Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	79019
Gene name	Centromere protein M
Gene symbol	CENPM
Synonyms (NCBI Gene)	C22orf18CENP-MPANE1
Chromosome	22
Chromosome location	22q13.2
Summary	The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protei

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Show/Hide all (199)

miRTarBase ID	miRNA	Experiments	Reference
MIRT044255	hsa-miR-106b-5p	CLASH	23622248
MIRT709253	hsa-miR-6072	HITS-CLIP	19536157
MIRT709251	hsa-miR-6891-3p	HITS-CLIP	19536157
MIRT709252	hsa-miR-136-5p	HITS-CLIP	19536157
MIRT709249	hsa-miR-4468	HITS-CLIP	19536157
MIRT709250	hsa-miR-4792	HITS-CLIP	19536157
MIRT709248	hsa-miR-130a-5p	HITS-CLIP	19536157
MIRT709247	hsa-miR-23a-3p	HITS-CLIP	19536157
MIRT709246	hsa-miR-23b-3p	HITS-CLIP	19536157
MIRT709245	hsa-miR-23c	HITS-CLIP	19536157
MIRT691293	hsa-miR-34b-3p	HITS-CLIP	23313552
MIRT631272	hsa-miR-216a-5p	HITS-CLIP	23313552
MIRT691292	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT691291	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT691290	hsa-miR-940	HITS-CLIP	23313552
MIRT691289	hsa-miR-3929	HITS-CLIP	23313552
MIRT691288	hsa-miR-4419b	HITS-CLIP	23313552
MIRT691287	hsa-miR-4478	HITS-CLIP	23313552
MIRT691286	hsa-miR-3614-5p	HITS-CLIP	23313552
MIRT691285	hsa-miR-6500-3p	HITS-CLIP	23313552
MIRT691284	hsa-miR-1207-3p	HITS-CLIP	23313552
MIRT691283	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT691282	hsa-miR-6787-3p	HITS-CLIP	23313552
MIRT691281	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT691280	hsa-miR-1827	HITS-CLIP	23313552
MIRT691279	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT691278	hsa-miR-423-3p	HITS-CLIP	23313552
MIRT691277	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT691276	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT691275	hsa-miR-665	HITS-CLIP	23313552
MIRT631272	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT631271	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT631269	hsa-miR-8088	HITS-CLIP	23824327
MIRT631270	hsa-miR-1267	HITS-CLIP	23824327
MIRT631268	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT631267	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT631266	hsa-miR-3135b	HITS-CLIP	23824327
MIRT631265	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT631264	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT631262	hsa-miR-3652	HITS-CLIP	23824327
MIRT631263	hsa-miR-4430	HITS-CLIP	23824327
MIRT631261	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT631260	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT631259	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT631258	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT631257	hsa-miR-5698	HITS-CLIP	23824327
MIRT631272	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT631271	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT631269	hsa-miR-8088	HITS-CLIP	23824327
MIRT631270	hsa-miR-1267	HITS-CLIP	23824327
MIRT631268	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT631266	hsa-miR-3135b	HITS-CLIP	23824327
MIRT631265	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT631264	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT631262	hsa-miR-3652	HITS-CLIP	23824327
MIRT631263	hsa-miR-4430	HITS-CLIP	23824327
MIRT631261	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT631260	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT631259	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT631258	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT631257	hsa-miR-5698	HITS-CLIP	23824327
MIRT644037	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT644036	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT644035	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT644034	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT644033	hsa-miR-29b-1-5p	HITS-CLIP	23824327
MIRT644032	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT644031	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT644030	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT644029	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT644028	hsa-miR-498	HITS-CLIP	23824327
MIRT631272	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT631271	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT631269	hsa-miR-8088	HITS-CLIP	23824327
MIRT631270	hsa-miR-1267	HITS-CLIP	23824327
MIRT631268	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT631267	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT631266	hsa-miR-3135b	HITS-CLIP	23824327
MIRT631265	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT631264	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT631262	hsa-miR-3652	HITS-CLIP	23824327
MIRT631263	hsa-miR-4430	HITS-CLIP	23824327
MIRT631261	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT631260	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT631259	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT631258	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT631257	hsa-miR-5698	HITS-CLIP	23824327
MIRT709253	hsa-miR-6072	HITS-CLIP	19536157
MIRT709251	hsa-miR-6891-3p	HITS-CLIP	19536157
MIRT709252	hsa-miR-136-5p	HITS-CLIP	19536157
MIRT709249	hsa-miR-4468	HITS-CLIP	19536157
MIRT709250	hsa-miR-4792	HITS-CLIP	19536157
MIRT709248	hsa-miR-130a-5p	HITS-CLIP	19536157
MIRT709247	hsa-miR-23a-3p	HITS-CLIP	19536157
MIRT709246	hsa-miR-23b-3p	HITS-CLIP	19536157
MIRT709245	hsa-miR-23c	HITS-CLIP	19536157
MIRT691293	hsa-miR-34b-3p	HITS-CLIP	23313552
MIRT631272	hsa-miR-216a-5p	HITS-CLIP	23313552
MIRT691292	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT691291	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT691290	hsa-miR-940	HITS-CLIP	23313552
MIRT691289	hsa-miR-3929	HITS-CLIP	23313552
MIRT691288	hsa-miR-4419b	HITS-CLIP	23313552
MIRT691287	hsa-miR-4478	HITS-CLIP	23313552
MIRT691286	hsa-miR-3614-5p	HITS-CLIP	23313552
MIRT691285	hsa-miR-6500-3p	HITS-CLIP	23313552
MIRT691284	hsa-miR-1207-3p	HITS-CLIP	23313552
MIRT691283	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT691282	hsa-miR-6787-3p	HITS-CLIP	23313552
MIRT691281	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT691280	hsa-miR-1827	HITS-CLIP	23313552
MIRT691279	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT691278	hsa-miR-423-3p	HITS-CLIP	23313552
MIRT691277	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT691276	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT691275	hsa-miR-665	HITS-CLIP	23313552
MIRT631272	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT631271	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT631269	hsa-miR-8088	HITS-CLIP	23824327
MIRT631270	hsa-miR-1267	HITS-CLIP	23824327
MIRT631268	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT631267	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT631266	hsa-miR-3135b	HITS-CLIP	23824327
MIRT631265	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT631264	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT631262	hsa-miR-3652	HITS-CLIP	23824327
MIRT631263	hsa-miR-4430	HITS-CLIP	23824327
MIRT631261	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT631260	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT631259	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT631258	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT631257	hsa-miR-5698	HITS-CLIP	23824327
MIRT631272	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT631271	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT631269	hsa-miR-8088	HITS-CLIP	23824327
MIRT631270	hsa-miR-1267	HITS-CLIP	23824327
MIRT631268	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT631266	hsa-miR-3135b	HITS-CLIP	23824327
MIRT631265	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT631264	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT631262	hsa-miR-3652	HITS-CLIP	23824327
MIRT631263	hsa-miR-4430	HITS-CLIP	23824327
MIRT631261	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT631260	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT631259	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT631258	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT631257	hsa-miR-5698	HITS-CLIP	23824327
MIRT644037	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT644036	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT644035	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT644034	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT644033	hsa-miR-29b-1-5p	HITS-CLIP	23824327
MIRT644032	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT644031	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT644030	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT644029	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT644028	hsa-miR-498	HITS-CLIP	23824327
MIRT631272	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT631271	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT631269	hsa-miR-8088	HITS-CLIP	23824327
MIRT631270	hsa-miR-1267	HITS-CLIP	23824327
MIRT631268	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT631267	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT631266	hsa-miR-3135b	HITS-CLIP	23824327
MIRT631265	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT631264	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT631262	hsa-miR-3652	HITS-CLIP	23824327
MIRT631263	hsa-miR-4430	HITS-CLIP	23824327
MIRT631261	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT631260	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT631259	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT631258	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT631257	hsa-miR-5698	HITS-CLIP	23824327
MIRT885028	hsa-miR-139-5p	CLIP-seq
MIRT885029	hsa-miR-1913	CLIP-seq
MIRT885030	hsa-miR-296-5p	CLIP-seq
MIRT885031	hsa-miR-324-3p	CLIP-seq
MIRT885032	hsa-miR-3689a-3p	CLIP-seq
MIRT885033	hsa-miR-3689c	CLIP-seq
MIRT885034	hsa-miR-4313	CLIP-seq
MIRT885035	hsa-miR-4481	CLIP-seq
MIRT885036	hsa-miR-4489	CLIP-seq
MIRT885037	hsa-miR-4648	CLIP-seq
MIRT885038	hsa-miR-4654	CLIP-seq
MIRT885039	hsa-miR-4727-5p	CLIP-seq
MIRT885040	hsa-miR-4728-5p	CLIP-seq
MIRT885041	hsa-miR-4745-5p	CLIP-seq
MIRT885042	hsa-miR-4769-5p	CLIP-seq
MIRT885043	hsa-miR-548v	CLIP-seq
MIRT885044	hsa-miR-639	CLIP-seq
MIRT885045	hsa-miR-720	CLIP-seq
MIRT885046	hsa-miR-103a	CLIP-seq
MIRT885047	hsa-miR-107	CLIP-seq
MIRT885048	hsa-miR-1184	CLIP-seq
MIRT885049	hsa-miR-1205	CLIP-seq
MIRT885050	hsa-miR-370	CLIP-seq
MIRT885051	hsa-miR-4418	CLIP-seq
MIRT885052	hsa-miR-509-3-5p	CLIP-seq
MIRT885053	hsa-miR-509-5p	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000776	Component	Kinetochore	IEA
GO:0000939	Component	Inner kinetochore	IPI	36085283
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	36085283
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007059	Process	Chromosome segregation	NAS	36085283

MIM	HGNC	e!Ensembl
610152	18352	ENSG00000100162

Q9NSP4

Protein name

Centromere protein M (CENP-M) (Interphase centromere complex protein 39) (Proliferation-associated nuclear element protein 1)

Protein function

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal)

PDB

4P0T , 4WAU , 7PKN , 7QOO , 7R5S , 7R5V , 7XHN , 7XHO , 7YWX , 7YYH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11111	CENP-M	1 → 172	Centromere protein M (CENP-M)	Family

Tissue specificity

TISSUE SPECIFICITY: Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated

Sequence

MSVLRPLDKLPGLNTATILLVGTEDALLQQLADSMLKEDCASELKVHLAKSLPLPSSVNR
PRIDLIVFVVNLHSKYSLQNTEESLRHVDASFFLGKVCFLATGAGRESHCSIHRHTVVKL
AHTYQSPLLYCDLEVEGFRATMAQRLVRVLQICAGHVPGVSALNLLSLLRSSEGPSLEDL

Sequence length

180

Interactions

View interactions

	Reactome
			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CARCINOMA, HEPATOCELLULAR	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (23)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Bladder Neoplasm	Bladder Neoplasm	BEFREE	31828101		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	33000180, 38200449	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	33000180	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	33591950	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	31828101		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	36635779	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	31612001		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	31612001		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	35496042	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Hereditary breast and ovarian cancer syndrome	Pubtator	38200449	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Neoplasms	Kidney neoplasm	Pubtator	36635779	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	15183305		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	28284560		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31703591		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	15183305		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	31703591		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	31828101		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	31612001		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	32705259	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	38179769	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASCAT_DG	26198764		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Scleroderma Systemic	Systemic sclerosis	Pubtator	23418382	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	31828101	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CENPM (centromere protein M)