Gene Gene information from NCBI Gene database.
Entrez ID 7257
Gene name Translin associated factor X
Gene symbol TSNAX
Synonyms (NCBI Gene)
C3POTRAX
Chromosome 1
Chromosome location 1q42.2
Summary This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may
miRNA miRNA information provided by mirtarbase database.
434
miRTarBase ID miRNA Experiments Reference
MIRT030855 hsa-miR-21-5p Microarray 18591254
MIRT064153 hsa-miR-548m PAR-CLIP 21572407
MIRT064156 hsa-miR-3646 PAR-CLIP 21572407
MIRT064154 hsa-miR-1252-3p PAR-CLIP 21572407
MIRT064149 hsa-miR-323a-3p PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26
GO ID Ontology Definition Evidence Reference
GO:0003677 Function DNA binding IEA
GO:0003677 Function DNA binding TAS 9013868
GO:0003697 Function Single-stranded DNA binding IEA
GO:0003723 Function RNA binding HDA 22681889
GO:0003723 Function RNA binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602964 12380 ENSG00000116918
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q99598
Protein name Translin-associated protein X (Translin-associated factor X)
Protein function Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.
PDB 3PJA , 3QB5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01997 Translin 51 264 Translin family Family
Sequence
Sequence length 290
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Small interfering RNA (siRNA) biogenesis
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BIPOLAR DISORDER Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MOOD DISORDERS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Asperger Syndrome Asperger Syndrome BEFREE 17579608
★☆☆☆☆
Found in Text Mining only
Autism Spectrum Disorder Autism Pubtator 19606485 Associate
★☆☆☆☆
Found in Text Mining only
Autism Spectrum Disorders Autism Spectrum Disorder BEFREE 19606485
★☆☆☆☆
Found in Text Mining only
Bipolar Disorder Bipolar Disorder BEFREE 15838535, 19760522, 21683752
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Bipolar Disorder Bipolar Disorder LHGDN 15838535
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Bipolar Disorder Bipolar Disorder PSYGENET_DG 15838535, 19760522, 21683752
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Carcinogenesis Carcinogenesis Pubtator 27183912 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 35833210 Associate
★☆☆☆☆
Found in Text Mining only
Chronic Periodontitis Periodontitis Pubtator 27601451 Associate
★☆☆☆☆
Found in Text Mining only
Depressive disorder Mental Depression BEFREE 19255581
★☆☆☆☆
Found in Text Mining only