Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	7265
Gene name	Tetratricopeptide repeat domain 1
Gene symbol	TTC1
Synonyms (NCBI Gene)	TPR1
Chromosome	5
Chromosome location	5q33.3
Summary	This gene encodes a protein that belongs to the tetratrico peptide repeat superfamily of proteins. The encoded protein plays a role in protein-protein interactions, and binds to the Galpha subunit of G protein-coupled receptors to activate the Ras signali

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miRTarBase ID	miRNA	Experiments	Reference
MIRT031698	hsa-miR-16-5p	Proteomics	18668040
MIRT051350	hsa-miR-15a-5p	CLASH	23622248
MIRT046424	hsa-miR-15b-5p	CLASH	23622248
MIRT1460784	hsa-miR-1197	CLIP-seq
MIRT1460785	hsa-miR-1207-5p	CLIP-seq
MIRT1460786	hsa-miR-1587	CLIP-seq
MIRT1460787	hsa-miR-15a	CLIP-seq
MIRT1460788	hsa-miR-15b	CLIP-seq
MIRT1460789	hsa-miR-16	CLIP-seq
MIRT1460790	hsa-miR-195	CLIP-seq
MIRT1460791	hsa-miR-3119	CLIP-seq
MIRT1460792	hsa-miR-3120-3p	CLIP-seq
MIRT1460793	hsa-miR-3126-5p	CLIP-seq
MIRT1460794	hsa-miR-3140-3p	CLIP-seq
MIRT1460795	hsa-miR-3188	CLIP-seq
MIRT1460796	hsa-miR-3620	CLIP-seq
MIRT1460797	hsa-miR-3679-3p	CLIP-seq
MIRT1460798	hsa-miR-3690	CLIP-seq
MIRT1460799	hsa-miR-378g	CLIP-seq
MIRT1460800	hsa-miR-3918	CLIP-seq
MIRT1460801	hsa-miR-424	CLIP-seq
MIRT1460802	hsa-miR-4254	CLIP-seq
MIRT1460803	hsa-miR-4433	CLIP-seq
MIRT1460804	hsa-miR-4437	CLIP-seq
MIRT1460805	hsa-miR-4459	CLIP-seq
MIRT1460806	hsa-miR-4492	CLIP-seq
MIRT1460807	hsa-miR-4498	CLIP-seq
MIRT1460808	hsa-miR-4512	CLIP-seq
MIRT1460809	hsa-miR-4638-3p	CLIP-seq
MIRT1460810	hsa-miR-4656	CLIP-seq
MIRT1460811	hsa-miR-4674	CLIP-seq
MIRT1460812	hsa-miR-4675	CLIP-seq
MIRT1460813	hsa-miR-4731-5p	CLIP-seq
MIRT1460814	hsa-miR-4736	CLIP-seq
MIRT1460815	hsa-miR-4741	CLIP-seq
MIRT1460816	hsa-miR-4763-3p	CLIP-seq
MIRT1460817	hsa-miR-4768-3p	CLIP-seq
MIRT1460818	hsa-miR-497	CLIP-seq
MIRT1460819	hsa-miR-499-3p	CLIP-seq
MIRT1460820	hsa-miR-499a-3p	CLIP-seq
MIRT1460821	hsa-miR-5096	CLIP-seq
MIRT1460822	hsa-miR-548n	CLIP-seq
MIRT1460823	hsa-miR-548t	CLIP-seq
MIRT1460824	hsa-miR-583	CLIP-seq
MIRT1460825	hsa-miR-762	CLIP-seq
MIRT1460826	hsa-miR-873	CLIP-seq
MIRT2138404	hsa-miR-1231	CLIP-seq
MIRT2138405	hsa-miR-1243	CLIP-seq
MIRT2138406	hsa-miR-1285	CLIP-seq
MIRT2138407	hsa-miR-150	CLIP-seq
MIRT1460786	hsa-miR-1587	CLIP-seq
MIRT1460791	hsa-miR-3119	CLIP-seq
MIRT1460794	hsa-miR-3140-3p	CLIP-seq
MIRT2138408	hsa-miR-3187-5p	CLIP-seq
MIRT1460795	hsa-miR-3188	CLIP-seq
MIRT2138409	hsa-miR-3614-3p	CLIP-seq
MIRT1460796	hsa-miR-3620	CLIP-seq
MIRT2138410	hsa-miR-3654	CLIP-seq
MIRT1460799	hsa-miR-378g	CLIP-seq
MIRT1460804	hsa-miR-4437	CLIP-seq
MIRT2138411	hsa-miR-4464	CLIP-seq
MIRT2138412	hsa-miR-4486	CLIP-seq
MIRT1460806	hsa-miR-4492	CLIP-seq
MIRT1460807	hsa-miR-4498	CLIP-seq
MIRT1460810	hsa-miR-4656	CLIP-seq
MIRT1460811	hsa-miR-4674	CLIP-seq
MIRT1460812	hsa-miR-4675	CLIP-seq
MIRT2138413	hsa-miR-4705	CLIP-seq
MIRT2138414	hsa-miR-4713-5p	CLIP-seq
MIRT1460813	hsa-miR-4731-5p	CLIP-seq
MIRT1460815	hsa-miR-4741	CLIP-seq
MIRT2138415	hsa-miR-4748	CLIP-seq
MIRT1460821	hsa-miR-5096	CLIP-seq
MIRT2138416	hsa-miR-532-3p	CLIP-seq
MIRT2138417	hsa-miR-612	CLIP-seq
MIRT2138418	hsa-miR-654-3p	CLIP-seq
MIRT1460825	hsa-miR-762	CLIP-seq
MIRT2138405	hsa-miR-1243	CLIP-seq
MIRT2138409	hsa-miR-3614-3p	CLIP-seq
MIRT2138410	hsa-miR-3654	CLIP-seq
MIRT1460804	hsa-miR-4437	CLIP-seq
MIRT1460811	hsa-miR-4674	CLIP-seq
MIRT2138405	hsa-miR-1243	CLIP-seq
MIRT2138409	hsa-miR-3614-3p	CLIP-seq
MIRT2138410	hsa-miR-3654	CLIP-seq
MIRT1460804	hsa-miR-4437	CLIP-seq
MIRT1460811	hsa-miR-4674	CLIP-seq
MIRT2138405	hsa-miR-1243	CLIP-seq
MIRT2652497	hsa-miR-1287	CLIP-seq
MIRT2652498	hsa-miR-1321	CLIP-seq
MIRT2652499	hsa-miR-140-3p	CLIP-seq
MIRT2652500	hsa-miR-1827	CLIP-seq
MIRT2652501	hsa-miR-214	CLIP-seq
MIRT2652502	hsa-miR-3125	CLIP-seq
MIRT1460793	hsa-miR-3126-5p	CLIP-seq
MIRT2652503	hsa-miR-3135b	CLIP-seq
MIRT1460794	hsa-miR-3140-3p	CLIP-seq
MIRT2652504	hsa-miR-3612	CLIP-seq
MIRT2138409	hsa-miR-3614-3p	CLIP-seq
MIRT2652505	hsa-miR-3619-5p	CLIP-seq
MIRT1460796	hsa-miR-3620	CLIP-seq
MIRT2138410	hsa-miR-3654	CLIP-seq
MIRT2652506	hsa-miR-3662	CLIP-seq
MIRT2652507	hsa-miR-3688-3p	CLIP-seq
MIRT1460799	hsa-miR-378g	CLIP-seq
MIRT2652508	hsa-miR-383	CLIP-seq
MIRT2652509	hsa-miR-3916	CLIP-seq
MIRT2652510	hsa-miR-4270	CLIP-seq
MIRT2652511	hsa-miR-4426	CLIP-seq
MIRT1460804	hsa-miR-4437	CLIP-seq
MIRT2652512	hsa-miR-4441	CLIP-seq
MIRT2652513	hsa-miR-4443	CLIP-seq
MIRT2652514	hsa-miR-4647	CLIP-seq
MIRT2652515	hsa-miR-4662b	CLIP-seq
MIRT1460811	hsa-miR-4674	CLIP-seq
MIRT2652516	hsa-miR-4694-3p	CLIP-seq
MIRT2652517	hsa-miR-4728-5p	CLIP-seq
MIRT2652518	hsa-miR-4739	CLIP-seq
MIRT2652519	hsa-miR-4756-5p	CLIP-seq
MIRT2652520	hsa-miR-4760-5p	CLIP-seq
MIRT2652521	hsa-miR-4772-5p	CLIP-seq
MIRT1460819	hsa-miR-499-3p	CLIP-seq
MIRT1460820	hsa-miR-499a-3p	CLIP-seq
MIRT1460821	hsa-miR-5096	CLIP-seq
MIRT1460822	hsa-miR-548n	CLIP-seq
MIRT1460823	hsa-miR-548t	CLIP-seq
MIRT2652522	hsa-miR-556-3p	CLIP-seq
MIRT2652523	hsa-miR-577	CLIP-seq
MIRT1460824	hsa-miR-583	CLIP-seq
MIRT2652524	hsa-miR-650	CLIP-seq
MIRT2652525	hsa-miR-761	CLIP-seq
MIRT1460826	hsa-miR-873	CLIP-seq
MIRT2138405	hsa-miR-1243	CLIP-seq
MIRT1460793	hsa-miR-3126-5p	CLIP-seq
MIRT1460794	hsa-miR-3140-3p	CLIP-seq
MIRT2138409	hsa-miR-3614-3p	CLIP-seq
MIRT1460796	hsa-miR-3620	CLIP-seq
MIRT2138410	hsa-miR-3654	CLIP-seq
MIRT2652506	hsa-miR-3662	CLIP-seq
MIRT2652507	hsa-miR-3688-3p	CLIP-seq
MIRT1460799	hsa-miR-378g	CLIP-seq
MIRT2652511	hsa-miR-4426	CLIP-seq
MIRT1460804	hsa-miR-4437	CLIP-seq
MIRT2652514	hsa-miR-4647	CLIP-seq
MIRT2652515	hsa-miR-4662b	CLIP-seq
MIRT1460811	hsa-miR-4674	CLIP-seq
MIRT2652516	hsa-miR-4694-3p	CLIP-seq
MIRT2652520	hsa-miR-4760-5p	CLIP-seq
MIRT1460819	hsa-miR-499-3p	CLIP-seq
MIRT1460820	hsa-miR-499a-3p	CLIP-seq
MIRT1460821	hsa-miR-5096	CLIP-seq
MIRT1460822	hsa-miR-548n	CLIP-seq
MIRT1460823	hsa-miR-548t	CLIP-seq
MIRT2652523	hsa-miR-577	CLIP-seq
MIRT1460824	hsa-miR-583	CLIP-seq
MIRT1460826	hsa-miR-873	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	9383998, 14985359, 15708368, 25036637, 25416956, 26871637, 28514442, 30021884, 32296183, 32814053, 33961781
GO:0005737	Component	Cytoplasm	IC	22711498
GO:0005778	Component	Peroxisomal membrane	HDA	21525035
GO:0005829	Component	Cytosol	IDA
GO:0006457	Process	Protein folding	NAS	8836031
GO:0006954	Process	Inflammatory response	IDA	10443688
GO:0030674	Function	Protein-macromolecule adaptor activity	IDA	22711498
GO:0050729	Process	Positive regulation of inflammatory response	IDA	23125416
GO:0050729	Process	Positive regulation of inflammatory response	TAS	23125416
GO:0051082	Function	Unfolded protein binding	NAS	8836031
GO:0070098	Process	Chemokine-mediated signaling pathway	ISS
GO:0070098	Process	Chemokine-mediated signaling pathway	ISS
GO:0150078	Process	Positive regulation of neuroinflammatory response	IDA	24854121
GO:0150078	Process	Positive regulation of neuroinflammatory response	ISS
GO:0150078	Process	Positive regulation of neuroinflammatory response	ISS

MIM	HGNC	e!Ensembl
601963	12391	ENSG00000113312

Q99614

Protein name

Tetratricopeptide repeat protein 1 (TPR repeat protein 1)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13181	TPR_8	122 → 149	Tetratricopeptide repeat	Repeat
PF00515	TPR_1	155 → 188	Tetratricopeptide repeat	Repeat

Sequence

MGEKSENCGVPEDLLNGLKVTDTQEAECAGPPVPDPKNQHSQSKLLRDDEAHLQEDQGEE
ECFHDCSASFEEEPGADKVENKSNEDVNSSELDEEYLIELEKNMSDEEKQKRREESTRLK
EEGNEQFKKGDYIEAESSYSRALEMCPSCFQKERSILFSNRAAARMKQDKKEMAINDCSK
AIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSIHQAREACMRLPKQIEERN
ERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR

Sequence length

292

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Abnormal brain morphology	Likely pathogenic	rs1060499752	RCV000454191	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Anxiety Disorders	Anxiety Disorder	BEFREE	23951166		★★★★★ ★☆☆☆☆ Found in Text Mining only

TTC1 (tetratricopeptide repeat domain 1)