Gene Gene information from NCBI Gene database.
Entrez ID 7534
Gene name Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Gene symbol YWHAZ
Synonyms (NCBI Gene)
14-3-3-zetaHEL-S-3HEL-S-93HEL4KCIP-1POPCHASYWHAD
Chromosome 8
Chromosome location 8q22.3
Summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to th
miRNA miRNA information provided by mirtarbase database.
1536
miRTarBase ID miRNA Experiments Reference
MIRT006983 hsa-miR-193b-3p Luciferase reporter assay 21512034
MIRT006983 hsa-miR-193b-3p Reporter assay;Proteomics 21512034
MIRT019886 hsa-miR-375 Reporter assay;Western blot;qRT-PCR;Microarray 20215506
MIRT020711 hsa-miR-155-5p Reporter assay;Other 20584899
MIRT023741 hsa-miR-1-3p Proteomics 18668040
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
65
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 21621563
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0001525 Process Angiogenesis IEA
GO:0003016 Process Respiratory system process IEA
GO:0003723 Function RNA binding HDA 22658674
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601288 12855 ENSG00000164924
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P63104
Protein name 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Protein function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to
PDB 1IB1 , 1QJA , 1QJB , 2C1J , 2C1N , 2O02 , 2WH0 , 3CU8 , 3NKX , 3RDH , 4BG6 , 4FJ3 , 4HKC , 4IHL , 4N7G , 4N7Y , 4N84 , 4WRQ , 4ZDR , 5D2D , 5D3F , 5EWZ , 5EXA , 5J31 , 5JM4 , 5M35 , 5M36 , 5M37 , 5NAS , 5ULO , 5WXN , 5XY9 , 6EF5 , 6EJL , 6EWW , 6F08 , 6F09 , 6FN9 , 6FNA , 6FNB , 6FNC , 6Q0K , 6RLZ , 6U2H , 6XAG , 6YMO , 6YO8 , 6YOS , 6ZFD , 6ZFG , 7D8H
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00244 14-03-2003 9 229 14-3-3 protein Domain
Sequence
Sequence length 245
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cell cycle
Oocyte meiosis
PI3K-Akt signaling pathway
Hippo signaling pathway
Hepatitis C
Hepatitis B
Viral carcinogenesis
  Activation of BAD and translocation to mitochondria
Deactivation of the beta-catenin transactivating complex
Rap1 signalling
GP1b-IX-V activation signalling
KSRP (KHSRP) binds and destabilizes mRNA
Interleukin-3, Interleukin-5 and GM-CSF signaling
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
NOTCH4 Activation and Transmission of Signal to the Nucleus
Regulation of localization of FOXO transcription factors
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
14
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Popov-Chang syndrome Pathogenic rs754522887, rs775309705, rs1563665760 RCV005638119
RCV005638120
RCV005638121
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTOSOMAL DOMINANT NON-SYNDROMIC INTELLECTUAL DISABILITY Disgenet, Orphanet
Disgenet, Orphanet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma of colon Adenocarcinoma Of Colon BEFREE 16458424
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 21396625
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 16369491, 30378158, 30684134
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 24135907
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyposis Coli Multiple polyposis syndrome BEFREE 8640784, 8707313, 8912789
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 10840038, 18256261, 26059363, 31989994 Associate
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 32366888 Stimulate
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 30283000
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic lateral sclerosis Pubtator 30283000 Inhibit
★☆☆☆☆
Found in Text Mining only
Anaplastic carcinoma Anaplastic Carcinoma CTD_human_DG 12376462
★☆☆☆☆
Found in Text Mining only