SCGB1A1 (secretoglobin family 1A member 1)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 7356
Gene name Secretoglobin family 1A member 1
Gene symbol SCGB1A1
Synonyms (NCBI Gene)
CC10CC16CCPBPCCSPUGBUP-1UP1
Chromosome 11
Chromosome location 11q12.3
Summary This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defec
miRNA miRNA information provided by mirtarbase database.
12
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (12)
miRTarBase ID miRNA Experiments Reference
MIRT1329344 hsa-miR-1273g CLIP-seq
MIRT1329345 hsa-miR-299-5p CLIP-seq
MIRT1329346 hsa-miR-4708-5p CLIP-seq
MIRT1329347 hsa-miR-4709-3p CLIP-seq
MIRT2097669 hsa-miR-2110 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (32)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0005515 Function Protein binding IPI 16423471, 18243143, 21516116, 25416956, 28514442, 31515488, 32296183, 32814053, 33961781
GO:0005576 Component Extracellular region IEA
GO:0005615 Component Extracellular space IBA
GO:0005615 Component Extracellular space IDA 21805676
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
192020 12523 ENSG00000149021
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P11684
Protein name Uteroglobin (Club cell phospholipid-binding protein) (CCPBP) (Club cells 10 kDa secretory protein) (CC10) (Secretoglobin family 1A member 1) (Urinary protein 1) (UP-1) (UP1) (Urine protein 1)
Protein function Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
PDB 7VF3 , 7VG7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01099 Uteroglobin 1 → 90 Uteroglobin family Domain
Tissue specificity TISSUE SPECIFICITY: Club cells (nonciliated cells of the surface epithelium of the pulmonary airways).
Sequence
Sequence length 91
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (7)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTHMA — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE AIRWAY DISEASE — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Chronic obstructive pulmonary disease association; Established risk allele ClinVar
GWAS catalog
★★★★★
★★★☆☆
Reported in Unknown/Other Associations (≥2 sources)
GLOMERULONEPHRITIS — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (125)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 10097146, 11193760, 15765918, 23613996, 28666642
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 16288213, 1634515
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 15148323
★★★★★
★☆☆☆☆
Found in Text Mining only
Allergic rhinitis (disorder) Allergic rhinitis BEFREE 20553297, 21255142, 21294974, 23242114, 30619295
★★★★★
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 28967121
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 20037209 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 10619808, 11258696, 12100044, 12642831, 12769755, 12859445, 15549500, 15677460, 15744536, 16387800, 17298427, 18702901, 19076932, 19128353, 20736038
View all (13 more)
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Asthma Asthma LHGDN 12642831, 15148962, 15467329, 15677460, 15744536, 16387800
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Asthma Asthma Pubtator 31322430, 32762031, 36352422, 9643286 Associate
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Asthma Asthma Pubtator 36066606 Inhibit
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations