Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	729359
Gene name	Perilipin 4
Gene symbol	PLIN4
Synonyms (NCBI Gene)	KIAA1881MDRVMRUPAVNIPA2S3-12
Chromosome	19
Chromosome location	19p13.3
Summary	Members of the perilipin family, such as PLIN4, coat intracellular lipid storage droplets (Wolins et al., 2003 [PubMed 12840023]).[supplied by OMIM, Feb 2010]

Show/Hide all (85)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017371	hsa-miR-335-5p	Microarray	18185580
MIRT1242839	hsa-miR-1207-3p	CLIP-seq
MIRT1242840	hsa-miR-1228	CLIP-seq
MIRT1242841	hsa-miR-1827	CLIP-seq
MIRT1242842	hsa-miR-24	CLIP-seq
MIRT1242843	hsa-miR-302f	CLIP-seq
MIRT1242844	hsa-miR-3124-3p	CLIP-seq
MIRT1242845	hsa-miR-3135b	CLIP-seq
MIRT1242846	hsa-miR-3187-3p	CLIP-seq
MIRT1242847	hsa-miR-342-3p	CLIP-seq
MIRT1242848	hsa-miR-342-5p	CLIP-seq
MIRT1242849	hsa-miR-3612	CLIP-seq
MIRT1242850	hsa-miR-3653	CLIP-seq
MIRT1242851	hsa-miR-3658	CLIP-seq
MIRT1242852	hsa-miR-3685	CLIP-seq
MIRT1242853	hsa-miR-384	CLIP-seq
MIRT1242854	hsa-miR-3944-3p	CLIP-seq
MIRT1242855	hsa-miR-3974	CLIP-seq
MIRT1242856	hsa-miR-4284	CLIP-seq
MIRT1242857	hsa-miR-4327	CLIP-seq
MIRT1242858	hsa-miR-4443	CLIP-seq
MIRT1242859	hsa-miR-4455	CLIP-seq
MIRT1242860	hsa-miR-4529-5p	CLIP-seq
MIRT1242861	hsa-miR-4651	CLIP-seq
MIRT1242862	hsa-miR-4664-5p	CLIP-seq
MIRT1242863	hsa-miR-4722-3p	CLIP-seq
MIRT1242864	hsa-miR-4753-3p	CLIP-seq
MIRT1242865	hsa-miR-493	CLIP-seq
MIRT1242866	hsa-miR-520f	CLIP-seq
MIRT1242867	hsa-miR-541	CLIP-seq
MIRT1242868	hsa-miR-608	CLIP-seq
MIRT1242869	hsa-miR-609	CLIP-seq
MIRT1242870	hsa-miR-636	CLIP-seq
MIRT1242871	hsa-miR-650	CLIP-seq
MIRT1242872	hsa-miR-654-5p	CLIP-seq
MIRT1242873	hsa-miR-935	CLIP-seq
MIRT2071762	hsa-miR-138	CLIP-seq
MIRT2071763	hsa-miR-2861	CLIP-seq
MIRT2071764	hsa-miR-296-5p	CLIP-seq
MIRT2071765	hsa-miR-3925-3p	CLIP-seq
MIRT2071766	hsa-miR-4685-5p	CLIP-seq
MIRT2071767	hsa-miR-4688	CLIP-seq
MIRT2071768	hsa-miR-4731-5p	CLIP-seq
MIRT2071769	hsa-miR-4749-3p	CLIP-seq
MIRT2071770	hsa-miR-486-3p	CLIP-seq
MIRT2071771	hsa-miR-766	CLIP-seq
MIRT2298917	hsa-miR-15a	CLIP-seq
MIRT2298918	hsa-miR-15b	CLIP-seq
MIRT2298919	hsa-miR-16	CLIP-seq
MIRT2298920	hsa-miR-1915	CLIP-seq
MIRT2298921	hsa-miR-195	CLIP-seq
MIRT2298922	hsa-miR-2355-5p	CLIP-seq
MIRT2298923	hsa-miR-424	CLIP-seq
MIRT2298924	hsa-miR-4323	CLIP-seq
MIRT2298925	hsa-miR-4691-5p	CLIP-seq
MIRT2298926	hsa-miR-497	CLIP-seq
MIRT2071762	hsa-miR-138	CLIP-seq
MIRT2071763	hsa-miR-2861	CLIP-seq
MIRT2392680	hsa-miR-4292	CLIP-seq
MIRT2071769	hsa-miR-4749-3p	CLIP-seq
MIRT2392681	hsa-miR-4763-5p	CLIP-seq
MIRT2392682	hsa-miR-548q	CLIP-seq
MIRT2595737	hsa-miR-1179	CLIP-seq
MIRT2595738	hsa-miR-125a-3p	CLIP-seq
MIRT2071762	hsa-miR-138	CLIP-seq
MIRT2595739	hsa-miR-3665	CLIP-seq
MIRT2595740	hsa-miR-4468	CLIP-seq
MIRT2595741	hsa-miR-4514	CLIP-seq
MIRT2595742	hsa-miR-4645-5p	CLIP-seq
MIRT2595743	hsa-miR-4673	CLIP-seq
MIRT2595744	hsa-miR-4692	CLIP-seq
MIRT2595745	hsa-miR-4736	CLIP-seq
MIRT2595746	hsa-miR-4792	CLIP-seq
MIRT2392682	hsa-miR-548q	CLIP-seq
MIRT2595747	hsa-miR-940	CLIP-seq
MIRT2595738	hsa-miR-125a-3p	CLIP-seq
MIRT2595739	hsa-miR-3665	CLIP-seq
MIRT2595740	hsa-miR-4468	CLIP-seq
MIRT2595741	hsa-miR-4514	CLIP-seq
MIRT2595742	hsa-miR-4645-5p	CLIP-seq
MIRT2595743	hsa-miR-4673	CLIP-seq
MIRT2595744	hsa-miR-4692	CLIP-seq
MIRT2595745	hsa-miR-4736	CLIP-seq
MIRT2595746	hsa-miR-4792	CLIP-seq
MIRT2595747	hsa-miR-940	CLIP-seq

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0005811	Component	Lipid droplet	IDA	21498505
GO:0005811	Component	Lipid droplet	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
613247	29393	ENSG00000167676

Q96Q06

Protein name

Perilipin-4 (Adipocyte protein S3-12)

Protein function

May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03036	Perilipin	1135 → 1353	Perilipin family	Family

Sequence

MQTLGSFFGSLPGFSSARNLVANAHSSARARPAADPTGAPAAEAAQPQAQVAAHPEQTAP
WTEKELQPSEKQMVSGAKDLVCSKMSRAKDAVSSGVASVVDVAKGVVQGGLDTTRSALTG
TKEVVSSGVTGAMDMAKGAVQGGLDTSKAVLTGTKDTVSTGLTGAVNVAKGTVQAGVDTT
KTVLTGTKDTVTTGVMGAVNLAKGTVQTGVETSKAVLTGTKDAVSTGLTGAVNVARGSIQ
TGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAMNV
AKGTIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTTKTVLTGTKNTVCSGV
TGAVNLAKEAIQGGLDTTKSMVMGTKDTMSTGLTGAANVAKGAMQTGLNTTQNIATGTKD
TVCSGVTGAMNLARGTIQTGVDTTKIVLTGTKDTVCSGVTGAANVAKGAVQGGLDTTKSV
LTGTKDAVSTGLTGAVNVAKGTVQTGVDTTKTVLTGTKDTVCSGVTSAVNVAKGAVQGGL
DTTKSVVIGTKDTMSTGLTGAANVAKGAVQTGVDTAKTVLTGTKDTVTTGLVGAVNVAKG
TVQTGMDTTKTVLTGTKDTIYSGVTSAVNVAKGAVQTGLKTTQNIATGTKNTFGSGVTSA
VNVAKGAAQTGVDTAKTVLTGTKDTVTTGLMGAVNVAKGTVQTSVDTTKTVLTGTKDTVC
SGVTGAANVAKGAIQGGLDTTKSVLTGTKDAVSTGLTGAVKLAKGTVQTGMDTTKTVLTG
TKDAVCSGVTGAANVAKGAVQMGVDTAKTVLTGTKDTVCSGVTGAANVAKGAVQTGLKTT
QNIATGTKNTLGSGVTGAAKVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNLAKGTVQ
TGVDTSKTVLTGTKDTVCSGVTGAVNVAKGTVQTGVDTAKTVLSGAKDAVTTGVTGAVNV
AKGTVQTGVDASKAVLMGTKDTVFSGVTGAMSMAKGAVQGGLDTTKTVLTGTKDAVSAGL
MGSGNVATGATHTGLSTFQNWLPSTPATSWGGLTSSRTTDNGGEQTALSPQEAPFSGIST
PPDVLSVGPEPAWEAAATTKGLATDVATFTQGAAPGREDTGLLATTHGPEEAPRLAMLQN
ELEGLGDIFHPMNAEEQAQLAASQPGPKVLSAEQGSYFVRLGDLGPSFRQRAFEHAVSHL
QHGQFQARDTLAQLQDCFRLIEKAQQAPEGQPRLDQGSGASAEDAAVQEERDAGVLSRVC
GLLRQLHTAYSGLVSSLQGLPAELQQPVGRARHSLCELYGIVASAGSVEELPAERLVQSR
EGVHQAWQGLEQLLEGLQHNPPLSWLVGPFALPAGGQ

Sequence length

1357

Interactions

View interactions

	KEGG
	PPAR signaling pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VACUOLAR NEUROMYOPATHY	—	CTD, ClinVar, Disgenet, GenCC CTD, ClinVar, Disgenet, GenCC CTD, ClinVar, Disgenet, GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (28)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adrenocortical Carcinoma	Adrenocortical carcinoma	Pubtator	35500219	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Angelman Syndrome	Angelman Syndrome	BEFREE	28387067		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	Pubtator	16183798	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive Disorder	Major depressive disorder	Pubtator	34341332	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	34680874	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	24403596	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	29361938	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	31003774		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dyslipidemias	Dyslipidemias	Pubtator	29361938	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	30895737		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy Absence	Absence epilepsy	Pubtator	25347071	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Defects Congenital	Congenital heart defect	Pubtator	25205790	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hydrocephalus	Hydrocephalus	Pubtator	30342661	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Diabetes mellitus, type 2	Pubtator	18812483	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Language Development Disorders	Language development disorders	Pubtator	28254235	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome	Metabolic syndrome	Pubtator	18812483	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome X	Metabolic Syndrome	BEFREE	18812483		★★★★★ ★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	Pubtator	30342661	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	15355432, 21533135		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	18812483, 28274232, 29361938	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	BEFREE	22210160, 31003774		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	29967574		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prader-Willi Syndrome	Prader-Willi Syndrome	LHGDN	16982806		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	LHGDN	15067324		★★★★★ ★☆☆☆☆ Found in Text Mining only
Speech Disorders	Speech Disorders	BEFREE	15470370		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	26330360	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	31537618		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	31537618, 35384527	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

PLIN4 (perilipin 4)