SHISA7 (shisa family member 7)

Gene

• Entrez ID: 729956
• Gene name: Shisa family member 7
• Gene symbol: SHISA7
• Synonyms (NCBI Gene): CKAMP59
• Chromosome: 19
• Chromosome location: 19q13.42

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT735154	hsa-miR-3681-5p	qRT-PCR	32655015
MIRT739069	hsa-miR-3922-5p	HITS-CLIP	33718276
MIRT739070	hsa-miR-4713-3p	HITS-CLIP	33718276
MIRT739074	hsa-miR-4769-5p	HITS-CLIP	33718276
MIRT739078	hsa-miR-576-3p	HITS-CLIP	33718276
MIRT1347122	hsa-miR-1184	CLIP-seq
MIRT1347123	hsa-miR-1205	CLIP-seq
MIRT1347124	hsa-miR-1207-5p	CLIP-seq
MIRT1347125	hsa-miR-1272	CLIP-seq
MIRT1347126	hsa-miR-1291	CLIP-seq
MIRT1347127	hsa-miR-1294	CLIP-seq
MIRT1347128	hsa-miR-1343	CLIP-seq
MIRT1347129	hsa-miR-143	CLIP-seq
MIRT1347130	hsa-miR-1827	CLIP-seq
MIRT739079	hsa-miR-183	CLIP-seq
MIRT1347131	hsa-miR-18a	CLIP-seq
MIRT1347132	hsa-miR-18b	CLIP-seq
MIRT1347133	hsa-miR-193a-5p	CLIP-seq
MIRT1347134	hsa-miR-2110	CLIP-seq
MIRT1347135	hsa-miR-218	CLIP-seq
MIRT1347136	hsa-miR-219-5p	CLIP-seq
MIRT1347137	hsa-miR-223	CLIP-seq
MIRT1347138	hsa-miR-2355-5p	CLIP-seq
MIRT1347139	hsa-miR-2467-3p	CLIP-seq
MIRT739077	hsa-miR-299-3p	CLIP-seq
MIRT1347140	hsa-miR-31	CLIP-seq
MIRT1347141	hsa-miR-3147	CLIP-seq
MIRT1347142	hsa-miR-3158-5p	CLIP-seq
MIRT1347143	hsa-miR-3173-3p	CLIP-seq
MIRT1347144	hsa-miR-3192	CLIP-seq
MIRT1347145	hsa-miR-339-5p	CLIP-seq
MIRT1347146	hsa-miR-33a	CLIP-seq
MIRT1347147	hsa-miR-33b	CLIP-seq
MIRT1347148	hsa-miR-346	CLIP-seq
MIRT1347149	hsa-miR-3612	CLIP-seq
MIRT1347150	hsa-miR-3613-3p	CLIP-seq
MIRT1347151	hsa-miR-361-3p	CLIP-seq
MIRT1347152	hsa-miR-3616-3p	CLIP-seq
MIRT1347153	hsa-miR-3622b-5p	CLIP-seq
MIRT1347154	hsa-miR-3654	CLIP-seq
MIRT1347155	hsa-miR-3682-3p	CLIP-seq
MIRT1347156	hsa-miR-3689a-3p	CLIP-seq
MIRT1347157	hsa-miR-3689c	CLIP-seq
MIRT1347158	hsa-miR-3689d	CLIP-seq
MIRT1347159	hsa-miR-3691-3p	CLIP-seq
MIRT1347160	hsa-miR-3907	CLIP-seq
MIRT1347161	hsa-miR-3943	CLIP-seq
MIRT1347162	hsa-miR-425	CLIP-seq
MIRT1347163	hsa-miR-4253	CLIP-seq
MIRT1347164	hsa-miR-4260	CLIP-seq
MIRT1347165	hsa-miR-4270	CLIP-seq
MIRT1347166	hsa-miR-4271	CLIP-seq
MIRT1347167	hsa-miR-4276	CLIP-seq
MIRT1347168	hsa-miR-4288	CLIP-seq
MIRT1347169	hsa-miR-4425	CLIP-seq
MIRT1347170	hsa-miR-4436a	CLIP-seq
MIRT1347171	hsa-miR-4441	CLIP-seq
MIRT1347172	hsa-miR-4492	CLIP-seq
MIRT1347173	hsa-miR-4498	CLIP-seq
MIRT1347174	hsa-miR-4505	CLIP-seq
MIRT739072	hsa-miR-450b-3p	CLIP-seq
MIRT1347175	hsa-miR-4535	CLIP-seq
MIRT739076	hsa-miR-4648	CLIP-seq
MIRT1347176	hsa-miR-4651	CLIP-seq
MIRT739075	hsa-miR-4654	CLIP-seq
MIRT1347177	hsa-miR-4655-5p	CLIP-seq
MIRT1347178	hsa-miR-4660	CLIP-seq
MIRT1347179	hsa-miR-4679	CLIP-seq
MIRT1347180	hsa-miR-4697-3p	CLIP-seq
MIRT1347181	hsa-miR-4710	CLIP-seq
MIRT1347182	hsa-miR-4721	CLIP-seq
MIRT1347183	hsa-miR-4725-3p	CLIP-seq
MIRT1347184	hsa-miR-4727-5p	CLIP-seq
MIRT1347185	hsa-miR-4728-5p	CLIP-seq
MIRT1347186	hsa-miR-4733-3p	CLIP-seq
MIRT1347187	hsa-miR-4735-3p	CLIP-seq
MIRT1347188	hsa-miR-4755-3p	CLIP-seq
MIRT1347189	hsa-miR-4763-3p	CLIP-seq
MIRT1347190	hsa-miR-4769-3p	CLIP-seq
MIRT1347191	hsa-miR-4770	CLIP-seq
MIRT1347192	hsa-miR-4782-3p	CLIP-seq
MIRT1347193	hsa-miR-486-3p	CLIP-seq
MIRT1347194	hsa-miR-490-5p	CLIP-seq
MIRT1347195	hsa-miR-492	CLIP-seq
MIRT1347196	hsa-miR-555	CLIP-seq
MIRT1347197	hsa-miR-581	CLIP-seq
MIRT1347198	hsa-miR-586	CLIP-seq
MIRT1347199	hsa-miR-593	CLIP-seq
MIRT1347200	hsa-miR-608	CLIP-seq
MIRT1347201	hsa-miR-632	CLIP-seq
MIRT1347202	hsa-miR-635	CLIP-seq
MIRT1347203	hsa-miR-636	CLIP-seq
MIRT739071	hsa-miR-638	CLIP-seq
MIRT1347204	hsa-miR-647	CLIP-seq
MIRT1347205	hsa-miR-650	CLIP-seq
MIRT1347206	hsa-miR-762	CLIP-seq
MIRT739073	hsa-miR-769-3p	CLIP-seq
MIRT1347207	hsa-miR-940	CLIP-seq
MIRT1347208	hsa-miR-941	CLIP-seq
MIRT1921298	hsa-miR-1275	CLIP-seq
MIRT1921299	hsa-miR-4299	CLIP-seq
MIRT1921300	hsa-miR-4310	CLIP-seq
MIRT1921301	hsa-miR-4665-5p	CLIP-seq
MIRT1347125	hsa-miR-1272	CLIP-seq
MIRT2102788	hsa-miR-1285	CLIP-seq
MIRT1347127	hsa-miR-1294	CLIP-seq
MIRT1347128	hsa-miR-1343	CLIP-seq
MIRT2102789	hsa-miR-146b-3p	CLIP-seq
MIRT1347131	hsa-miR-18a	CLIP-seq
MIRT1347132	hsa-miR-18b	CLIP-seq
MIRT2102790	hsa-miR-224	CLIP-seq
MIRT1347139	hsa-miR-2467-3p	CLIP-seq
MIRT2102791	hsa-miR-2861	CLIP-seq
MIRT2102792	hsa-miR-3128	CLIP-seq
MIRT2102793	hsa-miR-3150b-3p	CLIP-seq
MIRT2102794	hsa-miR-3173-5p	CLIP-seq
MIRT2102795	hsa-miR-3187-5p	CLIP-seq
MIRT1347144	hsa-miR-3192	CLIP-seq
MIRT2102796	hsa-miR-326	CLIP-seq
MIRT2102797	hsa-miR-330-5p	CLIP-seq
MIRT2102798	hsa-miR-34a	CLIP-seq
MIRT2102799	hsa-miR-34c-5p	CLIP-seq
MIRT1347156	hsa-miR-3689a-3p	CLIP-seq
MIRT1347157	hsa-miR-3689c	CLIP-seq
MIRT1347158	hsa-miR-3689d	CLIP-seq
MIRT2102800	hsa-miR-3690	CLIP-seq
MIRT2102801	hsa-miR-378	CLIP-seq
MIRT2102802	hsa-miR-378b	CLIP-seq
MIRT2102803	hsa-miR-378c	CLIP-seq
MIRT2102804	hsa-miR-378d	CLIP-seq
MIRT2102805	hsa-miR-378e	CLIP-seq
MIRT2102806	hsa-miR-378f	CLIP-seq
MIRT2102807	hsa-miR-378g	CLIP-seq
MIRT2102808	hsa-miR-378h	CLIP-seq
MIRT2102809	hsa-miR-378i	CLIP-seq
MIRT2102810	hsa-miR-422a	CLIP-seq
MIRT1347162	hsa-miR-425	CLIP-seq
MIRT2102811	hsa-miR-4254	CLIP-seq
MIRT2102812	hsa-miR-4292	CLIP-seq
MIRT2102813	hsa-miR-4308	CLIP-seq
MIRT2102814	hsa-miR-4419a	CLIP-seq
MIRT2102815	hsa-miR-4468	CLIP-seq
MIRT2102816	hsa-miR-4486	CLIP-seq
MIRT1347172	hsa-miR-4492	CLIP-seq
MIRT1347173	hsa-miR-4498	CLIP-seq
MIRT2102817	hsa-miR-449a	CLIP-seq
MIRT2102818	hsa-miR-449b	CLIP-seq
MIRT1347174	hsa-miR-4505	CLIP-seq
MIRT2102819	hsa-miR-4510	CLIP-seq
MIRT2102820	hsa-miR-4522	CLIP-seq
MIRT1347177	hsa-miR-4655-5p	CLIP-seq
MIRT2102821	hsa-miR-4689	CLIP-seq
MIRT2102822	hsa-miR-4720-5p	CLIP-seq
MIRT1347185	hsa-miR-4728-5p	CLIP-seq
MIRT1347186	hsa-miR-4733-3p	CLIP-seq
MIRT1347187	hsa-miR-4735-3p	CLIP-seq
MIRT2102823	hsa-miR-4738-5p	CLIP-seq
MIRT2102824	hsa-miR-4763-5p	CLIP-seq
MIRT2102825	hsa-miR-4784	CLIP-seq
MIRT2102826	hsa-miR-4799-3p	CLIP-seq
MIRT2102827	hsa-miR-515-3p	CLIP-seq
MIRT2102828	hsa-miR-519e	CLIP-seq
MIRT1347196	hsa-miR-555	CLIP-seq
MIRT2102829	hsa-miR-612	CLIP-seq
MIRT1347206	hsa-miR-762	CLIP-seq
MIRT2102830	hsa-miR-766	CLIP-seq
MIRT2102831	hsa-miR-874	CLIP-seq
MIRT2327178	hsa-miR-1197	CLIP-seq
MIRT2327179	hsa-miR-1207-3p	CLIP-seq
MIRT1347127	hsa-miR-1294	CLIP-seq
MIRT1347128	hsa-miR-1343	CLIP-seq
MIRT1347130	hsa-miR-1827	CLIP-seq
MIRT2327180	hsa-miR-185	CLIP-seq
MIRT1347131	hsa-miR-18a	CLIP-seq
MIRT1347132	hsa-miR-18b	CLIP-seq
MIRT2327181	hsa-miR-1915	CLIP-seq
MIRT1347139	hsa-miR-2467-3p	CLIP-seq
MIRT2327182	hsa-miR-3125	CLIP-seq
MIRT1347144	hsa-miR-3192	CLIP-seq
MIRT2102796	hsa-miR-326	CLIP-seq
MIRT2102797	hsa-miR-330-5p	CLIP-seq
MIRT1347156	hsa-miR-3689a-3p	CLIP-seq
MIRT1347157	hsa-miR-3689c	CLIP-seq
MIRT2327183	hsa-miR-3913-3p	CLIP-seq
MIRT2327184	hsa-miR-3916	CLIP-seq
MIRT1347162	hsa-miR-425	CLIP-seq
MIRT2102811	hsa-miR-4254	CLIP-seq
MIRT2327185	hsa-miR-4257	CLIP-seq
MIRT2327186	hsa-miR-4306	CLIP-seq
MIRT2327187	hsa-miR-4314	CLIP-seq
MIRT2102815	hsa-miR-4468	CLIP-seq
MIRT1347172	hsa-miR-4492	CLIP-seq
MIRT1347173	hsa-miR-4498	CLIP-seq
MIRT1347174	hsa-miR-4505	CLIP-seq
MIRT2102820	hsa-miR-4522	CLIP-seq
MIRT2327188	hsa-miR-4644	CLIP-seq
MIRT2327189	hsa-miR-4646-5p	CLIP-seq
MIRT1347176	hsa-miR-4651	CLIP-seq
MIRT1347177	hsa-miR-4655-5p	CLIP-seq
MIRT1347181	hsa-miR-4710	CLIP-seq
MIRT1347185	hsa-miR-4728-5p	CLIP-seq
MIRT1347187	hsa-miR-4735-3p	CLIP-seq
MIRT2327190	hsa-miR-489	CLIP-seq
MIRT2327191	hsa-miR-499-3p	CLIP-seq
MIRT2327192	hsa-miR-499a-3p	CLIP-seq
MIRT1347196	hsa-miR-555	CLIP-seq
MIRT1347200	hsa-miR-608	CLIP-seq
MIRT1347204	hsa-miR-647	CLIP-seq
MIRT1347206	hsa-miR-762	CLIP-seq
MIRT2327193	hsa-miR-936	CLIP-seq
MIRT1347144	hsa-miR-3192	CLIP-seq
MIRT1347156	hsa-miR-3689a-3p	CLIP-seq
MIRT1347157	hsa-miR-3689c	CLIP-seq
MIRT1347185	hsa-miR-4728-5p	CLIP-seq
MIRT1347139	hsa-miR-2467-3p	CLIP-seq
MIRT1347144	hsa-miR-3192	CLIP-seq
MIRT1347156	hsa-miR-3689a-3p	CLIP-seq
MIRT1347157	hsa-miR-3689c	CLIP-seq
MIRT2102815	hsa-miR-4468	CLIP-seq
MIRT1347172	hsa-miR-4492	CLIP-seq
MIRT1347173	hsa-miR-4498	CLIP-seq
MIRT1347174	hsa-miR-4505	CLIP-seq
MIRT1347185	hsa-miR-4728-5p	CLIP-seq
MIRT1347206	hsa-miR-762	CLIP-seq
MIRT1347139	hsa-miR-2467-3p	CLIP-seq
MIRT1347144	hsa-miR-3192	CLIP-seq
MIRT1347156	hsa-miR-3689a-3p	CLIP-seq
MIRT1347157	hsa-miR-3689c	CLIP-seq
MIRT2102815	hsa-miR-4468	CLIP-seq
MIRT1347172	hsa-miR-4492	CLIP-seq
MIRT1347173	hsa-miR-4498	CLIP-seq
MIRT1347174	hsa-miR-4505	CLIP-seq
MIRT1347185	hsa-miR-4728-5p	CLIP-seq
MIRT1347206	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IEA
GO:0007214	Process	Gamma-aminobutyric acid signaling pathway	IBA
GO:0007214	Process	Gamma-aminobutyric acid signaling pathway	IEA
GO:0007214	Process	Gamma-aminobutyric acid signaling pathway	ISS
GO:0007613	Process	Memory	IEA
GO:0007613	Process	Memory	ISS
GO:0014069	Component	Postsynaptic density	IBA
GO:0014069	Component	Postsynaptic density	IEA
GO:0014069	Component	Postsynaptic density	ISS
GO:0016020	Component	Membrane	IEA
GO:0032281	Component	AMPA glutamate receptor complex	ISS
GO:0032591	Component	Dendritic spine membrane	IBA
GO:0035255	Function	Ionotropic glutamate receptor binding	ISS
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IBA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0050811	Function	GABA receptor binding	IBA
GO:0050811	Function	GABA receptor binding	IEA
GO:0050811	Function	GABA receptor binding	ISS
GO:0097112	Process	Gamma-aminobutyric acid receptor clustering	IBA
GO:0097112	Process	Gamma-aminobutyric acid receptor clustering	IEA
GO:0097112	Process	Gamma-aminobutyric acid receptor clustering	ISS
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098978	Component	Glutamatergic synapse	ISS
GO:0098985	Component	Asymmetric, glutamatergic, excitatory synapse	ISS
GO:0099634	Component	Postsynaptic specialization membrane	IEA
GO:0106040	Process	Regulation of GABA-A receptor activity	ISS
GO:1900273	Process	Positive regulation of long-term synaptic potentiation	IEA
GO:1900273	Process	Positive regulation of long-term synaptic potentiation	ISS
GO:1904717	Process	Regulation of AMPA glutamate receptor clustering	ISS
GO:2000311	Process	Regulation of AMPA receptor activity	ISS

Other IDs

• MIM: 617328
• HGNC: 35409
• e!Ensembl: ENSG00000187902

Protein

• UniProt ID: A6NL88
• Protein name: Protein shisa-7 (Cystine-knot AMPAR modulating protein of 59 kDa) (CKAMP59) (GABA(A) receptor auxiliary subunit Shisa7) (Protein shisa-6-like)
• Protein function: Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain. Enhances the action of benzodiazepine,
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13908	Shisa	79 → 152	Wnt and FGF inhibitory regulator	Family

• Sequence:

  MPALLLLVLLASSAGQARARPSNATSAEPAGPLPALLAHLRRLTGALTGGGGAASPGANG
  TRTGPAGGAGAAARAPPPAELCHGYYDVMGQYDATFNCSTGSYRFCCGTCHYRFCCEHRH
  MRLAQASCSNYDTPRWATTPPPLAGGAGGAGGAGGGPGPGQAGWLEGGRTGGAGGRGGEG
  PGGSTAYVVCGVISFALAVGVGAKVAFSKASRAPRAHRDINVPRALVDILRHQAGPGTRP
  DRARSSSLTPGIGGPDSMPPRTPKNLYNTVKTPNLDWRALPPPSPSLHYSTLSCSRSFHN
  LSHLPPSYEAAVKSELNRYSSLKRLAEKDLDEAYLKRRPLELPRGTLPLHALRRPGTGGG
  YRMEAWGGPEELGLAPAPNPRRVMSQEHLLGDGGRSRYEFTLPRARLVSQEHLLLSSPEA
  LRQSREHLLSPPRSPALPPDPTARASLAASHSNLLLGPGGPPTPLRGLPPPSSLHAHHHH
  ALHGSPQPAWMSDAGGGGGTLARRPPFQRQGTLEQLQFIPGHHLPQHLRTASKNEVTV

• Sequence length: 538

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Glaucoma Open Angle	Open angle glaucoma	Pubtator	36727359	Associate	★☆☆☆☆ Found in Text Mining only