DUSP26 (dual specificity phosphatase 26)

Gene

• Entrez ID: 78986
• Gene name: Dual specificity phosphatase 26
• Gene symbol: DUSP26
• Synonyms (NCBI Gene): DSP-4, DUSP24, LDP-4, LDP4, MKP-8, MKP8, NATA1, NEAP, SKRP3
• Chromosome: 8
• Chromosome location: 8p12
• Summary: This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene dependi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT440766	hsa-miR-377-3p	HITS-CLIP	24374217
MIRT440764	hsa-miR-544a	HITS-CLIP	24374217
MIRT440766	hsa-miR-377-3p	HITS-CLIP	24374217
MIRT440764	hsa-miR-544a	HITS-CLIP	24374217
MIRT947800	hsa-miR-1257	CLIP-seq
MIRT947801	hsa-miR-1273f	CLIP-seq
MIRT947802	hsa-miR-1291	CLIP-seq
MIRT947803	hsa-miR-1909	CLIP-seq
MIRT947804	hsa-miR-3199	CLIP-seq
MIRT947805	hsa-miR-3202	CLIP-seq
MIRT947806	hsa-miR-328	CLIP-seq
MIRT947807	hsa-miR-4271	CLIP-seq
MIRT947808	hsa-miR-4436b-3p	CLIP-seq
MIRT947809	hsa-miR-4475	CLIP-seq
MIRT947810	hsa-miR-4725-3p	CLIP-seq
MIRT947811	hsa-miR-4747-5p	CLIP-seq
MIRT947812	hsa-miR-4756-3p	CLIP-seq
MIRT1980820	hsa-miR-377	CLIP-seq
MIRT1980821	hsa-miR-544	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	16581800
GO:0002039	Function	P53 binding	IPI	20562916
GO:0004721	Function	Phosphoprotein phosphatase activity	IDA	19043453
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	20562916, 25416956, 32296183
GO:0005634	Component	Nucleus	IDA	15796912
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	15796912, 19043453
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA	19043453
GO:0005794	Component	Golgi apparatus	IEA
GO:0006470	Process	Protein dephosphorylation	IDA	19043453
GO:0008138	Function	Protein tyrosine/serine/threonine phosphatase activity	IBA
GO:0008138	Function	Protein tyrosine/serine/threonine phosphatase activity	IDA	20562916
GO:0008138	Function	Protein tyrosine/serine/threonine phosphatase activity	IEA
GO:0008138	Function	Protein tyrosine/serine/threonine phosphatase activity	IMP	15796912
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IEA
GO:0033549	Function	MAP kinase phosphatase activity	IBA
GO:0043409	Process	Negative regulation of MAPK cascade	IBA
GO:0045785	Process	Positive regulation of cell adhesion	IMP	19043453
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	16581800
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	IDA	16581800

Other IDs

• MIM: 618368
• HGNC: 28161
• e!Ensembl: ENSG00000133878

Protein

• UniProt ID: Q9BV47
• Protein name: Dual specificity protein phosphatase 26 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase SKRP3) (Low-molecular-mass dual-specificity phosphatase 4) (DSP-4) (LDP-4) (Mitogen-activated protein kinase phosphatase 8) (MAP kinase phosphatase 8) (MKP-8
• Protein function: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid ca
• PDB: 2E0T, 4B04, 4HRF, 5GTJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00782	DSPc	69 → 204	Dual specificity phosphatase, catalytic domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer. {ECO:0000269|PubMed:15796912, ECO:0000269|
• Sequence:

  MCPGNWLWASMTFMARFSRSSSRSPVRTRGTLEEMPTVQHPFLNVFELERLLYTGKTACN
  HADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAYEGLGIRYLGVEAHD
  SPAFDMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIK
  KVKDHRGIIPNRGFLRQLLALDRRLRQGLEA

• Sequence length: 211

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations