Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	79003
Gene name	MIS12 kinetochore complex component
Gene symbol	MIS12
Synonyms (NCBI Gene)	2510025F08RikKNTC2APMTW1hMis12
Chromosome	17
Chromosome location	17p13.2

262

Show/Hide all (262)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004855	hsa-miR-192-5p	Luciferase reporter assayqRT-PCR	19074876
MIRT024957	hsa-miR-215-5p	Microarray	19074876
MIRT004855	hsa-miR-192-5p	Reporter assay;Microarray;Other	19074876
MIRT028251	hsa-miR-32-5p	Sequencing	20371350
MIRT051265	hsa-miR-16-5p	CLASH	23622248
MIRT047693	hsa-miR-10a-5p	CLASH	23622248
MIRT1149421	hsa-miR-1197	CLIP-seq
MIRT1149422	hsa-miR-1225-3p	CLIP-seq
MIRT1149423	hsa-miR-1227	CLIP-seq
MIRT1149424	hsa-miR-1233	CLIP-seq
MIRT1149425	hsa-miR-1262	CLIP-seq
MIRT1149426	hsa-miR-1287	CLIP-seq
MIRT1149427	hsa-miR-129-5p	CLIP-seq
MIRT1149428	hsa-miR-132	CLIP-seq
MIRT1149429	hsa-miR-1825	CLIP-seq
MIRT1149430	hsa-miR-1827	CLIP-seq
MIRT1149431	hsa-miR-186	CLIP-seq
MIRT1149432	hsa-miR-1910	CLIP-seq
MIRT1149433	hsa-miR-199a-5p	CLIP-seq
MIRT1149434	hsa-miR-199b-5p	CLIP-seq
MIRT1149435	hsa-miR-2115	CLIP-seq
MIRT1149436	hsa-miR-212	CLIP-seq
MIRT1149437	hsa-miR-300	CLIP-seq
MIRT1149438	hsa-miR-3125	CLIP-seq
MIRT1149439	hsa-miR-3133	CLIP-seq
MIRT1149440	hsa-miR-3135b	CLIP-seq
MIRT1149441	hsa-miR-3140-3p	CLIP-seq
MIRT1149442	hsa-miR-3145-5p	CLIP-seq
MIRT1149443	hsa-miR-3182	CLIP-seq
MIRT1149444	hsa-miR-3613-3p	CLIP-seq
MIRT1149445	hsa-miR-3614-5p	CLIP-seq
MIRT1149446	hsa-miR-3617	CLIP-seq
MIRT1149447	hsa-miR-3649	CLIP-seq
MIRT1149448	hsa-miR-3682-5p	CLIP-seq
MIRT1149449	hsa-miR-3689a-3p	CLIP-seq
MIRT1149450	hsa-miR-3689c	CLIP-seq
MIRT1149451	hsa-miR-371-5p	CLIP-seq
MIRT1149452	hsa-miR-371b-5p	CLIP-seq
MIRT1149453	hsa-miR-378	CLIP-seq
MIRT1149454	hsa-miR-378b	CLIP-seq
MIRT1149455	hsa-miR-378c	CLIP-seq
MIRT1149456	hsa-miR-378d	CLIP-seq
MIRT1149457	hsa-miR-378e	CLIP-seq
MIRT1149458	hsa-miR-378f	CLIP-seq
MIRT1149459	hsa-miR-378h	CLIP-seq
MIRT1149460	hsa-miR-378i	CLIP-seq
MIRT1149461	hsa-miR-381	CLIP-seq
MIRT1149462	hsa-miR-3916	CLIP-seq
MIRT1149463	hsa-miR-3925-3p	CLIP-seq
MIRT1149464	hsa-miR-3929	CLIP-seq
MIRT1149465	hsa-miR-3974	CLIP-seq
MIRT1149466	hsa-miR-422a	CLIP-seq
MIRT1149467	hsa-miR-4252	CLIP-seq
MIRT1149468	hsa-miR-4317	CLIP-seq
MIRT1149469	hsa-miR-4419b	CLIP-seq
MIRT1149470	hsa-miR-4436a	CLIP-seq
MIRT1149471	hsa-miR-4459	CLIP-seq
MIRT1149472	hsa-miR-4475	CLIP-seq
MIRT1149473	hsa-miR-4478	CLIP-seq
MIRT1149474	hsa-miR-4521	CLIP-seq
MIRT1149475	hsa-miR-4649-3p	CLIP-seq
MIRT1149476	hsa-miR-4701-3p	CLIP-seq
MIRT1149477	hsa-miR-4704-3p	CLIP-seq
MIRT1149478	hsa-miR-4722-5p	CLIP-seq
MIRT1149479	hsa-miR-4728-5p	CLIP-seq
MIRT1149480	hsa-miR-4774-5p	CLIP-seq
MIRT1149481	hsa-miR-4777-3p	CLIP-seq
MIRT1149482	hsa-miR-4796-3p	CLIP-seq
MIRT1149483	hsa-miR-4800-5p	CLIP-seq
MIRT1149484	hsa-miR-485-3p	CLIP-seq
MIRT1149485	hsa-miR-485-5p	CLIP-seq
MIRT1149486	hsa-miR-490-3p	CLIP-seq
MIRT1149487	hsa-miR-508-5p	CLIP-seq
MIRT1149488	hsa-miR-5095	CLIP-seq
MIRT1149489	hsa-miR-516a-3p	CLIP-seq
MIRT1149490	hsa-miR-518a-5p	CLIP-seq
MIRT1149491	hsa-miR-520g	CLIP-seq
MIRT1149492	hsa-miR-520h	CLIP-seq
MIRT1149493	hsa-miR-527	CLIP-seq
MIRT1149494	hsa-miR-542-3p	CLIP-seq
MIRT1149495	hsa-miR-545	CLIP-seq
MIRT1149496	hsa-miR-570	CLIP-seq
MIRT1149497	hsa-miR-583	CLIP-seq
MIRT1149498	hsa-miR-584	CLIP-seq
MIRT1149499	hsa-miR-641	CLIP-seq
MIRT1149500	hsa-miR-649	CLIP-seq
MIRT1149501	hsa-miR-875-5p	CLIP-seq
MIRT1149502	hsa-miR-890	CLIP-seq
MIRT1149503	hsa-miR-940	CLIP-seq
MIRT1149427	hsa-miR-129-5p	CLIP-seq
MIRT1149428	hsa-miR-132	CLIP-seq
MIRT1149432	hsa-miR-1910	CLIP-seq
MIRT1149436	hsa-miR-212	CLIP-seq
MIRT1149442	hsa-miR-3145-5p	CLIP-seq
MIRT2042506	hsa-miR-3155	CLIP-seq
MIRT2042507	hsa-miR-3155b	CLIP-seq
MIRT1149446	hsa-miR-3617	CLIP-seq
MIRT1149449	hsa-miR-3689a-3p	CLIP-seq
MIRT1149450	hsa-miR-3689c	CLIP-seq
MIRT2042508	hsa-miR-4438	CLIP-seq
MIRT2042509	hsa-miR-4477a	CLIP-seq
MIRT1149479	hsa-miR-4728-5p	CLIP-seq
MIRT2042510	hsa-miR-484	CLIP-seq
MIRT1149498	hsa-miR-584	CLIP-seq
MIRT1149499	hsa-miR-641	CLIP-seq
MIRT1149502	hsa-miR-890	CLIP-seq
MIRT1149421	hsa-miR-1197	CLIP-seq
MIRT1149422	hsa-miR-1225-3p	CLIP-seq
MIRT1149424	hsa-miR-1233	CLIP-seq
MIRT1149428	hsa-miR-132	CLIP-seq
MIRT1149430	hsa-miR-1827	CLIP-seq
MIRT1149436	hsa-miR-212	CLIP-seq
MIRT2272157	hsa-miR-3157-5p	CLIP-seq
MIRT1149445	hsa-miR-3614-5p	CLIP-seq
MIRT1149449	hsa-miR-3689a-3p	CLIP-seq
MIRT1149450	hsa-miR-3689c	CLIP-seq
MIRT1149464	hsa-miR-3929	CLIP-seq
MIRT2272158	hsa-miR-3973	CLIP-seq
MIRT2272159	hsa-miR-3977	CLIP-seq
MIRT2272160	hsa-miR-4257	CLIP-seq
MIRT1149469	hsa-miR-4419b	CLIP-seq
MIRT1149470	hsa-miR-4436a	CLIP-seq
MIRT1149471	hsa-miR-4459	CLIP-seq
MIRT1149473	hsa-miR-4478	CLIP-seq
MIRT1149475	hsa-miR-4649-3p	CLIP-seq
MIRT1149478	hsa-miR-4722-5p	CLIP-seq
MIRT1149479	hsa-miR-4728-5p	CLIP-seq
MIRT2272161	hsa-miR-4731-3p	CLIP-seq
MIRT2272162	hsa-miR-4801	CLIP-seq
MIRT1149485	hsa-miR-485-5p	CLIP-seq
MIRT1149491	hsa-miR-520g	CLIP-seq
MIRT1149492	hsa-miR-520h	CLIP-seq
MIRT1149498	hsa-miR-584	CLIP-seq
MIRT1149502	hsa-miR-890	CLIP-seq
MIRT1149503	hsa-miR-940	CLIP-seq
MIRT1149421	hsa-miR-1197	CLIP-seq
MIRT1149422	hsa-miR-1225-3p	CLIP-seq
MIRT1149424	hsa-miR-1233	CLIP-seq
MIRT1149430	hsa-miR-1827	CLIP-seq
MIRT1149445	hsa-miR-3614-5p	CLIP-seq
MIRT1149449	hsa-miR-3689a-3p	CLIP-seq
MIRT1149450	hsa-miR-3689c	CLIP-seq
MIRT1149464	hsa-miR-3929	CLIP-seq
MIRT1149469	hsa-miR-4419b	CLIP-seq
MIRT1149470	hsa-miR-4436a	CLIP-seq
MIRT1149471	hsa-miR-4459	CLIP-seq
MIRT1149473	hsa-miR-4478	CLIP-seq
MIRT1149475	hsa-miR-4649-3p	CLIP-seq
MIRT1149478	hsa-miR-4722-5p	CLIP-seq
MIRT1149479	hsa-miR-4728-5p	CLIP-seq
MIRT1149485	hsa-miR-485-5p	CLIP-seq
MIRT1149502	hsa-miR-890	CLIP-seq
MIRT1149503	hsa-miR-940	CLIP-seq
MIRT2454149	hsa-miR-330-3p	CLIP-seq
MIRT2454150	hsa-miR-4762-5p	CLIP-seq
MIRT2454151	hsa-miR-548l	CLIP-seq
MIRT2454152	hsa-miR-548n	CLIP-seq
MIRT1149421	hsa-miR-1197	CLIP-seq
MIRT1149422	hsa-miR-1225-3p	CLIP-seq
MIRT1149423	hsa-miR-1227	CLIP-seq
MIRT1149424	hsa-miR-1233	CLIP-seq
MIRT2571168	hsa-miR-1254	CLIP-seq
MIRT1149425	hsa-miR-1262	CLIP-seq
MIRT2571169	hsa-miR-1276	CLIP-seq
MIRT1149426	hsa-miR-1287	CLIP-seq
MIRT1149430	hsa-miR-1827	CLIP-seq
MIRT2571170	hsa-miR-27a	CLIP-seq
MIRT2571171	hsa-miR-27b	CLIP-seq
MIRT2571172	hsa-miR-3116	CLIP-seq
MIRT1149440	hsa-miR-3135b	CLIP-seq
MIRT2571173	hsa-miR-3174	CLIP-seq
MIRT1149443	hsa-miR-3182	CLIP-seq
MIRT2571174	hsa-miR-338-5p	CLIP-seq
MIRT1149445	hsa-miR-3614-5p	CLIP-seq
MIRT2571175	hsa-miR-3647-3p	CLIP-seq
MIRT1149449	hsa-miR-3689a-3p	CLIP-seq
MIRT1149450	hsa-miR-3689c	CLIP-seq
MIRT2571176	hsa-miR-3690	CLIP-seq
MIRT1149453	hsa-miR-378	CLIP-seq
MIRT1149454	hsa-miR-378b	CLIP-seq
MIRT1149455	hsa-miR-378c	CLIP-seq
MIRT1149456	hsa-miR-378d	CLIP-seq
MIRT1149457	hsa-miR-378e	CLIP-seq
MIRT1149458	hsa-miR-378f	CLIP-seq
MIRT1149459	hsa-miR-378h	CLIP-seq
MIRT1149460	hsa-miR-378i	CLIP-seq
MIRT1149464	hsa-miR-3929	CLIP-seq
MIRT1149465	hsa-miR-3974	CLIP-seq
MIRT1149466	hsa-miR-422a	CLIP-seq
MIRT1149467	hsa-miR-4252	CLIP-seq
MIRT2272160	hsa-miR-4257	CLIP-seq
MIRT2571177	hsa-miR-4316	CLIP-seq
MIRT1149469	hsa-miR-4419b	CLIP-seq
MIRT1149470	hsa-miR-4436a	CLIP-seq
MIRT1149471	hsa-miR-4459	CLIP-seq
MIRT2571178	hsa-miR-4462	CLIP-seq
MIRT2571179	hsa-miR-4469	CLIP-seq
MIRT1149473	hsa-miR-4478	CLIP-seq
MIRT1149474	hsa-miR-4521	CLIP-seq
MIRT2571180	hsa-miR-4638-3p	CLIP-seq
MIRT1149475	hsa-miR-4649-3p	CLIP-seq
MIRT2571181	hsa-miR-4687-3p	CLIP-seq
MIRT2571182	hsa-miR-4700-3p	CLIP-seq
MIRT1149476	hsa-miR-4701-3p	CLIP-seq
MIRT1149478	hsa-miR-4722-5p	CLIP-seq
MIRT1149479	hsa-miR-4728-5p	CLIP-seq
MIRT2571183	hsa-miR-4781-3p	CLIP-seq
MIRT1149485	hsa-miR-485-5p	CLIP-seq
MIRT1149486	hsa-miR-490-3p	CLIP-seq
MIRT2571184	hsa-miR-512-5p	CLIP-seq
MIRT2571185	hsa-miR-513a-5p	CLIP-seq
MIRT1149494	hsa-miR-542-3p	CLIP-seq
MIRT2571186	hsa-miR-647	CLIP-seq
MIRT1149500	hsa-miR-649	CLIP-seq
MIRT1149502	hsa-miR-890	CLIP-seq
MIRT2571187	hsa-miR-921	CLIP-seq
MIRT1149503	hsa-miR-940	CLIP-seq
MIRT1149421	hsa-miR-1197	CLIP-seq
MIRT1149422	hsa-miR-1225-3p	CLIP-seq
MIRT1149423	hsa-miR-1227	CLIP-seq
MIRT1149424	hsa-miR-1233	CLIP-seq
MIRT2571168	hsa-miR-1254	CLIP-seq
MIRT1149425	hsa-miR-1262	CLIP-seq
MIRT2571169	hsa-miR-1276	CLIP-seq
MIRT1149430	hsa-miR-1827	CLIP-seq
MIRT2571170	hsa-miR-27a	CLIP-seq
MIRT2571171	hsa-miR-27b	CLIP-seq
MIRT2571172	hsa-miR-3116	CLIP-seq
MIRT2571174	hsa-miR-338-5p	CLIP-seq
MIRT1149445	hsa-miR-3614-5p	CLIP-seq
MIRT2571175	hsa-miR-3647-3p	CLIP-seq
MIRT1149447	hsa-miR-3649	CLIP-seq
MIRT1149449	hsa-miR-3689a-3p	CLIP-seq
MIRT1149450	hsa-miR-3689c	CLIP-seq
MIRT2571176	hsa-miR-3690	CLIP-seq
MIRT1149464	hsa-miR-3929	CLIP-seq
MIRT1149467	hsa-miR-4252	CLIP-seq
MIRT2272160	hsa-miR-4257	CLIP-seq
MIRT1149469	hsa-miR-4419b	CLIP-seq
MIRT1149470	hsa-miR-4436a	CLIP-seq
MIRT1149471	hsa-miR-4459	CLIP-seq
MIRT2571178	hsa-miR-4462	CLIP-seq
MIRT2571179	hsa-miR-4469	CLIP-seq
MIRT1149472	hsa-miR-4475	CLIP-seq
MIRT1149473	hsa-miR-4478	CLIP-seq
MIRT2571180	hsa-miR-4638-3p	CLIP-seq
MIRT1149475	hsa-miR-4649-3p	CLIP-seq
MIRT2571181	hsa-miR-4687-3p	CLIP-seq
MIRT2571182	hsa-miR-4700-3p	CLIP-seq
MIRT1149476	hsa-miR-4701-3p	CLIP-seq
MIRT1149478	hsa-miR-4722-5p	CLIP-seq
MIRT1149479	hsa-miR-4728-5p	CLIP-seq
MIRT2571183	hsa-miR-4781-3p	CLIP-seq
MIRT1149485	hsa-miR-485-5p	CLIP-seq
MIRT1149486	hsa-miR-490-3p	CLIP-seq
MIRT2571184	hsa-miR-512-5p	CLIP-seq
MIRT2571185	hsa-miR-513a-5p	CLIP-seq
MIRT1149494	hsa-miR-542-3p	CLIP-seq
MIRT2571186	hsa-miR-647	CLIP-seq
MIRT1149500	hsa-miR-649	CLIP-seq
MIRT1149502	hsa-miR-890	CLIP-seq
MIRT1149503	hsa-miR-940	CLIP-seq

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000070	Process	Mitotic sister chromatid segregation	IBA
GO:0000278	Process	Mitotic cell cycle	IEA
GO:0000444	Component	MIS12/MIND type complex	IBA
GO:0000444	Component	MIS12/MIND type complex	IDA	16585270, 20819937, 27881301
GO:0000444	Component	MIS12/MIND type complex	NAS	21633384
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000776	Component	Kinetochore	IDA	15371340
GO:0000776	Component	Kinetochore	IEA
GO:0000776	Component	Kinetochore	NAS	21633384, 23418356
GO:0000922	Component	Spindle pole	NAS	21633384
GO:0000940	Component	Outer kinetochore	IDA	24530301
GO:0005515	Function	Protein binding	IPI	15371340, 15502821, 20360068, 23334297, 24981860, 25416956, 26496610, 27705803, 27881301, 28514442, 32296183, 33961781, 35271311, 37398436
GO:0005634	Component	Nucleus	IDA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	21633384
GO:0005694	Component	Chromosome	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007059	Process	Chromosome segregation	IEA
GO:0007059	Process	Chromosome segregation	IMP	12515822, 16585270
GO:0008608	Process	Attachment of spindle microtubules to kinetochore	NAS	21633384
GO:0051301	Process	Cell division	IEA
GO:0051315	Process	Attachment of mitotic spindle microtubules to kinetochore	IMP	23891108
GO:0051382	Process	Kinetochore assembly	IBA
GO:0051382	Process	Kinetochore assembly	IDA	16585270

MIM	HGNC	e!Ensembl
609178	24967	ENSG00000167842

Q9H081

Protein name

Protein MIS12 homolog

Protein function

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (PubMed:12515822, PubMed:15502821, PubMed:16585270). Essential for proper kinetochore microtubule attachment

PDB

5LSJ , 5LSK , 8PPR , 8Q5H

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05859	Mis12	8 → 140	Mis12 protein	Family

Sequence

MSVDPMTYEAQFFGFTPQTCMLRIYIAFQDYLFEVMQAVEQVILKKLDGIPDCDISPVQI
RKCTEKFLCFMKGHFDNLFSKMEQLFLQLILRIPSNILLPEDKCKETPYSEEDFQHLQKE
IEQLQEKYKTELCTKQALLAELEEQKIVQAKLKQTLTFFDELHNVGRDHGTSDFRESLVS
LVQNSRKLQNIRDNVEKESKRLKIS

Sequence length

205

Interactions

View interactions

	Reactome
			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	31222108	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only

MIS12 (MIS12 kinetochore complex component)