ZKSCAN8 (zinc finger with KRAB and SCAN domains 8)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 7745
Gene name Zinc finger with KRAB and SCAN domains 8
Gene symbol ZKSCAN8
Synonyms (NCBI Gene)
LD5-1ZNF192ZSCAN40
Chromosome 6
Chromosome location 6p22.1
miRNA miRNA information provided by mirtarbase database.
54
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (54)
miRTarBase ID miRNA Experiments Reference
MIRT018290 hsa-miR-335-5p Microarray 18185580
MIRT024197 hsa-miR-221-3p Sequencing 20371350
MIRT027721 hsa-miR-98-5p Microarray 19088304
MIRT037331 hsa-miR-877-5p CLASH 23622248
MIRT544796 hsa-miR-4506 PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (10)
GO ID Ontology Definition Evidence Reference
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 28514442, 32296183, 32814053, 33961781
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
602240 12983 ENSG00000198315
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q15776
Protein name Zinc finger protein with KRAB and SCAN domains 8 (LD5-1) (Zinc finger protein 192)
Protein function May be involved in transcriptional regulation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02023 SCAN 47 → 134 SCAN domain Domain
PF01352 KRAB 221 → 259 KRAB box Family
PF00096 zf-C2H2 322 → 344 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 350 → 372 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 378 → 400 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 406 → 428 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 434 → 456 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 462 → 484 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 490 → 512 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 518 → 540 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 546 → 568 Zinc finger, C2H2 type Domain
Sequence 
MAEESRKPSAPSPPDQTPEEDLVIVKVEEDHGWDQESSLHESNPLGQEVFRLRFRQLRYQ
ETLGPREALIQLRALCHQWLRPDLNTKEQILELLVLEQFLTILPEELQTLVKEHQLENGE
EVVTLLEDLERQIDILGRPVSARVHGHRVLWEEVVHSASAPEPPNTQLQSEATQHKSPVP
QESQERAMSTSQSPTRSQKGSSGDQEMTATLLTAGFQTLEKIEDMAVSLIREEWLLDPSQ
KDLCRDNRPENFRNMFSLGGETRSENRELASKQVISTGIQPHGETAAKCNGDVIRGLEHE
EARDLLGRLERQRGNPTQERRHKCDECGKSFAQSSGLVRHWRIHTGEKPYQCNVCGKAFS
YRSALLSHQDIHNKVKRYHCKECGKAFSQNTGLILHQRIHTGEKPYQCNQCGKAFSQSAG
LILHQRIHSGERPYECNECGKAFSHSSHLIGHQRIHTGEKPYECDECGKTFRRSSHLIGH
QRSHTGEKPYKCNECGRAFSQKSGLIEHQRIHTGERPYKCKECGKAFNGNTGLIQHLRIH
TGEKPYQCNECGKAFIQRSSLIRHQRIHSGEKSESISV
Sequence length 578
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Generic Transcription Pathway
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (4)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
AUTISM SPECTRUM DISORDER — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 1 DIABETES MELLITUS — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (3)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Hemochromatosis Hemochromatosis BEFREE 8673473
★★★★★
★☆☆☆☆
Found in Text Mining only
HEMOCHROMATOSIS, TYPE 1 Hemochromatosis BEFREE 8673473
★★★★★
★☆☆☆☆
Found in Text Mining only
Hereditary hemochromatosis Hereditary Hemochromatosis BEFREE 8673473
★★★★★
★☆☆☆☆
Found in Text Mining only