Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7203
Gene name	Chaperonin containing TCP1 subunit 3
Gene symbol	CCT3
Synonyms (NCBI Gene)	CCT-gammaCCTGNEDSVHPIG48TCP-1-gammaTRIC5
Chromosome	1
Chromosome location	1q22
Summary	The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different p

156

Show/Hide all (156)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019519	hsa-miR-151a-5p	Sequencing	20371350
MIRT022720	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT025020	hsa-miR-183-5p	Sequencing	20371350
MIRT027135	hsa-miR-103a-3p	Sequencing	20371350
MIRT031786	hsa-miR-16-5p	Sequencing	20371350
MIRT047351	hsa-miR-34a-5p	CLASH	23622248
MIRT046847	hsa-miR-221-3p	CLASH	23622248
MIRT046847	hsa-miR-221-3p	CLASH	23622248
MIRT044775	hsa-miR-320a	CLASH	23622248
MIRT038250	hsa-miR-330-5p	CLASH	23622248
MIRT038250	hsa-miR-330-5p	CLASH	23622248
MIRT036217	hsa-miR-320b	CLASH	23622248
MIRT035989	hsa-miR-1301-3p	CLASH	23622248
MIRT873353	hsa-miR-1237	CLIP-seq
MIRT873354	hsa-miR-1253	CLIP-seq
MIRT873355	hsa-miR-128	CLIP-seq
MIRT873356	hsa-miR-1302	CLIP-seq
MIRT873357	hsa-miR-1343	CLIP-seq
MIRT873358	hsa-miR-149	CLIP-seq
MIRT873359	hsa-miR-188-5p	CLIP-seq
MIRT873360	hsa-miR-1913	CLIP-seq
MIRT873361	hsa-miR-223	CLIP-seq
MIRT873362	hsa-miR-24	CLIP-seq
MIRT873363	hsa-miR-3064-5p	CLIP-seq
MIRT873364	hsa-miR-3123	CLIP-seq
MIRT873365	hsa-miR-3135	CLIP-seq
MIRT873366	hsa-miR-3148	CLIP-seq
MIRT873367	hsa-miR-3160-3p	CLIP-seq
MIRT873368	hsa-miR-3175	CLIP-seq
MIRT873369	hsa-miR-3199	CLIP-seq
MIRT873370	hsa-miR-324-3p	CLIP-seq
MIRT873371	hsa-miR-338-5p	CLIP-seq
MIRT873372	hsa-miR-3614-3p	CLIP-seq
MIRT873373	hsa-miR-3616-5p	CLIP-seq
MIRT873374	hsa-miR-3647-5p	CLIP-seq
MIRT873375	hsa-miR-3664-3p	CLIP-seq
MIRT873376	hsa-miR-3688-3p	CLIP-seq
MIRT873377	hsa-miR-3925-5p	CLIP-seq
MIRT873378	hsa-miR-3976	CLIP-seq
MIRT873379	hsa-miR-3978	CLIP-seq
MIRT873380	hsa-miR-4255	CLIP-seq
MIRT873381	hsa-miR-4261	CLIP-seq
MIRT873382	hsa-miR-4284	CLIP-seq
MIRT873383	hsa-miR-4298	CLIP-seq
MIRT873384	hsa-miR-4302	CLIP-seq
MIRT873385	hsa-miR-4313	CLIP-seq
MIRT873386	hsa-miR-4326	CLIP-seq
MIRT873387	hsa-miR-4475	CLIP-seq
MIRT873388	hsa-miR-4487	CLIP-seq
MIRT873389	hsa-miR-4488	CLIP-seq
MIRT873390	hsa-miR-4515	CLIP-seq
MIRT873391	hsa-miR-4522	CLIP-seq
MIRT873392	hsa-miR-4539	CLIP-seq
MIRT873393	hsa-miR-4666-5p	CLIP-seq
MIRT873394	hsa-miR-4694-3p	CLIP-seq
MIRT873395	hsa-miR-4697-3p	CLIP-seq
MIRT873396	hsa-miR-4697-5p	CLIP-seq
MIRT873397	hsa-miR-4711-3p	CLIP-seq
MIRT873398	hsa-miR-4760-5p	CLIP-seq
MIRT873399	hsa-miR-4774-3p	CLIP-seq
MIRT873400	hsa-miR-4794	CLIP-seq
MIRT873401	hsa-miR-511	CLIP-seq
MIRT873402	hsa-miR-522	CLIP-seq
MIRT873403	hsa-miR-548a-3p	CLIP-seq
MIRT873404	hsa-miR-548e	CLIP-seq
MIRT873405	hsa-miR-548f	CLIP-seq
MIRT873406	hsa-miR-558	CLIP-seq
MIRT873407	hsa-miR-562	CLIP-seq
MIRT873408	hsa-miR-573	CLIP-seq
MIRT873409	hsa-miR-637	CLIP-seq
MIRT873410	hsa-miR-873	CLIP-seq
MIRT873354	hsa-miR-1253	CLIP-seq
MIRT873361	hsa-miR-223	CLIP-seq
MIRT873364	hsa-miR-3123	CLIP-seq
MIRT873366	hsa-miR-3148	CLIP-seq
MIRT873367	hsa-miR-3160-3p	CLIP-seq
MIRT873377	hsa-miR-3925-5p	CLIP-seq
MIRT873378	hsa-miR-3976	CLIP-seq
MIRT873379	hsa-miR-3978	CLIP-seq
MIRT873384	hsa-miR-4302	CLIP-seq
MIRT873388	hsa-miR-4487	CLIP-seq
MIRT873393	hsa-miR-4666-5p	CLIP-seq
MIRT873395	hsa-miR-4697-3p	CLIP-seq
MIRT873397	hsa-miR-4711-3p	CLIP-seq
MIRT873401	hsa-miR-511	CLIP-seq
MIRT873403	hsa-miR-548a-3p	CLIP-seq
MIRT873404	hsa-miR-548e	CLIP-seq
MIRT873405	hsa-miR-548f	CLIP-seq
MIRT873406	hsa-miR-558	CLIP-seq
MIRT873353	hsa-miR-1237	CLIP-seq
MIRT873359	hsa-miR-188-5p	CLIP-seq
MIRT873392	hsa-miR-4539	CLIP-seq
MIRT873353	hsa-miR-1237	CLIP-seq
MIRT2196058	hsa-miR-138	CLIP-seq
MIRT873358	hsa-miR-149	CLIP-seq
MIRT873359	hsa-miR-188-5p	CLIP-seq
MIRT873362	hsa-miR-24	CLIP-seq
MIRT873363	hsa-miR-3064-5p	CLIP-seq
MIRT873365	hsa-miR-3135	CLIP-seq
MIRT873368	hsa-miR-3175	CLIP-seq
MIRT2196059	hsa-miR-33a	CLIP-seq
MIRT2196060	hsa-miR-33b	CLIP-seq
MIRT873372	hsa-miR-3614-3p	CLIP-seq
MIRT873373	hsa-miR-3616-5p	CLIP-seq
MIRT873374	hsa-miR-3647-5p	CLIP-seq
MIRT873375	hsa-miR-3664-3p	CLIP-seq
MIRT873376	hsa-miR-3688-3p	CLIP-seq
MIRT873381	hsa-miR-4261	CLIP-seq
MIRT873382	hsa-miR-4284	CLIP-seq
MIRT873391	hsa-miR-4522	CLIP-seq
MIRT873392	hsa-miR-4539	CLIP-seq
MIRT873394	hsa-miR-4694-3p	CLIP-seq
MIRT873399	hsa-miR-4774-3p	CLIP-seq
MIRT873400	hsa-miR-4794	CLIP-seq
MIRT873402	hsa-miR-522	CLIP-seq
MIRT873407	hsa-miR-562	CLIP-seq
MIRT873408	hsa-miR-573	CLIP-seq
MIRT873410	hsa-miR-873	CLIP-seq
MIRT2196058	hsa-miR-138	CLIP-seq
MIRT873358	hsa-miR-149	CLIP-seq
MIRT873362	hsa-miR-24	CLIP-seq
MIRT873363	hsa-miR-3064-5p	CLIP-seq
MIRT873365	hsa-miR-3135	CLIP-seq
MIRT873368	hsa-miR-3175	CLIP-seq
MIRT2196059	hsa-miR-33a	CLIP-seq
MIRT2196060	hsa-miR-33b	CLIP-seq
MIRT873372	hsa-miR-3614-3p	CLIP-seq
MIRT873373	hsa-miR-3616-5p	CLIP-seq
MIRT873374	hsa-miR-3647-5p	CLIP-seq
MIRT873375	hsa-miR-3664-3p	CLIP-seq
MIRT873382	hsa-miR-4284	CLIP-seq
MIRT873391	hsa-miR-4522	CLIP-seq
MIRT873399	hsa-miR-4774-3p	CLIP-seq
MIRT873400	hsa-miR-4794	CLIP-seq
MIRT873407	hsa-miR-562	CLIP-seq
MIRT873408	hsa-miR-573	CLIP-seq
MIRT873410	hsa-miR-873	CLIP-seq
MIRT2196058	hsa-miR-138	CLIP-seq
MIRT873358	hsa-miR-149	CLIP-seq
MIRT873362	hsa-miR-24	CLIP-seq
MIRT873363	hsa-miR-3064-5p	CLIP-seq
MIRT873365	hsa-miR-3135	CLIP-seq
MIRT873368	hsa-miR-3175	CLIP-seq
MIRT2196059	hsa-miR-33a	CLIP-seq
MIRT2196060	hsa-miR-33b	CLIP-seq
MIRT873372	hsa-miR-3614-3p	CLIP-seq
MIRT873373	hsa-miR-3616-5p	CLIP-seq
MIRT873374	hsa-miR-3647-5p	CLIP-seq
MIRT873375	hsa-miR-3664-3p	CLIP-seq
MIRT873382	hsa-miR-4284	CLIP-seq
MIRT873391	hsa-miR-4522	CLIP-seq
MIRT873399	hsa-miR-4774-3p	CLIP-seq
MIRT873400	hsa-miR-4794	CLIP-seq
MIRT873407	hsa-miR-562	CLIP-seq
MIRT873408	hsa-miR-573	CLIP-seq
MIRT873410	hsa-miR-873	CLIP-seq

Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0002199	Component	Zona pellucida receptor complex	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	12620389, 16189514, 25416956, 25467444, 27705803, 28514442, 30021884, 31980649, 32296183, 33144677, 33961781, 37045861
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005832	Component	Chaperonin-containing T-complex	IBA
GO:0005832	Component	Chaperonin-containing T-complex	IDA	23011926, 30955883
GO:0005832	Component	Chaperonin-containing T-complex	IEA
GO:0005832	Component	Chaperonin-containing T-complex	IPI	22133715
GO:0005832	Component	Chaperonin-containing T-complex	TAS	25467444
GO:0005856	Component	Cytoskeleton	TAS	8001976
GO:0005874	Component	Microtubule	IDA	21525035
GO:0005874	Component	Microtubule	IEA
GO:0006457	Process	Protein folding	IBA
GO:0006457	Process	Protein folding	IDA	22133715, 30955883
GO:0006457	Process	Protein folding	IEA
GO:0006457	Process	Protein folding	IMP	25467444
GO:0006457	Process	Protein folding	TAS	8001976
GO:0007339	Process	Binding of sperm to zona pellucida	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0032212	Process	Positive regulation of telomere maintenance via telomerase	IEA
GO:0032212	Process	Positive regulation of telomere maintenance via telomerase	IMP	25467444
GO:0044183	Function	Protein folding chaperone	IDA	25467444, 30955883
GO:0044183	Function	Protein folding chaperone	IEA
GO:0044297	Component	Cell body	IEA
GO:0050821	Process	Protein stabilization	IEA
GO:0050821	Process	Protein stabilization	IMP	25467444
GO:0051082	Function	Unfolded protein binding	IBA
GO:0051082	Function	Unfolded protein binding	IEA
GO:0051082	Function	Unfolded protein binding	TAS	8573069
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0140662	Function	ATP-dependent protein folding chaperone	IEA
GO:1904871	Process	Positive regulation of protein localization to Cajal body	HMP	25467444
GO:1904874	Process	Positive regulation of telomerase RNA localization to Cajal body	HMP	25467444

MIM	HGNC	e!Ensembl
600114	1616	ENSG00000163468

P49368

Protein name

T-complex protein 1 subunit gamma (TCP-1-gamma) (EC 3.6.1.-) (CCT-gamma) (Chaperonin containing T-complex polypeptide 1 subunit 3) (hTRiC5)

Protein function

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TR

PDB

6NR8 , 6NR9 , 6NRA , 6NRB , 6NRC , 6NRD , 6QB8 , 7LUM , 7LUP , 7NVL , 7NVM , 7NVN , 7NVO , 7TRG , 7TTN , 7TTT , 7TUB , 7WU7 , 7WZ3 , 7X0A , 7X0S , 7X0V , 7X3J , 7X3U , 7X6Q , 7X7Y , 8HKI , 8I1U , 8I6J , 8I9U , 8IB8 , 8SFE , 8SFF , 8SG8 , 8SG9 , 8SGC , 8SGL , 8SGQ , 8SH9 , 8SHA , 8SHD , 8SHE , 8SHF , 8SHG , 8SHL , 8SHN , 8SHO , 8SHP , 8SHQ , 8SHT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00118	Cpn60_TCP1	33 → 527	TCP-1/cpn60 chaperonin family	Family

Sequence

MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMT
NDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPT
VVISAYRKALDDMISTLKKISIPVDISDSDMMLNIINSSITTKAISRWSSLACNIALDAV
KMVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVL
LDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLA
QHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYF
TFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAH
ALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGV
NGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQSRQGGAP
DAGQE

Sequence length

545

Interactions

View interactions

	Reactome
			Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDER	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental disorder with speech or visual impairment and brain hypomyelination	Uncertain significance	ClinVar ClinVar, GWAS catalog, HPO ClinVar, GWAS catalog, HPO	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (34)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma	Adenocarcinoma	BEFREE	30104334		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	28379421, 28447237, 31675993		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	34505628, 37092305	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	12079511, 18277965, 26229401, 28086821, 31811111, 37092305, 37301543	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	35773623	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	23868055	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	19098285		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	19098285	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	31852111	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dystrophia myotonica 2	Myotonic dystrophy	BEFREE	12076668, 15231584, 15322428, 15363905, 15503094, 15652222, 16753177, 16776586, 16876389, 18057971, 18974556, 19345584, 19590039, 19683984, 20458885 View all (17 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Eosinophilic myositis (disorder)	Eosinophilic Myositis	BEFREE	25443993		★★★★★ ★☆☆☆☆ Found in Text Mining only
FRIEDREICH ATAXIA 1	Friedreich Ataxia	BEFREE	16793772		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	30451371, 31707687		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	30451371, 31707687		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	LHGDN	12586295		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	26229401, 26739059, 30473171		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	31852111	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	28379421, 28447237, 31675993		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	29903505		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26739059		★★★★★ ★☆☆☆☆ Found in Text Mining only
Micrognathism	Micrognathism	BEFREE	15703188		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myotonic Disorders	Myotonic Disorders	BEFREE	16920640		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myotonic Dystrophy	Myotonic dystrophy	Pubtator	12970845, 34687219, 36018009	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myotonic Dystrophy	Myotonic dystrophy	BEFREE	14681885, 14722159, 15114529, 15704146, 16920640, 17942744, 19822739, 20406734, 20939737, 22846424, 23252746, 25443993, 30561649		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myotonic Dystrophy	Myotonic dystrophy	Pubtator	18804219, 23097607, 26384951	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	29805652		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	29903505		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	25443993		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	LHGDN	19165527		★★★★★ ★☆☆☆☆ Found in Text Mining only
Secondary malignant neoplasm of colon and/or rectum	Colorectal Neoplasms	BEFREE	30318772		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	34505628	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	27116183		★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	37833621	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	34651664	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CCT3 (chaperonin containing TCP1 subunit 3)