Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7325
Gene name	Ubiquitin conjugating enzyme E2 E2
Gene symbol	UBE2E2
Synonyms (NCBI Gene)	UBCH8
Chromosome	3
Chromosome location	3p24.3

114

Show/Hide all (114)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045536	hsa-miR-149-5p	CLASH	23622248
MIRT045236	hsa-miR-186-5p	CLASH	23622248
MIRT1467423	hsa-miR-1207-5p	CLIP-seq
MIRT1467424	hsa-miR-128	CLIP-seq
MIRT1467425	hsa-miR-185	CLIP-seq
MIRT1467426	hsa-miR-3125	CLIP-seq
MIRT1467427	hsa-miR-3202	CLIP-seq
MIRT1467428	hsa-miR-3916	CLIP-seq
MIRT1467429	hsa-miR-4264	CLIP-seq
MIRT1467430	hsa-miR-4306	CLIP-seq
MIRT1467431	hsa-miR-4311	CLIP-seq
MIRT1467432	hsa-miR-4476	CLIP-seq
MIRT1467433	hsa-miR-4644	CLIP-seq
MIRT1467434	hsa-miR-4736	CLIP-seq
MIRT1467435	hsa-miR-4763-3p	CLIP-seq
MIRT1467436	hsa-miR-4796-3p	CLIP-seq
MIRT1467437	hsa-miR-4797-3p	CLIP-seq
MIRT1467438	hsa-miR-4797-5p	CLIP-seq
MIRT1467439	hsa-miR-548t	CLIP-seq
MIRT2140471	hsa-miR-132	CLIP-seq
MIRT2140472	hsa-miR-212	CLIP-seq
MIRT2140473	hsa-miR-3126-5p	CLIP-seq
MIRT2140474	hsa-miR-3182	CLIP-seq
MIRT2140475	hsa-miR-4709-5p	CLIP-seq
MIRT2140476	hsa-miR-4728-5p	CLIP-seq
MIRT2140477	hsa-miR-4734	CLIP-seq
MIRT1467423	hsa-miR-1207-5p	CLIP-seq
MIRT2361215	hsa-miR-1272	CLIP-seq
MIRT1467424	hsa-miR-128	CLIP-seq
MIRT2361216	hsa-miR-1322	CLIP-seq
MIRT2361217	hsa-miR-300	CLIP-seq
MIRT2361218	hsa-miR-3177-5p	CLIP-seq
MIRT2361219	hsa-miR-3613-3p	CLIP-seq
MIRT2361220	hsa-miR-369-3p	CLIP-seq
MIRT2361221	hsa-miR-374c	CLIP-seq
MIRT2361222	hsa-miR-381	CLIP-seq
MIRT2361223	hsa-miR-4461	CLIP-seq
MIRT2361224	hsa-miR-4658	CLIP-seq
MIRT2361225	hsa-miR-4691-3p	CLIP-seq
MIRT2361226	hsa-miR-4698	CLIP-seq
MIRT2361227	hsa-miR-4719	CLIP-seq
MIRT1467434	hsa-miR-4736	CLIP-seq
MIRT2361228	hsa-miR-4758-5p	CLIP-seq
MIRT1467435	hsa-miR-4763-3p	CLIP-seq
MIRT1467436	hsa-miR-4796-3p	CLIP-seq
MIRT2361229	hsa-miR-499-3p	CLIP-seq
MIRT2361230	hsa-miR-499a-3p	CLIP-seq
MIRT2361231	hsa-miR-520f	CLIP-seq
MIRT2361232	hsa-miR-522	CLIP-seq
MIRT1467439	hsa-miR-548t	CLIP-seq
MIRT2361233	hsa-miR-548u	CLIP-seq
MIRT2361234	hsa-miR-570	CLIP-seq
MIRT2361235	hsa-miR-640	CLIP-seq
MIRT2361236	hsa-miR-655	CLIP-seq
MIRT1467424	hsa-miR-128	CLIP-seq
MIRT2396579	hsa-miR-3157-5p	CLIP-seq
MIRT2396580	hsa-miR-361-5p	CLIP-seq
MIRT2361221	hsa-miR-374c	CLIP-seq
MIRT2361223	hsa-miR-4461	CLIP-seq
MIRT2361224	hsa-miR-4658	CLIP-seq
MIRT2361225	hsa-miR-4691-3p	CLIP-seq
MIRT2361228	hsa-miR-4758-5p	CLIP-seq
MIRT2361231	hsa-miR-520f	CLIP-seq
MIRT2361236	hsa-miR-655	CLIP-seq
MIRT2462780	hsa-miR-1197	CLIP-seq
MIRT2462781	hsa-miR-1226	CLIP-seq
MIRT2462782	hsa-miR-3158-3p	CLIP-seq
MIRT2462783	hsa-miR-4436a	CLIP-seq
MIRT2462784	hsa-miR-4446-3p	CLIP-seq
MIRT2462785	hsa-miR-4733-3p	CLIP-seq
MIRT2462786	hsa-miR-548v	CLIP-seq
MIRT2361215	hsa-miR-1272	CLIP-seq
MIRT2655044	hsa-miR-1297	CLIP-seq
MIRT2361216	hsa-miR-1322	CLIP-seq
MIRT2655045	hsa-miR-26a	CLIP-seq
MIRT2655046	hsa-miR-26b	CLIP-seq
MIRT2655047	hsa-miR-3065-5p	CLIP-seq
MIRT2655048	hsa-miR-3148	CLIP-seq
MIRT2655049	hsa-miR-3153	CLIP-seq
MIRT2655050	hsa-miR-3163	CLIP-seq
MIRT2655051	hsa-miR-3662	CLIP-seq
MIRT1467431	hsa-miR-4311	CLIP-seq
MIRT2655052	hsa-miR-4465	CLIP-seq
MIRT2655053	hsa-miR-4668-3p	CLIP-seq
MIRT2655054	hsa-miR-4668-5p	CLIP-seq
MIRT2655055	hsa-miR-4712-3p	CLIP-seq
MIRT2655056	hsa-miR-4733-5p	CLIP-seq
MIRT2655057	hsa-miR-4762-5p	CLIP-seq
MIRT2655058	hsa-miR-498	CLIP-seq
MIRT2655059	hsa-miR-548c-3p	CLIP-seq
MIRT2361234	hsa-miR-570	CLIP-seq
MIRT2655060	hsa-miR-577	CLIP-seq
MIRT2655061	hsa-miR-605	CLIP-seq
MIRT2462781	hsa-miR-1226	CLIP-seq
MIRT2361215	hsa-miR-1272	CLIP-seq
MIRT2655044	hsa-miR-1297	CLIP-seq
MIRT2361216	hsa-miR-1322	CLIP-seq
MIRT2655045	hsa-miR-26a	CLIP-seq
MIRT2655046	hsa-miR-26b	CLIP-seq
MIRT2655048	hsa-miR-3148	CLIP-seq
MIRT2655049	hsa-miR-3153	CLIP-seq
MIRT2462782	hsa-miR-3158-3p	CLIP-seq
MIRT2462784	hsa-miR-4446-3p	CLIP-seq
MIRT2655052	hsa-miR-4465	CLIP-seq
MIRT2655053	hsa-miR-4668-3p	CLIP-seq
MIRT2655054	hsa-miR-4668-5p	CLIP-seq
MIRT2462785	hsa-miR-4733-3p	CLIP-seq
MIRT2655056	hsa-miR-4733-5p	CLIP-seq
MIRT2655057	hsa-miR-4762-5p	CLIP-seq
MIRT2655058	hsa-miR-498	CLIP-seq
MIRT2655059	hsa-miR-548c-3p	CLIP-seq
MIRT2462786	hsa-miR-548v	CLIP-seq
MIRT2361234	hsa-miR-570	CLIP-seq
MIRT2655061	hsa-miR-605	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	20061386
GO:0005515	Function	Protein binding	IPI	17460044, 19549727, 21516116, 24446487, 25416956, 26752685, 28514442, 29892012, 31515488, 32296183, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0006513	Process	Protein monoubiquitination	IDA	27237050
GO:0006513	Process	Protein monoubiquitination	IEA
GO:0006974	Process	DNA damage response	IMP	21628527
GO:0010629	Process	Negative regulation of gene expression	IDA	39096901
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0032020	Process	ISG15-protein conjugation	IBA
GO:0032020	Process	ISG15-protein conjugation	IDA	16428300
GO:0042296	Function	ISG15 transferase activity	IBA
GO:0042296	Function	ISG15 transferase activity	IDA	16428300
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IBA
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IDA	9371400, 21628527, 27237050
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IEA
GO:0070534	Process	Protein K63-linked ubiquitination	IBA
GO:0070534	Process	Protein K63-linked ubiquitination	IDA	20061386
GO:0070936	Process	Protein K48-linked ubiquitination	IBA
GO:0070936	Process	Protein K48-linked ubiquitination	IDA	20061386
GO:0070936	Process	Protein K48-linked ubiquitination	IEA
GO:0070979	Process	Protein K11-linked ubiquitination	IBA
GO:0070979	Process	Protein K11-linked ubiquitination	IDA	20061386
GO:1900087	Process	Positive regulation of G1/S transition of mitotic cell cycle	IGI	21628527

MIM	HGNC	e!Ensembl
602163	12478	ENSG00000182247

Q96LR5

Protein name

Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2)

Protein function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.

PDB

1Y6L , 6W9A

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00179	UQ_con	59 → 196	Ubiquitin-conjugating enzyme	Domain

Sequence

MSTEAQRVDDSPSTSGGSSDGDQRESVQQEPEREQVQPKKKEGKISSKTAAKLSTSAKRI
QKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFSPDYPFKPPK
VTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQ
YMTNRAEHDRMARQWTKRYAT

Sequence length

201

Interactions

View interactions

	KEGG		Reactome
	Ubiquitin mediated proteolysis		Antigen processing: Ubiquitination & Proteasome degradation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (11)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, NON-INSULIN-DEPENDENT	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, TYPE 2	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC RETINOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESPIRATORY SYSTEM DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VITILIGO	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (31)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute Promyelocytic Leukemia	Promyelocytic Leukemia	BEFREE	26026090		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenoma	Adenoma	BEFREE	27914986		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	18566215, 22185919		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	27914986		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	31428903		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	22491060	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	29157076		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	29157076		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Gestational	Gestational diabetes	Pubtator	23862583	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	27281273	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	26020062, 27175665, 27655316, 35456451	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	20818381, 25337779, 26020062, 27175665, 29871606		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	GWASDB_DG	20818381, 22158537, 22885922, 23300278, 24509480		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	CTD_human_DG	20818381		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	GWASCAT_DG	22885922, 24509480, 26818947, 28869590, 30054458, 30595370, 30718926		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Eczema	Eczema	GWASCAT_DG	30595370		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	28186990		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	28186990		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatocellular Adenoma	Hepatocellular adenoma	CTD_human_DG	27914986		★★★★★ ★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Diabetes mellitus, type 2	Pubtator	26020062	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	28043811		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	28043811		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	27914986		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	18566215, 22185919		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	28186990		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	29157076		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome X	Metabolic Syndrome	BEFREE	28919193		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	26506425		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	18566215		★★★★★ ★☆☆☆☆ Found in Text Mining only
PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE	Parkinson Disease	BEFREE	11692161		★★★★★ ★☆☆☆☆ Found in Text Mining only
Vitiligo	Vitiligo	GWASCAT_DG	27723757		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

UBE2E2 (ubiquitin conjugating enzyme E2 E2)