Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7692
Gene name	Zinc finger protein 133
Gene symbol	ZNF133
Synonyms (NCBI Gene)	ZNF150pHZ-13pHZ-66
Chromosome	20
Chromosome location	20p11.23

Show/Hide all (22)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029486	hsa-miR-26b-5p	Microarray	19088304
MIRT1516355	hsa-miR-105	CLIP-seq
MIRT1516356	hsa-miR-132	CLIP-seq
MIRT1516357	hsa-miR-212	CLIP-seq
MIRT1516358	hsa-miR-30a	CLIP-seq
MIRT1516359	hsa-miR-30b	CLIP-seq
MIRT1516360	hsa-miR-30c	CLIP-seq
MIRT1516361	hsa-miR-30d	CLIP-seq
MIRT1516362	hsa-miR-30e	CLIP-seq
MIRT1516363	hsa-miR-3121-5p	CLIP-seq
MIRT1516355	hsa-miR-105	CLIP-seq
MIRT1516356	hsa-miR-132	CLIP-seq
MIRT1516357	hsa-miR-212	CLIP-seq
MIRT1516363	hsa-miR-3121-5p	CLIP-seq
MIRT2441810	hsa-miR-3152-5p	CLIP-seq
MIRT2441811	hsa-miR-4540	CLIP-seq
MIRT2441812	hsa-miR-4646-3p	CLIP-seq
MIRT2441813	hsa-miR-4774-3p	CLIP-seq
MIRT2441810	hsa-miR-3152-5p	CLIP-seq
MIRT2441811	hsa-miR-4540	CLIP-seq
MIRT2441812	hsa-miR-4646-3p	CLIP-seq
MIRT2441813	hsa-miR-4774-3p	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	7649249
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003700	Function	DNA-binding transcription factor activity	TAS	9278146
GO:0005515	Function	Protein binding	IPI	20195357, 25416956
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
604075	12917	ENSG00000125846

P52736

Protein name

Zinc finger protein 133 (Zinc finger protein 150)

Protein function

May be involved in transcriptional regulation as a repressor.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01352	KRAB	1 → 41	KRAB box	Family
PF00096	zf-C2H2	214 → 236	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	242 → 264	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	270 → 292	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	298 → 320	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	326 → 348	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	354 → 376	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	382 → 404	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	410 → 432	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	438 → 460	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	466 → 488	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	494 → 516	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	522 → 544	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	606 → 631	Zinc finger, C2H2 type	Domain

Tissue specificity

TISSUE SPECIFICITY: Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Sequence

MAFRDVAVDFTQDEWRLLSPAQRTLYREVMLENYSNLVSLGISFSKPELITQLEQGKETW
REEKKCSPATCPADPEPELYLDPFCPPGFSSQKFPMQHVLCNHPPWIFTCLCAEGNIQPG
DPGPGDQEKQQQASEGRPWSDQAEGPEGEGAMPLFGRTKKRTLGAFSRPPQRQPVSSRNG
LRGVELEASPAQSGNPEETDKLLKRIEVLGFGTVNCGECGLSFSKMTNLLSHQRIHSGEK
PYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKSTLIIHERTHSGEKPYMC
SECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVRHQRTHLEEKTIVCSDCG
LGFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRTHSKEKPYVCGVCGHSFS
QNSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGEKPIVCKDCGRGFSQQSN
LIRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYVCRECGRGFSHQAGLIRH
KRKHSREKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCRECGQGFLQKSHLTLHQMTH
TGEKPYVCKTCGRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPCAGQPSDSLYSL

Sequence length

654

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alagille Syndrome	Alagille Syndrome	BEFREE	7557990		★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	37466093	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Corneal Dystrophy Posterior Polymorphous 1	Posterior polymorphous corneal dystrophy	Pubtator	23049806	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
CORNEAL ENDOTHELIAL DYSTROPHY 1, AUTOSOMAL DOMINANT	CORNEAL ENDOTHELIAL DYSTROPHY	BEFREE	23049806		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	30851117		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	37466093	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
von Willebrand Disease Type 2	Von willebrand disorder	Pubtator	32577795	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZNF133 (zinc finger protein 133)