Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	7268
Gene name	Tetratricopeptide repeat domain 4
Gene symbol	TTC4
Synonyms (NCBI Gene)	CNS1
Chromosome	1
Chromosome location	1p32.3
Summary	This gene encodes a protein that contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions and chaperone activity. The encoded protein interacts with heat shock proteins 70 and 90. Alternative splicing results in multiple

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miRTarBase ID	miRNA	Experiments	Reference
MIRT619061	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT619060	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT619059	hsa-miR-764	HITS-CLIP	23824327
MIRT619058	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT619056	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT619055	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT619054	hsa-miR-1281	HITS-CLIP	23824327
MIRT619053	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT652041	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT652040	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT619052	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676858	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT619051	hsa-miR-640	HITS-CLIP	23824327
MIRT619061	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT619060	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT619059	hsa-miR-764	HITS-CLIP	23824327
MIRT619058	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT619057	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT619056	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT619055	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT619054	hsa-miR-1281	HITS-CLIP	23824327
MIRT619053	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT676859	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT652041	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT652040	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT619052	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676858	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT619051	hsa-miR-640	HITS-CLIP	23824327
MIRT619061	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT619060	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT619059	hsa-miR-764	HITS-CLIP	23824327
MIRT619058	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT619056	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT619055	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT619054	hsa-miR-1281	HITS-CLIP	23824327
MIRT619051	hsa-miR-640	HITS-CLIP	23824327
MIRT619061	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT619060	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT619059	hsa-miR-764	HITS-CLIP	23824327
MIRT619058	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT619057	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT619056	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT619055	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT619054	hsa-miR-1281	HITS-CLIP	23824327
MIRT619053	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT652041	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT652040	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT619052	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT619051	hsa-miR-640	HITS-CLIP	23824327
MIRT631514	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT631513	hsa-miR-520h	HITS-CLIP	23824327
MIRT619061	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT619060	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT619057	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT619056	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT619055	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT619054	hsa-miR-1281	HITS-CLIP	23824327
MIRT619053	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT619052	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT619051	hsa-miR-640	HITS-CLIP	23824327
MIRT631512	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT619061	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT619060	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT619059	hsa-miR-764	HITS-CLIP	23824327
MIRT619058	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT619057	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT619056	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT619055	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT619054	hsa-miR-1281	HITS-CLIP	23824327
MIRT619053	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT619052	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT619051	hsa-miR-640	HITS-CLIP	23824327
MIRT619061	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT619060	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT619059	hsa-miR-764	HITS-CLIP	23824327
MIRT619058	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT619056	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT619055	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT619054	hsa-miR-1281	HITS-CLIP	23824327
MIRT619053	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT652041	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT652040	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT619052	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676858	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT619051	hsa-miR-640	HITS-CLIP	23824327
MIRT619061	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT619060	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT619059	hsa-miR-764	HITS-CLIP	23824327
MIRT619058	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT619057	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT619056	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT619055	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT619054	hsa-miR-1281	HITS-CLIP	23824327
MIRT619053	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT676859	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT652041	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT652040	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT619052	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676858	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT619051	hsa-miR-640	HITS-CLIP	23824327
MIRT619061	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT619060	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT619059	hsa-miR-764	HITS-CLIP	23824327
MIRT619058	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT619056	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT619055	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT619054	hsa-miR-1281	HITS-CLIP	23824327
MIRT619051	hsa-miR-640	HITS-CLIP	23824327
MIRT619061	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT619060	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT619059	hsa-miR-764	HITS-CLIP	23824327
MIRT619058	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT619057	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT619056	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT619055	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT619054	hsa-miR-1281	HITS-CLIP	23824327
MIRT619053	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT652041	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT652040	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT619052	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT619051	hsa-miR-640	HITS-CLIP	23824327
MIRT631514	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT631513	hsa-miR-520h	HITS-CLIP	23824327
MIRT619061	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT619060	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT619057	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT619056	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT619055	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT619054	hsa-miR-1281	HITS-CLIP	23824327
MIRT619053	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT619052	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT619051	hsa-miR-640	HITS-CLIP	23824327
MIRT631512	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT619061	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT619060	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT619059	hsa-miR-764	HITS-CLIP	23824327
MIRT619058	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT619057	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT619056	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT619055	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT619054	hsa-miR-1281	HITS-CLIP	23824327
MIRT619053	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT619052	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT619051	hsa-miR-640	HITS-CLIP	23824327
MIRT1461773	hsa-miR-103a	CLIP-seq
MIRT1461774	hsa-miR-107	CLIP-seq
MIRT1461775	hsa-miR-1184	CLIP-seq
MIRT1461776	hsa-miR-223	CLIP-seq
MIRT1461777	hsa-miR-3158-5p	CLIP-seq
MIRT1461778	hsa-miR-3166	CLIP-seq
MIRT1461779	hsa-miR-3664-5p	CLIP-seq
MIRT1461780	hsa-miR-4281	CLIP-seq
MIRT1461781	hsa-miR-4418	CLIP-seq
MIRT1461782	hsa-miR-4536	CLIP-seq
MIRT1461783	hsa-miR-4714-5p	CLIP-seq
MIRT1461784	hsa-miR-4771	CLIP-seq
MIRT1461785	hsa-miR-509-3-5p	CLIP-seq
MIRT1461786	hsa-miR-509-5p	CLIP-seq
MIRT1461787	hsa-miR-922	CLIP-seq
MIRT2138733	hsa-miR-1261	CLIP-seq
MIRT2138734	hsa-miR-1915	CLIP-seq
MIRT2138735	hsa-miR-2355-5p	CLIP-seq
MIRT2138736	hsa-miR-2392	CLIP-seq
MIRT2138737	hsa-miR-2467-5p	CLIP-seq
MIRT2138738	hsa-miR-3134	CLIP-seq
MIRT2138739	hsa-miR-361-3p	CLIP-seq
MIRT2138740	hsa-miR-4268	CLIP-seq
MIRT2138741	hsa-miR-4533	CLIP-seq
MIRT2138742	hsa-miR-4759	CLIP-seq
MIRT1461773	hsa-miR-103a	CLIP-seq
MIRT1461774	hsa-miR-107	CLIP-seq
MIRT1461775	hsa-miR-1184	CLIP-seq
MIRT2359592	hsa-miR-1323	CLIP-seq
MIRT2359593	hsa-miR-2467-3p	CLIP-seq
MIRT2359594	hsa-miR-3125	CLIP-seq
MIRT1461777	hsa-miR-3158-5p	CLIP-seq
MIRT2359595	hsa-miR-335	CLIP-seq
MIRT2359596	hsa-miR-3609	CLIP-seq
MIRT2359597	hsa-miR-3678-3p	CLIP-seq
MIRT2359598	hsa-miR-3915	CLIP-seq
MIRT2359599	hsa-miR-3916	CLIP-seq
MIRT2359600	hsa-miR-3928	CLIP-seq
MIRT1461781	hsa-miR-4418	CLIP-seq
MIRT1461782	hsa-miR-4536	CLIP-seq
MIRT1461785	hsa-miR-509-3-5p	CLIP-seq
MIRT1461786	hsa-miR-509-5p	CLIP-seq
MIRT2359601	hsa-miR-548a-3p	CLIP-seq
MIRT2359602	hsa-miR-548ah	CLIP-seq
MIRT2359603	hsa-miR-548e	CLIP-seq
MIRT2359604	hsa-miR-548f	CLIP-seq
MIRT2359605	hsa-miR-548o	CLIP-seq
MIRT1461787	hsa-miR-922	CLIP-seq
MIRT1461773	hsa-miR-103a	CLIP-seq
MIRT1461774	hsa-miR-107	CLIP-seq
MIRT1461775	hsa-miR-1184	CLIP-seq
MIRT2652933	hsa-miR-1200	CLIP-seq
MIRT2652934	hsa-miR-1243	CLIP-seq
MIRT2652935	hsa-miR-128	CLIP-seq
MIRT2652936	hsa-miR-1289	CLIP-seq
MIRT2652937	hsa-miR-182	CLIP-seq
MIRT2652938	hsa-miR-183	CLIP-seq
MIRT2652939	hsa-miR-1910	CLIP-seq
MIRT2652940	hsa-miR-1912	CLIP-seq
MIRT2652941	hsa-miR-204	CLIP-seq
MIRT2652942	hsa-miR-211	CLIP-seq
MIRT1461776	hsa-miR-223	CLIP-seq
MIRT2359593	hsa-miR-2467-3p	CLIP-seq
MIRT2652943	hsa-miR-2681	CLIP-seq
MIRT2652944	hsa-miR-27a	CLIP-seq
MIRT2652945	hsa-miR-27b	CLIP-seq
MIRT2652946	hsa-miR-2909	CLIP-seq
MIRT2652947	hsa-miR-3074-5p	CLIP-seq
MIRT2652948	hsa-miR-3119	CLIP-seq
MIRT2652949	hsa-miR-3124-3p	CLIP-seq
MIRT2652950	hsa-miR-3185	CLIP-seq
MIRT2652951	hsa-miR-3198	CLIP-seq
MIRT2652952	hsa-miR-3200-5p	CLIP-seq
MIRT2652953	hsa-miR-340	CLIP-seq
MIRT2652954	hsa-miR-3647-3p	CLIP-seq
MIRT2652955	hsa-miR-3667-5p	CLIP-seq
MIRT2359597	hsa-miR-3678-3p	CLIP-seq
MIRT2652956	hsa-miR-3913-3p	CLIP-seq
MIRT2652957	hsa-miR-3926	CLIP-seq
MIRT2652958	hsa-miR-4278	CLIP-seq
MIRT1461780	hsa-miR-4281	CLIP-seq
MIRT2652959	hsa-miR-4294	CLIP-seq
MIRT2652960	hsa-miR-4309	CLIP-seq
MIRT2652961	hsa-miR-4324	CLIP-seq
MIRT1461781	hsa-miR-4418	CLIP-seq
MIRT2652962	hsa-miR-4470	CLIP-seq
MIRT2652963	hsa-miR-4474-3p	CLIP-seq
MIRT2652964	hsa-miR-451b	CLIP-seq
MIRT2652965	hsa-miR-4534	CLIP-seq
MIRT1461782	hsa-miR-4536	CLIP-seq
MIRT2652966	hsa-miR-4682	CLIP-seq
MIRT2652967	hsa-miR-4691-5p	CLIP-seq
MIRT2652968	hsa-miR-4722-3p	CLIP-seq
MIRT1461785	hsa-miR-509-3-5p	CLIP-seq
MIRT1461786	hsa-miR-509-5p	CLIP-seq
MIRT2652969	hsa-miR-544b	CLIP-seq
MIRT2652970	hsa-miR-548s	CLIP-seq
MIRT2652971	hsa-miR-576-3p	CLIP-seq
MIRT2652972	hsa-miR-668	CLIP-seq
MIRT1461787	hsa-miR-922	CLIP-seq
MIRT1461773	hsa-miR-103a	CLIP-seq
MIRT1461774	hsa-miR-107	CLIP-seq
MIRT1461775	hsa-miR-1184	CLIP-seq
MIRT2652933	hsa-miR-1200	CLIP-seq
MIRT2652934	hsa-miR-1243	CLIP-seq
MIRT2652935	hsa-miR-128	CLIP-seq
MIRT2652936	hsa-miR-1289	CLIP-seq
MIRT2652937	hsa-miR-182	CLIP-seq
MIRT2652938	hsa-miR-183	CLIP-seq
MIRT2652939	hsa-miR-1910	CLIP-seq
MIRT2652940	hsa-miR-1912	CLIP-seq
MIRT2694442	hsa-miR-1913	CLIP-seq
MIRT2652941	hsa-miR-204	CLIP-seq
MIRT2652942	hsa-miR-211	CLIP-seq
MIRT1461776	hsa-miR-223	CLIP-seq
MIRT2359593	hsa-miR-2467-3p	CLIP-seq
MIRT2652943	hsa-miR-2681	CLIP-seq
MIRT2652944	hsa-miR-27a	CLIP-seq
MIRT2652945	hsa-miR-27b	CLIP-seq
MIRT2652946	hsa-miR-2909	CLIP-seq
MIRT2652947	hsa-miR-3074-5p	CLIP-seq
MIRT2652948	hsa-miR-3119	CLIP-seq
MIRT2652949	hsa-miR-3124-3p	CLIP-seq
MIRT2652950	hsa-miR-3185	CLIP-seq
MIRT2652951	hsa-miR-3198	CLIP-seq
MIRT2652952	hsa-miR-3200-5p	CLIP-seq
MIRT2694443	hsa-miR-324-3p	CLIP-seq
MIRT2652953	hsa-miR-340	CLIP-seq
MIRT2652954	hsa-miR-3647-3p	CLIP-seq
MIRT2652955	hsa-miR-3667-5p	CLIP-seq
MIRT2359597	hsa-miR-3678-3p	CLIP-seq
MIRT2652956	hsa-miR-3913-3p	CLIP-seq
MIRT2652957	hsa-miR-3926	CLIP-seq
MIRT2652958	hsa-miR-4278	CLIP-seq
MIRT1461780	hsa-miR-4281	CLIP-seq
MIRT2652959	hsa-miR-4294	CLIP-seq
MIRT2652960	hsa-miR-4309	CLIP-seq
MIRT2694444	hsa-miR-4313	CLIP-seq
MIRT2652961	hsa-miR-4324	CLIP-seq
MIRT1461781	hsa-miR-4418	CLIP-seq
MIRT2652962	hsa-miR-4470	CLIP-seq
MIRT2652963	hsa-miR-4474-3p	CLIP-seq
MIRT2652964	hsa-miR-451b	CLIP-seq
MIRT2652965	hsa-miR-4534	CLIP-seq
MIRT1461782	hsa-miR-4536	CLIP-seq
MIRT2652966	hsa-miR-4682	CLIP-seq
MIRT2652967	hsa-miR-4691-5p	CLIP-seq
MIRT2652968	hsa-miR-4722-3p	CLIP-seq
MIRT1461785	hsa-miR-509-3-5p	CLIP-seq
MIRT1461786	hsa-miR-509-5p	CLIP-seq
MIRT2652969	hsa-miR-544b	CLIP-seq
MIRT2652970	hsa-miR-548s	CLIP-seq
MIRT2652971	hsa-miR-576-3p	CLIP-seq
MIRT2652972	hsa-miR-668	CLIP-seq
MIRT1461787	hsa-miR-922	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	18320024, 25036637, 28514442, 29251827, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	18320024, 29251827
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005737	Component	Cytoplasm	IDA	29251827
GO:0005737	Component	Cytoplasm	IEA
GO:0006457	Process	Protein folding	IBA
GO:0030544	Function	Hsp70 protein binding	IBA
GO:0045087	Process	Innate immune response	IEA
GO:0045087	Process	Innate immune response	IMP	29251827
GO:0051607	Process	Defense response to virus	IEA
GO:0051607	Process	Defense response to virus	IMP	29251827
GO:0051879	Function	Hsp90 protein binding	IBA
GO:0051879	Function	Hsp90 protein binding	IEA

MIM	HGNC	e!Ensembl
606753	12394	ENSG00000243725

O95801

Protein name

Tetratricopeptide repeat protein 4 (TPR repeat protein 4)

Protein function

May act as a co-chaperone for HSP90AB1 (PubMed:18320024). Promotes Sendai virus (SeV)-induced host cell innate immune responses (PubMed:29251827).

PDB

6HFO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18972	Wheel	259 → 377	Cns1/TTC4 Wheel domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in proliferating tissue and tumor cell lines but not in normal cell lines. {ECO:0000269|PubMed:18320024}.

Sequence

MEQPGQDPTSDDVMDSFLEKFQSQPYRGGFHEDQWEKEFEKVPLFMSRAPSEIDPRENPD
LACLQSIIFDEERSPEEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKKKCADPDLNAVLY
TNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQI
DAKEKKLLEMRAKADKLKRIEQRDVRKANLKEKKERNQNEALLQAIKARNIRLSEAACED
EDSASEGLGELFLDGLSTENPHGARLSLDGQGRLSWPVLFLYPEYAQSDFISAFHEDSRF
IDHLMVMFGETPSWDLEQKYCPDNLEVYFEDEDRAELYRVPAKSTLLQVLQHQRYFVKAL
TPAFLVCVGSSPFCKNFLRGRKVYQIR

Sequence length

387

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (25)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	30303520		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute monocytic leukemia	Monocytic Leukemia	BEFREE	20658610		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	30303520		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	10639601, 18320024, 9933562		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	18320024	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	30303520		★★★★★ ★☆☆☆☆ Found in Text Mining only
CNS disorder	CNS Disorder	BEFREE	20658610, 28535084		★★★★★ ★☆☆☆☆ Found in Text Mining only
Crigler Najjar syndrome, type 1	Crigler-Najjar syndrome	BEFREE	31495946		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cutaneous Melanoma	Melanoma	BEFREE	11126369		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	29604048		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	29604048		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	31647813		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	30619047		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	30619047		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	23695515, 7760095, 9581848		★★★★★ ★☆☆☆☆ Found in Text Mining only
gliosarcoma	Gliosarcoma	BEFREE	7760095		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperbilirubinemia	Hyperbilirubinemia	BEFREE	31495946		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	20658610		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	10639601, 18320024, 9933562		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31655267		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	10639601		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	11126369, 18320024		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	LHGDN	18320024		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	18320024	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	10639601, 10873101, 11126369, 15564139, 18320024, 23695515, 7760095		★★★★★ ★☆☆☆☆ Found in Text Mining only

TTC4 (tetratricopeptide repeat domain 4)