UQCC6 (ubiquinol-cytochrome c reductase complex assembly factor 6)

Gene

• Entrez ID: 728568
• Gene name: Ubiquinol-cytochrome c reductase complex assembly factor 6
• Gene symbol: UQCC6
• Synonyms (NCBI Gene): BR, BRAWNIN, C12orf73
• Chromosome: 12
• Chromosome location: 12q23.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT574861	hsa-miR-455-3p	PAR-CLIP	20371350
MIRT574860	hsa-miR-5588-3p	PAR-CLIP	20371350
MIRT574859	hsa-miR-1910-5p	PAR-CLIP	20371350
MIRT574858	hsa-miR-186-3p	PAR-CLIP	20371350
MIRT574857	hsa-miR-2052	PAR-CLIP	20371350
MIRT574856	hsa-miR-1468-5p	PAR-CLIP	20371350
MIRT574855	hsa-miR-515-5p	PAR-CLIP	20371350
MIRT574854	hsa-miR-519e-5p	PAR-CLIP	20371350
MIRT574853	hsa-miR-8081	PAR-CLIP	20371350
MIRT574852	hsa-miR-30a-3p	PAR-CLIP	20371350
MIRT574851	hsa-miR-30d-3p	PAR-CLIP	20371350
MIRT574850	hsa-miR-30e-3p	PAR-CLIP	20371350
MIRT574849	hsa-miR-8055	PAR-CLIP	20371350
MIRT444087	hsa-miR-4464	PAR-CLIP	22100165
MIRT444086	hsa-miR-4748	PAR-CLIP	22100165
MIRT444085	hsa-miR-5193	PAR-CLIP	22100165
MIRT444084	hsa-miR-660-3p	PAR-CLIP	22100165
MIRT444083	hsa-miR-1266-3p	PAR-CLIP	22100165
MIRT444082	hsa-miR-1267	PAR-CLIP	22100165
MIRT444081	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT444080	hsa-miR-655-5p	PAR-CLIP	22100165
MIRT444079	hsa-miR-377-5p	PAR-CLIP	22100165
MIRT444078	hsa-miR-6086	PAR-CLIP	22100165
MIRT444077	hsa-miR-4691-5p	PAR-CLIP	22100165
MIRT444075	hsa-miR-6792-3p	PAR-CLIP	22100165
MIRT444076	hsa-miR-6749-3p	PAR-CLIP	22100165
MIRT444074	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT444087	hsa-miR-4464	PAR-CLIP	22100165
MIRT444086	hsa-miR-4748	PAR-CLIP	22100165
MIRT444085	hsa-miR-5193	PAR-CLIP	22100165
MIRT444084	hsa-miR-660-3p	PAR-CLIP	22100165
MIRT444083	hsa-miR-1266-3p	PAR-CLIP	22100165
MIRT444082	hsa-miR-1267	PAR-CLIP	22100165
MIRT444081	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT444080	hsa-miR-655-5p	PAR-CLIP	22100165
MIRT444079	hsa-miR-377-5p	PAR-CLIP	22100165
MIRT444078	hsa-miR-6086	PAR-CLIP	22100165
MIRT444077	hsa-miR-4691-5p	PAR-CLIP	22100165
MIRT444075	hsa-miR-6792-3p	PAR-CLIP	22100165
MIRT444076	hsa-miR-6749-3p	PAR-CLIP	22100165
MIRT444074	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT574861	hsa-miR-455-3p	PAR-CLIP	20371350
MIRT574860	hsa-miR-5588-3p	PAR-CLIP	20371350
MIRT574859	hsa-miR-1910-5p	PAR-CLIP	20371350
MIRT574858	hsa-miR-186-3p	PAR-CLIP	20371350
MIRT574857	hsa-miR-2052	PAR-CLIP	20371350
MIRT574856	hsa-miR-1468-5p	PAR-CLIP	20371350
MIRT574855	hsa-miR-515-5p	PAR-CLIP	20371350
MIRT574854	hsa-miR-519e-5p	PAR-CLIP	20371350
MIRT574853	hsa-miR-8081	PAR-CLIP	20371350
MIRT574852	hsa-miR-30a-3p	PAR-CLIP	20371350
MIRT574851	hsa-miR-30d-3p	PAR-CLIP	20371350
MIRT574850	hsa-miR-30e-3p	PAR-CLIP	20371350
MIRT574849	hsa-miR-8055	PAR-CLIP	20371350
MIRT444087	hsa-miR-4464	PAR-CLIP	22100165
MIRT444086	hsa-miR-4748	PAR-CLIP	22100165
MIRT444085	hsa-miR-5193	PAR-CLIP	22100165
MIRT444084	hsa-miR-660-3p	PAR-CLIP	22100165
MIRT444083	hsa-miR-1266-3p	PAR-CLIP	22100165
MIRT444082	hsa-miR-1267	PAR-CLIP	22100165
MIRT444081	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT444080	hsa-miR-655-5p	PAR-CLIP	22100165
MIRT444079	hsa-miR-377-5p	PAR-CLIP	22100165
MIRT444078	hsa-miR-6086	PAR-CLIP	22100165
MIRT444077	hsa-miR-4691-5p	PAR-CLIP	22100165
MIRT444075	hsa-miR-6792-3p	PAR-CLIP	22100165
MIRT444076	hsa-miR-6749-3p	PAR-CLIP	22100165
MIRT444074	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT444087	hsa-miR-4464	PAR-CLIP	22100165
MIRT444086	hsa-miR-4748	PAR-CLIP	22100165
MIRT444085	hsa-miR-5193	PAR-CLIP	22100165
MIRT444084	hsa-miR-660-3p	PAR-CLIP	22100165
MIRT444083	hsa-miR-1266-3p	PAR-CLIP	22100165
MIRT444082	hsa-miR-1267	PAR-CLIP	22100165
MIRT444081	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT444080	hsa-miR-655-5p	PAR-CLIP	22100165
MIRT444079	hsa-miR-377-5p	PAR-CLIP	22100165
MIRT444078	hsa-miR-6086	PAR-CLIP	22100165
MIRT444077	hsa-miR-4691-5p	PAR-CLIP	22100165
MIRT444075	hsa-miR-6792-3p	PAR-CLIP	22100165
MIRT444076	hsa-miR-6749-3p	PAR-CLIP	22100165
MIRT444074	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT831752	hsa-miR-1305	CLIP-seq
MIRT831753	hsa-miR-1537	CLIP-seq
MIRT831754	hsa-miR-155	CLIP-seq
MIRT831755	hsa-miR-190	CLIP-seq
MIRT831756	hsa-miR-190b	CLIP-seq
MIRT831757	hsa-miR-203	CLIP-seq
MIRT831758	hsa-miR-224	CLIP-seq
MIRT831759	hsa-miR-27a	CLIP-seq
MIRT831760	hsa-miR-27b	CLIP-seq
MIRT831761	hsa-miR-3682-3p	CLIP-seq
MIRT831762	hsa-miR-433	CLIP-seq
MIRT831763	hsa-miR-448	CLIP-seq
MIRT831764	hsa-miR-4530	CLIP-seq
MIRT831765	hsa-miR-4642	CLIP-seq
MIRT831766	hsa-miR-4705	CLIP-seq
MIRT831767	hsa-miR-4795-3p	CLIP-seq
MIRT831768	hsa-miR-4798-3p	CLIP-seq
MIRT831769	hsa-miR-513a-3p	CLIP-seq
MIRT831770	hsa-miR-513a-5p	CLIP-seq
MIRT831771	hsa-miR-522	CLIP-seq
MIRT831772	hsa-miR-656	CLIP-seq
MIRT831773	hsa-miR-664	CLIP-seq
MIRT831774	hsa-miR-922	CLIP-seq
MIRT831775	hsa-miR-95	CLIP-seq
MIRT1946329	hsa-miR-1244	CLIP-seq
MIRT831752	hsa-miR-1305	CLIP-seq
MIRT831753	hsa-miR-1537	CLIP-seq
MIRT1946330	hsa-miR-202	CLIP-seq
MIRT1946331	hsa-miR-302a	CLIP-seq
MIRT1946332	hsa-miR-302b	CLIP-seq
MIRT1946333	hsa-miR-302c	CLIP-seq
MIRT1946334	hsa-miR-302d	CLIP-seq
MIRT1946335	hsa-miR-302e	CLIP-seq
MIRT1946336	hsa-miR-372	CLIP-seq
MIRT1946337	hsa-miR-373	CLIP-seq
MIRT1946338	hsa-miR-4328	CLIP-seq
MIRT1946339	hsa-miR-4477b	CLIP-seq
MIRT831764	hsa-miR-4530	CLIP-seq
MIRT831766	hsa-miR-4705	CLIP-seq
MIRT1946340	hsa-miR-4720-3p	CLIP-seq
MIRT831768	hsa-miR-4798-3p	CLIP-seq
MIRT1946341	hsa-miR-4804-3p	CLIP-seq
MIRT1946342	hsa-miR-498	CLIP-seq
MIRT831769	hsa-miR-513a-3p	CLIP-seq
MIRT1946343	hsa-miR-519a	CLIP-seq
MIRT1946344	hsa-miR-519b-3p	CLIP-seq
MIRT1946345	hsa-miR-519c-3p	CLIP-seq
MIRT1946346	hsa-miR-520a-3p	CLIP-seq
MIRT1946347	hsa-miR-520b	CLIP-seq
MIRT1946348	hsa-miR-520c-3p	CLIP-seq
MIRT1946349	hsa-miR-520d-3p	CLIP-seq
MIRT1946350	hsa-miR-520e	CLIP-seq
MIRT1946351	hsa-miR-520f	CLIP-seq
MIRT831774	hsa-miR-922	CLIP-seq
MIRT831775	hsa-miR-95	CLIP-seq
MIRT831752	hsa-miR-1305	CLIP-seq
MIRT1946330	hsa-miR-202	CLIP-seq
MIRT2184643	hsa-miR-3173-3p	CLIP-seq
MIRT2184644	hsa-miR-3607-3p	CLIP-seq
MIRT2184645	hsa-miR-412	CLIP-seq
MIRT2184646	hsa-miR-4659a-3p	CLIP-seq
MIRT2184647	hsa-miR-4659b-3p	CLIP-seq
MIRT2184648	hsa-miR-4792	CLIP-seq
MIRT831769	hsa-miR-513a-3p	CLIP-seq
MIRT831775	hsa-miR-95	CLIP-seq
MIRT831764	hsa-miR-4530	CLIP-seq
MIRT831768	hsa-miR-4798-3p	CLIP-seq
MIRT831774	hsa-miR-922	CLIP-seq
MIRT2445081	hsa-miR-1273d	CLIP-seq
MIRT2445082	hsa-miR-548u	CLIP-seq
MIRT2488328	hsa-miR-1250	CLIP-seq
MIRT2488329	hsa-miR-1298	CLIP-seq
MIRT1946330	hsa-miR-202	CLIP-seq
MIRT2488330	hsa-miR-217	CLIP-seq
MIRT2184643	hsa-miR-3173-3p	CLIP-seq
MIRT2488331	hsa-miR-324-5p	CLIP-seq
MIRT2184644	hsa-miR-3607-3p	CLIP-seq
MIRT2488332	hsa-miR-361-3p	CLIP-seq
MIRT2488333	hsa-miR-365	CLIP-seq
MIRT2488334	hsa-miR-3664-5p	CLIP-seq
MIRT2488335	hsa-miR-3908	CLIP-seq
MIRT2184645	hsa-miR-412	CLIP-seq
MIRT2488336	hsa-miR-4272	CLIP-seq
MIRT2488337	hsa-miR-4313	CLIP-seq
MIRT2488338	hsa-miR-4422	CLIP-seq
MIRT2488339	hsa-miR-4475	CLIP-seq
MIRT2488340	hsa-miR-4509	CLIP-seq
MIRT2488341	hsa-miR-4521	CLIP-seq
MIRT2184646	hsa-miR-4659a-3p	CLIP-seq
MIRT2184647	hsa-miR-4659b-3p	CLIP-seq
MIRT2488342	hsa-miR-4714-5p	CLIP-seq
MIRT2488343	hsa-miR-4744	CLIP-seq
MIRT2488344	hsa-miR-4746-3p	CLIP-seq
MIRT2488345	hsa-miR-4777-5p	CLIP-seq
MIRT2184648	hsa-miR-4792	CLIP-seq
MIRT2488346	hsa-miR-4799-5p	CLIP-seq
MIRT2488347	hsa-miR-518d-5p	CLIP-seq
MIRT2488348	hsa-miR-519b-5p	CLIP-seq
MIRT2488349	hsa-miR-519c-5p	CLIP-seq
MIRT2488350	hsa-miR-520c-5p	CLIP-seq
MIRT2488351	hsa-miR-520d-5p	CLIP-seq
MIRT2488352	hsa-miR-524-5p	CLIP-seq
MIRT2488353	hsa-miR-526a	CLIP-seq
MIRT831773	hsa-miR-664	CLIP-seq
MIRT2488354	hsa-miR-760	CLIP-seq
MIRT2488328	hsa-miR-1250	CLIP-seq
MIRT2676349	hsa-miR-1262	CLIP-seq
MIRT2488329	hsa-miR-1298	CLIP-seq
MIRT1946330	hsa-miR-202	CLIP-seq
MIRT2488330	hsa-miR-217	CLIP-seq
MIRT2184643	hsa-miR-3173-3p	CLIP-seq
MIRT2488331	hsa-miR-324-5p	CLIP-seq
MIRT2184644	hsa-miR-3607-3p	CLIP-seq
MIRT2488333	hsa-miR-365	CLIP-seq
MIRT2488334	hsa-miR-3664-5p	CLIP-seq
MIRT2488335	hsa-miR-3908	CLIP-seq
MIRT2184645	hsa-miR-412	CLIP-seq
MIRT2488338	hsa-miR-4422	CLIP-seq
MIRT2488339	hsa-miR-4475	CLIP-seq
MIRT2488340	hsa-miR-4509	CLIP-seq
MIRT2488341	hsa-miR-4521	CLIP-seq
MIRT2184646	hsa-miR-4659a-3p	CLIP-seq
MIRT2184647	hsa-miR-4659b-3p	CLIP-seq
MIRT2676350	hsa-miR-4701-3p	CLIP-seq
MIRT2488342	hsa-miR-4714-5p	CLIP-seq
MIRT2488343	hsa-miR-4744	CLIP-seq
MIRT2488344	hsa-miR-4746-3p	CLIP-seq
MIRT2184648	hsa-miR-4792	CLIP-seq
MIRT2488346	hsa-miR-4799-5p	CLIP-seq
MIRT831773	hsa-miR-664	CLIP-seq
MIRT2488354	hsa-miR-760	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32161263
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IDA	34969438
GO:0005743	Component	Mitochondrial inner membrane	IDA	32161263
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0033617	Process	Mitochondrial cytochrome c oxidase assembly	IDA	34969438
GO:0034551	Process	Mitochondrial respiratory chain complex III assembly	IBA
GO:0034551	Process	Mitochondrial respiratory chain complex III assembly	IEA
GO:0034551	Process	Mitochondrial respiratory chain complex III assembly	IMP	32161263
GO:0034551	Process	Mitochondrial respiratory chain complex III assembly	ISS

Other IDs

• MIM: 618812
• HGNC: 34450
• e!Ensembl: ENSG00000204954

Protein

• UniProt ID: Q69YU5
• Protein name: Ubiquinol-cytochrome c reductase complex assembly factor 6 (Protein BRAWNIN)
• Protein function: Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chai
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14990	DUF4516	1 → 46	Domain of unknown function (DUF4516)	Family

• Tissue specificity: TISSUE SPECIFICITY: Cardiac and skeletal muscle (at protein level). {ECO:0000269|PubMed:32161263}.
• Sequence:

  MPAGVPMSTYLKMFAASLLAMCAGAEVVHRYYRPDLTIPEIPPKRGELKTELLGLKERKH
  KPQVSQQEELK

• Sequence length: 71

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Neoplasms	Breast neoplasm	Pubtator	15387710	Associate	★☆☆☆☆ Found in Text Mining only