Gene Gene information from NCBI Gene database.
Entrez ID 768211
Gene name RELT like 1
Gene symbol RELL1
Synonyms (NCBI Gene)
-
Chromosome 4
Chromosome location 4p14
miRNA miRNA information provided by mirtarbase database.
602
miRTarBase ID miRNA Experiments Reference
MIRT1300076 hsa-miR-1202 CLIP-seq
MIRT1300077 hsa-miR-1207-5p CLIP-seq
MIRT1300078 hsa-miR-124 CLIP-seq
MIRT1300079 hsa-miR-1266 CLIP-seq
MIRT1300080 hsa-miR-1270 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 22052202, 32296183
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IDA
GO:0005886 Component Plasma membrane IEA
GO:0015630 Component Microtubule cytoskeleton IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611212 27379 ENSG00000181826
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IUW5
Protein name RELT-like protein 1
Protein function Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12606 RELT 58 99 Tumour necrosis factor receptor superfamily member 19 Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Expressed at highest levels in the placenta, skeletal muscle, spleen and testis. {ECO:0000269|PubMed:16389068}.
Sequence
MAPRALPGSAVLAAAVFVGGAVSSPLVAPDNGSSRTLHSRTETTPSPSNDTGNGHPEYIA
YALVPVFFIMGLFGVLICHLLKKKGYRCTTEAEQDIEEE
KVEKIELNDSVNENSDTVGQI
VHYIMKNEANADVLKAMVADNSLYDPESPVTPSTPGSPPVSPGPLSPGGTPGKHVCGHHL
HTVGGVVERDVCHRCRHKRWHFIKPTNKSRESRPRRQGEVTVLSVGRFRVTKVEHKSNQK
ERRSLMSVSGAETVNGEVPATPVKRERSGTE
Sequence length 271
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Cytokine-cytokine receptor interaction  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCOLIOSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Glioblastoma Glioblastoma Pubtator 34646273 Associate
★☆☆☆☆
Found in Text Mining only
Lymphatic Metastasis Lymphatic metastasis Pubtator 35027539 Inhibit
★☆☆☆☆
Found in Text Mining only
Stomach Neoplasms Stomach neoplasms Pubtator 35027539 Associate
★☆☆☆☆
Found in Text Mining only