UBE2I (ubiquitin conjugating enzyme E2 I)

Gene

• Entrez ID: 7329
• Gene name: Ubiquitin conjugating enzyme E2 I
• Gene symbol: UBE2I
• Synonyms (NCBI Gene): C358B7.1, P18, UBC9
• Chromosome: 16
• Chromosome location: 16p13.3
• Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conju

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT003339	hsa-miR-30e-5p	Review	20026422
MIRT003339	hsa-miR-30e-5p	Luciferase reporter assay, qRT-PCR, Western blot	19223510
MIRT003339	hsa-miR-30e-5p	Luciferase reporter assay, qRT-PCR, Western blot	19223510
MIRT005090	hsa-miR-30c-5p	Luciferase reporter assay, qRT-PCR, Western blot	19223510
MIRT005090	hsa-miR-30c-5p	Luciferase reporter assay, qRT-PCR, Western blot	19223510
MIRT005088	hsa-miR-188-5p	qRT-PCR, Western blot	19223510
MIRT005087	hsa-miR-200c-3p	qRT-PCR, Western blot	19223510
MIRT023885	hsa-miR-1-3p	Proteomics	18668040
MIRT032401	hsa-let-7b-5p	Proteomics	18668040
MIRT043111	hsa-miR-324-5p	CLASH	23622248
MIRT053795	hsa-miR-214-3p	Luciferase reporter assay, qRT-PCR, Western blot	23187003
MIRT737310	hsa-miR-195-3p	Microarray, qRT-PCR	27144577
MIRT1467905	hsa-miR-200b	CLIP-seq
MIRT1467906	hsa-miR-200c	CLIP-seq
MIRT1467907	hsa-miR-203	CLIP-seq
MIRT1467908	hsa-miR-30a	CLIP-seq
MIRT1467909	hsa-miR-30b	CLIP-seq
MIRT1467910	hsa-miR-30c	CLIP-seq
MIRT1467911	hsa-miR-30d	CLIP-seq
MIRT1467912	hsa-miR-30e	CLIP-seq
MIRT1467913	hsa-miR-3120-3p	CLIP-seq
MIRT1467914	hsa-miR-3613-5p	CLIP-seq
MIRT1467915	hsa-miR-374a	CLIP-seq
MIRT1467916	hsa-miR-374b	CLIP-seq
MIRT1467917	hsa-miR-3913-3p	CLIP-seq
MIRT1467918	hsa-miR-3960	CLIP-seq
MIRT1467919	hsa-miR-409-3p	CLIP-seq
MIRT1467920	hsa-miR-429	CLIP-seq
MIRT1467921	hsa-miR-4480	CLIP-seq
MIRT1467922	hsa-miR-4649-3p	CLIP-seq
MIRT1467923	hsa-miR-4699-3p	CLIP-seq
MIRT1467924	hsa-miR-4775	CLIP-seq
MIRT1467925	hsa-miR-4795-5p	CLIP-seq
MIRT1467926	hsa-miR-489	CLIP-seq
MIRT1467927	hsa-miR-519a	CLIP-seq
MIRT1467928	hsa-miR-519b-3p	CLIP-seq
MIRT1467929	hsa-miR-519c-3p	CLIP-seq
MIRT1467930	hsa-miR-587	CLIP-seq
MIRT1467931	hsa-miR-590-3p	CLIP-seq
MIRT1467932	hsa-miR-652	CLIP-seq
MIRT1467933	hsa-miR-7	CLIP-seq
MIRT2140615	hsa-miR-125a-3p	CLIP-seq
MIRT2140616	hsa-miR-15a	CLIP-seq
MIRT2140617	hsa-miR-15b	CLIP-seq
MIRT2140618	hsa-miR-16	CLIP-seq
MIRT2140619	hsa-miR-195	CLIP-seq
MIRT2140620	hsa-miR-2467-5p	CLIP-seq
MIRT2140621	hsa-miR-297	CLIP-seq
MIRT2140622	hsa-miR-3064-3p	CLIP-seq
MIRT2140623	hsa-miR-3149	CLIP-seq
MIRT2140624	hsa-miR-3154	CLIP-seq
MIRT2140625	hsa-miR-3188	CLIP-seq
MIRT2140626	hsa-miR-3661	CLIP-seq
MIRT2140627	hsa-miR-3667-3p	CLIP-seq
MIRT2140628	hsa-miR-371b-5p	CLIP-seq
MIRT1467918	hsa-miR-3960	CLIP-seq
MIRT2140629	hsa-miR-3975	CLIP-seq
MIRT2140630	hsa-miR-424	CLIP-seq
MIRT2140631	hsa-miR-4289	CLIP-seq
MIRT2140632	hsa-miR-4457	CLIP-seq
MIRT1467922	hsa-miR-4649-3p	CLIP-seq
MIRT2140633	hsa-miR-4690-3p	CLIP-seq
MIRT2140634	hsa-miR-4726-3p	CLIP-seq
MIRT2140635	hsa-miR-4777-5p	CLIP-seq
MIRT2140636	hsa-miR-485-5p	CLIP-seq
MIRT2140637	hsa-miR-497	CLIP-seq
MIRT2140638	hsa-miR-518d-5p	CLIP-seq
MIRT2140639	hsa-miR-519b-5p	CLIP-seq
MIRT2140640	hsa-miR-519c-5p	CLIP-seq
MIRT2140641	hsa-miR-520c-5p	CLIP-seq
MIRT2140642	hsa-miR-526a	CLIP-seq
MIRT2140643	hsa-miR-615-5p	CLIP-seq
MIRT2140644	hsa-miR-616	CLIP-seq
MIRT2140645	hsa-miR-624	CLIP-seq
MIRT2140646	hsa-miR-631	CLIP-seq
MIRT1467932	hsa-miR-652	CLIP-seq
MIRT1467933	hsa-miR-7	CLIP-seq
MIRT2361521	hsa-miR-10a	CLIP-seq
MIRT2361522	hsa-miR-10b	CLIP-seq
MIRT2361523	hsa-miR-1253	CLIP-seq
MIRT2140615	hsa-miR-125a-3p	CLIP-seq
MIRT2361524	hsa-miR-1275	CLIP-seq
MIRT2361525	hsa-miR-1301	CLIP-seq
MIRT1467905	hsa-miR-200b	CLIP-seq
MIRT1467906	hsa-miR-200c	CLIP-seq
MIRT1467907	hsa-miR-203	CLIP-seq
MIRT1467913	hsa-miR-3120-3p	CLIP-seq
MIRT2361526	hsa-miR-3130-3p	CLIP-seq
MIRT2361527	hsa-miR-3163	CLIP-seq
MIRT2361528	hsa-miR-3177-3p	CLIP-seq
MIRT2361529	hsa-miR-3194-3p	CLIP-seq
MIRT2361530	hsa-miR-331-3p	CLIP-seq
MIRT2361531	hsa-miR-3688-3p	CLIP-seq
MIRT1467915	hsa-miR-374a	CLIP-seq
MIRT1467916	hsa-miR-374b	CLIP-seq
MIRT1467917	hsa-miR-3913-3p	CLIP-seq
MIRT2361532	hsa-miR-3928	CLIP-seq
MIRT2361533	hsa-miR-3944-5p	CLIP-seq
MIRT1467918	hsa-miR-3960	CLIP-seq
MIRT2361534	hsa-miR-4261	CLIP-seq
MIRT2140631	hsa-miR-4289	CLIP-seq
MIRT1467920	hsa-miR-429	CLIP-seq
MIRT2361535	hsa-miR-4292	CLIP-seq
MIRT1467921	hsa-miR-4480	CLIP-seq
MIRT2361536	hsa-miR-4525	CLIP-seq
MIRT1467922	hsa-miR-4649-3p	CLIP-seq
MIRT2361537	hsa-miR-4652-5p	CLIP-seq
MIRT2361538	hsa-miR-4660	CLIP-seq
MIRT2361539	hsa-miR-4665-5p	CLIP-seq
MIRT1467923	hsa-miR-4699-3p	CLIP-seq
MIRT2361540	hsa-miR-4723-5p	CLIP-seq
MIRT2361541	hsa-miR-4725-5p	CLIP-seq
MIRT2140634	hsa-miR-4726-3p	CLIP-seq
MIRT2361542	hsa-miR-4763-5p	CLIP-seq
MIRT1467924	hsa-miR-4775	CLIP-seq
MIRT2361543	hsa-miR-4793-3p	CLIP-seq
MIRT1467926	hsa-miR-489	CLIP-seq
MIRT2361544	hsa-miR-504	CLIP-seq
MIRT2361545	hsa-miR-5047	CLIP-seq
MIRT1467927	hsa-miR-519a	CLIP-seq
MIRT1467928	hsa-miR-519b-3p	CLIP-seq
MIRT1467929	hsa-miR-519c-3p	CLIP-seq
MIRT1467930	hsa-miR-587	CLIP-seq
MIRT1467931	hsa-miR-590-3p	CLIP-seq
MIRT2140644	hsa-miR-616	CLIP-seq
MIRT2361546	hsa-miR-625	CLIP-seq
MIRT2361547	hsa-miR-637	CLIP-seq
MIRT1467932	hsa-miR-652	CLIP-seq
MIRT1467933	hsa-miR-7	CLIP-seq
MIRT2140615	hsa-miR-125a-3p	CLIP-seq
MIRT2140634	hsa-miR-4726-3p	CLIP-seq
MIRT1467932	hsa-miR-652	CLIP-seq
MIRT1467933	hsa-miR-7	CLIP-seq
MIRT2361521	hsa-miR-10a	CLIP-seq
MIRT2361522	hsa-miR-10b	CLIP-seq
MIRT2655289	hsa-miR-1252	CLIP-seq
MIRT1467905	hsa-miR-200b	CLIP-seq
MIRT1467906	hsa-miR-200c	CLIP-seq
MIRT1467907	hsa-miR-203	CLIP-seq
MIRT1467913	hsa-miR-3120-3p	CLIP-seq
MIRT2361527	hsa-miR-3163	CLIP-seq
MIRT2655290	hsa-miR-3613-3p	CLIP-seq
MIRT2361531	hsa-miR-3688-3p	CLIP-seq
MIRT1467915	hsa-miR-374a	CLIP-seq
MIRT1467916	hsa-miR-374b	CLIP-seq
MIRT1467917	hsa-miR-3913-3p	CLIP-seq
MIRT1467918	hsa-miR-3960	CLIP-seq
MIRT2361534	hsa-miR-4261	CLIP-seq
MIRT1467920	hsa-miR-429	CLIP-seq
MIRT2361541	hsa-miR-4725-5p	CLIP-seq
MIRT1467924	hsa-miR-4775	CLIP-seq
MIRT1467926	hsa-miR-489	CLIP-seq
MIRT2361544	hsa-miR-504	CLIP-seq
MIRT2655291	hsa-miR-548n	CLIP-seq
MIRT2655292	hsa-miR-548t	CLIP-seq
MIRT2655293	hsa-miR-561	CLIP-seq
MIRT1467931	hsa-miR-590-3p	CLIP-seq
MIRT1467932	hsa-miR-652	CLIP-seq
MIRT1467933	hsa-miR-7	CLIP-seq
MIRT2361521	hsa-miR-10a	CLIP-seq
MIRT2361522	hsa-miR-10b	CLIP-seq
MIRT2655289	hsa-miR-1252	CLIP-seq
MIRT1467905	hsa-miR-200b	CLIP-seq
MIRT1467906	hsa-miR-200c	CLIP-seq
MIRT1467907	hsa-miR-203	CLIP-seq
MIRT1467913	hsa-miR-3120-3p	CLIP-seq
MIRT2361527	hsa-miR-3163	CLIP-seq
MIRT2655290	hsa-miR-3613-3p	CLIP-seq
MIRT2361531	hsa-miR-3688-3p	CLIP-seq
MIRT1467915	hsa-miR-374a	CLIP-seq
MIRT1467916	hsa-miR-374b	CLIP-seq
MIRT1467917	hsa-miR-3913-3p	CLIP-seq
MIRT1467918	hsa-miR-3960	CLIP-seq
MIRT2361534	hsa-miR-4261	CLIP-seq
MIRT1467920	hsa-miR-429	CLIP-seq
MIRT2361541	hsa-miR-4725-5p	CLIP-seq
MIRT1467924	hsa-miR-4775	CLIP-seq
MIRT1467926	hsa-miR-489	CLIP-seq
MIRT2361544	hsa-miR-504	CLIP-seq
MIRT2655291	hsa-miR-548n	CLIP-seq
MIRT2655292	hsa-miR-548t	CLIP-seq
MIRT2655293	hsa-miR-561	CLIP-seq
MIRT1467931	hsa-miR-590-3p	CLIP-seq
MIRT1467932	hsa-miR-652	CLIP-seq
MIRT1467933	hsa-miR-7	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
WT1	Repression	8798754

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	19955185
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	TAS
GO:0000166	Function	Nucleotide binding	IEA
GO:0000795	Component	Synaptonemal complex	TAS	8610150
GO:0001221	Function	Transcription coregulator binding	IPI	20215116
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	9885291, 10871618, 11112409, 11278694, 11313457, 11735126, 12072434, 14516784, 14752048, 15231748, 15983381, 16154161, 16166628, 16189514, 16494873, 16631117, 16713569, 16730941, 16732283, 16998888, 17036045, 17037517, 17491593, 17643372, 17956732, 18087039, 18264111, 18624398, 1945
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	9223278, 14752048, 16631117, 27068747
GO:0005634	Component	Nucleus	IEA
GO:0005635	Component	Nuclear envelope	TAS
GO:0005643	Component	Nuclear pore	NAS	27160050
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	9223278
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	TAS	8565643
GO:0007059	Process	Chromosome segregation	IEA
GO:0007084	Process	Mitotic nuclear membrane reassembly	TAS
GO:0008134	Function	Transcription factor binding	IPI	19744555
GO:0016604	Component	Nuclear body	IEA
GO:0016605	Component	PML body	IDA	9885291
GO:0016740	Function	Transferase activity	IEA
GO:0016925	Process	Protein sumoylation	IBA
GO:0016925	Process	Protein sumoylation	IDA	15660128, 19955185, 21968017, 22194619, 25187565
GO:0016925	Process	Protein sumoylation	IEA
GO:0016925	Process	Protein sumoylation	IMP	26620705
GO:0016925	Process	Protein sumoylation	TAS
GO:0019789	Function	SUMO transferase activity	EXP	11877416, 12641448, 16029420
GO:0019789	Function	SUMO transferase activity	IEA
GO:0019789	Function	SUMO transferase activity	TAS
GO:0019899	Function	Enzyme binding	IPI	17087506
GO:0030335	Process	Positive regulation of cell migration	IMP	20023705
GO:0036211	Process	Protein modification process	TAS	8798754
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEA
GO:0043398	Function	HLH domain binding	IEA
GO:0044388	Function	Small protein activating enzyme binding	IPI	15660128
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	16631117
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050804	Process	Modulation of chemical synaptic transmission	IEA
GO:0051168	Process	Nuclear export	EXP	27160050
GO:0051301	Process	Cell division	IEA
GO:0061656	Function	SUMO conjugating enzyme activity	IBA
GO:0061656	Function	SUMO conjugating enzyme activity	IDA	19955185, 25187565
GO:0061656	Function	SUMO conjugating enzyme activity	IEA
GO:0071535	Function	RING-like zinc finger domain binding	IPI	19407830
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099523	Component	Presynaptic cytosol	IEA
GO:0099524	Component	Postsynaptic cytosol	IEA
GO:0106068	Component	SUMO ligase complex	IEA
GO:0106068	Component	SUMO ligase complex	IPI	22194619
GO:1990234	Component	Transferase complex	IDA	19955185

Other IDs

• MIM: 601661
• HGNC: 12485
• e!Ensembl: ENSG00000103275

Protein

• UniProt ID: P63279
• Protein name: SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
• Protein function: Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catal
• PDB: 1A3S, 1KPS, 1Z5S, 2GRN, 2GRO, 2GRP, 2GRQ, 2GRR, 2O25, 2PE6, 2PX9, 2XWU, 3A4S, 3UIN, 3UIO, 3UIP, 4W5V, 4Y1L, 5D2M, 5F6D, 5F6E, 5F6U, 5F6V, 5F6W, 5F6X, 5F6Y, 5FQ2, 6SYF, 8ODR, 9B62
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00179	UQ_con	8 → 152	Ubiquitin-conjugating enzyme	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus. {ECO:0000269|PubMed:8610150}.
• Sequence:

  MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKL
  RMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELL
  NEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS

• Sequence length: 158

Pathways

KEGG:

Nucleocytoplasmic transport
NF-kappa B signaling pathway
Ubiquitin mediated proteolysis
MicroRNAs in cancer

Reactome:

Vitamin D (calciferol) metabolism
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMOylation of DNA damage response and repair proteins
SUMO E3 ligases SUMOylate target proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Postmitotic nuclear pore complex (NPC) reformation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CARCINOMA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute leukemia	Leukemia	BEFREE	8637234		★☆☆☆☆ Found in Text Mining only
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	7606004, 8637234		★☆☆☆☆ Found in Text Mining only
Acute monocytic leukemia	Monocytic Leukemia	BEFREE	17671234		★☆☆☆☆ Found in Text Mining only
Acute Promyelocytic Leukemia	Promyelocytic Leukemia	BEFREE	27030546		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Adenocarcinoma	BEFREE	11948124		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	16300471, 16758298, 28572537		★☆☆☆☆ Found in Text Mining only
Adrenoleukodystrophy	Adrenoleukodystrophy	BEFREE	29401608		★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	8637234		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	18675254	Associate	★☆☆☆☆ Found in Text Mining only
Alzheimer Disease, Late Onset	Alzheimer disease	BEFREE	19765634		★☆☆☆☆ Found in Text Mining only
Anaplastic carcinoma	Anaplastic Carcinoma	CTD_human_DG	16316942		★☆☆☆☆ Found in Text Mining only
Angelman Syndrome	Angelman Syndrome	BEFREE	30020076		★☆☆☆☆ Found in Text Mining only
ARTERIAL TORTUOSITY SYNDROME	Arterial Tortuosity Syndrome	BEFREE	30073364		★☆☆☆☆ Found in Text Mining only
Arthritis, Psoriatic	Psoriatic Arthritis	BEFREE	28689116		★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	8397372		★☆☆☆☆ Found in Text Mining only
Bloom Syndrome	Bloom Syndrome	BEFREE	10806190		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	19358266, 19760037, 20023705, 20863840, 23873416, 24809779, 27259808, 27878232, 9636670		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	19223510	Stimulate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	21880185, 23873416, 24086615, 30011797	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	19965618, 21880185, 28253371	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	CTD_human_DG	16316942		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma Ductal	Ductal carcinoma	Pubtator	21880185	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	28572537, 36193060, 36748193	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	19223510, 23381475		★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	23708104	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	16300471, 16758298, 23708104, 28572537		★☆☆☆☆ Found in Text Mining only
Carcinoma, Spindle-Cell	Carcinoma	CTD_human_DG	16316942		★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	Pubtator	32827359	Associate	★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	7606004, 8637234		★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	36193060	Associate	★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	36193060	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	25805818		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	26416353, 36193060, 37950153	Associate	★☆☆☆☆ Found in Text Mining only
Congenital chromosomal disease	Congenital Chromosomal Disease	BEFREE	30894510		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	28659381		★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	27226330		★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	29299635, 31767832		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	29299635, 31767832		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	22114711	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	31767832		★☆☆☆☆ Found in Text Mining only
Diabetic Retinopathy	Diabetic Retinopathy	BEFREE	29138839		★☆☆☆☆ Found in Text Mining only
Digestive System Neoplasms	Digestive system neoplasm	Pubtator	36193060	Associate	★☆☆☆☆ Found in Text Mining only
Ductal Breast Carcinoma	Breast Carcinoma	BEFREE	23873416		★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	35830453	Associate	★☆☆☆☆ Found in Text Mining only
Epithelial ovarian cancer	Ovarian cancer	BEFREE	23708104		★☆☆☆☆ Found in Text Mining only
Familial Alzheimer Disease (FAD)	Alzheimer disease	BEFREE	18675254		★☆☆☆☆ Found in Text Mining only
Familial medullary thyroid carcinoma	Medullary thyroid carcinoma	BEFREE	18316595		★☆☆☆☆ Found in Text Mining only
Fibrosis, Liver	Liver Fibrosis	BEFREE	28358817		★☆☆☆☆ Found in Text Mining only
Frontotemporal Dementia	Frontotemporal dementia	Pubtator	25580532	Inhibit	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	31267313		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	31267313		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	23187003		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	23187003	Associate	★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	28253371	Associate	★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic Neoplasms	BEFREE	8628020		★☆☆☆☆ Found in Text Mining only
Hepatoblastoma	Hepatoblastoma	BEFREE	8397372		★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Hereditary breast and ovarian cancer syndrome	Pubtator	24086615	Associate	★☆☆☆☆ Found in Text Mining only
Hyperparathyroidism	Hyperparathyroidism	BEFREE	15009006		★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	30612578	Associate	★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	28659381		★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Diabetes mellitus, type 2	Pubtator	22114711	Associate	★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	7577621, 8397372, 9031081, 9639410		★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	17671234	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	17671234		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	22685290, 28240261, 28572537, 28646552		★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver cirrhosis	Pubtator	28358817	Associate	★☆☆☆☆ Found in Text Mining only
Liver Failure	Liver failure	Pubtator	28358817	Associate	★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	22685290		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	30612578	Associate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	21880185	Associate	★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	8397372, 8628020, 9031081		★☆☆☆☆ Found in Text Mining only
Lymphoma, Large-Cell, Follicular	Lymphoma	BEFREE	7579381		★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin	Non-Hodgkin lymphoma	BEFREE	7579381		★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin, Familial	Lymphoma	BEFREE	7579381		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	19358266, 19760037, 20023705, 20863840, 23873416, 24809779, 27259808, 9636670		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	19223510, 23381475, 7882351, 8631583		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	16300471, 16758298, 28572537		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	29467540		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	16300471, 19287951, 21344391, 23187003, 25860128, 26416353, 28253371, 28572537, 29298882, 8397372, 8637248, 9973200		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	19358266, 19760037, 8840966		★☆☆☆☆ Found in Text Mining only
Medullary carcinoma of thyroid	Megalencephaly, Polymicrogyria, Polydactyly, Hydrocephalus Syndrome	BEFREE	18316595, 20878247		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	16300471, 16758298, 17297476, 28572537, 9724087		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	LHGDN	17297476		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	28572537	Associate	★☆☆☆☆ Found in Text Mining only
Meningioma	Meningioma	BEFREE	10736068, 11263500		★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	27226330		★☆☆☆☆ Found in Text Mining only
Metastatic Prostate Carcinoma	Metastatic Prostate Carcinoma	BEFREE	30631151		★☆☆☆☆ Found in Text Mining only
Mild cognitive disorder	Cognitive disorder	BEFREE	19765634		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	11840272, 19965618, 9012694		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	19965618	Associate	★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	28549617, 9111168		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	10736068, 11343236, 11840272, 15735760, 16758298, 19223510, 19760037, 19859084, 20023705, 21147068, 21344391, 22685290, 2278968, 25805818, 25860128, 27878232, 28572537, 28627623, 29467540, 29996906, 7577621, 7579381, 8397372, 8570224, 8631583, 8637248, 8840966, 9639410, 9724087		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	8665486		★☆☆☆☆ Found in Text Mining only
Neuroectodermal Tumors	Neuroectodermal Tumors	BEFREE	2278968		★☆☆☆☆ Found in Text Mining only
Neuroendocrine Tumors	Neuroendocrine Tumors	BEFREE	2278968		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	19859084, 21145615, 30612578		★☆☆☆☆ Found in Text Mining only
Oestrogen receptor positive breast cancer	Oestrogen Receptor Positive Breast Cancer	BEFREE	24086615		★☆☆☆☆ Found in Text Mining only
oligodendroglioma	Oligodendroglioma	BEFREE	10994011		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	29956745, 8603340		★☆☆☆☆ Found in Text Mining only
Ovarian Carcinoma	Ovarian Carcinoma	BEFREE	16300471, 16758298, 28572537		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	28572537	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	36193060	Associate	★☆☆☆☆ Found in Text Mining only
Parathyroid Adenoma	Parathyroid Adenoma	BEFREE	15009006, 9286748		★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic ovary syndrome	Pubtator	35830453	Associate	★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	7606004		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	29467540		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	30631151	Associate	★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	BEFREE	11343236, 27229858		★☆☆☆☆ Found in Text Mining only
Retinopathy of Prematurity	Retinopathy	BEFREE	11466260, 26694999		★☆☆☆☆ Found in Text Mining only
Rett Syndrome	Rett Syndrome	BEFREE	10745042		★☆☆☆☆ Found in Text Mining only
Rett Syndrome	Rett syndrome	Pubtator	10745042	Associate	★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	BEFREE	8603340		★☆☆☆☆ Found in Text Mining only
Severe Acute Respiratory Syndrome	Severe Acute Respiratory Syndrome	LHGDN	17037517		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	32064753, 36444596	Associate	★☆☆☆☆ Found in Text Mining only
Status Epilepticus	Status Epilepticus	BEFREE	31760199		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	36193060	Associate	★☆☆☆☆ Found in Text Mining only
Undifferentiated carcinoma	Carcinoma	CTD_human_DG	16316942		★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	33244139	Associate	★☆☆☆☆ Found in Text Mining only
Well Differentiated Oligodendroglioma	Oligodendroglioma	BEFREE	10994011		★☆☆☆☆ Found in Text Mining only