Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7700
Gene name	Zinc finger protein 141
Gene symbol	ZNF141
Synonyms (NCBI Gene)	D4S90pHZ-44
Chromosome	4
Chromosome location	4p16.3
Summary	The protein encoded by this gene is a zinc finger protein that may be a tumor suppressor. Defects in this gene have been associated with autosomal recessive postaxial polydactyly type A. [provided by RefSeq, Jan 2017]

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SNP ID	Visualize variation	Clinical significance	Consequence
rs587776959	C>T	Pathogenic-likely-pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant, intron variant

Show/Hide all (70)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028830	hsa-miR-26b-5p	Microarray	19088304
MIRT650461	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT650460	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT650459	hsa-miR-940	HITS-CLIP	23824327
MIRT650458	hsa-miR-3929	HITS-CLIP	23824327
MIRT650457	hsa-miR-4419b	HITS-CLIP	23824327
MIRT650456	hsa-miR-4478	HITS-CLIP	23824327
MIRT519276	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT650455	hsa-miR-6078	HITS-CLIP	23824327
MIRT650454	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT650453	hsa-miR-1827	HITS-CLIP	23824327
MIRT519272	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT650452	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT650451	hsa-miR-665	HITS-CLIP	23824327
MIRT519277	hsa-miR-302f	PAR-CLIP	23446348
MIRT519276	hsa-miR-4768-3p	PAR-CLIP	23446348
MIRT519275	hsa-miR-4740-3p	PAR-CLIP	23446348
MIRT519274	hsa-miR-219b-3p	PAR-CLIP	23446348
MIRT519273	hsa-miR-6134	PAR-CLIP	23446348
MIRT519272	hsa-miR-4722-5p	PAR-CLIP	23446348
MIRT519271	hsa-miR-6880-5p	PAR-CLIP	23446348
MIRT519270	hsa-miR-7847-3p	PAR-CLIP	23446348
MIRT519269	hsa-miR-1273e	PAR-CLIP	23446348
MIRT650461	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT650460	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT650459	hsa-miR-940	HITS-CLIP	23824327
MIRT650458	hsa-miR-3929	HITS-CLIP	23824327
MIRT650457	hsa-miR-4419b	HITS-CLIP	23824327
MIRT650456	hsa-miR-4478	HITS-CLIP	23824327
MIRT519276	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT650455	hsa-miR-6078	HITS-CLIP	23824327
MIRT650454	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT650453	hsa-miR-1827	HITS-CLIP	23824327
MIRT519272	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT650452	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT650451	hsa-miR-665	HITS-CLIP	23824327
MIRT519277	hsa-miR-302f	PAR-CLIP	23446348
MIRT519276	hsa-miR-4768-3p	PAR-CLIP	23446348
MIRT519275	hsa-miR-4740-3p	PAR-CLIP	23446348
MIRT519274	hsa-miR-219b-3p	PAR-CLIP	23446348
MIRT519273	hsa-miR-6134	PAR-CLIP	23446348
MIRT519272	hsa-miR-4722-5p	PAR-CLIP	23446348
MIRT519271	hsa-miR-6880-5p	PAR-CLIP	23446348
MIRT519270	hsa-miR-7847-3p	PAR-CLIP	23446348
MIRT519269	hsa-miR-1273e	PAR-CLIP	23446348
MIRT1516572	hsa-miR-3064-3p	CLIP-seq
MIRT1516573	hsa-miR-3159	CLIP-seq
MIRT1516574	hsa-miR-3167	CLIP-seq
MIRT1516575	hsa-miR-3674	CLIP-seq
MIRT1516576	hsa-miR-4464	CLIP-seq
MIRT1516577	hsa-miR-4715-3p	CLIP-seq
MIRT1516578	hsa-miR-4748	CLIP-seq
MIRT1516579	hsa-miR-4776-3p	CLIP-seq
MIRT1516580	hsa-miR-876-5p	CLIP-seq
MIRT1516572	hsa-miR-3064-3p	CLIP-seq
MIRT1516573	hsa-miR-3159	CLIP-seq
MIRT1516575	hsa-miR-3674	CLIP-seq
MIRT1516576	hsa-miR-4464	CLIP-seq
MIRT1516577	hsa-miR-4715-3p	CLIP-seq
MIRT1516578	hsa-miR-4748	CLIP-seq
MIRT1516579	hsa-miR-4776-3p	CLIP-seq
MIRT1516572	hsa-miR-3064-3p	CLIP-seq
MIRT1516573	hsa-miR-3159	CLIP-seq
MIRT1516574	hsa-miR-3167	CLIP-seq
MIRT1516575	hsa-miR-3674	CLIP-seq
MIRT1516576	hsa-miR-4464	CLIP-seq
MIRT1516577	hsa-miR-4715-3p	CLIP-seq
MIRT1516578	hsa-miR-4748	CLIP-seq
MIRT1516579	hsa-miR-4776-3p	CLIP-seq
MIRT1516580	hsa-miR-876-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	7649249
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006366	Process	Transcription by RNA polymerase II	TAS	8268908
GO:0008270	Function	Zinc ion binding	IEA
GO:0009653	Process	Anatomical structure morphogenesis	TAS	8268908
GO:0035108	Process	Limb morphogenesis	IMP	23160277
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
194648	12926	ENSG00000131127

Q15928

Protein name

Zinc finger protein 141

Protein function

May be involved in transcriptional regulation as a repressor. Plays a role in limb development.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01352	KRAB	3 → 44	KRAB box	Family
PF00096	zf-C2H2	227 → 249	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	255 → 277	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	283 → 305	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	311 → 333	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	339 → 361	Zinc finger, C2H2 type	Domain
PF13912	zf-C2H2_6	367 → 392		Domain
PF00096	zf-C2H2	395 → 417	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	423 → 445	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	451 → 473	Zinc finger, C2H2 type	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously low expression.

Sequence

MELLTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSLGVAISNPDLVTCLEQRK
EPYNVKIHKIVARPPAMCSHFTQDHWPVQGIEDSFHKLILRRYEKCGHDNLQLRKGCKSL
NECKLQKGGYNEFNECLSTTQSKILQCKASVKVVSKFSNSNKRKTRHTGEKHFKECGKSF
QKFSHLTQHKVIHAGEKPYTCEECGKAFKWSLIFNEHKRIHTGEKPFTCEECGSIFTTSS
HFAKHKIIHTGEKPYKCEECGKAFNRFTTLTKHKRIHAGEKPITCEECRKIFTSSSNFAK
HKRIHTGEKPYKCEECGKAFNRSTTLTKHKRIHTGEKPYTCEECGKAFRQSSKLNEHKKV
HTGERPYKCDECGKAFGRSRVLNEHKKIHTGEKPYKCEECGKAFRRSTDRSQHKKIHSAD
KPYKCKECDKAFKQFSLLSQHKKIHTVDKPYKCKDCDKAFKRFSHLNKHKKIHT

Sequence length

474

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Polydactyly, postaxial, type A6	Likely pathogenic; Pathogenic	rs587776959	RCV000043502	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
POSTAXIAL POLYDACTYLY TYPE A	—	Disgenet Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ZNF141-related disorder	Benign; Uncertain significance; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (12)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Huntington Disease	Huntington Disease	BEFREE	1350884, 1829583, 2521771, 2531224, 2574148, 7760321		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intestinal Diseases	Intestinal disease	Pubtator	17071588	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polydactyly	Polydactyly	GENOMICS_ENGLAND_DG	23160277		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polydactyly	Polydactyly	Pubtator	28488682, 31115189	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
POLYDACTYLY, POSTAXIAL	Polydactyly	BEFREE	23160277		★★★★★ ★☆☆☆☆ Found in Text Mining only
POLYDACTYLY, POSTAXIAL, TYPE A6	Polydactyly	UNIPROT_DG	23160277		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
POLYDACTYLY, POSTAXIAL, TYPE A6	Polydactyly	GENOMICS_ENGLAND_DG	23160277		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
POLYDACTYLY, POSTAXIAL, TYPE A6	Polydactyly	CLINVAR_DG	23160277		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Postaxial polydactyly type A	Polydactyly	BEFREE	23160277		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Postaxial polydactyly type A	Polydactyly	ORPHANET_DG	23160277, 26394607		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ulnar polydactyly of fingers	Postaxial hand polydactyly	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Wolf-Hirschhorn Syndrome	Wolf-Hirschhorn Syndrome	BEFREE	8268908		★★★★★ ★☆☆☆☆ Found in Text Mining only

ZNF141 (zinc finger protein 141)