Gene Gene information from NCBI Gene database.
Entrez ID 7408
Gene name Vasodilator stimulated phosphoprotein
Gene symbol VASP
Synonyms (NCBI Gene)
-
Chromosome 19
Chromosome location 19q13.32
Summary Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the
miRNA miRNA information provided by mirtarbase database.
195
miRTarBase ID miRNA Experiments Reference
MIRT006292 hsa-miR-610 Luciferase reporter assayWestern blot 22189055
MIRT006292 hsa-miR-610 Luciferase reporter assayWestern blot 22189055
MIRT006292 hsa-miR-610 Luciferase reporter assayWestern blot 22189055
MIRT006292 hsa-miR-610 Luciferase reporter assayWestern blot 22189055
MIRT006292 hsa-miR-610 Luciferase reporter assayWestern blot 22189055
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
40
GO ID Ontology Definition Evidence Reference
GO:0001843 Process Neural tube closure IBA
GO:0001843 Process Neural tube closure IEA
GO:0003779 Function Actin binding IEA
GO:0005515 Function Protein binding IPI 8836115, 16189514, 16631741, 16940418, 17599063, 20195357, 21423205, 21911467, 23153535, 24076653, 25416956, 28514442, 29892012, 30021884, 32296183, 32814053, 33961781, 35044719, 35271311
GO:0005522 Function Profilin binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601703 12652 ENSG00000125753
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P50552
Protein name Vasodilator-stimulated phosphoprotein (VASP)
Protein function Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP pr
PDB 1EGX , 1USD , 1USE , 2PAV , 2PBD , 3CHW , 8GAT , 8GAU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00568 WH1 1 110 WH1 domain Domain
PF08776 VASP_tetra 341 377 VASP tetramerisation domain Coiled-coil
Tissue specificity TISSUE SPECIFICITY: Highly expressed in platelets. {ECO:0000269|PubMed:7828592}.
Sequence
MSETVICSSRATVMLYDDGNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQV
VINCAIVRGVKYNQATPNFHQWRDARQVWGLNFGSKEDAAQFAAGMASAL
EALEGGGPPP
PPALPTWSVPNGPSPEEVEQQKRQQPGPSEHIERRVSNAGGPPAPPAGGPPPPPGPPPPP
GPPPPPGLPPSGVPAAAHGAGGGPPPAPPLPAAQGPGGGGAGAPGLAAAIAGAKLRKVSK
QEEASGGPTAPKAESGRSGGGGLMEEMNAMLARRRKATQVGEKTPKDESANQEEPEARVP
AQSESVRRPWEKNSTTLPRMKSSSSVTTSETQPCTPSSSDYSDLQRVKQELLEEVKKELQ
KVKEEIIEAFVQELRKR
GSP
Sequence length 380
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Rap1 signaling pathway
cGMP-PKG signaling pathway
Focal adhesion
Tight junction
Platelet activation
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
  Signaling by ROBO receptors
Cell-extracellular matrix interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Acute myeloid leukemia Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Coronary Syndrome Coronary Syndrome BEFREE 17938809, 29268886, 31351022
★☆☆☆☆
Found in Text Mining only
Acute Coronary Syndrome Coronary Syndrome LHGDN 19059569
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyposis Coli Multiple polyposis syndrome BEFREE 29910076
★☆☆☆☆
Found in Text Mining only
Angina Unstable Angina pectoris Pubtator 20467748 Associate
★☆☆☆☆
Found in Text Mining only
Atrial Fibrillation Atrial Fibrillation BEFREE 29914380
★☆☆☆☆
Found in Text Mining only
Blood Platelet Disorders Platelet disorder Pubtator 23116430 Inhibit
★☆☆☆☆
Found in Text Mining only
Blood Platelet Disorders Platelet disorder Pubtator 24361322 Associate
★☆☆☆☆
Found in Text Mining only
Borderline Personality Disorder Borderline personality disorder BEFREE 30463566
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 19171136, 22320863, 25961924, 26336132, 28209486, 30008913, 30806044, 31257464, 31754343, 31831834
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 26336132, 28209486, 32141559, 37890607 Associate
★☆☆☆☆
Found in Text Mining only