Gene Gene information from NCBI Gene database.
Entrez ID 7555
Gene name CCHC-type zinc finger nucleic acid binding protein
Gene symbol CNBP
Synonyms (NCBI Gene)
CNBP1DM2PROMMRNF163ZCCHC22ZNF9
Chromosome 3
Chromosome location 3q21.3
Summary This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also funct
miRNA miRNA information provided by mirtarbase database.
1346
miRTarBase ID miRNA Experiments Reference
MIRT052598 hsa-let-7a-5p CLASH 23622248
MIRT051588 hsa-let-7e-5p CLASH 23622248
MIRT051588 hsa-let-7e-5p CLASH 23622248
MIRT050198 hsa-miR-26a-5p CLASH 23622248
MIRT044933 hsa-miR-186-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
29
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 23774591
GO:0003676 Function Nucleic acid binding IEA
GO:0003677 Function DNA binding IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003727 Function Single-stranded RNA binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
116955 13164 ENSG00000169714
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P62633
Protein name CCHC-type zinc finger nucleic acid binding protein (Cellular nucleic acid-binding protein) (CNBP) (Zinc finger protein 9)
Protein function Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (PubMed:2562787). Has a role as transactivator of the Myc promoter (By
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00098 zf-CCHC 4 21 Zinc knuckle Domain
PF00098 zf-CCHC 52 69 Zinc knuckle Domain
PF00098 zf-CCHC 72 89 Zinc knuckle Domain
PF00098 zf-CCHC 96 113 Zinc knuckle Domain
PF00098 zf-CCHC 117 134 Zinc knuckle Domain
PF00098 zf-CCHC 135 152 Zinc knuckle Domain
PF00098 zf-CCHC 156 173 Zinc knuckle Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the liver, kidney, spleen, testis, lung, muscle and adrenal glands. {ECO:0000269|PubMed:2562787}.
Sequence
Sequence length 177
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CNBP-related disorder Benign; Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DYSTROPHIA MYOTONICA 2 Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MYOTONIC DYSTROPHY CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MYOTONIC DYSTROPHY 2 HPO
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Erythroblastic Leukemia Erythroblastic Leukemia BEFREE 23609441
★☆☆☆☆
Found in Text Mining only
Anemia, Diamond-Blackfan Anemia BEFREE 30700418
★☆☆☆☆
Found in Text Mining only
Aortic Valve Stenosis Aortic Valve Sclerosis BEFREE 19470430
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 15388640, 24300912, 25188917, 30777884
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma Pubtator 17052361 Stimulate
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 15388640, 24300912, 25188917, 30777884
★☆☆☆☆
Found in Text Mining only
B-Cell Lymphomas B-Cell Lymphoma BEFREE 19758361
★☆☆☆☆
Found in Text Mining only
Brain Neoplasms Brain Neoplasms BEFREE 15994924
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 12531699
★☆☆☆☆
Found in Text Mining only
Cataract Cataract HPO_DG
★☆☆☆☆
Found in Text Mining only