Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	758
Gene name	Metallophosphoesterase domain containing 1
Gene symbol	MPPED1
Synonyms (NCBI Gene)	239ABC22orf1FAM1A
Chromosome	22
Chromosome location	22q13.2

Show/Hide all (97)

miRTarBase ID	miRNA	Experiments	Reference
MIRT716611	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT716610	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT716609	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT716608	hsa-miR-4638-5p	HITS-CLIP	19536157
MIRT716607	hsa-miR-378g	HITS-CLIP	19536157
MIRT716606	hsa-miR-7152-3p	HITS-CLIP	19536157
MIRT716605	hsa-miR-6131	HITS-CLIP	19536157
MIRT716604	hsa-miR-516a-3p	HITS-CLIP	19536157
MIRT716603	hsa-miR-516b-3p	HITS-CLIP	19536157
MIRT716602	hsa-miR-7162-5p	HITS-CLIP	19536157
MIRT716601	hsa-miR-6781-5p	HITS-CLIP	19536157
MIRT716600	hsa-miR-27a-5p	HITS-CLIP	19536157
MIRT716599	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT716598	hsa-miR-6783-3p	HITS-CLIP	19536157
MIRT716597	hsa-miR-1238-3p	HITS-CLIP	19536157
MIRT716611	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT716610	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT716609	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT716608	hsa-miR-4638-5p	HITS-CLIP	19536157
MIRT716607	hsa-miR-378g	HITS-CLIP	19536157
MIRT716606	hsa-miR-7152-3p	HITS-CLIP	19536157
MIRT716605	hsa-miR-6131	HITS-CLIP	19536157
MIRT716604	hsa-miR-516a-3p	HITS-CLIP	19536157
MIRT716603	hsa-miR-516b-3p	HITS-CLIP	19536157
MIRT716602	hsa-miR-7162-5p	HITS-CLIP	19536157
MIRT716601	hsa-miR-6781-5p	HITS-CLIP	19536157
MIRT716600	hsa-miR-27a-5p	HITS-CLIP	19536157
MIRT716599	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT716598	hsa-miR-6783-3p	HITS-CLIP	19536157
MIRT716597	hsa-miR-1238-3p	HITS-CLIP	19536157
MIRT1156624	hsa-miR-1207-5p	CLIP-seq
MIRT1156625	hsa-miR-1224-3p	CLIP-seq
MIRT1156626	hsa-miR-1260	CLIP-seq
MIRT1156627	hsa-miR-1260b	CLIP-seq
MIRT1156628	hsa-miR-1280	CLIP-seq
MIRT1156629	hsa-miR-1909	CLIP-seq
MIRT1156630	hsa-miR-3137	CLIP-seq
MIRT1156631	hsa-miR-3150a-3p	CLIP-seq
MIRT1156632	hsa-miR-3160-3p	CLIP-seq
MIRT1156633	hsa-miR-3175	CLIP-seq
MIRT1156634	hsa-miR-34a	CLIP-seq
MIRT1156635	hsa-miR-34c-5p	CLIP-seq
MIRT1156636	hsa-miR-3686	CLIP-seq
MIRT1156637	hsa-miR-3943	CLIP-seq
MIRT1156638	hsa-miR-4436b-3p	CLIP-seq
MIRT1156639	hsa-miR-4462	CLIP-seq
MIRT1156640	hsa-miR-449a	CLIP-seq
MIRT1156641	hsa-miR-449b	CLIP-seq
MIRT1156642	hsa-miR-4688	CLIP-seq
MIRT1156643	hsa-miR-4747-5p	CLIP-seq
MIRT1156644	hsa-miR-4763-3p	CLIP-seq
MIRT1156645	hsa-miR-4778-5p	CLIP-seq
MIRT1156646	hsa-miR-486-3p	CLIP-seq
MIRT1156647	hsa-miR-491-5p	CLIP-seq
MIRT1156648	hsa-miR-532-3p	CLIP-seq
MIRT1156649	hsa-miR-602	CLIP-seq
MIRT1156650	hsa-miR-625	CLIP-seq
MIRT1156651	hsa-miR-939	CLIP-seq
MIRT2044848	hsa-miR-1227	CLIP-seq
MIRT2044849	hsa-miR-1265	CLIP-seq
MIRT2044850	hsa-miR-1914	CLIP-seq
MIRT2044851	hsa-miR-2964a-5p	CLIP-seq
MIRT2044852	hsa-miR-339-5p	CLIP-seq
MIRT2044853	hsa-miR-4715-3p	CLIP-seq
MIRT2044854	hsa-miR-4746-5p	CLIP-seq
MIRT2274073	hsa-miR-1252	CLIP-seq
MIRT2274074	hsa-miR-24	CLIP-seq
MIRT2274075	hsa-miR-3202	CLIP-seq
MIRT2274076	hsa-miR-3677-5p	CLIP-seq
MIRT2274077	hsa-miR-4284	CLIP-seq
MIRT2274078	hsa-miR-4310	CLIP-seq
MIRT2274079	hsa-miR-4533	CLIP-seq
MIRT2274080	hsa-miR-4743	CLIP-seq
MIRT1156645	hsa-miR-4778-5p	CLIP-seq
MIRT2274081	hsa-miR-512-5p	CLIP-seq
MIRT1156624	hsa-miR-1207-5p	CLIP-seq
MIRT1156629	hsa-miR-1909	CLIP-seq
MIRT1156634	hsa-miR-34a	CLIP-seq
MIRT1156635	hsa-miR-34c-5p	CLIP-seq
MIRT1156638	hsa-miR-4436b-3p	CLIP-seq
MIRT1156640	hsa-miR-449a	CLIP-seq
MIRT1156641	hsa-miR-449b	CLIP-seq
MIRT1156642	hsa-miR-4688	CLIP-seq
MIRT1156644	hsa-miR-4763-3p	CLIP-seq
MIRT1156646	hsa-miR-486-3p	CLIP-seq
MIRT1156647	hsa-miR-491-5p	CLIP-seq
MIRT1156649	hsa-miR-602	CLIP-seq
MIRT2391021	hsa-miR-877	CLIP-seq
MIRT2685236	hsa-miR-15a	CLIP-seq
MIRT2685237	hsa-miR-15b	CLIP-seq
MIRT2685238	hsa-miR-16	CLIP-seq
MIRT2685239	hsa-miR-195	CLIP-seq
MIRT2685240	hsa-miR-2278	CLIP-seq
MIRT2685241	hsa-miR-424	CLIP-seq
MIRT2685242	hsa-miR-497	CLIP-seq
MIRT2685243	hsa-miR-646	CLIP-seq
MIRT2685244	hsa-miR-665	CLIP-seq

Show/Hide all (5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005575	Component	Cellular_component	ND
GO:0008150	Process	Biological_process	ND
GO:0016787	Function	Hydrolase activity	IEA

MIM	HGNC	e!Ensembl
602112	1306	ENSG00000186732

O15442

Protein name

Metallophosphoesterase domain-containing protein 1 (EC 3.1.-.-) (Adult brain protein 239) (239AB)

Protein function

May have metallophosphoesterase activity (in vitro).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00149	Metallophos	90 → 288	Calcineurin-like phosphoesterase	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed predominantly in adult brain.

Sequence

MWRSRWDASVLKAEALALLPCGLGMAFSQSHVMAARRHQHSRLIIEVDEYSSNPTQAFTF
YNINQGRFQPPHVQMVDPVPHDAPKPPGYTRFVCVSDTHSRTDPIQMPYGDVLIHAGDFT
ELGLPSEVKKFNEWLGSLPYEYKIVIAGNHELTFDQEFMADLIKQDFYYFPSVSKLKPEN
YENVQSLLTNCIYLQDSEVTVRGFRIYGSPWQPWFYGWGFNLPRGQALLEKWNLIPEGVD
ILITHGPPLGFLDWVPKKMQRVGCVELLNTVQRRVQPRLHVFGHIHEGYGVMADGTTTYV
NASVCTVNYQPVNPPIVIDLPTPRNS

Sequence length

326

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, BASAL CELL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Chronic Periodontitis	Periodontitis	BEFREE	30409304		★★★★★ ★☆☆☆☆ Found in Text Mining only

MPPED1 (metallophosphoesterase domain containing 1)