SLC30A1 (solute carrier family 30 member 1)

Gene

• Entrez ID: 7779
• Gene name: Solute carrier family 30 member 1
• Gene symbol: SLC30A1
• Synonyms (NCBI Gene): ZNT1, ZRC1
• Chromosome: 1
• Chromosome location: 1q32.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001501	hsa-miR-155-5p	pSILAC	18668040
MIRT001501	hsa-miR-155-5p	Proteomics;Other	18668040
MIRT031411	hsa-miR-16-5p	Proteomics	18668040
MIRT032247	hsa-let-7b-5p	Proteomics	18668040
MIRT041483	hsa-miR-193b-3p	CLASH	23622248
MIRT039676	hsa-miR-615-3p	CLASH	23622248
MIRT653644	hsa-miR-548ac	HITS-CLIP	23824327
MIRT653643	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT653642	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT653641	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT653640	hsa-miR-548z	HITS-CLIP	23824327
MIRT653639	hsa-miR-548aa	HITS-CLIP	23824327
MIRT653638	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT653637	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT653636	hsa-miR-497-3p	HITS-CLIP	23824327
MIRT653634	hsa-miR-6776-3p	HITS-CLIP	23824327
MIRT561578	hsa-miR-4524b-3p	PAR-CLIP	20371350
MIRT561577	hsa-miR-4501	PAR-CLIP	20371350
MIRT561576	hsa-miR-496	PAR-CLIP	20371350
MIRT561575	hsa-miR-6744-5p	PAR-CLIP	20371350
MIRT561574	hsa-miR-3611	PAR-CLIP	20371350
MIRT485102	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT485101	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT485100	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT485099	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT485098	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT485097	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT485096	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT485095	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT485094	hsa-miR-3133	PAR-CLIP	21572407
MIRT485093	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT492261	hsa-miR-5692a	PAR-CLIP	21572407
MIRT485092	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT485091	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT485090	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT485089	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT485088	hsa-miR-4506	PAR-CLIP	21572407
MIRT492260	hsa-miR-5571-5p	PAR-CLIP	21572407
MIRT554219	hsa-miR-888-5p	PAR-CLIP	21572407
MIRT485087	hsa-miR-7705	PAR-CLIP	21572407
MIRT546464	hsa-miR-6728-3p	PAR-CLIP	21572407
MIRT485086	hsa-miR-187-5p	PAR-CLIP	21572407
MIRT554218	hsa-miR-6830-3p	PAR-CLIP	21572407
MIRT001501	hsa-miR-155-5p	PAR-CLIP	21572407
MIRT492259	hsa-miR-3191-5p	PAR-CLIP	21572407
MIRT485085	hsa-miR-33a-5p	PAR-CLIP	21572407
MIRT485084	hsa-miR-33b-5p	PAR-CLIP	21572407
MIRT554217	hsa-miR-511-5p	PAR-CLIP	21572407
MIRT485102	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT485101	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT485100	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT485099	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT485098	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT485097	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT485096	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT485095	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT485094	hsa-miR-3133	PAR-CLIP	21572407
MIRT485093	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT492261	hsa-miR-5692a	PAR-CLIP	21572407
MIRT485092	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT485091	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT485090	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT485089	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT485088	hsa-miR-4506	PAR-CLIP	21572407
MIRT492260	hsa-miR-5571-5p	PAR-CLIP	21572407
MIRT485087	hsa-miR-7705	PAR-CLIP	21572407
MIRT546464	hsa-miR-6728-3p	PAR-CLIP	21572407
MIRT485086	hsa-miR-187-5p	PAR-CLIP	21572407
MIRT001501	hsa-miR-155-5p	PAR-CLIP	21572407
MIRT492259	hsa-miR-3191-5p	PAR-CLIP	21572407
MIRT485085	hsa-miR-33a-5p	PAR-CLIP	21572407
MIRT485084	hsa-miR-33b-5p	PAR-CLIP	21572407
MIRT485102	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT485101	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT485100	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT485099	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT485098	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT485097	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT485096	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT485095	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT485094	hsa-miR-3133	PAR-CLIP	23592263
MIRT485093	hsa-miR-186-5p	PAR-CLIP	23592263
MIRT492261	hsa-miR-5692a	PAR-CLIP	23592263
MIRT485092	hsa-miR-519a-3p	PAR-CLIP	23592263
MIRT485091	hsa-miR-519b-3p	PAR-CLIP	23592263
MIRT485090	hsa-miR-519c-3p	PAR-CLIP	23592263
MIRT485088	hsa-miR-4506	PAR-CLIP	23592263
MIRT492260	hsa-miR-5571-5p	PAR-CLIP	23592263
MIRT485086	hsa-miR-187-5p	PAR-CLIP	23592263
MIRT492259	hsa-miR-3191-5p	PAR-CLIP	23592263
MIRT485085	hsa-miR-33a-5p	PAR-CLIP	23592263
MIRT485084	hsa-miR-33b-5p	PAR-CLIP	23592263
MIRT485102	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT485101	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT485100	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT485099	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT485098	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT485097	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT485096	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT485095	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT485094	hsa-miR-3133	PAR-CLIP	23592263
MIRT485093	hsa-miR-186-5p	PAR-CLIP	23592263
MIRT485092	hsa-miR-519a-3p	PAR-CLIP	23592263
MIRT485091	hsa-miR-519b-3p	PAR-CLIP	23592263
MIRT485090	hsa-miR-519c-3p	PAR-CLIP	23592263
MIRT485089	hsa-miR-1277-5p	PAR-CLIP	23592263
MIRT485088	hsa-miR-4506	PAR-CLIP	23592263
MIRT485087	hsa-miR-7705	PAR-CLIP	23592263
MIRT485086	hsa-miR-187-5p	PAR-CLIP	23592263
MIRT001501	hsa-miR-155-5p	PAR-CLIP	23592263
MIRT485085	hsa-miR-33a-5p	PAR-CLIP	23592263
MIRT485084	hsa-miR-33b-5p	PAR-CLIP	23592263
MIRT653644	hsa-miR-548ac	HITS-CLIP	23824327
MIRT653643	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT653642	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT653641	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT653640	hsa-miR-548z	HITS-CLIP	23824327
MIRT653639	hsa-miR-548aa	HITS-CLIP	23824327
MIRT653638	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT653637	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT653636	hsa-miR-497-3p	HITS-CLIP	23824327
MIRT653634	hsa-miR-6776-3p	HITS-CLIP	23824327
MIRT561578	hsa-miR-4524b-3p	PAR-CLIP	20371350
MIRT561577	hsa-miR-4501	PAR-CLIP	20371350
MIRT561576	hsa-miR-496	PAR-CLIP	20371350
MIRT561575	hsa-miR-6744-5p	PAR-CLIP	20371350
MIRT561574	hsa-miR-3611	PAR-CLIP	20371350
MIRT485102	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT485101	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT485100	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT485099	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT485098	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT485097	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT485096	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT485095	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT485094	hsa-miR-3133	PAR-CLIP	21572407
MIRT485093	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT492261	hsa-miR-5692a	PAR-CLIP	21572407
MIRT485092	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT485091	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT485090	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT485089	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT485088	hsa-miR-4506	PAR-CLIP	21572407
MIRT492260	hsa-miR-5571-5p	PAR-CLIP	21572407
MIRT554219	hsa-miR-888-5p	PAR-CLIP	21572407
MIRT485087	hsa-miR-7705	PAR-CLIP	21572407
MIRT546464	hsa-miR-6728-3p	PAR-CLIP	21572407
MIRT485086	hsa-miR-187-5p	PAR-CLIP	21572407
MIRT554218	hsa-miR-6830-3p	PAR-CLIP	21572407
MIRT001501	hsa-miR-155-5p	PAR-CLIP	21572407
MIRT492259	hsa-miR-3191-5p	PAR-CLIP	21572407
MIRT485085	hsa-miR-33a-5p	PAR-CLIP	21572407
MIRT485084	hsa-miR-33b-5p	PAR-CLIP	21572407
MIRT554217	hsa-miR-511-5p	PAR-CLIP	21572407
MIRT485102	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT485101	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT485100	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT485099	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT485098	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT485097	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT485096	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT485095	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT485094	hsa-miR-3133	PAR-CLIP	21572407
MIRT485093	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT492261	hsa-miR-5692a	PAR-CLIP	21572407
MIRT485092	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT485091	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT485090	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT485089	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT485088	hsa-miR-4506	PAR-CLIP	21572407
MIRT492260	hsa-miR-5571-5p	PAR-CLIP	21572407
MIRT485087	hsa-miR-7705	PAR-CLIP	21572407
MIRT546464	hsa-miR-6728-3p	PAR-CLIP	21572407
MIRT485086	hsa-miR-187-5p	PAR-CLIP	21572407
MIRT001501	hsa-miR-155-5p	PAR-CLIP	21572407
MIRT492259	hsa-miR-3191-5p	PAR-CLIP	21572407
MIRT485085	hsa-miR-33a-5p	PAR-CLIP	21572407
MIRT485084	hsa-miR-33b-5p	PAR-CLIP	21572407
MIRT485102	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT485101	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT485100	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT485099	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT485098	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT485097	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT485096	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT485095	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT485094	hsa-miR-3133	PAR-CLIP	23592263
MIRT485093	hsa-miR-186-5p	PAR-CLIP	23592263
MIRT492261	hsa-miR-5692a	PAR-CLIP	23592263
MIRT485092	hsa-miR-519a-3p	PAR-CLIP	23592263
MIRT485091	hsa-miR-519b-3p	PAR-CLIP	23592263
MIRT485090	hsa-miR-519c-3p	PAR-CLIP	23592263
MIRT485088	hsa-miR-4506	PAR-CLIP	23592263
MIRT492260	hsa-miR-5571-5p	PAR-CLIP	23592263
MIRT485086	hsa-miR-187-5p	PAR-CLIP	23592263
MIRT492259	hsa-miR-3191-5p	PAR-CLIP	23592263
MIRT485085	hsa-miR-33a-5p	PAR-CLIP	23592263
MIRT485084	hsa-miR-33b-5p	PAR-CLIP	23592263
MIRT485102	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT485101	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT485100	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT485099	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT485098	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT485097	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT485096	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT485095	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT485094	hsa-miR-3133	PAR-CLIP	23592263
MIRT485093	hsa-miR-186-5p	PAR-CLIP	23592263
MIRT485092	hsa-miR-519a-3p	PAR-CLIP	23592263
MIRT485091	hsa-miR-519b-3p	PAR-CLIP	23592263
MIRT485090	hsa-miR-519c-3p	PAR-CLIP	23592263
MIRT485089	hsa-miR-1277-5p	PAR-CLIP	23592263
MIRT485088	hsa-miR-4506	PAR-CLIP	23592263
MIRT485087	hsa-miR-7705	PAR-CLIP	23592263
MIRT485086	hsa-miR-187-5p	PAR-CLIP	23592263
MIRT001501	hsa-miR-155-5p	PAR-CLIP	23592263
MIRT485085	hsa-miR-33a-5p	PAR-CLIP	23592263
MIRT485084	hsa-miR-33b-5p	PAR-CLIP	23592263
MIRT1359084	hsa-miR-182	CLIP-seq
MIRT1359085	hsa-miR-3671	CLIP-seq
MIRT1359086	hsa-miR-4275	CLIP-seq
MIRT1359087	hsa-miR-4276	CLIP-seq
MIRT1359088	hsa-miR-4422	CLIP-seq
MIRT1359089	hsa-miR-4470	CLIP-seq
MIRT1359090	hsa-miR-4704-5p	CLIP-seq
MIRT1359091	hsa-miR-548p	CLIP-seq
MIRT1359092	hsa-miR-890	CLIP-seq
MIRT2106338	hsa-miR-4255	CLIP-seq
MIRT2106339	hsa-miR-548a-3p	CLIP-seq
MIRT2106340	hsa-miR-548e	CLIP-seq
MIRT2106341	hsa-miR-548f	CLIP-seq
MIRT2330631	hsa-miR-2681	CLIP-seq
MIRT2330632	hsa-miR-3148	CLIP-seq
MIRT2330633	hsa-miR-3153	CLIP-seq
MIRT1359086	hsa-miR-4275	CLIP-seq
MIRT2330634	hsa-miR-4668-3p	CLIP-seq
MIRT2330635	hsa-miR-4668-5p	CLIP-seq
MIRT1359090	hsa-miR-4704-5p	CLIP-seq
MIRT2330636	hsa-miR-548c-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0001701	Process	In utero embryonic development	IEA
GO:0005385	Function	Zinc ion transmembrane transporter activity	IBA
GO:0005385	Function	Zinc ion transmembrane transporter activity	IEA
GO:0005385	Function	Zinc ion transmembrane transporter activity	ISS
GO:0005385	Function	Zinc ion transmembrane transporter activity	TAS
GO:0005515	Function	Protein binding	IPI	18158319, 25657003, 36204728
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	18158319
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	18158319
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA	18158319
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IDA	17349999, 32441444
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006812	Process	Monoatomic cation transport	IEA
GO:0006829	Process	Zinc ion transport	IEA
GO:0006829	Process	Zinc ion transport	ISS
GO:0006874	Process	Intracellular calcium ion homeostasis	IEA
GO:0006874	Process	Intracellular calcium ion homeostasis	ISS
GO:0006882	Process	Intracellular zinc ion homeostasis	IBA
GO:0006882	Process	Intracellular zinc ion homeostasis	IDA	18158319
GO:0006882	Process	Intracellular zinc ion homeostasis	IEA
GO:0006882	Process	Intracellular zinc ion homeostasis	ISS
GO:0008324	Function	Monoatomic cation transmembrane transporter activity	IEA
GO:0010312	Process	Detoxification of zinc ion	IBA
GO:0015297	Function	Antiporter activity	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IDA	31471319
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0019855	Function	Calcium channel inhibitor activity	IBA
GO:0019855	Function	Calcium channel inhibitor activity	IEA
GO:0019855	Function	Calcium channel inhibitor activity	ISS
GO:0030315	Component	T-tubule	IEA
GO:0030315	Component	T-tubule	ISS
GO:0030425	Component	Dendrite	IEA
GO:0030659	Component	Cytoplasmic vesicle membrane	IDA	32441444
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031965	Component	Nuclear membrane	IDA	18158319
GO:0031965	Component	Nuclear membrane	IEA
GO:0042742	Process	Defense response to bacterium	IDA	32441444
GO:0046872	Function	Metal ion binding	IEA
GO:0046929	Process	Negative regulation of neurotransmitter secretion	IEA
GO:0046929	Process	Negative regulation of neurotransmitter secretion	ISS
GO:0055085	Process	Transmembrane transport	IEA
GO:0061003	Process	Positive regulation of dendritic spine morphogenesis	IEA
GO:0062111	Process	Zinc ion import into organelle	IDA	32441444
GO:0062111	Process	Zinc ion import into organelle	IEA
GO:0070509	Process	Calcium ion import	IEA
GO:0070574	Process	Cadmium ion transmembrane transport	IEA
GO:0070574	Process	Cadmium ion transmembrane transport	ISS
GO:0071577	Process	Zinc ion transmembrane transport	IBA
GO:0071577	Process	Zinc ion transmembrane transport	TAS
GO:0071584	Process	Negative regulation of zinc ion transmembrane import	IEA
GO:0071584	Process	Negative regulation of zinc ion transmembrane import	ISS
GO:0071585	Process	Detoxification of cadmium ion	IEA
GO:0090281	Process	Negative regulation of calcium ion import	IEA
GO:0090281	Process	Negative regulation of calcium ion import	ISS
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0099092	Component	Postsynaptic density, intracellular component	IEA
GO:0099573	Component	Glutamatergic postsynaptic density	IEA
GO:0140826	Function	Zinc:proton antiporter activity	IEA
GO:0140826	Function	Zinc:proton antiporter activity	ISS
GO:0140882	Process	Zinc export across plasma membrane	IEA
GO:0140882	Process	Zinc export across plasma membrane	ISS
GO:1902897	Process	Regulation of postsynaptic density protein 95 clustering	IEA

Other IDs

• MIM: 609521
• HGNC: 11012
• e!Ensembl: ENSG00000170385

Protein

• UniProt ID: Q9Y6M5
• Protein name: Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1)
• Protein function: Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could
• PDB: 8J2G, 8XM6, 8XMA, 8XMF, 8XMJ, 8ZB0, 8ZSB, 8ZSZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01545	Cation_efflux	11 → 284	Cation efflux family	Family

• Sequence:

  MGCWGRNRGRLLCMLALTFMFMVLEVVVSRVTSSLAMLSDSFHMLSDVLALVVALVAERF
  ARRTHATQKNTFGWIRAEVMGALVNAIFLTGLCFAILLEAIERFIEPHEMQQPLVVLGVG
  VAGLLVNVLGLCLFHHHSGFSQDSGHGHSHGGHGHGHGLPKGPRVKSTRPGSSDINVAPG
  EQGPDQEETNTLVANTSNSNGLKLDPADPENPRSGDTVEVQVNGNLVREPDHMELEEDRA
  GQLNMRGVFLHVLGDALGSVIVVVNALVFYFSWKGCSEGDFCVNPCFPDPCKAFVEIINS
  THASVYEAGPCWVLYLDPTLCVVMVCILLYTTYPLLKESALILLQTVPKQIDIRNLIKEL
  RNVEGVEEVHELHVWQLAGSRIIATAHIKCEDPTSYMEVAKTIKDVFHNHGIHATTIQPE
  FASVGSKSSVVPCELACRTQCALKQCCGTLPQAPSGKDAEKTPAVSISCLELSNNLEKKP
  RRTKAENIPAVVIEIKNMPNKQPESSL

• Sequence length: 507

Pathways

KEGG:

Mineral absorption

Reactome:

Zinc efflux and compartmentalization by the SLC30 family

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC KIDNEY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KIDNEY FAILURE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RETINOPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEIZURES	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	27300264	Associate	★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial Fibrillation	BEFREE	17971132, 20201890		★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial Fibrillation	LHGDN	17971132		★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	30584327		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	17473989, 20859692, 23921484		★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	30584327		★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	26338969		★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	31364107		★☆☆☆☆ Found in Text Mining only
Cleft Lip with or without Cleft Palate	Cleft Lip With Or Without Cleft Palate	BEFREE	21478106		★☆☆☆☆ Found in Text Mining only
Clonic Seizures	Clonic Seizures	CTD_human_DG	23266720		★☆☆☆☆ Found in Text Mining only
Complex partial seizures	Seizure	CTD_human_DG	23266720		★☆☆☆☆ Found in Text Mining only
Depressive Disorder Major	Major depressive disorder	Pubtator	27661418	Stimulate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	22528778, 25156968		★☆☆☆☆ Found in Text Mining only
Epidermodysplasia Verruciformis	Epidermodysplasia verruciformis	Pubtator	18158319	Associate	★☆☆☆☆ Found in Text Mining only
Epidermodysplasia Verruciformis	Epidermodysplasia Verruciformis	BEFREE	18727487, 22903682, 29439479		★☆☆☆☆ Found in Text Mining only
Epileptic drop attack	Hypotonic seizures	CTD_human_DG	23266720		★☆☆☆☆ Found in Text Mining only
Generalized seizures	Seizure	CTD_human_DG	23266720		★☆☆☆☆ Found in Text Mining only
Jacksonian Seizure	Jacksonian Seizure	CTD_human_DG	23266720		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	17363595		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	17473989, 20859692, 23921484		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	26338969		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	31364107		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	14568174		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	30584327		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	17786585		★☆☆☆☆ Found in Text Mining only
Mild cognitive disorder	Cognitive disorder	BEFREE	18997297		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	32915786	Associate	★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	30623748	Associate	★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	31364107		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	31364107	Associate	★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	14568174		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	27833104, 35049094	Associate	★☆☆☆☆ Found in Text Mining only
Single Seizure	Seizure	CTD_human_DG	23266720		★☆☆☆☆ Found in Text Mining only
Tonic - clonic seizures	Seizure	CTD_human_DG	23266720		★☆☆☆☆ Found in Text Mining only
Visual seizure	Seizure	CTD_human_DG	23266720		★☆☆☆☆ Found in Text Mining only