329	CLIP-seq
MIRT1491560	hsa-miR-337-5p	CLIP-seq
MIRT1491561	hsa-miR-342-3p	CLIP-seq
MIRT1491563	hsa-miR-362-3p	CLIP-seq
MIRT2148158	hsa-miR-3653	CLIP-seq
MIRT2148159	hsa-miR-3658	CLIP-seq
MIRT1491565	hsa-miR-376a	CLIP-seq
MIRT1491566	hsa-miR-376b	CLIP-seq
MIRT1491569	hsa-miR-3929	CLIP-seq
MIRT1491570	hsa-miR-3941	CLIP-seq
MIRT2148160	hsa-miR-4252	CLIP-seq
MIRT1491574	hsa-miR-4419b	CLIP-seq
MIRT2148161	hsa-miR-4462	CLIP-seq
MIRT1491577	hsa-miR-4469	CLIP-seq
MIRT1491578	hsa-miR-4478	CLIP-seq
MIRT1491579	hsa-miR-4485	CLIP-seq
MIRT1491580	hsa-miR-4494	CLIP-seq
MIRT2148162	hsa-miR-4525	CLIP-seq
MIRT2148163	hsa-miR-4652-5p	CLIP-seq
MIRT2148164	hsa-miR-4665-5p	CLIP-seq
MIRT2148165	hsa-miR-4691-5p	CLIP-seq
MIRT1491585	hsa-miR-4700-3p	CLIP-seq
MIRT2148166	hsa-miR-4723-5p	CLIP-seq
MIRT2148167	hsa-miR-4778-3p	CLIP-seq
MIRT1491592	hsa-miR-484	CLIP-seq
MIRT1491593	hsa-miR-499a-5p	CLIP-seq
MIRT2148168	hsa-miR-511	CLIP-seq
MIRT2148169	hsa-miR-548ae	CLIP-seq
MIRT2148170	hsa-miR-548aj	CLIP-seq
MIRT2148171	hsa-miR-548am	CLIP-seq
MIRT2148172	hsa-miR-548b-3p	CLIP-seq
MIRT2148173	hsa-miR-548x	CLIP-seq
MIRT1491597	hsa-miR-603	CLIP-seq
MIRT2148174	hsa-miR-605	CLIP-seq
MIRT2148175	hsa-miR-625	CLIP-seq
MIRT1491598	hsa-miR-873	CLIP-seq
MIRT2148152	hsa-miR-1275	CLIP-seq
MIRT2368656	hsa-miR-1914	CLIP-seq
MIRT2368657	hsa-miR-197	CLIP-seq
MIRT2148156	hsa-miR-3140-3p	CLIP-seq
MIRT2368658	hsa-miR-3154	CLIP-seq
MIRT1491553	hsa-miR-3155	CLIP-seq
MIRT1491554	hsa-miR-3155b	CLIP-seq
MIRT2368659	hsa-miR-3162-5p	CLIP-seq
MIRT1491560	hsa-miR-337-5p	CLIP-seq
MIRT1491561	hsa-miR-342-3p	CLIP-seq
MIRT1491569	hsa-miR-3929	CLIP-seq
MIRT1491574	hsa-miR-4419b	CLIP-seq
MIRT1491576	hsa-miR-4457	CLIP-seq
MIRT1491578	hsa-miR-4478	CLIP-seq
MIRT1491579	hsa-miR-4485	CLIP-seq
MIRT2148162	hsa-miR-4525	CLIP-seq
MIRT2148163	hsa-miR-4652-5p	CLIP-seq
MIRT2148164	hsa-miR-4665-5p	CLIP-seq
MIRT2148166	hsa-miR-4723-5p	CLIP-seq
MIRT1491592	hsa-miR-484	CLIP-seq
MIRT2368660	hsa-miR-5096	CLIP-seq
MIRT2148168	hsa-miR-511	CLIP-seq
MIRT1491596	hsa-miR-513b	CLIP-seq
MIRT2148175	hsa-miR-625	CLIP-seq
MIRT2368656	hsa-miR-1914	CLIP-seq
MIRT2368658	hsa-miR-3154	CLIP-seq
MIRT1491561	hsa-miR-342-3p	CLIP-seq
MIRT1491562	hsa-miR-3616-3p	CLIP-seq
MIRT1491575	hsa-miR-4436b-3p	CLIP-seq
MIRT1491576	hsa-miR-4457	CLIP-seq
MIRT1491596	hsa-miR-513b	CLIP-seq
MIRT2148154	hsa-miR-1915	CLIP-seq
MIRT2148172	hsa-miR-548b-3p	CLIP-seq
MIRT2148150	hsa-miR-1238	CLIP-seq
MIRT2148153	hsa-miR-134	CLIP-seq
MIRT1491540	hsa-miR-1912	CLIP-seq
MIRT2148155	hsa-miR-3118	CLIP-seq
MIRT1491553	hsa-miR-3155	CLIP-seq
MIRT1491554	hsa-miR-3155b	CLIP-seq
MIRT2148157	hsa-miR-3164	CLIP-seq
MIRT1491560	hsa-miR-337-5p	CLIP-seq
MIRT2148158	hsa-miR-3653	CLIP-seq
MIRT2148159	hsa-miR-3658	CLIP-seq
MIRT1491568	hsa-miR-3914	CLIP-seq
MIRT1491569	hsa-miR-3929	CLIP-seq
MIRT1491574	hsa-miR-4419b	CLIP-seq
MIRT1491577	hsa-miR-4469	CLIP-seq
MIRT1491578	hsa-miR-4478	CLIP-seq
MIRT1491579	hsa-miR-4485	CLIP-seq
MIRT1491582	hsa-miR-4666-5p	CLIP-seq
MIRT2148165	hsa-miR-4691-5p	CLIP-seq
MIRT1491585	hsa-miR-4700-3p	CLIP-seq
MIRT1491592	hsa-miR-484	CLIP-seq
MIRT1491598	hsa-miR-873	CLIP-seq
MIRT2148150	hsa-miR-1238	CLIP-seq
MIRT2148153	hsa-miR-134	CLIP-seq
MIRT1491540	hsa-miR-1912	CLIP-seq
MIRT2148155	hsa-miR-3118	CLIP-seq
MIRT1491553	hsa-miR-3155	CLIP-seq
MIRT1491554	hsa-miR-3155b	CLIP-seq
MIRT2148157	hsa-miR-3164	CLIP-seq
MIRT1491560	hsa-miR-337-5p	CLIP-seq
MIRT2148158	hsa-miR-3653	CLIP-seq
MIRT2148159	hsa-miR-3658	CLIP-seq
MIRT1491568	hsa-miR-3914	CLIP-seq
MIRT1491569	hsa-miR-3929	CLIP-seq
MIRT1491574	hsa-miR-4419b	CLIP-seq
MIRT1491577	hsa-miR-4469	CLIP-seq
MIRT1491578	hsa-miR-4478	CLIP-seq
MIRT1491579	hsa-miR-4485	CLIP-seq
MIRT1491582	hsa-miR-4666-5p	CLIP-seq
MIRT2148165	hsa-miR-4691-5p	CLIP-seq
MIRT1491585	hsa-miR-4700-3p	CLIP-seq
MIRT1491592	hsa-miR-484	CLIP-seq
MIRT1491598	hsa-miR-873	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IEA
GO:0000387	Process	Spliceosomal snRNP assembly	NAS	11756452
GO:0003713	Function	Transcription coactivator activity	IGI	12972618
GO:0005515	Function	Protein binding	IPI	11756452, 16087681, 19188445, 20951943, 22365833, 23071334, 23892143, 25284789, 26763441, 26912361, 27337956, 32814053, 33376131
GO:0005634	Component	Nucleus	IDA	21081503
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IGI	12972618
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	19188445, 27337956
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	IGI	12972618
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IDA	18984161, 21081503
GO:0005829	Component	Cytosol	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0007309	Process	Oocyte axis specification	IBA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0008327	Function	Methyl-CpG binding	IDA	25284789
GO:0031465	Component	Cul4B-RING E3 ubiquitin ligase complex	IEA
GO:0034709	Component	Methylosome	IBA
GO:0034709	Component	Methylosome	IDA	11756452, 18984161, 25284789
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0048026	Process	Positive regulation of mRNA splicing, via spliceosome	NAS	11756452
GO:0060528	Process	Secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	IEA
GO:0060767	Process	Epithelial cell proliferation involved in prostate gland development	IEA
GO:0060770	Process	Negative regulation of epithelial cell proliferation involved in prostate gland development	IEA
GO:1990234	Component	Transferase complex	IEA
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IEA

Other IDs

• MIM: 611734
• HGNC: 29652
• e!Ensembl: ENSG00000116455

Protein

• UniProt ID: Q9BQA1
• Protein name: Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50)
• Protein function: Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm prot
• PDB: 4GQB, 4X60, 4X61, 4X63, 5C9Z, 5EMJ, 5EMK, 5EML, 5EMM, 5FA5, 6CKC, 6K1S, 6RLL, 6RLQ, 6UGH, 6UXX, 6UXY, 6V0N, 6V0O, 6V0P, 7BO7, 7KIB, 7KIC, 7KID, 7L1G, 7M05, 7MX7, 7MXA, 7MXC, 7MXG, 7MXN, 7S0U, 7S1P, 7S1Q, 7S1R, 7S1S, 7SER, 7SES, 7U30, 7UOH, 7UY1, 7UYF, 7ZUP, 7ZUQ, 7ZUU, 7ZUY, 7ZV2, 7ZVL, 7ZVU, 8CSG, 8CTB
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	157 → 196	WD domain, G-beta repeat	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, spleen, testis, uterus, prostate and thymus. In testis, expressed in germ cells and Leydig cells, but not in peritubular myocytes, nor in Sertoli cells. Expressed in prostate cancers, in semi
• Sequence:

  MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWL
  FKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFC
  KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKD
  SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV
  DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFV
  RDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE

• Sequence length: 342

Pathways

Reactome:

snRNP Assembly
RMTs methylate histone arginines

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
OVARIAN NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	22665061, 27270440		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	37681455	Associate	★☆☆☆☆ Found in Text Mining only
Benign Prostatic Hyperplasia	Benign Prostatic Hyperplasia	BEFREE	17032745		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	19840198, 27270440, 28977470, 30392062		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	19840198, 22022581, 27270440, 28977470	Associate	★☆☆☆☆ Found in Text Mining only
Cap Myopathy	Cap myopathy	Pubtator	28826481	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	19840198	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Intraductal Noninfiltrating	Intraductal noninfiltrating carcinoma	Pubtator	19840198	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	22665061, 25277535, 26988096		★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	27270440	Associate	★☆☆☆☆ Found in Text Mining only
Leydig Cell Tumor	Leydig Cell Tumor	BEFREE	17437848		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	27480244		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	19840198, 28977470, 30392062		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	22665061, 25277535, 26988096		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	CTD_human_DG	22022581		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	17032745, 18356297, 19840198, 23734213, 27480244		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	17437848, 23734213, 25662273, 27270440, 30282801		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22665061, 28854561		★☆☆☆☆ Found in Text Mining only
Noninfiltrating Intraductal Carcinoma	Ductal carcinoma	BEFREE	19840198		★☆☆☆☆ Found in Text Mining only
Ovarian Diseases	Ovarian diseases	Pubtator	22022581	Associate	★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	CTD_human_DG	22022581		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	22022581, 28407786	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate carcinoma	Prostate cancer	BEFREE	17032745, 18356297, 19840198, 23734213, 27480244		★☆☆☆☆ Found in Text Mining only
Prostatic Hyperplasia	Prostatic Hyperplasia	BEFREE	17032745		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	LHGDN	17032745, 18356297		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	18356297	Associate	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	19840198	Inhibit	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	29706654		★☆☆☆☆ Found in Text Mining only
Seminoma	Seminoma	BEFREE	17437848		★☆☆☆☆ Found in Text Mining only
Spinal Muscular Atrophy	Spinal Muscular Atrophy	BEFREE	10206524, 8981949, 9245983		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	28854561		★☆☆☆☆ Found in Text Mining only
Testicular Neoplasms	Testicular Neoplasms	BEFREE	17437848		★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	34326253	Associate	★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	34326253	Associate	★☆☆☆☆ Found in Text Mining only
Trichothiodystrophy Syndromes	Trichothiodystrophy	BEFREE	28977422		★☆☆☆☆ Found in Text Mining only
Vascular Diseases	Vascular disease	Pubtator	37681455	Associate	★☆☆☆☆ Found in Text Mining only
Xeroderma Pigmentosum	Xeroderma Pigmentosum	BEFREE	28977422		★☆☆☆☆ Found in Text Mining only