Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	729438
Gene name	Cytosolic arginine sensor for mTORC1 subunit 2
Gene symbol	CASTOR2
Synonyms (NCBI Gene)	GATSL1GATSL2
Chromosome	7
Chromosome location	7q11.23

161

Show/Hide all (161)

miRTarBase ID	miRNA	Experiments	Reference
MIRT668215	hsa-miR-6758-5p	HITS-CLIP	23824327
MIRT668214	hsa-miR-6856-5p	HITS-CLIP	23824327
MIRT668213	hsa-miR-3976	HITS-CLIP	23824327
MIRT668212	hsa-miR-376a-3p	HITS-CLIP	23824327
MIRT668211	hsa-miR-376b-3p	HITS-CLIP	23824327
MIRT668210	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT623835	hsa-miR-4523	HITS-CLIP	23824327
MIRT623833	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT623832	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT623831	hsa-miR-4421	HITS-CLIP	23824327
MIRT623830	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT623826	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT623825	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT623824	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT628190	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT623822	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT623821	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT623820	hsa-miR-7703	HITS-CLIP	23824327
MIRT623835	hsa-miR-4523	HITS-CLIP	23824327
MIRT623834	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT623833	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT623832	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT623831	hsa-miR-4421	HITS-CLIP	23824327
MIRT623830	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT623829	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT623828	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT623827	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT623826	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT623825	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT623824	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT628190	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT623822	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT623821	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT623820	hsa-miR-7703	HITS-CLIP	23824327
MIRT657933	hsa-miR-6873-5p	HITS-CLIP	23824327
MIRT657932	hsa-miR-6750-5p	HITS-CLIP	23824327
MIRT657931	hsa-miR-6822-5p	HITS-CLIP	23824327
MIRT657930	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT657929	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT657928	hsa-miR-4471	HITS-CLIP	23824327
MIRT657927	hsa-miR-8059	HITS-CLIP	23824327
MIRT657926	hsa-miR-877-5p	HITS-CLIP	23824327
MIRT657925	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT657924	hsa-miR-1303	HITS-CLIP	23824327
MIRT628191	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT623833	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT623832	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT623831	hsa-miR-4421	HITS-CLIP	23824327
MIRT623830	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT623829	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT623828	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT623827	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT623826	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT623825	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT623824	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT628190	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT623823	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT623822	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT623821	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT623820	hsa-miR-7703	HITS-CLIP	23824327
MIRT623834	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT623833	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT623832	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT623831	hsa-miR-4421	HITS-CLIP	23824327
MIRT623830	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT623829	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT623828	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT623827	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT623826	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT623825	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT623824	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT628190	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT623823	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT623822	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT623821	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT623820	hsa-miR-7703	HITS-CLIP	23824327
MIRT628191	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT623833	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT623832	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT623831	hsa-miR-4421	HITS-CLIP	23824327
MIRT623830	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT623829	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT623828	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT623827	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT623826	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT623825	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT623824	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT628190	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT623823	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT623822	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT623821	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT623820	hsa-miR-7703	HITS-CLIP	23824327
MIRT628191	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT623834	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT623833	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT623832	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT623831	hsa-miR-4421	HITS-CLIP	23824327
MIRT623830	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT623829	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT623828	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT623827	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT623826	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT623825	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT623824	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT628190	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT623823	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT623822	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT623821	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT623820	hsa-miR-7703	HITS-CLIP	23824327
MIRT623835	hsa-miR-4523	HITS-CLIP	23824327
MIRT623834	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT623833	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT623832	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT623831	hsa-miR-4421	HITS-CLIP	23824327
MIRT623830	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT623829	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT623828	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT623827	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT623826	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT623825	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT623824	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT623823	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT623822	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT623821	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT623820	hsa-miR-7703	HITS-CLIP	23824327
MIRT616413	hsa-miR-4687-5p	HITS-CLIP	23824327
MIRT616412	hsa-miR-4269	HITS-CLIP	23824327
MIRT616411	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT616410	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT616409	hsa-miR-4673	HITS-CLIP	23824327
MIRT616408	hsa-miR-6840-5p	HITS-CLIP	23824327
MIRT616407	hsa-miR-4258	HITS-CLIP	23824327
MIRT616406	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT616405	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT616404	hsa-miR-1233-3p	HITS-CLIP	23824327
MIRT616403	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT616402	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT616401	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT616400	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT502391	hsa-miR-182-5p	PAR-CLIP	24398324
MIRT502390	hsa-miR-96-5p	PAR-CLIP	24398324
MIRT502389	hsa-miR-1271-5p	PAR-CLIP	24398324
MIRT502388	hsa-miR-191-5p	PAR-CLIP	24398324
MIRT502387	hsa-miR-580-5p	PAR-CLIP	24398324
MIRT502386	hsa-miR-3664-3p	PAR-CLIP	24398324
MIRT502385	hsa-miR-1266-5p	PAR-CLIP	24398324
MIRT502384	hsa-miR-4518	PAR-CLIP	24398324
MIRT502383	hsa-miR-5093	PAR-CLIP	24398324
MIRT502382	hsa-miR-4642	PAR-CLIP	24398324
MIRT444702	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT444701	hsa-miR-7160-3p	PAR-CLIP	22100165
MIRT444700	hsa-miR-3065-5p	PAR-CLIP	22100165
MIRT444699	hsa-miR-676-5p	PAR-CLIP	22100165
MIRT444698	hsa-miR-3616-3p	PAR-CLIP	22100165
MIRT444697	hsa-miR-4721	PAR-CLIP	22100165
MIRT444696	hsa-miR-7159-5p	PAR-CLIP	22100165
MIRT444695	hsa-miR-505-3p	PAR-CLIP	22100165
MIRT444694	hsa-miR-421	PAR-CLIP	22100165
MIRT444693	hsa-miR-6834-5p	PAR-CLIP	22100165
MIRT444692	hsa-miR-1226-5p	PAR-CLIP	22100165
MIRT444691	hsa-miR-6734-5p	PAR-CLIP	22100165

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	26972053, 28514442, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	26972053
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0034618	Function	Arginine binding	IDA	26972053
GO:0042802	Function	Identical protein binding	IDA	26972053
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	26972053
GO:0061700	Component	GATOR2 complex	IDA	26972053
GO:1903577	Process	Cellular response to L-arginine	IBA
GO:1904262	Process	Negative regulation of TORC1 signaling	IBA
GO:1904262	Process	Negative regulation of TORC1 signaling	IEA
GO:1904262	Process	Negative regulation of TORC1 signaling	IMP	26972053

MIM	HGNC	e!Ensembl
617033	37073	ENSG00000274070

A6NHX0

Protein name

Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2)

Protein function

Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind ar

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18700	Castor1_N	9 → 69	Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain	Domain
PF13840	ACT_7	71 → 141	ACT domain	Domain
PF13840	ACT_7	259 → 323	ACT domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000303|PubMed:26972053}.

Sequence

MELHILEHRLQVASVAKESIPLFTYGLIKLAFLSSKTRCKFFSLTETPEDYTIIVDEEGF
LELPSSEHLSVADATWLALNVVSGGGSFSSSQPIGVTKIAKSVIAPLADQNISVFMLSTY
QTDFILVRERDLPFVTHTLSSEFTILRVVNGETVAAENLGITNGFVKPKLVQRPVIHPLS
SPSNRFCVTSLDPDTLPAVATLLMDVMFYSNGVKDPMATGDDCGHIRFFSFSLIEGYISL
VMDVQTQQRFPSNLLFTSASGELWKMVRIGGQPLGFDECGIVAQISEPLAAADIPAYYIS
TFKFDHALVPEENINGVISALKVSQAEKH

Sequence length

329

Interactions

View interactions

	KEGG		Reactome
	mTOR signaling pathway		Amino acids regulate mTORC1

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESTROGEN-RECEPTOR NEGATIVE BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinogenesis	Carcinogenesis	Pubtator	31305263	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kaposi Sarcoma	Kaposi Sarcoma	BEFREE	31305263		★★★★★ ★☆☆☆☆ Found in Text Mining only

CASTOR2 (cytosolic arginine sensor for mTORC1 subunit 2)