CRISP2 (cysteine rich secretory protein 2)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 7180
Gene name Cysteine rich secretory protein 2
Gene symbol CRISP2
Synonyms (NCBI Gene)
CRISP-2CT36GAPDL5TPX1TSP1
Chromosome 6
Chromosome location 6p12.3
miRNA miRNA information provided by mirtarbase database.
15
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (15)
miRTarBase ID miRNA Experiments Reference
MIRT437694 hsa-miR-27a-3p MicroarrayqRT-PCR 22815788
MIRT437703 hsa-miR-27b-3p MicroarrayqRT-PCR 22815788
MIRT437703 hsa-miR-27b-3p qRT-PCRLuciferase reporter assayWestern blot 25505194
MIRT909777 hsa-miR-501-3p CLIP-seq
MIRT909778 hsa-miR-502-3p CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
4
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (4)
GO ID Ontology Definition Evidence Reference
GO:0005576 Component Extracellular region IEA
GO:0005615 Component Extracellular space IBA
GO:0005615 Component Extracellular space TAS 8665901
GO:0019953 Process Sexual reproduction IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
187430 12024 ENSG00000124490
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P16562
Protein name Cysteine-rich secretory protein 2 (CRISP-2) (Cancer/testis antigen 36) (CT36) (Testis-specific protein TPX-1)
Protein function May regulate some ion channels' activity and thereby regulate calcium fluxes during sperm capacitation.
PDB 2CQ7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00188 CAP 41 → 169 Cysteine-rich secretory protein family Domain
PF08562 Crisp 189 → 243 Crisp Domain
Tissue specificity TISSUE SPECIFICITY: Testis and epididymis.
Sequence
Sequence length 243
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (2)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CAROTID ARTERY DISEASE — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma Likely benign ClinVar
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (122)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 18425817, 26222671
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 19435835
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 12358136, 18425817
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Medulloblastoma Medulloblastoma BEFREE 20876797
★★★★★
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm Aortic Aneurysm BEFREE 28364044
★★★★★
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm, Abdominal Aortic Aneurysm BEFREE 28364044
★★★★★
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 26178021, 28345659, 28698603
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Arthritis BEFREE 29088724
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis, Psoriatic Psoriatic Arthritis BEFREE 29415890
★★★★★
★☆☆☆☆
Found in Text Mining only
Asthenozoospermia Asthenozoospermia BEFREE 25505194, 27517483, 31778754
★★★★★
★☆☆☆☆
Found in Text Mining only