Gene Gene information from NCBI Gene database.
Entrez ID 7763
Gene name Zinc finger AN1-type containing 5
Gene symbol ZFAND5
Synonyms (NCBI Gene)
ZA20D2ZFAND5AZNF216
Chromosome 9
Chromosome location 9q21.13
miRNA miRNA information provided by mirtarbase database.
810
miRTarBase ID miRNA Experiments Reference
MIRT027817 hsa-miR-98-5p Microarray 19088304
MIRT031245 hsa-miR-19b-3p Sequencing 20371350
MIRT031311 hsa-miR-18a-5p Sequencing 20371350
MIRT051626 hsa-let-7e-5p CLASH 23622248
MIRT051626 hsa-let-7e-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
GO ID Ontology Definition Evidence Reference
GO:0001701 Process In utero embryonic development IEA
GO:0001944 Process Vasculature development IEA
GO:0003016 Process Respiratory system process IEA
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 16424905, 28514442, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604761 13008 ENSG00000107372
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O76080
Protein name AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216)
Protein function Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of N
PDB 7QXW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01754 zf-A20 12 35 A20-like zinc finger Family
PF01428 zf-AN1 154 191 AN1-like Zinc finger Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in skeletal muscle. Expressed in fetal cochlea. Also expressed in infant brain, fetal heart, pancreatic islet, melanocyte, pineal gland, placenta, corneal stroma, and parathyroid tumor. Weakly expressed or undetectable
Sequence
MAQETNQTPGPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQQNSGRMSPMGTASGSNSPT
SDSASVQRADTSLNNCEGAAGSTSEKSRNVPVAALPVTQQMTEMSISREDKITTPKTEVS
EPVVTQPSPSVSQPSTSQSEEKAPELPKPKKNRCFMCRKKVGLTGFDCRCGNLFCGLHRY
SDKHNCPYDYK
AEAAAKIRKENPVVVAEKIQRI
Sequence length 213
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
DISORDER OF DEVELOPMENT OR MORPHOGENESIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIVERTICULITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCOLIOSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Colorectal Neoplasms Colorectal neoplasm Pubtator 37705049 Associate
★☆☆☆☆
Found in Text Mining only
Esophageal Neoplasms Esophagus Neoplasm GWASDB_DG 22960999
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 31641376
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of prostate Prostate cancer CTD_human_DG 17199135
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 27732953
★☆☆☆☆
Found in Text Mining only
Medulloblastoma Medulloblastoma BEFREE 27732953
★☆☆☆☆
Found in Text Mining only
Nasopharyngeal Carcinoma Nasopharyngeal carcinoma Pubtator 16308470 Associate
★☆☆☆☆
Found in Text Mining only
Nasopharyngeal carcinoma Nasopharyngeal Carcinoma BEFREE 27732953
★☆☆☆☆
Found in Text Mining only
Prostatic Neoplasms Prostatic Neoplasms CTD_human_DG 17199135
★★☆☆☆
Found in Text Mining + Unknown/Other Associations