SLC15A5 (solute carrier family 15 member 5)

Gene

• Entrez ID: 729025
• Gene name: Solute carrier family 15 member 5
• Gene symbol: SLC15A5
• Synonyms (NCBI Gene): -
• Chromosome: 12
• Chromosome location: 12p12.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1352784	hsa-miR-3919	CLIP-seq
MIRT1352785	hsa-miR-4756-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	24550280, 30126976
GO:0015031	Process	Protein transport	IEA
GO:0015293	Function	Symporter activity	IEA
GO:0015833	Process	Peptide transport	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0022857	Function	Transmembrane transporter activity	IBA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0055085	Process	Transmembrane transport	IBA
GO:0055085	Process	Transmembrane transport	IEA

Other IDs

• MIM: 620324
• HGNC: 33455
• e!Ensembl: ENSG00000188991

Protein

• UniProt ID: A6NIM6
• Protein name: Solute carrier family 15 member 5
• Protein function: Proton oligopeptide cotransporter.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00854	PTR2	108 → 500	POT family	Family

• Sequence:

  MSVTGFTITDEKVHLYHSIEKEKTVRHIGDLCSSHSVKKIQVGICLLLVELCERFTFFEV
  VCNMIPFCTIKLGYHNCQAAILNLCFIGTSILTPVFVRWLTDVYLGRNKLVYICLFLHFL
  GTALLSVVAFPLEDFYLGTYHAVNNIPKTEQHRLFYVALLTICLGIGGVRAIVCPLGAFG
  LQEYGSQKTMSFFNWFYWLMNLNATIVFLGISYIQHSQAWALVLLIPFMSMLMAVITLHM
  IYYNLIYQSEKRCSLLTGVGVLVSALKTCHPQYCHLGRDVTSQLDHAKEKNGGCYSELHV
  EDTTFFLTLLPLFIFQLLYRMCIMQIPSGYYLQTMNSNLNLDGFLLPIAVMNAISSLPLL
  ILAPFLEYFSTCLFPSKRVGSFLSTCIIAGNLFAALSVMIAGFFEIHRKHFPAVEQPLSG
  KVLTVSSMPCFYLILQYVLLGVAETLVNPALSVISYRFVPSNVRGTSMNFLTLFNGFGCF
  TGALLVKLVYLISDGNWFPNTLNKGNLESFFFFLASLTLLNVLGFCSVSQRYCNLNHFNA
  QNIRGSNLEETLLLHEKSLKFYGSIQEFSSSIDLWETAL

• Sequence length: 579

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LARGE ARTERY STROKE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations