LRP8 (LDL receptor related protein 8)

Gene

• Entrez ID: 7804
• Gene name: LDL receptor related protein 8
• Gene symbol: LRP8
• Synonyms (NCBI Gene): APOER2, HSZ75190, LRP-8, MCI1
• Chromosome: 1
• Chromosome location: 1p32.3
• Summary: This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal d

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs5174	C>T	Risk-factor	Genic downstream transcript variant, coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020152	hsa-miR-130b-3p	Sequencing	20371350
MIRT024366	hsa-miR-215-5p	Microarray	19074876
MIRT026507	hsa-miR-192-5p	Microarray	19074876
MIRT031127	hsa-miR-19b-3p	Sequencing	20371350
MIRT046111	hsa-miR-30b-5p	CLASH	23622248
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT656638	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT140086	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT522734	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT522733	hsa-miR-3119	PAR-CLIP	23446348
MIRT522732	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT440313	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT440313	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT656638	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT140086	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT522734	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT522733	hsa-miR-3119	PAR-CLIP	23446348
MIRT522732	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT1118218	hsa-miR-103a	CLIP-seq
MIRT1118219	hsa-miR-105	CLIP-seq
MIRT1118220	hsa-miR-107	CLIP-seq
MIRT1118221	hsa-miR-1184	CLIP-seq
MIRT1118222	hsa-miR-1200	CLIP-seq
MIRT1118223	hsa-miR-1202	CLIP-seq
MIRT1118224	hsa-miR-1205	CLIP-seq
MIRT1118225	hsa-miR-1237	CLIP-seq
MIRT1118226	hsa-miR-1248	CLIP-seq
MIRT1118227	hsa-miR-1251	CLIP-seq
MIRT1118228	hsa-miR-1257	CLIP-seq
MIRT1118229	hsa-miR-1262	CLIP-seq
MIRT1118230	hsa-miR-1269	CLIP-seq
MIRT1118231	hsa-miR-1269b	CLIP-seq
MIRT1118232	hsa-miR-1273f	CLIP-seq
MIRT1118233	hsa-miR-1275	CLIP-seq
MIRT1118234	hsa-miR-1276	CLIP-seq
MIRT1118235	hsa-miR-1288	CLIP-seq
MIRT1118236	hsa-miR-129-5p	CLIP-seq
MIRT1118237	hsa-miR-130a	CLIP-seq
MIRT1118238	hsa-miR-130b	CLIP-seq
MIRT1118239	hsa-miR-1322	CLIP-seq
MIRT1118240	hsa-miR-140-5p	CLIP-seq
MIRT1118241	hsa-miR-143	CLIP-seq
MIRT1118242	hsa-miR-148a	CLIP-seq
MIRT1118243	hsa-miR-148b	CLIP-seq
MIRT1118244	hsa-miR-152	CLIP-seq
MIRT1118245	hsa-miR-214	CLIP-seq
MIRT1118246	hsa-miR-216a	CLIP-seq
MIRT1118247	hsa-miR-216b	CLIP-seq
MIRT1118248	hsa-miR-217	CLIP-seq
MIRT1118249	hsa-miR-219-1-3p	CLIP-seq
MIRT1118250	hsa-miR-224	CLIP-seq
MIRT1118251	hsa-miR-2467-5p	CLIP-seq
MIRT1118252	hsa-miR-301a	CLIP-seq
MIRT1118253	hsa-miR-301b	CLIP-seq
MIRT1118254	hsa-miR-3065-3p	CLIP-seq
MIRT1118255	hsa-miR-3074-5p	CLIP-seq
MIRT1118256	hsa-miR-3124-3p	CLIP-seq
MIRT1118257	hsa-miR-3126-3p	CLIP-seq
MIRT1118258	hsa-miR-3128	CLIP-seq
MIRT1118259	hsa-miR-3138	CLIP-seq
MIRT1118260	hsa-miR-3158-5p	CLIP-seq
MIRT1118261	hsa-miR-3159	CLIP-seq
MIRT1118262	hsa-miR-3160-3p	CLIP-seq
MIRT1118263	hsa-miR-3165	CLIP-seq
MIRT1118264	hsa-miR-3174	CLIP-seq
MIRT1118265	hsa-miR-3189-5p	CLIP-seq
MIRT1118266	hsa-miR-3192	CLIP-seq
MIRT1118267	hsa-miR-3199	CLIP-seq
MIRT1118268	hsa-miR-328	CLIP-seq
MIRT1118269	hsa-miR-330-3p	CLIP-seq
MIRT1118270	hsa-miR-345	CLIP-seq
MIRT1118271	hsa-miR-3591-5p	CLIP-seq
MIRT1118272	hsa-miR-3606	CLIP-seq
MIRT1118273	hsa-miR-3613-3p	CLIP-seq
MIRT1118274	hsa-miR-3614-5p	CLIP-seq
MIRT1118275	hsa-miR-3619-5p	CLIP-seq
MIRT1118276	hsa-miR-3647-3p	CLIP-seq
MIRT1118277	hsa-miR-365	CLIP-seq
MIRT1118278	hsa-miR-3650	CLIP-seq
MIRT1118279	hsa-miR-3666	CLIP-seq
MIRT1118280	hsa-miR-3934	CLIP-seq
MIRT1118281	hsa-miR-3935	CLIP-seq
MIRT1118282	hsa-miR-3972	CLIP-seq
MIRT1118283	hsa-miR-4259	CLIP-seq
MIRT1118284	hsa-miR-4271	CLIP-seq
MIRT1118285	hsa-miR-4291	CLIP-seq
MIRT1118286	hsa-miR-4295	CLIP-seq
MIRT1118287	hsa-miR-4307	CLIP-seq
MIRT1118288	hsa-miR-4314	CLIP-seq
MIRT1118289	hsa-miR-4328	CLIP-seq
MIRT1118290	hsa-miR-4418	CLIP-seq
MIRT1118291	hsa-miR-4422	CLIP-seq
MIRT1118292	hsa-miR-4481	CLIP-seq
MIRT1118293	hsa-miR-4487	CLIP-seq
MIRT1118294	hsa-miR-4488	CLIP-seq
MIRT1118295	hsa-miR-4515	CLIP-seq
MIRT1118296	hsa-miR-4525	CLIP-seq
MIRT1118297	hsa-miR-454	CLIP-seq
MIRT1118298	hsa-miR-455-5p	CLIP-seq
MIRT1118299	hsa-miR-4646-5p	CLIP-seq
MIRT1118300	hsa-miR-4665-5p	CLIP-seq
MIRT1118301	hsa-miR-4671-3p	CLIP-seq
MIRT1118302	hsa-miR-4679	CLIP-seq
MIRT1118303	hsa-miR-4687-3p	CLIP-seq
MIRT1118304	hsa-miR-4695-3p	CLIP-seq
MIRT1118305	hsa-miR-4697-5p	CLIP-seq
MIRT1118306	hsa-miR-4699-3p	CLIP-seq
MIRT1118307	hsa-miR-4701-3p	CLIP-seq
MIRT1118308	hsa-miR-4703-3p	CLIP-seq
MIRT1118309	hsa-miR-4708-5p	CLIP-seq
MIRT1118310	hsa-miR-4711-5p	CLIP-seq
MIRT1118311	hsa-miR-4715-5p	CLIP-seq
MIRT1118312	hsa-miR-4720-5p	CLIP-seq
MIRT1118313	hsa-miR-4723-5p	CLIP-seq
MIRT1118314	hsa-miR-4725-3p	CLIP-seq
MIRT1118315	hsa-miR-4740-5p	CLIP-seq
MIRT1118316	hsa-miR-4745-5p	CLIP-seq
MIRT1118317	hsa-miR-4747-5p	CLIP-seq
MIRT1118318	hsa-miR-4752	CLIP-seq
MIRT1118319	hsa-miR-4753-3p	CLIP-seq
MIRT1118320	hsa-miR-4755-3p	CLIP-seq
MIRT1118321	hsa-miR-4758-3p	CLIP-seq
MIRT1118322	hsa-miR-4758-5p	CLIP-seq
MIRT1118323	hsa-miR-4766-5p	CLIP-seq
MIRT1118324	hsa-miR-4770	CLIP-seq
MIRT1118325	hsa-miR-4776-3p	CLIP-seq
MIRT1118326	hsa-miR-4790-3p	CLIP-seq
MIRT1118327	hsa-miR-4792	CLIP-seq
MIRT1118328	hsa-miR-4799-3p	CLIP-seq
MIRT1118329	hsa-miR-4800-5p	CLIP-seq
MIRT1118330	hsa-miR-488	CLIP-seq
MIRT1118331	hsa-miR-491-3p	CLIP-seq
MIRT1118332	hsa-miR-500a	CLIP-seq
MIRT1118333	hsa-miR-501-3p	CLIP-seq
MIRT1118334	hsa-miR-502-3p	CLIP-seq
MIRT1118335	hsa-miR-509-3-5p	CLIP-seq
MIRT1118336	hsa-miR-509-3p	CLIP-seq
MIRT1118337	hsa-miR-509-5p	CLIP-seq
MIRT1118338	hsa-miR-513a-3p	CLIP-seq
MIRT1118339	hsa-miR-520d-5p	CLIP-seq
MIRT1118340	hsa-miR-524-5p	CLIP-seq
MIRT1118341	hsa-miR-548t	CLIP-seq
MIRT1118342	hsa-miR-558	CLIP-seq
MIRT1118343	hsa-miR-571	CLIP-seq
MIRT1118344	hsa-miR-578	CLIP-seq
MIRT1118345	hsa-miR-587	CLIP-seq
MIRT1118346	hsa-miR-605	CLIP-seq
MIRT1118347	hsa-miR-617	CLIP-seq
MIRT1118348	hsa-miR-625	CLIP-seq
MIRT1118349	hsa-miR-647	CLIP-seq
MIRT1118350	hsa-miR-659	CLIP-seq
MIRT1118351	hsa-miR-761	CLIP-seq
MIRT1118352	hsa-miR-892a	CLIP-seq
MIRT1118353	hsa-miR-921	CLIP-seq
MIRT1118354	hsa-miR-922	CLIP-seq
MIRT1118355	hsa-miR-1207-5p	CLIP-seq
MIRT1118356	hsa-miR-1208	CLIP-seq
MIRT1118357	hsa-miR-1227	CLIP-seq
MIRT1118233	hsa-miR-1275	CLIP-seq
MIRT1118358	hsa-miR-1281	CLIP-seq
MIRT1118359	hsa-miR-1299	CLIP-seq
MIRT1118237	hsa-miR-130a	CLIP-seq
MIRT1118238	hsa-miR-130b	CLIP-seq
MIRT1118360	hsa-miR-142-3p	CLIP-seq
MIRT1118242	hsa-miR-148a	CLIP-seq
MIRT1118243	hsa-miR-148b	CLIP-seq
MIRT1118244	hsa-miR-152	CLIP-seq
MIRT1118249	hsa-miR-219-1-3p	CLIP-seq
MIRT1118252	hsa-miR-301a	CLIP-seq
MIRT1118253	hsa-miR-301b	CLIP-seq
MIRT1118257	hsa-miR-3126-3p	CLIP-seq
MIRT1118258	hsa-miR-3128	CLIP-seq
MIRT1118268	hsa-miR-328	CLIP-seq
MIRT1118279	hsa-miR-3666	CLIP-seq
MIRT1118361	hsa-miR-3910	CLIP-seq
MIRT1118362	hsa-miR-4252	CLIP-seq
MIRT1118283	hsa-miR-4259	CLIP-seq
MIRT1118363	hsa-miR-4280	CLIP-seq
MIRT1118286	hsa-miR-4295	CLIP-seq
MIRT1118287	hsa-miR-4307	CLIP-seq
MIRT1118364	hsa-miR-4318	CLIP-seq
MIRT1118365	hsa-miR-4420	CLIP-seq
MIRT1118294	hsa-miR-4488	CLIP-seq
MIRT1118297	hsa-miR-454	CLIP-seq
MIRT1118366	hsa-miR-4633-5p	CLIP-seq
MIRT1118367	hsa-miR-4662a-5p	CLIP-seq
MIRT1118300	hsa-miR-4665-5p	CLIP-seq
MIRT1118301	hsa-miR-4671-3p	CLIP-seq
MIRT1118368	hsa-miR-4693-5p	CLIP-seq
MIRT1118305	hsa-miR-4697-5p	CLIP-seq
MIRT1118369	hsa-miR-4720-3p	CLIP-seq
MIRT1118312	hsa-miR-4720-5p	CLIP-seq
MIRT1118370	hsa-miR-4729	CLIP-seq
MIRT1118371	hsa-miR-4736	CLIP-seq
MIRT1118317	hsa-miR-4747-5p	CLIP-seq
MIRT1118372	hsa-miR-4763-3p	CLIP-seq
MIRT1118328	hsa-miR-4799-3p	CLIP-seq
MIRT1118373	hsa-miR-4804-3p	CLIP-seq
MIRT1118374	hsa-miR-5096	CLIP-seq
MIRT1118375	hsa-miR-520a-5p	CLIP-seq
MIRT1118376	hsa-miR-525-5p	CLIP-seq
MIRT1118377	hsa-miR-532-5p	CLIP-seq
MIRT1118343	hsa-miR-571	CLIP-seq
MIRT1118350	hsa-miR-659	CLIP-seq
MIRT1118378	hsa-miR-7	CLIP-seq
MIRT1118379	hsa-miR-759	CLIP-seq
MIRT1118380	hsa-miR-875-3p	CLIP-seq
MIRT1118352	hsa-miR-892a	CLIP-seq
MIRT1118357	hsa-miR-1227	CLIP-seq
MIRT2033463	hsa-miR-25	CLIP-seq
MIRT2033464	hsa-miR-302f	CLIP-seq
MIRT1118260	hsa-miR-3158-5p	CLIP-seq
MIRT2033465	hsa-miR-3188	CLIP-seq
MIRT2033466	hsa-miR-32	CLIP-seq
MIRT2033467	hsa-miR-363	CLIP-seq
MIRT2033468	hsa-miR-367	CLIP-seq
MIRT1118362	hsa-miR-4252	CLIP-seq
MIRT1118308	hsa-miR-4703-3p	CLIP-seq
MIRT1118319	hsa-miR-4753-3p	CLIP-seq
MIRT2033469	hsa-miR-4762-3p	CLIP-seq
MIRT1118323	hsa-miR-4766-5p	CLIP-seq
MIRT2033470	hsa-miR-4768-5p	CLIP-seq
MIRT1118339	hsa-miR-520d-5p	CLIP-seq
MIRT1118340	hsa-miR-524-5p	CLIP-seq
MIRT2033471	hsa-miR-643	CLIP-seq
MIRT2033472	hsa-miR-92a	CLIP-seq
MIRT2033473	hsa-miR-92b	CLIP-seq
MIRT2263859	hsa-miR-518a-5p	CLIP-seq
MIRT2263860	hsa-miR-527	CLIP-seq
MIRT2263861	hsa-miR-106a	CLIP-seq
MIRT2263862	hsa-miR-106b	CLIP-seq
MIRT2263863	hsa-miR-17	CLIP-seq
MIRT2263864	hsa-miR-20a	CLIP-seq
MIRT2263865	hsa-miR-20b	CLIP-seq
MIRT2263866	hsa-miR-2276	CLIP-seq
MIRT2263867	hsa-miR-302a	CLIP-seq
MIRT2263868	hsa-miR-302b	CLIP-seq
MIRT2263869	hsa-miR-302c	CLIP-seq
MIRT2263870	hsa-miR-302d	CLIP-seq
MIRT2263871	hsa-miR-302e	CLIP-seq
MIRT2263872	hsa-miR-3074-3p	CLIP-seq
MIRT2263873	hsa-miR-3125	CLIP-seq
MIRT1118258	hsa-miR-3128	CLIP-seq
MIRT2263874	hsa-miR-3202	CLIP-seq
MIRT1118274	hsa-miR-3614-5p	CLIP-seq
MIRT2263875	hsa-miR-372	CLIP-seq
MIRT2263876	hsa-miR-373	CLIP-seq
MIRT2263877	hsa-miR-377	CLIP-seq
MIRT2263878	hsa-miR-3916	CLIP-seq
MIRT2263879	hsa-miR-4277	CLIP-seq
MIRT1118289	hsa-miR-4328	CLIP-seq
MIRT2263880	hsa-miR-4436b-5p	CLIP-seq
MIRT2263881	hsa-miR-4476	CLIP-seq
MIRT2263882	hsa-miR-4533	CLIP-seq
MIRT2263883	hsa-miR-4772-3p	CLIP-seq
MIRT2263884	hsa-miR-493	CLIP-seq
MIRT2263885	hsa-miR-512-3p	CLIP-seq
MIRT2263859	hsa-miR-518a-5p	CLIP-seq
MIRT2263886	hsa-miR-519d	CLIP-seq
MIRT2263887	hsa-miR-520a-3p	CLIP-seq
MIRT2263888	hsa-miR-520b	CLIP-seq
MIRT2263889	hsa-miR-520c-3p	CLIP-seq
MIRT2263890	hsa-miR-520d-3p	CLIP-seq
MIRT2263891	hsa-miR-520e	CLIP-seq
MIRT2263892	hsa-miR-520g	CLIP-seq
MIRT2263893	hsa-miR-520h	CLIP-seq
MIRT2263860	hsa-miR-527	CLIP-seq
MIRT2263894	hsa-miR-544	CLIP-seq
MIRT2263895	hsa-miR-642b	CLIP-seq
MIRT1118350	hsa-miR-659	CLIP-seq
MIRT2263896	hsa-miR-889	CLIP-seq
MIRT1118354	hsa-miR-922	CLIP-seq
MIRT2263897	hsa-miR-93	CLIP-seq
MIRT1118356	hsa-miR-1208	CLIP-seq
MIRT2390321	hsa-miR-3187-3p	CLIP-seq
MIRT1118362	hsa-miR-4252	CLIP-seq
MIRT2390322	hsa-miR-4273	CLIP-seq
MIRT2390323	hsa-miR-4435	CLIP-seq
MIRT1118366	hsa-miR-4633-5p	CLIP-seq
MIRT1118367	hsa-miR-4662a-5p	CLIP-seq
MIRT2390324	hsa-miR-4677-5p	CLIP-seq
MIRT2390325	hsa-miR-4701-5p	CLIP-seq
MIRT1118370	hsa-miR-4729	CLIP-seq
MIRT1118377	hsa-miR-532-5p	CLIP-seq
MIRT2390326	hsa-miR-548s	CLIP-seq
MIRT2390327	hsa-miR-588	CLIP-seq
MIRT2438447	hsa-miR-3183	CLIP-seq
MIRT2438448	hsa-miR-3667-5p	CLIP-seq
MIRT2438449	hsa-miR-3978	CLIP-seq
MIRT2438450	hsa-miR-4723-3p	CLIP-seq
MIRT1118357	hsa-miR-1227	CLIP-seq
MIRT2563074	hsa-miR-1914	CLIP-seq
MIRT2563075	hsa-miR-2355-5p	CLIP-seq
MIRT2563076	hsa-miR-2467-3p	CLIP-seq
MIRT2563077	hsa-miR-33a	CLIP-seq
MIRT2563078	hsa-miR-33b	CLIP-seq
MIRT2563079	hsa-miR-3678-3p	CLIP-seq
MIRT2563080	hsa-miR-3679-3p	CLIP-seq
MIRT2563081	hsa-miR-4327	CLIP-seq
MIRT2033469	hsa-miR-4762-3p	CLIP-seq
MIRT1118323	hsa-miR-4766-5p	CLIP-seq
MIRT2263892	hsa-miR-520g	CLIP-seq
MIRT2263893	hsa-miR-520h	CLIP-seq
MIRT2563082	hsa-miR-543	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HIC1	Repression	24076391

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	TAS
GO:0001540	Function	Amyloid-beta binding	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	TAS	8626535
GO:0005041	Function	Low-density lipoprotein particle receptor activity	IEA
GO:0005041	Function	Low-density lipoprotein particle receptor activity	TAS	20005821
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	12950167, 17548821, 19116273, 20223215, 32814053, 33961781
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IEA
GO:0005875	Component	Microtubule associated complex	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	30873003
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS
GO:0005886	Component	Plasma membrane	TAS
GO:0005901	Component	Caveola	IBA
GO:0005901	Component	Caveola	IDA	11369809
GO:0006508	Process	Proteolysis	NAS	11152697
GO:0006629	Process	Lipid metabolic process	NAS	11152697
GO:0006629	Process	Lipid metabolic process	TAS	8626535
GO:0006897	Process	Endocytosis	IDA	8626535
GO:0006897	Process	Endocytosis	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0008035	Function	High-density lipoprotein particle binding	IEA
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IC	11152697
GO:0016020	Component	Membrane	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	NAS	11152697
GO:0019894	Function	Kinesin binding	IEA
GO:0021517	Process	Ventral spinal cord development	IBA
GO:0021517	Process	Ventral spinal cord development	IEA
GO:0021541	Process	Ammon gyrus development	IEA
GO:0021541	Process	Ammon gyrus development	ISS
GO:0021766	Process	Hippocampus development	IEA
GO:0021819	Process	Layer formation in cerebral cortex	IEA
GO:0021819	Process	Layer formation in cerebral cortex	ISS
GO:0021819	Process	Layer formation in cerebral cortex	ISS
GO:0021987	Process	Cerebral cortex development	IEA
GO:0030229	Function	Very-low-density lipoprotein particle receptor activity	IDA	8626535
GO:0030229	Function	Very-low-density lipoprotein particle receptor activity	IEA
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0034185	Function	Apolipoprotein binding	IC	8626535
GO:0034185	Function	Apolipoprotein binding	IEA
GO:0038024	Function	Cargo receptor activity	NAS	10571240
GO:0038025	Function	Reelin receptor activity	IEA
GO:0038025	Function	Reelin receptor activity	ISS
GO:0038026	Process	Reelin-mediated signaling pathway	IEA
GO:0038026	Process	Reelin-mediated signaling pathway	ISS
GO:0038026	Process	Reelin-mediated signaling pathway	ISS
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0042981	Process	Regulation of apoptotic process	ISS
GO:0043025	Component	Neuronal cell body	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	ISS
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0045088	Process	Regulation of innate immune response	IEA
GO:0045088	Process	Regulation of innate immune response	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048306	Function	Calcium-dependent protein binding	IEA
GO:0048813	Process	Dendrite morphogenesis	IEA
GO:0050804	Process	Modulation of chemical synaptic transmission	IEA
GO:0050804	Process	Modulation of chemical synaptic transmission	ISS
GO:0061003	Process	Positive regulation of dendritic spine morphogenesis	IEA
GO:0061003	Process	Positive regulation of dendritic spine morphogenesis	ISS
GO:0071363	Process	Cellular response to growth factor stimulus	IEA
GO:0071397	Process	Cellular response to cholesterol	IEA
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:1900006	Process	Positive regulation of dendrite development	IEA
GO:1900006	Process	Positive regulation of dendrite development	ISS
GO:2001222	Process	Regulation of neuron migration	ISS

Other IDs

• MIM: 602600
• HGNC: 6700
• e!Ensembl: ENSG00000157193

Protein

• UniProt ID: Q14114
• Protein name: Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2)
• Protein function: Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands (PubMed:12899622, PubMed:12950167, PubMed:20223215, PubMed:30873003). LRP8 participates in transmitting the extracellular Reelin signal to intracellular signa
• PDB: 3A7Q, 5B4X, 5B4Y, 7UCX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00057	Ldl_recept_a	45 → 81	Low-density lipoprotein receptor domain class A	Repeat
  PF00057	Ldl_recept_a	84 → 122	Low-density lipoprotein receptor domain class A	Repeat
  PF00057	Ldl_recept_a	125 → 163	Low-density lipoprotein receptor domain class A	Repeat
  PF00057	Ldl_recept_a	165 → 201	Low-density lipoprotein receptor domain class A	Repeat
  PF00057	Ldl_recept_a	204 → 245	Low-density lipoprotein receptor domain class A	Repeat
  PF00057	Ldl_recept_a	257 → 294	Low-density lipoprotein receptor domain class A	Repeat
  PF00057	Ldl_recept_a	297 → 333	Low-density lipoprotein receptor domain class A	Repeat
  PF14670	FXa_inhibition	340 → 374		Domain
  PF00058	Ldl_recept_b	462 → 506	Low-density lipoprotein receptor repeat class B	Repeat
  PF00058	Ldl_recept_b	509 → 549	Low-density lipoprotein receptor repeat class B	Repeat
  PF00058	Ldl_recept_b	552 → 593	Low-density lipoprotein receptor repeat class B	Repeat
  PF00058	Ldl_recept_b	596 → 638	Low-density lipoprotein receptor repeat class B	Repeat
  PF00058	Ldl_recept_b	639 → 679	Low-density lipoprotein receptor repeat class B	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Expressed mainly in brain and placenta. Also expressed in platelets and megakaryocytic cells. Not expressed in the liver. {ECO:0000269|PubMed:10218790, ECO:0000269|PubMed:10508213}.
• Sequence:

  MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI
  PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA
  TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCL
  AAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDE
  AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCR
  GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC
  TCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGK
  SPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMD
  KASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLS
  EPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYW
  VDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGL
  EISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCA
  CPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSL
  TAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALL
  CMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRP
  LWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDD
  GLP

• Sequence length: 963

Pathways

Reactome:

Platelet sensitization by LDL
Retinoid metabolism and transport

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMERS DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC ISCHEMIC HEART DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERIOSCLEROSIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY HEART DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC NEPHROPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GILLES DE LA TOURETTE SYNDROME	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IRRITABLE BOWEL SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LRP8-related disorder	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	Disgenet, GWAS catalog Disgenet, GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myocardial infarction, susceptibility to, 1	risk factor	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet, GWAS catalog Disgenet, GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UNIPOLAR DEPRESSION	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	35466940, 35886870, 38093390	Associate	★☆☆☆☆ Found in Text Mining only
Amyloidosis	Amyloidosis	BEFREE	29442527		★☆☆☆☆ Found in Text Mining only
Antiphospholipid Syndrome	Antiphospholipid Syndrome	BEFREE	21119114, 29500169		★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	24840660, 29727700, 31412739		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	24840660, 29727700, 31412739		★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	BEFREE	23333377		★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	Pubtator	36039581	Associate	★☆☆☆☆ Found in Text Mining only
Behcet Syndrome	Behcet disease	Pubtator	39191728	Inhibit	★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar disorder	Pubtator	39191728	Associate	★☆☆☆☆ Found in Text Mining only
Blood Platelet Disorders	Platelet disorder	Pubtator	10508213	Associate	★☆☆☆☆ Found in Text Mining only
Bone Diseases	Bone Disease	BEFREE	26048454		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	30227220		★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	31412739		★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognitive disorder	BEFREE	31269452		★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	38093390	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37770979	Associate	★☆☆☆☆ Found in Text Mining only
Coronary Arteriosclerosis	Coronary Arteriosclerosis	BEFREE	24867879		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Artery Disease	Coronary artery disease	BEFREE	17847002, 18592168, 22404453, 23524007, 24867879		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	17847002, 23524007, 24867879	Associate	★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease Autosomal Dominant 1	Coronary artery disease	Pubtator	24867879	Associate	★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	24867879		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dementia	Dementia	BEFREE	17614163		★☆☆☆☆ Found in Text Mining only
Familial Alzheimer Disease (FAD)	Alzheimer disease	BEFREE	27810638		★☆☆☆☆ Found in Text Mining only
Gastrointestinal Neoplasms	Gastrointestinal neoplasm	Pubtator	36753304	Associate	★☆☆☆☆ Found in Text Mining only
Hyperlipidemia	Hyperlipidemia	BEFREE	30066942		★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	31269452		★☆☆☆☆ Found in Text Mining only
Learning Disabilities	Learning disorders	Pubtator	29240611	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	35246020	Associate	★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	20493228		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Major Depressive Disorder	Mental Depression	PSYGENET_DG	20493228		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of breast	Breast Cancer	BEFREE	30227220		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	19760415		★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Medulloblastoma	Pubtator	36273157	Associate	★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	23142051		★☆☆☆☆ Found in Text Mining only
Mild cognitive disorder	Cognitive disorder	BEFREE	31543811		★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	17847002, 18592168, 19439088, 23524007, 24840660, 24867879, 29032149		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myocardial Infarction	Myocardial infarction	Pubtator	17847002, 19439088, 23524007, 24867879	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myocardial Infarction	Myocardial Infarction	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neoplasms	Neoplasms	BEFREE	19760415, 30227220		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	22614235		★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	38093390	Associate	★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	22889673		★☆☆☆☆ Found in Text Mining only
Polyendocrinopathies, Autoimmune	Autoimmune Polyendocrinopathy	BEFREE	25546421, 28129662, 28267395, 29500169		★☆☆☆☆ Found in Text Mining only
Presenile dementia	Senile Dementia	BEFREE	17614163		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	30444038	Associate	★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychosis	GWASDB_DG	23164818		★☆☆☆☆ Found in Text Mining only
Pulmonary Arterial Hypertension	Pulmonary arterial hypertension	Pubtator	30081553	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	17936586, 22419519		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	17936586, 22419519		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Senile Plaques	Senile Plaques	BEFREE	15351437		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	24260584	Associate	★☆☆☆☆ Found in Text Mining only
Thrombosis	Thrombosis	Pubtator	12807892	Associate	★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	30227220		★☆☆☆☆ Found in Text Mining only
Unipolar Depression	Mental Depression	BEFREE	20493228		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Unipolar Depression	Mental Depression	PSYGENET_DG	20493228		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Vascular Diseases	Vascular Diseases	BEFREE	31412739		★☆☆☆☆ Found in Text Mining only