Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	7739
Gene name	Zinc finger protein 185 with LIM domain
Gene symbol	ZNF185
Synonyms (NCBI Gene)	SCELL
Chromosome	X
Chromosome location	Xq28
Summary	Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a LIM-domain zinc finger protein. The LIM domain is composed of two contiguous

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Show/Hide all (181)

miRTarBase ID	miRNA	Experiments	Reference
MIRT689983	hsa-miR-4694-3p	HITS-CLIP	23313552
MIRT689982	hsa-miR-224-3p	HITS-CLIP	23313552
MIRT689981	hsa-miR-522-3p	HITS-CLIP	23313552
MIRT689980	hsa-miR-3183	HITS-CLIP	23313552
MIRT689979	hsa-miR-4723-3p	HITS-CLIP	23313552
MIRT689978	hsa-miR-6769b-3p	HITS-CLIP	23313552
MIRT689977	hsa-miR-1283	HITS-CLIP	23313552
MIRT689976	hsa-miR-6817-3p	HITS-CLIP	23313552
MIRT689975	hsa-miR-146a-3p	HITS-CLIP	23313552
MIRT689974	hsa-miR-301a-5p	HITS-CLIP	23313552
MIRT689973	hsa-miR-301b-5p	HITS-CLIP	23313552
MIRT689972	hsa-miR-3921	HITS-CLIP	23313552
MIRT689971	hsa-miR-4653-5p	HITS-CLIP	23313552
MIRT689970	hsa-miR-873-5p	HITS-CLIP	23313552
MIRT689969	hsa-miR-1-3p	HITS-CLIP	23313552
MIRT689968	hsa-miR-206	HITS-CLIP	23313552
MIRT689967	hsa-miR-613	HITS-CLIP	23313552
MIRT689966	hsa-miR-1207-5p	HITS-CLIP	23313552
MIRT689965	hsa-miR-4763-3p	HITS-CLIP	23313552
MIRT689964	hsa-miR-4736	HITS-CLIP	23313552
MIRT689963	hsa-miR-4326	HITS-CLIP	23313552
MIRT689962	hsa-miR-579-3p	HITS-CLIP	23313552
MIRT689961	hsa-miR-664b-3p	HITS-CLIP	23313552
MIRT689960	hsa-miR-7111-3p	HITS-CLIP	23313552
MIRT689959	hsa-miR-6780a-3p	HITS-CLIP	23313552
MIRT689958	hsa-miR-6881-3p	HITS-CLIP	23313552
MIRT689957	hsa-miR-7150	HITS-CLIP	23313552
MIRT689956	hsa-miR-182-5p	HITS-CLIP	23313552
MIRT689955	hsa-miR-1271-5p	HITS-CLIP	23313552
MIRT689954	hsa-miR-96-5p	HITS-CLIP	23313552
MIRT689953	hsa-miR-4436b-3p	HITS-CLIP	23313552
MIRT689983	hsa-miR-4694-3p	HITS-CLIP	23313552
MIRT689982	hsa-miR-224-3p	HITS-CLIP	23313552
MIRT689981	hsa-miR-522-3p	HITS-CLIP	23313552
MIRT689980	hsa-miR-3183	HITS-CLIP	23313552
MIRT689979	hsa-miR-4723-3p	HITS-CLIP	23313552
MIRT689978	hsa-miR-6769b-3p	HITS-CLIP	23313552
MIRT689977	hsa-miR-1283	HITS-CLIP	23313552
MIRT689976	hsa-miR-6817-3p	HITS-CLIP	23313552
MIRT689975	hsa-miR-146a-3p	HITS-CLIP	23313552
MIRT689974	hsa-miR-301a-5p	HITS-CLIP	23313552
MIRT689973	hsa-miR-301b-5p	HITS-CLIP	23313552
MIRT689972	hsa-miR-3921	HITS-CLIP	23313552
MIRT689971	hsa-miR-4653-5p	HITS-CLIP	23313552
MIRT689970	hsa-miR-873-5p	HITS-CLIP	23313552
MIRT689969	hsa-miR-1-3p	HITS-CLIP	23313552
MIRT689968	hsa-miR-206	HITS-CLIP	23313552
MIRT689967	hsa-miR-613	HITS-CLIP	23313552
MIRT689966	hsa-miR-1207-5p	HITS-CLIP	23313552
MIRT689965	hsa-miR-4763-3p	HITS-CLIP	23313552
MIRT689964	hsa-miR-4736	HITS-CLIP	23313552
MIRT689963	hsa-miR-4326	HITS-CLIP	23313552
MIRT689962	hsa-miR-579-3p	HITS-CLIP	23313552
MIRT689961	hsa-miR-664b-3p	HITS-CLIP	23313552
MIRT689960	hsa-miR-7111-3p	HITS-CLIP	23313552
MIRT689959	hsa-miR-6780a-3p	HITS-CLIP	23313552
MIRT689958	hsa-miR-6881-3p	HITS-CLIP	23313552
MIRT689957	hsa-miR-7150	HITS-CLIP	23313552
MIRT689956	hsa-miR-182-5p	HITS-CLIP	23313552
MIRT689955	hsa-miR-1271-5p	HITS-CLIP	23313552
MIRT689954	hsa-miR-96-5p	HITS-CLIP	23313552
MIRT689953	hsa-miR-4436b-3p	HITS-CLIP	23313552
MIRT1517259	hsa-miR-4475	CLIP-seq
MIRT1517260	hsa-miR-4643	CLIP-seq
MIRT1517261	hsa-miR-103b	CLIP-seq
MIRT1517262	hsa-miR-1207-3p	CLIP-seq
MIRT1517263	hsa-miR-1225-5p	CLIP-seq
MIRT1517264	hsa-miR-124	CLIP-seq
MIRT1517265	hsa-miR-1253	CLIP-seq
MIRT1517266	hsa-miR-1343	CLIP-seq
MIRT1517267	hsa-miR-155	CLIP-seq
MIRT1517268	hsa-miR-21	CLIP-seq
MIRT1517269	hsa-miR-2117	CLIP-seq
MIRT1517270	hsa-miR-27a	CLIP-seq
MIRT1517271	hsa-miR-27b	CLIP-seq
MIRT1517272	hsa-miR-3064-3p	CLIP-seq
MIRT1517273	hsa-miR-3074-5p	CLIP-seq
MIRT1517274	hsa-miR-3115	CLIP-seq
MIRT1517275	hsa-miR-3125	CLIP-seq
MIRT1517276	hsa-miR-3154	CLIP-seq
MIRT1517277	hsa-miR-3159	CLIP-seq
MIRT1517278	hsa-miR-3171	CLIP-seq
MIRT1517279	hsa-miR-3190	CLIP-seq
MIRT1517280	hsa-miR-3591-5p	CLIP-seq
MIRT1517281	hsa-miR-3612	CLIP-seq
MIRT1517282	hsa-miR-3616-3p	CLIP-seq
MIRT1517283	hsa-miR-365	CLIP-seq
MIRT1517284	hsa-miR-3675-5p	CLIP-seq
MIRT1517285	hsa-miR-3690	CLIP-seq
MIRT1517286	hsa-miR-3714	CLIP-seq
MIRT1517287	hsa-miR-3910	CLIP-seq
MIRT1517288	hsa-miR-3916	CLIP-seq
MIRT1517289	hsa-miR-4252	CLIP-seq
MIRT1517290	hsa-miR-4254	CLIP-seq
MIRT1517291	hsa-miR-4264	CLIP-seq
MIRT1517292	hsa-miR-4273	CLIP-seq
MIRT1517293	hsa-miR-4290	CLIP-seq
MIRT1517294	hsa-miR-4305	CLIP-seq
MIRT1517295	hsa-miR-4320	CLIP-seq
MIRT1517296	hsa-miR-4328	CLIP-seq
MIRT1517297	hsa-miR-4422	CLIP-seq
MIRT1517298	hsa-miR-4443	CLIP-seq
MIRT1517299	hsa-miR-4450	CLIP-seq
MIRT1517300	hsa-miR-4457	CLIP-seq
MIRT1517301	hsa-miR-4481	CLIP-seq
MIRT1517302	hsa-miR-4633-3p	CLIP-seq
MIRT1517303	hsa-miR-4661-5p	CLIP-seq
MIRT1517304	hsa-miR-4662a-3p	CLIP-seq
MIRT1517305	hsa-miR-4677-3p	CLIP-seq
MIRT1517306	hsa-miR-4679	CLIP-seq
MIRT1517307	hsa-miR-4715-3p	CLIP-seq
MIRT1517308	hsa-miR-4720-3p	CLIP-seq
MIRT1517309	hsa-miR-4721	CLIP-seq
MIRT1517310	hsa-miR-4745-5p	CLIP-seq
MIRT1517311	hsa-miR-4758-5p	CLIP-seq
MIRT1517312	hsa-miR-4762-5p	CLIP-seq
MIRT1517313	hsa-miR-4764-5p	CLIP-seq
MIRT1517314	hsa-miR-4766-5p	CLIP-seq
MIRT1517315	hsa-miR-4795-3p	CLIP-seq
MIRT1517316	hsa-miR-4797-3p	CLIP-seq
MIRT1517317	hsa-miR-487a	CLIP-seq
MIRT1517318	hsa-miR-488	CLIP-seq
MIRT1517319	hsa-miR-506	CLIP-seq
MIRT1517320	hsa-miR-513a-5p	CLIP-seq
MIRT1517321	hsa-miR-513b	CLIP-seq
MIRT1517322	hsa-miR-520a-5p	CLIP-seq
MIRT1517323	hsa-miR-525-5p	CLIP-seq
MIRT1517324	hsa-miR-580	CLIP-seq
MIRT1517325	hsa-miR-590-5p	CLIP-seq
MIRT1517326	hsa-miR-648	CLIP-seq
MIRT1517327	hsa-miR-650	CLIP-seq
MIRT1517328	hsa-miR-7	CLIP-seq
MIRT1517329	hsa-miR-891b	CLIP-seq
MIRT2156168	hsa-miR-4521	CLIP-seq
MIRT2156169	hsa-miR-4668-3p	CLIP-seq
MIRT2156170	hsa-miR-4793-3p	CLIP-seq
MIRT1517263	hsa-miR-1225-5p	CLIP-seq
MIRT1517267	hsa-miR-155	CLIP-seq
MIRT2375750	hsa-miR-199a-3p	CLIP-seq
MIRT2375751	hsa-miR-199b-3p	CLIP-seq
MIRT1517270	hsa-miR-27a	CLIP-seq
MIRT1517271	hsa-miR-27b	CLIP-seq
MIRT1517274	hsa-miR-3115	CLIP-seq
MIRT1517275	hsa-miR-3125	CLIP-seq
MIRT2375752	hsa-miR-3127-5p	CLIP-seq
MIRT2375753	hsa-miR-3129-5p	CLIP-seq
MIRT1517277	hsa-miR-3159	CLIP-seq
MIRT2375754	hsa-miR-329	CLIP-seq
MIRT2375755	hsa-miR-34c-3p	CLIP-seq
MIRT2375756	hsa-miR-362-3p	CLIP-seq
MIRT1517283	hsa-miR-365	CLIP-seq
MIRT2375757	hsa-miR-3664-5p	CLIP-seq
MIRT1517284	hsa-miR-3675-5p	CLIP-seq
MIRT2375758	hsa-miR-383	CLIP-seq
MIRT1517288	hsa-miR-3916	CLIP-seq
MIRT2375759	hsa-miR-3941	CLIP-seq
MIRT2375760	hsa-miR-4270	CLIP-seq
MIRT1517292	hsa-miR-4273	CLIP-seq
MIRT1517293	hsa-miR-4290	CLIP-seq
MIRT2375761	hsa-miR-4441	CLIP-seq
MIRT1517299	hsa-miR-4450	CLIP-seq
MIRT1517260	hsa-miR-4643	CLIP-seq
MIRT2156169	hsa-miR-4668-3p	CLIP-seq
MIRT2375762	hsa-miR-4714-5p	CLIP-seq
MIRT2375763	hsa-miR-4731-3p	CLIP-seq
MIRT1517312	hsa-miR-4762-5p	CLIP-seq
MIRT2375764	hsa-miR-4772-5p	CLIP-seq
MIRT1517315	hsa-miR-4795-3p	CLIP-seq
MIRT2375765	hsa-miR-4801	CLIP-seq
MIRT1517320	hsa-miR-513a-5p	CLIP-seq
MIRT1517322	hsa-miR-520a-5p	CLIP-seq
MIRT1517323	hsa-miR-525-5p	CLIP-seq
MIRT2375766	hsa-miR-603	CLIP-seq
MIRT2375767	hsa-miR-606	CLIP-seq
MIRT2375768	hsa-miR-885-5p	CLIP-seq
MIRT2375769	hsa-miR-9	CLIP-seq
MIRT2375770	hsa-miR-936	CLIP-seq
MIRT2695763	hsa-miR-1236	CLIP-seq
MIRT2695764	hsa-miR-2276	CLIP-seq
MIRT2695765	hsa-miR-4330	CLIP-seq
MIRT2695766	hsa-miR-4772-3p	CLIP-seq

Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005925	Component	Focal adhesion	IEA
GO:0008270	Function	Zinc ion binding	TAS	9268636
GO:0046872	Function	Metal ion binding	IEA
GO:0070161	Component	Anchoring junction	IEA

MIM	HGNC	e!Ensembl
300381	12976	ENSG00000147394

O15231

Protein name

Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A)

Protein function

May be involved in the regulation of cellular proliferation and/or differentiation.

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Expressed in placenta, pancreas and kidney. Also expressed in prostate, testis, ovary and blood.

Sequence

MSISALGGRTKGKPLPPGEEERNNVLKQMKVRTTLKGDKSWITKQDESEGRTIELPSGRS
RATSFSSAGEVPKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTPKSAASLVR
TANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEA
ASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARS
TPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPD
VEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPE
GLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEA
WQERPGAPRGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVA
TKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPS
SCMVTVTVTATSEQPHIYIPAPASELDSSSTTKGILFVKEYVNASEVSSGKPVSARYSNV
SSIEDSFAMEKKPPCGSTPYSERTTGGICTYCNREIRDCPKITLEHLGICCHEYCFKCGI
CSKPMGDLLDQIFIHRDTIHCGKCYEKLF

Sequence length

689

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTISTIC DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEARING LOSS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous cell carcinoma of the head and neck	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (24)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	27655485		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alport Syndrome	Alport Syndrome	BEFREE	2654472		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	27768594	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	15731117		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	35111149	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	30337687	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Pancreatic Ductal	Pancreatic Ductal Carcinoma	BEFREE	28927124		★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	30201491		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary nephritis	Hereditary Nephritis	BEFREE	2654472		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inborn Errors of Metabolism	Inborn Errors Of Metabolism	BEFREE	28834604		★★★★★ ★☆☆☆☆ Found in Text Mining only
Infertility Male	Male infertility	Pubtator	39267058	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	27768594		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	8766521		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	15731117		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	15731117		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	12873976		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	27768594		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	27655485, 28927124		★★★★★ ★☆☆☆☆ Found in Text Mining only
Paroxysmal Nonkinesigenic Dyskinesia 1	Paroxysmal nonkinesigenic dyskinesia	BEFREE	28927124		★★★★★ ★☆☆☆☆ Found in Text Mining only
Personality Disorders	Personality Disorders	BEFREE	16451681		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	12873976		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	12873976		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	30337687		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	30337687	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZNF185 (zinc finger protein 185 with LIM domain)