UNG (uracil DNA glycosylase)

Gene

• Entrez ID: 7374
• Gene name: Uracil DNA glycosylase
• Gene symbol: UNG
• Synonyms (NCBI Gene): DGU, HIGM4, HIGM5, UDG, UNG1, UNG15, UNG2
• Chromosome: 12
• Chromosome location: 12q24.11
• Summary: This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER)

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs104894380	T>C	Pathogenic	Coding sequence variant, missense variant
rs772214871	C>T	Pathogenic	Coding sequence variant, stop gained
rs1555264685	C>-	Likely-pathogenic	Frameshift variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT007301	hsa-miR-16-5p	Luciferase reporter assay	23228472
MIRT007302	hsa-miR-34c-5p	Luciferase reporter assay	23228472
MIRT007303	hsa-miR-199a-5p	Luciferase reporter assay	23228472
MIRT024454	hsa-miR-215-5p	Microarray	19074876
MIRT026620	hsa-miR-192-5p	Microarray	19074876
MIRT030474	hsa-miR-24-3p	Microarray	19748357
MIRT049999	hsa-miR-28-5p	CLASH	23622248
MIRT045987	hsa-miR-125b-5p	CLASH	23622248
MIRT038623	hsa-miR-129-2-3p	CLASH	23622248
MIRT270184	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT335132	hsa-miR-3169	HITS-CLIP	21572407
MIRT270188	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT510572	hsa-miR-4686	HITS-CLIP	21572407
MIRT270182	hsa-miR-204-3p	HITS-CLIP	21572407
MIRT270186	hsa-miR-4646-5p	HITS-CLIP	21572407
MIRT062350	hsa-miR-3148	HITS-CLIP	21572407
MIRT270185	hsa-miR-4515	HITS-CLIP	21572407
MIRT270187	hsa-miR-4668-5p	HITS-CLIP	21572407
MIRT510568	hsa-miR-3153	HITS-CLIP	21572407
MIRT510567	hsa-miR-6733-5p	HITS-CLIP	21572407
MIRT510566	hsa-miR-6739-5p	HITS-CLIP	21572407
MIRT270183	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT270184	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT270188	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT510572	hsa-miR-4686	PAR-CLIP	20371350
MIRT510571	hsa-miR-20a-3p	PAR-CLIP	20371350
MIRT270182	hsa-miR-204-3p	PAR-CLIP	20371350
MIRT270186	hsa-miR-4646-5p	PAR-CLIP	20371350
MIRT062349	hsa-miR-1911-5p	PAR-CLIP	20371350
MIRT510569	hsa-miR-6076	PAR-CLIP	20371350
MIRT510570	hsa-miR-6797-3p	PAR-CLIP	20371350
MIRT062350	hsa-miR-3148	PAR-CLIP	20371350
MIRT270187	hsa-miR-4668-5p	PAR-CLIP	20371350
MIRT510568	hsa-miR-3153	PAR-CLIP	20371350
MIRT510567	hsa-miR-6733-5p	PAR-CLIP	20371350
MIRT510566	hsa-miR-6739-5p	PAR-CLIP	20371350
MIRT510565	hsa-miR-3682-5p	PAR-CLIP	20371350
MIRT270183	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT270184	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT335132	hsa-miR-3169	PAR-CLIP	21572407
MIRT270188	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT510572	hsa-miR-4686	PAR-CLIP	21572407
MIRT510571	hsa-miR-20a-3p	PAR-CLIP	21572407
MIRT270182	hsa-miR-204-3p	PAR-CLIP	21572407
MIRT270186	hsa-miR-4646-5p	PAR-CLIP	21572407
MIRT062349	hsa-miR-1911-5p	PAR-CLIP	21572407
MIRT510569	hsa-miR-6076	PAR-CLIP	21572407
MIRT510570	hsa-miR-6797-3p	PAR-CLIP	21572407
MIRT062350	hsa-miR-3148	PAR-CLIP	21572407
MIRT270185	hsa-miR-4515	PAR-CLIP	21572407
MIRT270187	hsa-miR-4668-5p	PAR-CLIP	21572407
MIRT510568	hsa-miR-3153	PAR-CLIP	21572407
MIRT510567	hsa-miR-6733-5p	PAR-CLIP	21572407
MIRT510566	hsa-miR-6739-5p	PAR-CLIP	21572407
MIRT510565	hsa-miR-3682-5p	PAR-CLIP	21572407
MIRT270183	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT270184	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT335132	hsa-miR-3169	PAR-CLIP	21572407
MIRT270188	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT510572	hsa-miR-4686	PAR-CLIP	21572407
MIRT510571	hsa-miR-20a-3p	PAR-CLIP	21572407
MIRT270182	hsa-miR-204-3p	PAR-CLIP	21572407
MIRT270186	hsa-miR-4646-5p	PAR-CLIP	21572407
MIRT062350	hsa-miR-3148	PAR-CLIP	21572407
MIRT270185	hsa-miR-4515	PAR-CLIP	21572407
MIRT270187	hsa-miR-4668-5p	PAR-CLIP	21572407
MIRT510568	hsa-miR-3153	PAR-CLIP	21572407
MIRT510567	hsa-miR-6733-5p	PAR-CLIP	21572407
MIRT510566	hsa-miR-6739-5p	PAR-CLIP	21572407
MIRT270183	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT270184	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT335132	hsa-miR-3169	PAR-CLIP	23446348
MIRT270188	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT510572	hsa-miR-4686	PAR-CLIP	23446348
MIRT510571	hsa-miR-20a-3p	PAR-CLIP	23446348
MIRT270182	hsa-miR-204-3p	PAR-CLIP	23446348
MIRT270186	hsa-miR-4646-5p	PAR-CLIP	23446348
MIRT062349	hsa-miR-1911-5p	PAR-CLIP	23446348
MIRT510569	hsa-miR-6076	PAR-CLIP	23446348
MIRT510570	hsa-miR-6797-3p	PAR-CLIP	23446348
MIRT062350	hsa-miR-3148	PAR-CLIP	23446348
MIRT270185	hsa-miR-4515	PAR-CLIP	23446348
MIRT270187	hsa-miR-4668-5p	PAR-CLIP	23446348
MIRT510568	hsa-miR-3153	PAR-CLIP	23446348
MIRT510567	hsa-miR-6733-5p	PAR-CLIP	23446348
MIRT510566	hsa-miR-6739-5p	PAR-CLIP	23446348
MIRT510565	hsa-miR-3682-5p	PAR-CLIP	23446348
MIRT270183	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT270184	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT335132	hsa-miR-3169	HITS-CLIP	21572407
MIRT270188	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT510572	hsa-miR-4686	HITS-CLIP	21572407
MIRT270182	hsa-miR-204-3p	HITS-CLIP	21572407
MIRT270186	hsa-miR-4646-5p	HITS-CLIP	21572407
MIRT062350	hsa-miR-3148	HITS-CLIP	21572407
MIRT270185	hsa-miR-4515	HITS-CLIP	21572407
MIRT270187	hsa-miR-4668-5p	HITS-CLIP	21572407
MIRT510568	hsa-miR-3153	HITS-CLIP	21572407
MIRT510567	hsa-miR-6733-5p	HITS-CLIP	21572407
MIRT510566	hsa-miR-6739-5p	HITS-CLIP	21572407
MIRT270183	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT270184	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT270188	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT510572	hsa-miR-4686	PAR-CLIP	20371350
MIRT510571	hsa-miR-20a-3p	PAR-CLIP	20371350
MIRT270182	hsa-miR-204-3p	PAR-CLIP	20371350
MIRT270186	hsa-miR-4646-5p	PAR-CLIP	20371350
MIRT062349	hsa-miR-1911-5p	PAR-CLIP	20371350
MIRT510569	hsa-miR-6076	PAR-CLIP	20371350
MIRT510570	hsa-miR-6797-3p	PAR-CLIP	20371350
MIRT062350	hsa-miR-3148	PAR-CLIP	20371350
MIRT270187	hsa-miR-4668-5p	PAR-CLIP	20371350
MIRT510568	hsa-miR-3153	PAR-CLIP	20371350
MIRT510567	hsa-miR-6733-5p	PAR-CLIP	20371350
MIRT510566	hsa-miR-6739-5p	PAR-CLIP	20371350
MIRT510565	hsa-miR-3682-5p	PAR-CLIP	20371350
MIRT270183	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT270184	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT335132	hsa-miR-3169	PAR-CLIP	21572407
MIRT270188	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT510572	hsa-miR-4686	PAR-CLIP	21572407
MIRT510571	hsa-miR-20a-3p	PAR-CLIP	21572407
MIRT270182	hsa-miR-204-3p	PAR-CLIP	21572407
MIRT270186	hsa-miR-4646-5p	PAR-CLIP	21572407
MIRT062349	hsa-miR-1911-5p	PAR-CLIP	21572407
MIRT510569	hsa-miR-6076	PAR-CLIP	21572407
MIRT510570	hsa-miR-6797-3p	PAR-CLIP	21572407
MIRT062350	hsa-miR-3148	PAR-CLIP	21572407
MIRT270185	hsa-miR-4515	PAR-CLIP	21572407
MIRT270187	hsa-miR-4668-5p	PAR-CLIP	21572407
MIRT510568	hsa-miR-3153	PAR-CLIP	21572407
MIRT510567	hsa-miR-6733-5p	PAR-CLIP	21572407
MIRT510566	hsa-miR-6739-5p	PAR-CLIP	21572407
MIRT510565	hsa-miR-3682-5p	PAR-CLIP	21572407
MIRT270183	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT270184	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT335132	hsa-miR-3169	PAR-CLIP	21572407
MIRT270188	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT510572	hsa-miR-4686	PAR-CLIP	21572407
MIRT510571	hsa-miR-20a-3p	PAR-CLIP	21572407
MIRT270182	hsa-miR-204-3p	PAR-CLIP	21572407
MIRT270186	hsa-miR-4646-5p	PAR-CLIP	21572407
MIRT062350	hsa-miR-3148	PAR-CLIP	21572407
MIRT270185	hsa-miR-4515	PAR-CLIP	21572407
MIRT270187	hsa-miR-4668-5p	PAR-CLIP	21572407
MIRT510568	hsa-miR-3153	PAR-CLIP	21572407
MIRT510567	hsa-miR-6733-5p	PAR-CLIP	21572407
MIRT510566	hsa-miR-6739-5p	PAR-CLIP	21572407
MIRT270183	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT270184	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT335132	hsa-miR-3169	PAR-CLIP	23446348
MIRT270188	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT510572	hsa-miR-4686	PAR-CLIP	23446348
MIRT510571	hsa-miR-20a-3p	PAR-CLIP	23446348
MIRT270182	hsa-miR-204-3p	PAR-CLIP	23446348
MIRT270186	hsa-miR-4646-5p	PAR-CLIP	23446348
MIRT062349	hsa-miR-1911-5p	PAR-CLIP	23446348
MIRT510569	hsa-miR-6076	PAR-CLIP	23446348
MIRT510570	hsa-miR-6797-3p	PAR-CLIP	23446348
MIRT062350	hsa-miR-3148	PAR-CLIP	23446348
MIRT270185	hsa-miR-4515	PAR-CLIP	23446348
MIRT270187	hsa-miR-4668-5p	PAR-CLIP	23446348
MIRT510568	hsa-miR-3153	PAR-CLIP	23446348
MIRT510567	hsa-miR-6733-5p	PAR-CLIP	23446348
MIRT510566	hsa-miR-6739-5p	PAR-CLIP	23446348
MIRT510565	hsa-miR-3682-5p	PAR-CLIP	23446348
MIRT270183	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT1475711	hsa-miR-101	CLIP-seq
MIRT1475712	hsa-miR-1261	CLIP-seq
MIRT1475713	hsa-miR-1273g	CLIP-seq
MIRT1475714	hsa-miR-1286	CLIP-seq
MIRT1475715	hsa-miR-1343	CLIP-seq
MIRT1475716	hsa-miR-15a	CLIP-seq
MIRT1475717	hsa-miR-15b	CLIP-seq
MIRT1475718	hsa-miR-16	CLIP-seq
MIRT1475719	hsa-miR-18a	CLIP-seq
MIRT1475720	hsa-miR-18b	CLIP-seq
MIRT1475721	hsa-miR-195	CLIP-seq
MIRT1475722	hsa-miR-214	CLIP-seq
MIRT1475723	hsa-miR-22	CLIP-seq
MIRT1475724	hsa-miR-2392	CLIP-seq
MIRT1475725	hsa-miR-3120-5p	CLIP-seq
MIRT1475726	hsa-miR-3128	CLIP-seq
MIRT1475727	hsa-miR-3144-5p	CLIP-seq
MIRT1475728	hsa-miR-3158-3p	CLIP-seq
MIRT1475729	hsa-miR-3166	CLIP-seq
MIRT1475730	hsa-miR-3182	CLIP-seq
MIRT1475731	hsa-miR-34a	CLIP-seq
MIRT1475732	hsa-miR-3609	CLIP-seq
MIRT1475733	hsa-miR-3619-5p	CLIP-seq
MIRT1475734	hsa-miR-3647-3p	CLIP-seq
MIRT1475735	hsa-miR-3649	CLIP-seq
MIRT1475736	hsa-miR-3654	CLIP-seq
MIRT1475737	hsa-miR-3689d	CLIP-seq
MIRT1475738	hsa-miR-3690	CLIP-seq
MIRT1475739	hsa-miR-371-5p	CLIP-seq
MIRT1475740	hsa-miR-371b-5p	CLIP-seq
MIRT1475741	hsa-miR-424	CLIP-seq
MIRT1475742	hsa-miR-4254	CLIP-seq
MIRT1475743	hsa-miR-4263	CLIP-seq
MIRT1475744	hsa-miR-4276	CLIP-seq
MIRT1475745	hsa-miR-4282	CLIP-seq
MIRT1475746	hsa-miR-4310	CLIP-seq
MIRT1475747	hsa-miR-4420	CLIP-seq
MIRT1475748	hsa-miR-4446-3p	CLIP-seq
MIRT1475749	hsa-miR-4470	CLIP-seq
MIRT1475750	hsa-miR-448	CLIP-seq
MIRT1475751	hsa-miR-449a	CLIP-seq
MIRT1475752	hsa-miR-449b	CLIP-seq
MIRT1475753	hsa-miR-4534	CLIP-seq
MIRT1475754	hsa-miR-4638-3p	CLIP-seq
MIRT1475755	hsa-miR-4639-5p	CLIP-seq
MIRT1475756	hsa-miR-4645-5p	CLIP-seq
MIRT1475757	hsa-miR-4673	CLIP-seq
MIRT1475758	hsa-miR-4675	CLIP-seq
MIRT1475759	hsa-miR-4684-3p	CLIP-seq
MIRT1475760	hsa-miR-4690-5p	CLIP-seq
MIRT1475761	hsa-miR-4722-5p	CLIP-seq
MIRT1475762	hsa-miR-4733-5p	CLIP-seq
MIRT1475763	hsa-miR-4735-3p	CLIP-seq
MIRT1475764	hsa-miR-4741	CLIP-seq
MIRT1475765	hsa-miR-4742-5p	CLIP-seq
MIRT1475766	hsa-miR-4753-5p	CLIP-seq
MIRT1475767	hsa-miR-4766-5p	CLIP-seq
MIRT1475768	hsa-miR-4769-3p	CLIP-seq
MIRT1475769	hsa-miR-4771	CLIP-seq
MIRT1475770	hsa-miR-4802-5p	CLIP-seq
MIRT1475771	hsa-miR-488	CLIP-seq
MIRT1475772	hsa-miR-497	CLIP-seq
MIRT1475773	hsa-miR-513c	CLIP-seq
MIRT1475774	hsa-miR-514b-5p	CLIP-seq
MIRT1475775	hsa-miR-520g	CLIP-seq
MIRT1475776	hsa-miR-520h	CLIP-seq
MIRT1475777	hsa-miR-544	CLIP-seq
MIRT1475778	hsa-miR-548aa	CLIP-seq
MIRT1475779	hsa-miR-548ac	CLIP-seq
MIRT1475780	hsa-miR-548ae	CLIP-seq
MIRT1475781	hsa-miR-548ah	CLIP-seq
MIRT1475782	hsa-miR-548aj	CLIP-seq
MIRT1475783	hsa-miR-548am	CLIP-seq
MIRT1475784	hsa-miR-548d-3p	CLIP-seq
MIRT1475785	hsa-miR-548p	CLIP-seq
MIRT1475786	hsa-miR-548u	CLIP-seq
MIRT1475787	hsa-miR-548x	CLIP-seq
MIRT1475788	hsa-miR-548z	CLIP-seq
MIRT1475789	hsa-miR-550a	CLIP-seq
MIRT1475790	hsa-miR-576-5p	CLIP-seq
MIRT1475791	hsa-miR-582-3p	CLIP-seq
MIRT1475792	hsa-miR-622	CLIP-seq
MIRT1475793	hsa-miR-646	CLIP-seq
MIRT1475794	hsa-miR-668	CLIP-seq
MIRT1475795	hsa-miR-761	CLIP-seq
MIRT1475796	hsa-miR-890	CLIP-seq
MIRT1475711	hsa-miR-101	CLIP-seq
MIRT1475797	hsa-miR-204	CLIP-seq
MIRT1475798	hsa-miR-211	CLIP-seq
MIRT1475726	hsa-miR-3128	CLIP-seq
MIRT1475731	hsa-miR-34a	CLIP-seq
MIRT1475732	hsa-miR-3609	CLIP-seq
MIRT1475734	hsa-miR-3647-3p	CLIP-seq
MIRT1475736	hsa-miR-3654	CLIP-seq
MIRT1475799	hsa-miR-3938	CLIP-seq
MIRT1475744	hsa-miR-4276	CLIP-seq
MIRT1475800	hsa-miR-4279	CLIP-seq
MIRT1475745	hsa-miR-4282	CLIP-seq
MIRT1475749	hsa-miR-4470	CLIP-seq
MIRT1475801	hsa-miR-4496	CLIP-seq
MIRT1475751	hsa-miR-449a	CLIP-seq
MIRT1475752	hsa-miR-449b	CLIP-seq
MIRT1475754	hsa-miR-4638-3p	CLIP-seq
MIRT1475762	hsa-miR-4733-5p	CLIP-seq
MIRT1475802	hsa-miR-4755-5p	CLIP-seq
MIRT1475775	hsa-miR-520g	CLIP-seq
MIRT1475776	hsa-miR-520h	CLIP-seq
MIRT1475779	hsa-miR-548ac	CLIP-seq
MIRT1475780	hsa-miR-548ae	CLIP-seq
MIRT1475781	hsa-miR-548ah	CLIP-seq
MIRT1475782	hsa-miR-548aj	CLIP-seq
MIRT1475783	hsa-miR-548am	CLIP-seq
MIRT1475784	hsa-miR-548d-3p	CLIP-seq
MIRT1475786	hsa-miR-548u	CLIP-seq
MIRT1475787	hsa-miR-548x	CLIP-seq
MIRT1475788	hsa-miR-548z	CLIP-seq
MIRT1475791	hsa-miR-582-3p	CLIP-seq
MIRT1475792	hsa-miR-622	CLIP-seq
MIRT1475803	hsa-miR-623	CLIP-seq
MIRT1475804	hsa-miR-633	CLIP-seq
MIRT1475796	hsa-miR-890	CLIP-seq
MIRT1475715	hsa-miR-1343	CLIP-seq
MIRT1475738	hsa-miR-3690	CLIP-seq
MIRT1475742	hsa-miR-4254	CLIP-seq
MIRT2143383	hsa-miR-4520a-3p	CLIP-seq
MIRT1475754	hsa-miR-4638-3p	CLIP-seq
MIRT1475768	hsa-miR-4769-3p	CLIP-seq
MIRT1475715	hsa-miR-1343	CLIP-seq
MIRT1475716	hsa-miR-15a	CLIP-seq
MIRT1475717	hsa-miR-15b	CLIP-seq
MIRT1475718	hsa-miR-16	CLIP-seq
MIRT1475719	hsa-miR-18a	CLIP-seq
MIRT1475720	hsa-miR-18b	CLIP-seq
MIRT1475721	hsa-miR-195	CLIP-seq
MIRT1475722	hsa-miR-214	CLIP-seq
MIRT1475723	hsa-miR-22	CLIP-seq
MIRT1475728	hsa-miR-3158-3p	CLIP-seq
MIRT1475733	hsa-miR-3619-5p	CLIP-seq
MIRT2363614	hsa-miR-3622b-5p	CLIP-seq
MIRT1475738	hsa-miR-3690	CLIP-seq
MIRT1475739	hsa-miR-371-5p	CLIP-seq
MIRT1475740	hsa-miR-371b-5p	CLIP-seq
MIRT1475741	hsa-miR-424	CLIP-seq
MIRT1475742	hsa-miR-4254	CLIP-seq
MIRT1475748	hsa-miR-4446-3p	CLIP-seq
MIRT2143383	hsa-miR-4520a-3p	CLIP-seq
MIRT1475754	hsa-miR-4638-3p	CLIP-seq
MIRT1475758	hsa-miR-4675	CLIP-seq
MIRT1475760	hsa-miR-4690-5p	CLIP-seq
MIRT1475763	hsa-miR-4735-3p	CLIP-seq
MIRT1475764	hsa-miR-4741	CLIP-seq
MIRT1475766	hsa-miR-4753-5p	CLIP-seq
MIRT1475767	hsa-miR-4766-5p	CLIP-seq
MIRT1475768	hsa-miR-4769-3p	CLIP-seq
MIRT1475771	hsa-miR-488	CLIP-seq
MIRT1475772	hsa-miR-497	CLIP-seq
MIRT1475773	hsa-miR-513c	CLIP-seq
MIRT1475774	hsa-miR-514b-5p	CLIP-seq
MIRT1475789	hsa-miR-550a	CLIP-seq
MIRT1475793	hsa-miR-646	CLIP-seq
MIRT1475795	hsa-miR-761	CLIP-seq
MIRT1475796	hsa-miR-890	CLIP-seq
MIRT1475726	hsa-miR-3128	CLIP-seq
MIRT1475749	hsa-miR-4470	CLIP-seq
MIRT1475791	hsa-miR-582-3p	CLIP-seq
MIRT1475793	hsa-miR-646	CLIP-seq
MIRT2657231	hsa-miR-146b-3p	CLIP-seq
MIRT1475716	hsa-miR-15a	CLIP-seq
MIRT1475717	hsa-miR-15b	CLIP-seq
MIRT1475718	hsa-miR-16	CLIP-seq
MIRT1475721	hsa-miR-195	CLIP-seq
MIRT1475722	hsa-miR-214	CLIP-seq
MIRT2657232	hsa-miR-2276	CLIP-seq
MIRT1475724	hsa-miR-2392	CLIP-seq
MIRT2657233	hsa-miR-3120-3p	CLIP-seq
MIRT1475727	hsa-miR-3144-5p	CLIP-seq
MIRT1475729	hsa-miR-3166	CLIP-seq
MIRT2657234	hsa-miR-3173-5p	CLIP-seq
MIRT1475733	hsa-miR-3619-5p	CLIP-seq
MIRT2363614	hsa-miR-3622b-5p	CLIP-seq
MIRT1475735	hsa-miR-3649	CLIP-seq
MIRT1475737	hsa-miR-3689d	CLIP-seq
MIRT2657235	hsa-miR-3929	CLIP-seq
MIRT1475741	hsa-miR-424	CLIP-seq
MIRT1475743	hsa-miR-4263	CLIP-seq
MIRT1475746	hsa-miR-4310	CLIP-seq
MIRT2657236	hsa-miR-4329	CLIP-seq
MIRT2657237	hsa-miR-4419b	CLIP-seq
MIRT1475747	hsa-miR-4420	CLIP-seq
MIRT2657238	hsa-miR-4478	CLIP-seq
MIRT1475753	hsa-miR-4534	CLIP-seq
MIRT1475755	hsa-miR-4639-5p	CLIP-seq
MIRT1475756	hsa-miR-4645-5p	CLIP-seq
MIRT1475757	hsa-miR-4673	CLIP-seq
MIRT1475760	hsa-miR-4690-5p	CLIP-seq
MIRT2657239	hsa-miR-4708-3p	CLIP-seq
MIRT1475765	hsa-miR-4742-5p	CLIP-seq
MIRT2657240	hsa-miR-4763-5p	CLIP-seq
MIRT1475767	hsa-miR-4766-5p	CLIP-seq
MIRT1475769	hsa-miR-4771	CLIP-seq
MIRT1475770	hsa-miR-4802-5p	CLIP-seq
MIRT1475772	hsa-miR-497	CLIP-seq
MIRT2657241	hsa-miR-545	CLIP-seq
MIRT1475778	hsa-miR-548aa	CLIP-seq
MIRT1475785	hsa-miR-548p	CLIP-seq
MIRT1475786	hsa-miR-548u	CLIP-seq
MIRT1475790	hsa-miR-576-5p	CLIP-seq
MIRT1475794	hsa-miR-668	CLIP-seq
MIRT1475795	hsa-miR-761	CLIP-seq
MIRT2657242	hsa-miR-874	CLIP-seq
MIRT2657231	hsa-miR-146b-3p	CLIP-seq
MIRT1475716	hsa-miR-15a	CLIP-seq
MIRT1475717	hsa-miR-15b	CLIP-seq
MIRT1475718	hsa-miR-16	CLIP-seq
MIRT1475721	hsa-miR-195	CLIP-seq
MIRT1475722	hsa-miR-214	CLIP-seq
MIRT2657232	hsa-miR-2276	CLIP-seq
MIRT1475724	hsa-miR-2392	CLIP-seq
MIRT2657233	hsa-miR-3120-3p	CLIP-seq
MIRT1475727	hsa-miR-3144-5p	CLIP-seq
MIRT1475729	hsa-miR-3166	CLIP-seq
MIRT2657234	hsa-miR-3173-5p	CLIP-seq
MIRT1475733	hsa-miR-3619-5p	CLIP-seq
MIRT2363614	hsa-miR-3622b-5p	CLIP-seq
MIRT1475735	hsa-miR-3649	CLIP-seq
MIRT1475737	hsa-miR-3689d	CLIP-seq
MIRT2657235	hsa-miR-3929	CLIP-seq
MIRT1475741	hsa-miR-424	CLIP-seq
MIRT1475743	hsa-miR-4263	CLIP-seq
MIRT1475746	hsa-miR-4310	CLIP-seq
MIRT2657236	hsa-miR-4329	CLIP-seq
MIRT2657237	hsa-miR-4419b	CLIP-seq
MIRT1475747	hsa-miR-4420	CLIP-seq
MIRT2657238	hsa-miR-4478	CLIP-seq
MIRT1475753	hsa-miR-4534	CLIP-seq
MIRT1475755	hsa-miR-4639-5p	CLIP-seq
MIRT1475756	hsa-miR-4645-5p	CLIP-seq
MIRT1475757	hsa-miR-4673	CLIP-seq
MIRT2657239	hsa-miR-4708-3p	CLIP-seq
MIRT1475765	hsa-miR-4742-5p	CLIP-seq
MIRT2657240	hsa-miR-4763-5p	CLIP-seq
MIRT1475767	hsa-miR-4766-5p	CLIP-seq
MIRT1475769	hsa-miR-4771	CLIP-seq
MIRT1475770	hsa-miR-4802-5p	CLIP-seq
MIRT1475772	hsa-miR-497	CLIP-seq
MIRT2657241	hsa-miR-545	CLIP-seq
MIRT1475778	hsa-miR-548aa	CLIP-seq
MIRT1475785	hsa-miR-548p	CLIP-seq
MIRT1475786	hsa-miR-548u	CLIP-seq
MIRT1475790	hsa-miR-576-5p	CLIP-seq
MIRT1475794	hsa-miR-668	CLIP-seq
MIRT1475795	hsa-miR-761	CLIP-seq
MIRT2657242	hsa-miR-874	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000012	Process	Single strand break repair	TAS	31981739
GO:0003684	Function	Damaged DNA binding	IDA	18973764
GO:0004844	Function	Uracil DNA N-glycosylase activity	IBA
GO:0004844	Function	Uracil DNA N-glycosylase activity	IDA	1923798, 12161446
GO:0004844	Function	Uracil DNA N-glycosylase activity	IEA
GO:0004844	Function	Uracil DNA N-glycosylase activity	NAS	9016624
GO:0004844	Function	Uracil DNA N-glycosylase activity	TAS	10805771, 31981739
GO:0005515	Function	Protein binding	IPI	10982866, 18973764, 24910198, 32814053
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	9016624
GO:0005654	Component	Nucleoplasm	IDA	12161446
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006284	Process	Base-excision repair	IDA	12161446
GO:0006284	Process	Base-excision repair	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0016446	Process	Somatic hypermutation of immunoglobulin genes	IEA
GO:0016447	Process	Somatic recombination of immunoglobulin gene segments	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016799	Function	Hydrolase activity, hydrolyzing N-glycosyl compounds	IEA
GO:0043024	Function	Ribosomal small subunit binding	IPI	18973764
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0045008	Process	Depyrimidination	TAS
GO:0045190	Process	Isotype switching	IEA
GO:0097510	Process	Base-excision repair, AP site formation via deaminated base removal	IBA
GO:0097510	Process	Base-excision repair, AP site formation via deaminated base removal	IDA	18973764

Other IDs

• MIM: 191525
• HGNC: 12572
• e!Ensembl: ENSG00000076248

Protein

• UniProt ID: P13051
• Protein name: Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)
• Protein function: Uracil-DNA glycosylase that hydrolyzes the N-glycosidic bond between uracil and deoxyribose in single- and double-stranded DNA (ssDNA and dsDNA) to release a free uracil residue and form an abasic (apurinic/apyrimidinic; AP) site. Excises uracil
• PDB: 1AKZ, 1DPU, 1EMH, 1EMJ, 1Q3F, 1SSP, 1UGH, 1YUO, 2HXM, 2OXM, 2OYT, 2SSP, 3FCF, 3FCI, 3FCK, 3FCL, 3TKB, 4SKN, 5AYR, 5JK7, 6VBA, 7V7C
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03167	UDG	140 → 302	Uracil DNA glycosylase superfamily	Domain

• Sequence:

  MIGQKTLYSFFSPSPARKRHAPSPEPAVQGTGVAGVPEESGDAAAIPAKKAPAGQEEPGT
  PPSSPLSAEQLDRIQRNKAAALLRLAARNVPVGFGESWKKHLSGEFGKPYFIKLMGFVAE
  ERKHYTVYPPPHQVFTWTQMCDIKDVKVVILGQDPYHGPNQAHGLCFSVQRPVPPPPSLE
  NIYKELSTDIEDFVHPGHGDLSGWAKQGVLLLNAVLTVRAHQANSHKERGWEQFTDAVVS
  WLNQNSNGLVFLLWGSYAQKKGSAIDRKRHHVLQTAHPSPLSVYRGFFGCRHFSKTNELL
  QKSGKKPIDWKEL

• Sequence length: 313

Pathways

KEGG:

Base excision repair
Primary immunodeficiency

Reactome:

Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Displacement of DNA glycosylase by APEX1

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Colorectal cancer	Likely pathogenic	rs748974541	RCV005931405	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Hyper-IgM syndrome type 5	Pathogenic; Likely pathogenic	rs2135882474, rs751126274, rs772764942, rs757311287, rs2042193330, rs1302020618, rs2499977965, rs759483250, rs2499976292, rs778896112, rs2499982456, rs104894380, rs1426188025, rs748974541, rs746878731, rs772214871	RCV001374665 RCV001387995 RCV003513623 RCV001994580 RCV002040511 RCV002251153 RCV002927038 RCV002974821 RCV003002484 RCV000013084 RCV000013085 RCV000013086 RCV000013087 RCV003513396 RCV003624665 RCV000701366	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BLOOM SYNDROME	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DYSGAMMAGLOBULINEMIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hereditary breast ovarian cancer syndrome	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPER-IGM IMMUNODEFICIENCY SYNDROME	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 5	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hyperimmunoglobulin M syndrome	Likely benign; Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Malignant tumor of esophagus	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UNG-related disorder	Likely benign; Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute leukemia	Leukemia	BEFREE	3474482		★☆☆☆☆ Found in Text Mining only
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	3474482		★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	3474482		★☆☆☆☆ Found in Text Mining only
Agammaglobulinemia	Agammaglobulinemia	Pubtator	19903677	Associate	★☆☆☆☆ Found in Text Mining only
Age related macular degeneration	Age-related macular degeneration	BEFREE	23202958, 23714858		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	31415677	Associate	★☆☆☆☆ Found in Text Mining only
Blast Phase	Blast phase chronic myelogenous leukemia	BEFREE	3474482		★☆☆☆☆ Found in Text Mining only
Bloom Syndrome	Bloom Syndrome	BEFREE	1742335, 2106500, 2155388, 3353381, 3948317		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bloom Syndrome	Bloom syndrome	Pubtator	1924305, 3353381	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bloom Syndrome	Bloom Syndrome	CTD_human_DG	2106500		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Neoplasms	Breast neoplasm	Pubtator	33675849	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	23873851		★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	17207936		★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	3474482		★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	21317926, 8625314		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	CTD_human_DG	15814641		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	17029639		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	CTD_human_DG	15814641		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal Neoplasms	Colorectal Neoplasms	LHGDN	17029639		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	17029639, 23873851, 33675849, 33795350	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Congenital contractural arachnodactyly	Congenital Contractural Arachnodactyly	BEFREE	18714155		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	28120895	Associate	★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic fibrosis	Pubtator	7683477	Associate	★☆☆☆☆ Found in Text Mining only
Dysgammaglobulinemia	Dysfibrinogenemia	Pubtator	19903677	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Epididymitis	Epididymitis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	25301111, 26194062		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	25301111, 26194062		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	26194062	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	9852992		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	9852992		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	15681472	Associate	★☆☆☆☆ Found in Text Mining only
Hyper-IgM Immunodeficiency Syndrome, Type 1	Hyper-IgM Immunodeficiency Syndrome	BEFREE	12840068, 15358621, 16860315, 20805886		★☆☆☆☆ Found in Text Mining only
Hyper-IgM Immunodeficiency Syndrome, Type 2	Hyper-IgM Immunodeficiency Syndrome	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Hyper-IgM Immunodeficiency Syndrome, Type 3	Hyper-IgM Immunodeficiency Syndrome	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Hyper-IgM Immunodeficiency Syndrome, Type 5	Hyper-IgM Immunodeficiency Syndrome	ORPHANET_DG	12958596, 15967827		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hyper-IgM Immunodeficiency Syndrome, Type 5	Hyper-IgM Immunodeficiency Syndrome	GENOMICS_ENGLAND_DG	12958596		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hyper-IgM Immunodeficiency Syndrome, Type 5	Hyper-IgM Immunodeficiency Syndrome	UNIPROT_DG	12958596, 15967827		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hyper-IgM Immunodeficiency Syndrome, Type 5	Hyper-IgM Immunodeficiency Syndrome	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hyper-IgM Immunodeficiency Syndrome, Type 5	Hyper-IgM Immunodeficiency Syndrome	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hyper-IgM syndrome type 5	Hyper-IgM Syndrome	Orphanet			★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Hyperimmunoglobulin M syndrome	Hyperimmunoglobulin M Syndrome	BEFREE	16860315, 20805886		★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Hyperimmunoglobulin M syndrome	Hyperimmunoglobulin M Syndrome	CTD_human_DG			★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Immune System Diseases	Immune system disease	Pubtator	3353381	Associate	★☆☆☆☆ Found in Text Mining only
Immunologic Deficiency Syndromes	Immunologic Deficiency Syndromes	HPO_DG			★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	3474482		★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	3474482		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31152021		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	23873851	Associate	★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	16860315		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	25301111, 26194062		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	23873851		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	19671688		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	1742335, 18676834, 19671688, 22138674, 22643842, 27517750, 27875297, 29642934		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	21317926, 8625314		★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	23047475, 3474482		★☆☆☆☆ Found in Text Mining only
Myotonic Dystrophy	Myotonic dystrophy	Pubtator	29269788	Associate	★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	33102573	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	1688517, 25154417, 27840062, 27875297		★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	17207936		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	30527192		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	7534293	Associate	★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	27875297, 30747491	Associate	★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	19671688		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	19671688	Associate	★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	22138674		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	23873851		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	25301111		★☆☆☆☆ Found in Text Mining only
Uterine Cervical Dysplasia	Uterine disease	Pubtator	30572497	Associate	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	30572497	Associate	★☆☆☆☆ Found in Text Mining only
Vesicular Stomatitis	Vesicular Stomatitis	BEFREE	20371602		★☆☆☆☆ Found in Text Mining only
Waldenstrom Macroglobulinemia	Waldenstrom macroglobulinemia	Pubtator	19903677	Associate	★☆☆☆☆ Found in Text Mining only
Xeroderma Pigmentosum	Xeroderma pigmentosum	Pubtator	8207043	Associate	★☆☆☆☆ Found in Text Mining only