OPN1MW2 (opsin 1, medium wave sensitive 2)

Gene

• Entrez ID: 728458
• Gene name: Opsin 1, medium wave sensitive 2
• Gene symbol: OPN1MW2
• Synonyms (NCBI Gene): GOP
• Chromosome: X
• Chromosome location: Xq28
• Summary: This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-term

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017065	hsa-miR-335-5p	Microarray	18185580
MIRT1204402	hsa-miR-4434	CLIP-seq
MIRT1204403	hsa-miR-4516	CLIP-seq
MIRT1204404	hsa-miR-4531	CLIP-seq
MIRT1204405	hsa-miR-4534	CLIP-seq
MIRT1204406	hsa-miR-4729	CLIP-seq
MIRT1204407	hsa-miR-5095	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001750	Component	Photoreceptor outer segment	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	20579627
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	2937147
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	2937147
GO:0007601	Process	Visual perception	IEA
GO:0007601	Process	Visual perception	TAS	10319869
GO:0007602	Process	Phototransduction	IBA
GO:0007602	Process	Phototransduction	IEA
GO:0008020	Function	G protein-coupled photoreceptor activity	IBA
GO:0009584	Process	Detection of visible light	IEA
GO:0009881	Function	Photoreceptor activity	IEA
GO:0009881	Function	Photoreceptor activity	IMP	8185948
GO:0009881	Function	Photoreceptor activity	TAS	1302020
GO:0016020	Component	Membrane	IEA
GO:0016038	Process	Absorption of visible light	IBA
GO:0032467	Process	Positive regulation of cytokinesis	IEA
GO:0032467	Process	Positive regulation of cytokinesis	IMP	22888021
GO:0042802	Function	Identical protein binding	IDA	28402104
GO:0071482	Process	Cellular response to light stimulus	IBA
GO:0097381	Component	Photoreceptor disc membrane	IEA
GO:0097381	Component	Photoreceptor disc membrane	TAS

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Interactions View interactions

Pathways

Reactome:

The retinoid cycle in cones (daylight vision)
Retinoid cycle disease events
G alpha (i) signalling events
Opsins

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Deuteranomaly	Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)