Gene Gene information from NCBI Gene database.
Entrez ID 7750
Gene name Zinc finger MYM-type containing 2
Gene symbol ZMYM2
Synonyms (NCBI Gene)
FIMMYMNECRCRAMPSCLLZNF198
Chromosome 13
Chromosome location 13q12.11
Summary The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) re
miRNA miRNA information provided by mirtarbase database.
449
miRTarBase ID miRNA Experiments Reference
MIRT030845 hsa-miR-21-5p Microarray 18591254
MIRT031158 hsa-miR-19b-3p Sequencing 20371350
MIRT052144 hsa-let-7b-5p CLASH 23622248
MIRT046293 hsa-miR-23b-3p CLASH 23622248
MIRT036270 hsa-miR-1229-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 26275350, 32296183
GO:0005634 Component Nucleus IDA 32891193
GO:0005634 Component Nucleus IEA
GO:0005829 Component Cytosol TAS
GO:0008270 Function Zinc ion binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602221 12989 ENSG00000121741
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UBW7
Protein name Zinc finger MYM-type protein 2 (Fused in myeloproliferative disorders protein) (Rearranged in atypical myeloproliferative disorder protein) (Zinc finger protein 198)
Protein function Involved in the negative regulation of transcription.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06467 zf-FCS 326 363 MYM-type Zinc finger with FCS sequence motif Domain
PF06467 zf-FCS 368 409 MYM-type Zinc finger with FCS sequence motif Domain
PF06467 zf-FCS 420 456 MYM-type Zinc finger with FCS sequence motif Domain
PF06467 zf-FCS 462 502 MYM-type Zinc finger with FCS sequence motif Domain
PF06467 zf-FCS 531 570 MYM-type Zinc finger with FCS sequence motif Domain
PF06467 zf-FCS 634 671 MYM-type Zinc finger with FCS sequence motif Domain
PF06467 zf-FCS 722 758 MYM-type Zinc finger with FCS sequence motif Domain
PF06467 zf-FCS 763 799 MYM-type Zinc finger with FCS sequence motif Domain
PF12012 DUF3504 1192 1360 Domain of unknown function (DUF3504) Family
Sequence
MDTSSVGGLELTDQTPVLLGSTAMATSLTNVGNSFSGPANPLVSRSNKFQNSSVEDDDDV
VFIEPVQPPPPSVPVVADQRTITFTSSKNEELQGNDSKITPSSKELASQKGSVSETIVID
DEEDMETNQGQEKNSSNFIERRPPETKNRTNDVDFSTSSFSRSKVNAGMGNSGITTEPDS
EIQIANVTTLETGVSSVNDGQLENTDGRDMNLMITHVTSLQNTNLGDVSNGLQSSNFGVN
IQTYTPSLTSQTKTGVGPFNPGRMNVAGDVFQNGESATHHNPDSWISQSASFPRNQKQPG
VDSLSPVASLPKQIFQPSVQQQPTKPVKVTCANCKKPLQKGQTAYQRKGSAHLFCSTTCL
SSF
SHKPAPKKLCVMCKKDITTMKGTIVAQVDSSESFQEFCSTSCLSLYEDKQNPTKGAL
NKSRCTICGKLTEIRHEVSFKNMTHKLCSDHCFNRY
RMANGLIMNCCEQCGEYLPSKGAG
NNVLVIDGQQKRFCCQSCVSEY
KQVGSHPSFLKEVRDHMQDSFLMQPEKYGKLTTCTGCR
TQCRFFDMTQCIGPNGYMEPYCSTACMNSH
KTKYAKSQSLGIICHFCKRNSLPQYQATMP
DGKLYNFCNSSCVAKFQALSMQSSPNGQFVAPSDIQLKCNYCKNSFCSKPEILEWENKVH
QFCSKTCSDDY
KKLHCIVTYCEYCQEEKTLHETVNFSGVKRPFCSEGCKLLYKQDFARRL
GLRCVTCNYCSQLCKKGATKELDGVVRDFCSEDCCKKFQDWYYKAARCDCCKSQGTLKER
VQWRGEMKHFCDQHCLLRF
YCQQNEPNMTTQKGPENLHYDQGCQTSRTKMTGSAPPPSPT
PNKEMKNKAVLCKPLTMTKATYCKPHMQTKSCQTDDTWRTEYVPVPIPVPVYIPVPMHMY
SQNIPVPTTVPVPVPVPVFLPAPLDSSEKIPAAIEELKSKVSSDALDTELLTMTDMMSED
EGKTETTNINSVIIETDIIGSDLLKNSDPETQSSMPDVPYEPDLDIEIDFPRAAEELDME
NEFLLPPVFGEEYEEQPRPRSKKKGAKRKAVSGYQSHDDSSDNSECSFPFKYTYGVNAWK
HWVKTRQLDEDLLVLDELKSSKSVKLKEDLLSHTTAELNYGLAHFVNEIRRPNGENYAPD
SIYYLCLGIQEYLCGSNRKDNIFIDPGYQTFEQELNKILRSWQPSILPDGSIFSRVEEDY
LWRIKQLGSHSPVALLNTLFYFNTKYFGLKTVEQHLRLSFGTVFRHWKKNPLTMENKACL
RYQVSSLCGTDNEDKITTGKRKHEDDEPVFEQIENTANPSRCPVKMFECYLSKSPQNLNQ
RMDVFYLQPECSSSTDSPVWYTSTSLDRNTLENMLVRVLL
VKDIYDKDNYELDEDTD
Sequence length 1377
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Signaling by cytosolic FGFR1 fusion mutants
Signaling by FGFR1 in disease
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
16
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Congenital anomaly of kidney and urinary tract Pathogenic; Likely pathogenic rs1309291116, rs2140253640, rs2139748846, rs2140576563, rs2140726371, rs753611080, rs757669327, rs2139746476, rs2139949646, rs2139974502, rs2140253913, rs2140369057, rs2140884265, rs2140884891, rs2502236129 RCV001849535
RCV001849536
RCV001849537
RCV001849538
RCV001849539
View all (10 more)
★★★★★
ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Neurodevelopmental abnormality Likely pathogenic rs765831882 RCV002244563
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Neurodevelopmental delay Likely pathogenic rs2140575082 RCV002274391
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Neurodevelopmental disorder Likely pathogenic; Pathogenic rs1299725201, rs2139974701, rs2139911544, rs2502237560 RCV002277712
RCV002277713
RCV002277714
RCV003389187
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CAKUT Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Colorectal cancer Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INTELLECTUAL DISABILITY CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute monocytic leukemia Monocytic Leukemia BEFREE 27005999
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 21480320
★☆☆☆☆
Found in Text Mining only
Aphasia Aphasia BEFREE 28322130
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 25010197
★☆☆☆☆
Found in Text Mining only
Attention Deficit Disorder Attention Deficit Hyperactivity Disorder BEFREE 12881819
★☆☆☆☆
Found in Text Mining only
Attention deficit hyperactivity disorder Attention Deficit Hyperactivity Disorder BEFREE 12881819
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 28410206
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma BEFREE 16434898, 17255760
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 21480320 Inhibit
★☆☆☆☆
Found in Text Mining only
Cerebral Palsy Cerebral palsy Pubtator 35076175 Associate
★☆☆☆☆
Found in Text Mining only