Gene Gene information from NCBI Gene database.
Entrez ID 7594
Gene name Zinc finger protein 43
Gene symbol ZNF43
Synonyms (NCBI Gene)
HTF6KOX27ZNF39L1
Chromosome 19
Chromosome location 19p12
Summary This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2
miRNA miRNA information provided by mirtarbase database.
581
miRTarBase ID miRNA Experiments Reference
MIRT661148 hsa-miR-34b-3p HITS-CLIP 23824327
MIRT661147 hsa-miR-4655-5p HITS-CLIP 23824327
MIRT661146 hsa-miR-6808-5p HITS-CLIP 23824327
MIRT661145 hsa-miR-6893-5p HITS-CLIP 23824327
MIRT661144 hsa-miR-940 HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8
GO ID Ontology Definition Evidence Reference
GO:0003677 Function DNA binding IEA
GO:0003677 Function DNA binding TAS 1711675
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
GO:0006355 Process Regulation of DNA-templated transcription IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603972 13109 ENSG00000198521
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P17038
Protein name Zinc finger protein 43 (Zinc finger protein 39) (Zinc finger protein HTF6) (Zinc finger protein KOX27)
Protein function May be involved in transcriptional regulation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01352 KRAB 3 44 KRAB box Family
PF00096 zf-C2H2 174 196 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 286 308 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 314 336 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 342 364 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 370 392 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 398 420 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 426 448 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 454 476 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 482 504 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 510 532 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 538 560 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 566 588 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 594 616 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 622 644 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 650 672 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 678 700 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 706 728 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 734 756 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 762 784 Zinc finger, C2H2 type Domain
Tissue specificity TISSUE SPECIFICITY: T- and B-cell lines.
Sequence
MGPLTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLGIAVSKPDLITCLEQEK
EPWEPMRRHEMVAKPPVMCSHFTQDFWPEQHIKDPFQKATLRRYKNCEHKNVHLKKDHKS
VDECKVHRGGYNGFNQCLPATQSKIFLFDKCVKAFHKFSNSNRHKISHTEKKLFKCKECG
KSFCMLPHLAQHKIIH
TRVNFCKCEKCGKAFNCPSIITKHKRINTGEKPYTCEECGKVFN
WSSRLTTHKKNYTRYKLYKCEECGKAFNKSSILTTHKIIRTGEKFYKCKECAKAFNQSSN
LTEHKKIH
PGEKPYKCEECGKAFNWPSTLTKHKRIHTGEKPYTCEECGKAFNQFSNLTTH
KRIH
TAEKFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTH
TGEKPYKCEECGKAFNWPSTLTKHNRIHTGEKPYKCEVCGKAFNQFSNLTTHKRIHTAEK
PYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWSSKLTEHKITHTGEKPYKC
EECGKAFNHFSILTKHKRIH
TGEKPYKCEECGKAFTQSSNLTTHKKIHTGEKFYKCEECG
KAFTQSSNLTTHKKIH
TGGKPYKCEECGKAFNQFSTLTKHKIIHTEEKPYKCEECGKAFK
WSSTLTKHKIIH
TGEKPYKCEECGKAFKLSSTLSTHKIIHTGEKPYKCEKCGKAFNRSSN
LIEHKKIH
TGEQPYKCEECGKAFNYSSHLNTHKRIHTKEQPYKCKECGKAFNQYSNLTTH
NKIH
TGEKLYKPEDVTVILTTPQTFSNIK
Sequence length 809
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Generic Transcription Pathway
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Colorectal Carcinoma Colorectal Cancer UNIPROT_DG
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 30999858, 36142151 Associate
★☆☆☆☆
Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck Squamous cell carcinoma Pubtator 35794182 Associate
★☆☆☆☆
Found in Text Mining only