Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7172
Gene name	Thiopurine S-methyltransferase
Gene symbol	TPMT
Synonyms (NCBI Gene)	TPMTD
Chromosome	6
Chromosome location	6p22.3
Summary	This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorph

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1142345	T>C,G	Drug-response, likely-benign, other	Coding sequence variant, missense variant
rs1800460	C>T	Drug-response, likely-benign, other	Coding sequence variant, missense variant
rs1800462	C>G	Drug-response	Coding sequence variant, missense variant
rs1800584	C>T	Drug-response	Splice acceptor variant
rs56019966	C>T	Drug-response, uncertain-significance	Intron variant
rs56161402	C>T	Drug-response	Coding sequence variant, missense variant
rs74423290	G>C	Drug-response	Coding sequence variant, missense variant
rs201695576	T>C	Drug-response	Coding sequence variant, missense variant
rs753545734	C>A,T	Drug-response	Coding sequence variant, missense variant
rs759836180	->T	Drug-response	Coding sequence variant, frameshift variant
rs1256618794	C>A	Drug-response	Coding sequence variant, missense variant

446

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miRTarBase ID	miRNA	Experiments
MIRT1449857	hsa-miR-10a	CLIP-seq
MIRT1449858	hsa-miR-10b	CLIP-seq
MIRT1449859	hsa-miR-1827	CLIP-seq
MIRT1449860	hsa-miR-2467-3p	CLIP-seq
MIRT1449861	hsa-miR-25	CLIP-seq
MIRT1449862	hsa-miR-28-5p	CLIP-seq
MIRT1449863	hsa-miR-3065-5p	CLIP-seq
MIRT1449864	hsa-miR-3122	CLIP-seq
MIRT1449865	hsa-miR-3132	CLIP-seq
MIRT1449866	hsa-miR-3139	CLIP-seq
MIRT1449867	hsa-miR-3147	CLIP-seq
MIRT1449868	hsa-miR-3160-3p	CLIP-seq
MIRT1449869	hsa-miR-3168	CLIP-seq
MIRT1449870	hsa-miR-3192	CLIP-seq
MIRT1449871	hsa-miR-32	CLIP-seq
MIRT1449872	hsa-miR-339-5p	CLIP-seq
MIRT1449873	hsa-miR-3609	CLIP-seq
MIRT1449874	hsa-miR-3612	CLIP-seq
MIRT1449875	hsa-miR-3622a-3p	CLIP-seq
MIRT1449876	hsa-miR-3622b-3p	CLIP-seq
MIRT1449877	hsa-miR-363	CLIP-seq
MIRT1449878	hsa-miR-367	CLIP-seq
MIRT1449879	hsa-miR-3689a-3p	CLIP-seq
MIRT1449880	hsa-miR-3689c	CLIP-seq
MIRT1449881	hsa-miR-3913-5p	CLIP-seq
MIRT1449882	hsa-miR-3929	CLIP-seq
MIRT1449883	hsa-miR-421	CLIP-seq
MIRT1449884	hsa-miR-4257	CLIP-seq
MIRT1449885	hsa-miR-4293	CLIP-seq
MIRT1449886	hsa-miR-4325	CLIP-seq
MIRT1449887	hsa-miR-4419b	CLIP-seq
MIRT1449888	hsa-miR-4421	CLIP-seq
MIRT1449889	hsa-miR-4433	CLIP-seq
MIRT1449890	hsa-miR-4459	CLIP-seq
MIRT1449891	hsa-miR-4478	CLIP-seq
MIRT1449892	hsa-miR-4487	CLIP-seq
MIRT1449893	hsa-miR-4649-3p	CLIP-seq
MIRT1449894	hsa-miR-4722-5p	CLIP-seq
MIRT1449895	hsa-miR-4725-5p	CLIP-seq
MIRT1449896	hsa-miR-4728-5p	CLIP-seq
MIRT1449897	hsa-miR-4768-3p	CLIP-seq
MIRT1449898	hsa-miR-4786-5p	CLIP-seq
MIRT1449899	hsa-miR-4799-5p	CLIP-seq
MIRT1449900	hsa-miR-485-5p	CLIP-seq
MIRT1449901	hsa-miR-490-3p	CLIP-seq
MIRT1449902	hsa-miR-504	CLIP-seq
MIRT1449903	hsa-miR-508-5p	CLIP-seq
MIRT1449904	hsa-miR-520g	CLIP-seq
MIRT1449905	hsa-miR-520h	CLIP-seq
MIRT1449906	hsa-miR-544b	CLIP-seq
MIRT1449907	hsa-miR-548ah	CLIP-seq
MIRT1449908	hsa-miR-558	CLIP-seq
MIRT1449909	hsa-miR-650	CLIP-seq
MIRT1449910	hsa-miR-708	CLIP-seq
MIRT1449911	hsa-miR-767-5p	CLIP-seq
MIRT1449912	hsa-miR-769-5p	CLIP-seq
MIRT1449913	hsa-miR-92a	CLIP-seq
MIRT1449914	hsa-miR-92b	CLIP-seq
MIRT1449915	hsa-miR-940	CLIP-seq
MIRT2134431	hsa-miR-1227	CLIP-seq
MIRT2134432	hsa-miR-1228	CLIP-seq
MIRT2134433	hsa-miR-1262	CLIP-seq
MIRT2134434	hsa-miR-1268	CLIP-seq
MIRT2134435	hsa-miR-1268b	CLIP-seq
MIRT1449859	hsa-miR-1827	CLIP-seq
MIRT1449860	hsa-miR-2467-3p	CLIP-seq
MIRT1449861	hsa-miR-25	CLIP-seq
MIRT2134436	hsa-miR-3140-3p	CLIP-seq
MIRT1449867	hsa-miR-3147	CLIP-seq
MIRT1449868	hsa-miR-3160-3p	CLIP-seq
MIRT2134437	hsa-miR-3169	CLIP-seq
MIRT1449870	hsa-miR-3192	CLIP-seq
MIRT1449871	hsa-miR-32	CLIP-seq
MIRT2134438	hsa-miR-34b	CLIP-seq
MIRT1449874	hsa-miR-3612	CLIP-seq
MIRT2134439	hsa-miR-3613-3p	CLIP-seq
MIRT1449875	hsa-miR-3622a-3p	CLIP-seq
MIRT2134440	hsa-miR-3622a-5p	CLIP-seq
MIRT1449876	hsa-miR-3622b-3p	CLIP-seq
MIRT1449877	hsa-miR-363	CLIP-seq
MIRT2134441	hsa-miR-3664-3p	CLIP-seq
MIRT1449878	hsa-miR-367	CLIP-seq
MIRT1449879	hsa-miR-3689a-3p	CLIP-seq
MIRT1449880	hsa-miR-3689c	CLIP-seq
MIRT2134442	hsa-miR-371b-5p	CLIP-seq
MIRT2134443	hsa-miR-3919	CLIP-seq
MIRT1449882	hsa-miR-3929	CLIP-seq
MIRT2134444	hsa-miR-3938	CLIP-seq
MIRT1449884	hsa-miR-4257	CLIP-seq
MIRT2134445	hsa-miR-4269	CLIP-seq
MIRT1449885	hsa-miR-4293	CLIP-seq
MIRT2134446	hsa-miR-4330	CLIP-seq
MIRT1449887	hsa-miR-4419b	CLIP-seq
MIRT1449889	hsa-miR-4433	CLIP-seq
MIRT1449890	hsa-miR-4459	CLIP-seq
MIRT1449891	hsa-miR-4478	CLIP-seq
MIRT2134447	hsa-miR-4486	CLIP-seq
MIRT1449892	hsa-miR-4487	CLIP-seq
MIRT2134448	hsa-miR-451b	CLIP-seq
MIRT1449893	hsa-miR-4649-3p	CLIP-seq
MIRT2134449	hsa-miR-4695-5p	CLIP-seq
MIRT2134450	hsa-miR-4701-3p	CLIP-seq
MIRT2134451	hsa-miR-4715-3p	CLIP-seq
MIRT1449894	hsa-miR-4722-5p	CLIP-seq
MIRT1449896	hsa-miR-4728-5p	CLIP-seq
MIRT2134452	hsa-miR-4735-5p	CLIP-seq
MIRT2134453	hsa-miR-4756-3p	CLIP-seq
MIRT1449897	hsa-miR-4768-3p	CLIP-seq
MIRT2134454	hsa-miR-4775	CLIP-seq
MIRT2134455	hsa-miR-4794	CLIP-seq
MIRT1449900	hsa-miR-485-5p	CLIP-seq
MIRT1449901	hsa-miR-490-3p	CLIP-seq
MIRT2134456	hsa-miR-500a	CLIP-seq
MIRT2134457	hsa-miR-510	CLIP-seq
MIRT2134458	hsa-miR-512-5p	CLIP-seq
MIRT1449908	hsa-miR-558	CLIP-seq
MIRT2134459	hsa-miR-585	CLIP-seq
MIRT1449909	hsa-miR-650	CLIP-seq
MIRT1449913	hsa-miR-92a	CLIP-seq
MIRT1449914	hsa-miR-92b	CLIP-seq
MIRT1449915	hsa-miR-940	CLIP-seq
MIRT1449857	hsa-miR-10a	CLIP-seq
MIRT1449858	hsa-miR-10b	CLIP-seq
MIRT2134431	hsa-miR-1227	CLIP-seq
MIRT2134432	hsa-miR-1228	CLIP-seq
MIRT2134433	hsa-miR-1262	CLIP-seq
MIRT2134434	hsa-miR-1268	CLIP-seq
MIRT2134435	hsa-miR-1268b	CLIP-seq
MIRT2355773	hsa-miR-1281	CLIP-seq
MIRT2355774	hsa-miR-1293	CLIP-seq
MIRT2355775	hsa-miR-1321	CLIP-seq
MIRT2355776	hsa-miR-135a	CLIP-seq
MIRT2355777	hsa-miR-135b	CLIP-seq
MIRT2355778	hsa-miR-150	CLIP-seq
MIRT1449859	hsa-miR-1827	CLIP-seq
MIRT1449860	hsa-miR-2467-3p	CLIP-seq
MIRT1449861	hsa-miR-25	CLIP-seq
MIRT2355779	hsa-miR-26a	CLIP-seq
MIRT2355780	hsa-miR-26b	CLIP-seq
MIRT1449863	hsa-miR-3065-5p	CLIP-seq
MIRT2355781	hsa-miR-3120-5p	CLIP-seq
MIRT1449864	hsa-miR-3122	CLIP-seq
MIRT2355782	hsa-miR-3125	CLIP-seq
MIRT2355783	hsa-miR-3127-5p	CLIP-seq
MIRT1449865	hsa-miR-3132	CLIP-seq
MIRT1449868	hsa-miR-3160-3p	CLIP-seq
MIRT2134437	hsa-miR-3169	CLIP-seq
MIRT1449870	hsa-miR-3192	CLIP-seq
MIRT1449871	hsa-miR-32	CLIP-seq
MIRT2355784	hsa-miR-3605-5p	CLIP-seq
MIRT1449874	hsa-miR-3612	CLIP-seq
MIRT1449875	hsa-miR-3622a-3p	CLIP-seq
MIRT2134440	hsa-miR-3622a-5p	CLIP-seq
MIRT1449876	hsa-miR-3622b-3p	CLIP-seq
MIRT1449877	hsa-miR-363	CLIP-seq
MIRT2355785	hsa-miR-3647-3p	CLIP-seq
MIRT2134441	hsa-miR-3664-3p	CLIP-seq
MIRT1449878	hsa-miR-367	CLIP-seq
MIRT1449879	hsa-miR-3689a-3p	CLIP-seq
MIRT1449880	hsa-miR-3689c	CLIP-seq
MIRT2355786	hsa-miR-378g	CLIP-seq
MIRT1449881	hsa-miR-3913-5p	CLIP-seq
MIRT2355787	hsa-miR-3916	CLIP-seq
MIRT2355788	hsa-miR-3926	CLIP-seq
MIRT1449882	hsa-miR-3929	CLIP-seq
MIRT2355789	hsa-miR-410	CLIP-seq
MIRT1449883	hsa-miR-421	CLIP-seq
MIRT1449884	hsa-miR-4257	CLIP-seq
MIRT2134445	hsa-miR-4269	CLIP-seq
MIRT2355790	hsa-miR-4270	CLIP-seq
MIRT1449887	hsa-miR-4419b	CLIP-seq
MIRT1449889	hsa-miR-4433	CLIP-seq
MIRT2355791	hsa-miR-4441	CLIP-seq
MIRT1449890	hsa-miR-4459	CLIP-seq
MIRT1449891	hsa-miR-4478	CLIP-seq
MIRT2355792	hsa-miR-4483	CLIP-seq
MIRT2134447	hsa-miR-4486	CLIP-seq
MIRT1449892	hsa-miR-4487	CLIP-seq
MIRT1449893	hsa-miR-4649-3p	CLIP-seq
MIRT2134449	hsa-miR-4695-5p	CLIP-seq
MIRT2355793	hsa-miR-4698	CLIP-seq
MIRT2134450	hsa-miR-4701-3p	CLIP-seq
MIRT2134451	hsa-miR-4715-3p	CLIP-seq
MIRT1449894	hsa-miR-4722-5p	CLIP-seq
MIRT1449896	hsa-miR-4728-5p	CLIP-seq
MIRT2355794	hsa-miR-4739	CLIP-seq
MIRT2355795	hsa-miR-4756-5p	CLIP-seq
MIRT1449897	hsa-miR-4768-3p	CLIP-seq
MIRT2134455	hsa-miR-4794	CLIP-seq
MIRT1449900	hsa-miR-485-5p	CLIP-seq
MIRT1449901	hsa-miR-490-3p	CLIP-seq
MIRT2355796	hsa-miR-495	CLIP-seq
MIRT2134457	hsa-miR-510	CLIP-seq
MIRT2134458	hsa-miR-512-5p	CLIP-seq
MIRT2355797	hsa-miR-548s	CLIP-seq
MIRT1449908	hsa-miR-558	CLIP-seq
MIRT2134459	hsa-miR-585	CLIP-seq
MIRT1449909	hsa-miR-650	CLIP-seq
MIRT2355798	hsa-miR-877	CLIP-seq
MIRT1449913	hsa-miR-92a	CLIP-seq
MIRT1449914	hsa-miR-92b	CLIP-seq
MIRT1449915	hsa-miR-940	CLIP-seq
MIRT2396247	hsa-miR-2110	CLIP-seq
MIRT1449862	hsa-miR-28-5p	CLIP-seq
MIRT1449863	hsa-miR-3065-5p	CLIP-seq
MIRT1449866	hsa-miR-3139	CLIP-seq
MIRT2396248	hsa-miR-3150a-3p	CLIP-seq
MIRT1449869	hsa-miR-3168	CLIP-seq
MIRT2396249	hsa-miR-3175	CLIP-seq
MIRT1449883	hsa-miR-421	CLIP-seq
MIRT2396250	hsa-miR-4259	CLIP-seq
MIRT1449885	hsa-miR-4293	CLIP-seq
MIRT1449889	hsa-miR-4433	CLIP-seq
MIRT1449890	hsa-miR-4459	CLIP-seq
MIRT2396251	hsa-miR-4514	CLIP-seq
MIRT2396252	hsa-miR-4692	CLIP-seq
MIRT1449897	hsa-miR-4768-3p	CLIP-seq
MIRT2396253	hsa-miR-571	CLIP-seq
MIRT1449910	hsa-miR-708	CLIP-seq
MIRT2396254	hsa-miR-939	CLIP-seq
MIRT1449857	hsa-miR-10a	CLIP-seq
MIRT1449858	hsa-miR-10b	CLIP-seq
MIRT2462208	hsa-miR-1267	CLIP-seq
MIRT2134434	hsa-miR-1268	CLIP-seq
MIRT2134435	hsa-miR-1268b	CLIP-seq
MIRT2355773	hsa-miR-1281	CLIP-seq
MIRT2462209	hsa-miR-129-5p	CLIP-seq
MIRT2355778	hsa-miR-150	CLIP-seq
MIRT2355779	hsa-miR-26a	CLIP-seq
MIRT2355780	hsa-miR-26b	CLIP-seq
MIRT2462210	hsa-miR-3149	CLIP-seq
MIRT2462211	hsa-miR-3194-3p	CLIP-seq
MIRT1449872	hsa-miR-339-5p	CLIP-seq
MIRT2134439	hsa-miR-3613-3p	CLIP-seq
MIRT2462212	hsa-miR-411	CLIP-seq
MIRT2462213	hsa-miR-431	CLIP-seq
MIRT1449888	hsa-miR-4421	CLIP-seq
MIRT2462214	hsa-miR-4423-5p	CLIP-seq
MIRT2134447	hsa-miR-4486	CLIP-seq
MIRT2462215	hsa-miR-4684-5p	CLIP-seq
MIRT2134451	hsa-miR-4715-3p	CLIP-seq
MIRT2134452	hsa-miR-4735-5p	CLIP-seq
MIRT2134454	hsa-miR-4775	CLIP-seq
MIRT2134455	hsa-miR-4794	CLIP-seq
MIRT2462216	hsa-miR-4797-5p	CLIP-seq
MIRT2462217	hsa-miR-483-5p	CLIP-seq
MIRT2462218	hsa-miR-548c-3p	CLIP-seq
MIRT2134459	hsa-miR-585	CLIP-seq
MIRT2462219	hsa-miR-590-3p	CLIP-seq
MIRT2462220	hsa-miR-593	CLIP-seq
MIRT2462221	hsa-miR-924	CLIP-seq
MIRT1449857	hsa-miR-10a	CLIP-seq
MIRT1449858	hsa-miR-10b	CLIP-seq
MIRT2134434	hsa-miR-1268	CLIP-seq
MIRT2134435	hsa-miR-1268b	CLIP-seq
MIRT2462209	hsa-miR-129-5p	CLIP-seq
MIRT2462210	hsa-miR-3149	CLIP-seq
MIRT1449872	hsa-miR-339-5p	CLIP-seq
MIRT2134439	hsa-miR-3613-3p	CLIP-seq
MIRT2462212	hsa-miR-411	CLIP-seq
MIRT1449888	hsa-miR-4421	CLIP-seq
MIRT2134447	hsa-miR-4486	CLIP-seq
MIRT2462215	hsa-miR-4684-5p	CLIP-seq
MIRT2134451	hsa-miR-4715-3p	CLIP-seq
MIRT2134452	hsa-miR-4735-5p	CLIP-seq
MIRT2134454	hsa-miR-4775	CLIP-seq
MIRT2134455	hsa-miR-4794	CLIP-seq
MIRT2462217	hsa-miR-483-5p	CLIP-seq
MIRT2462218	hsa-miR-548c-3p	CLIP-seq
MIRT2134459	hsa-miR-585	CLIP-seq
MIRT2462219	hsa-miR-590-3p	CLIP-seq
MIRT2462220	hsa-miR-593	CLIP-seq
MIRT1449857	hsa-miR-10a	CLIP-seq
MIRT1449858	hsa-miR-10b	CLIP-seq
MIRT2462208	hsa-miR-1267	CLIP-seq
MIRT2134434	hsa-miR-1268	CLIP-seq
MIRT2134435	hsa-miR-1268b	CLIP-seq
MIRT2355773	hsa-miR-1281	CLIP-seq
MIRT2462209	hsa-miR-129-5p	CLIP-seq
MIRT1449859	hsa-miR-1827	CLIP-seq
MIRT2649293	hsa-miR-186	CLIP-seq
MIRT2649294	hsa-miR-1915	CLIP-seq
MIRT2649295	hsa-miR-203	CLIP-seq
MIRT2649296	hsa-miR-214	CLIP-seq
MIRT1449860	hsa-miR-2467-3p	CLIP-seq
MIRT1449861	hsa-miR-25	CLIP-seq
MIRT2355779	hsa-miR-26a	CLIP-seq
MIRT2355780	hsa-miR-26b	CLIP-seq
MIRT1449862	hsa-miR-28-5p	CLIP-seq
MIRT1449863	hsa-miR-3065-5p	CLIP-seq
MIRT1449864	hsa-miR-3122	CLIP-seq
MIRT2649297	hsa-miR-3127-3p	CLIP-seq
MIRT1449865	hsa-miR-3132	CLIP-seq
MIRT2649298	hsa-miR-3133	CLIP-seq
MIRT1449866	hsa-miR-3139	CLIP-seq
MIRT2462210	hsa-miR-3149	CLIP-seq
MIRT2649299	hsa-miR-3158-5p	CLIP-seq
MIRT1449868	hsa-miR-3160-3p	CLIP-seq
MIRT1449869	hsa-miR-3168	CLIP-seq
MIRT2649300	hsa-miR-3189-5p	CLIP-seq
MIRT1449870	hsa-miR-3192	CLIP-seq
MIRT2462211	hsa-miR-3194-3p	CLIP-seq
MIRT1449871	hsa-miR-32	CLIP-seq
MIRT1449872	hsa-miR-339-5p	CLIP-seq
MIRT1449874	hsa-miR-3612	CLIP-seq
MIRT2134439	hsa-miR-3613-3p	CLIP-seq
MIRT2649301	hsa-miR-3619-5p	CLIP-seq
MIRT1449875	hsa-miR-3622a-3p	CLIP-seq
MIRT2134440	hsa-miR-3622a-5p	CLIP-seq
MIRT1449876	hsa-miR-3622b-3p	CLIP-seq
MIRT1449877	hsa-miR-363	CLIP-seq
MIRT1449878	hsa-miR-367	CLIP-seq
MIRT1449879	hsa-miR-3689a-3p	CLIP-seq
MIRT1449880	hsa-miR-3689c	CLIP-seq
MIRT2649302	hsa-miR-371-5p	CLIP-seq
MIRT2134442	hsa-miR-371b-5p	CLIP-seq
MIRT1449881	hsa-miR-3913-5p	CLIP-seq
MIRT2462212	hsa-miR-411	CLIP-seq
MIRT1449883	hsa-miR-421	CLIP-seq
MIRT1449884	hsa-miR-4257	CLIP-seq
MIRT2649303	hsa-miR-4274	CLIP-seq
MIRT2649304	hsa-miR-4291	CLIP-seq
MIRT1449885	hsa-miR-4293	CLIP-seq
MIRT2462213	hsa-miR-431	CLIP-seq
MIRT2134446	hsa-miR-4330	CLIP-seq
MIRT1449888	hsa-miR-4421	CLIP-seq
MIRT2462214	hsa-miR-4423-5p	CLIP-seq
MIRT1449889	hsa-miR-4433	CLIP-seq
MIRT1449890	hsa-miR-4459	CLIP-seq
MIRT2134447	hsa-miR-4486	CLIP-seq
MIRT1449892	hsa-miR-4487	CLIP-seq
MIRT2649305	hsa-miR-4652-3p	CLIP-seq
MIRT2649306	hsa-miR-4672	CLIP-seq
MIRT2462215	hsa-miR-4684-5p	CLIP-seq
MIRT2134451	hsa-miR-4715-3p	CLIP-seq
MIRT1449894	hsa-miR-4722-5p	CLIP-seq
MIRT2649307	hsa-miR-4726-3p	CLIP-seq
MIRT1449896	hsa-miR-4728-5p	CLIP-seq
MIRT2134452	hsa-miR-4735-5p	CLIP-seq
MIRT2649308	hsa-miR-4758-3p	CLIP-seq
MIRT1449897	hsa-miR-4768-3p	CLIP-seq
MIRT2134454	hsa-miR-4775	CLIP-seq
MIRT2134455	hsa-miR-4794	CLIP-seq
MIRT2462216	hsa-miR-4797-5p	CLIP-seq
MIRT1449899	hsa-miR-4799-5p	CLIP-seq
MIRT2462217	hsa-miR-483-5p	CLIP-seq
MIRT1449901	hsa-miR-490-3p	CLIP-seq
MIRT2649309	hsa-miR-513a-3p	CLIP-seq
MIRT1449906	hsa-miR-544b	CLIP-seq
MIRT2462218	hsa-miR-548c-3p	CLIP-seq
MIRT1449908	hsa-miR-558	CLIP-seq
MIRT2134459	hsa-miR-585	CLIP-seq
MIRT2462219	hsa-miR-590-3p	CLIP-seq
MIRT2462220	hsa-miR-593	CLIP-seq
MIRT1449909	hsa-miR-650	CLIP-seq
MIRT1449910	hsa-miR-708	CLIP-seq
MIRT2649310	hsa-miR-761	CLIP-seq
MIRT1449911	hsa-miR-767-5p	CLIP-seq
MIRT2649311	hsa-miR-922	CLIP-seq
MIRT2462221	hsa-miR-924	CLIP-seq
MIRT1449913	hsa-miR-92a	CLIP-seq
MIRT1449914	hsa-miR-92b	CLIP-seq
MIRT1449915	hsa-miR-940	CLIP-seq
MIRT1449857	hsa-miR-10a	CLIP-seq
MIRT1449858	hsa-miR-10b	CLIP-seq
MIRT2134431	hsa-miR-1227	CLIP-seq
MIRT2134432	hsa-miR-1228	CLIP-seq
MIRT2134434	hsa-miR-1268	CLIP-seq
MIRT2134435	hsa-miR-1268b	CLIP-seq
MIRT2355773	hsa-miR-1281	CLIP-seq
MIRT2462209	hsa-miR-129-5p	CLIP-seq
MIRT1449859	hsa-miR-1827	CLIP-seq
MIRT2649294	hsa-miR-1915	CLIP-seq
MIRT2649295	hsa-miR-203	CLIP-seq
MIRT2649296	hsa-miR-214	CLIP-seq
MIRT1449860	hsa-miR-2467-3p	CLIP-seq
MIRT1449861	hsa-miR-25	CLIP-seq
MIRT2355779	hsa-miR-26a	CLIP-seq
MIRT2355780	hsa-miR-26b	CLIP-seq
MIRT1449862	hsa-miR-28-5p	CLIP-seq
MIRT1449863	hsa-miR-3065-5p	CLIP-seq
MIRT1449864	hsa-miR-3122	CLIP-seq
MIRT2649297	hsa-miR-3127-3p	CLIP-seq
MIRT1449865	hsa-miR-3132	CLIP-seq
MIRT1449866	hsa-miR-3139	CLIP-seq
MIRT2462210	hsa-miR-3149	CLIP-seq
MIRT1449868	hsa-miR-3160-3p	CLIP-seq
MIRT1449869	hsa-miR-3168	CLIP-seq
MIRT2649300	hsa-miR-3189-5p	CLIP-seq
MIRT1449870	hsa-miR-3192	CLIP-seq
MIRT1449871	hsa-miR-32	CLIP-seq
MIRT1449872	hsa-miR-339-5p	CLIP-seq
MIRT1449874	hsa-miR-3612	CLIP-seq
MIRT2134439	hsa-miR-3613-3p	CLIP-seq
MIRT2649301	hsa-miR-3619-5p	CLIP-seq
MIRT1449875	hsa-miR-3622a-3p	CLIP-seq
MIRT2134440	hsa-miR-3622a-5p	CLIP-seq
MIRT1449876	hsa-miR-3622b-3p	CLIP-seq
MIRT1449877	hsa-miR-363	CLIP-seq
MIRT1449878	hsa-miR-367	CLIP-seq
MIRT1449879	hsa-miR-3689a-3p	CLIP-seq
MIRT1449880	hsa-miR-3689c	CLIP-seq
MIRT2649302	hsa-miR-371-5p	CLIP-seq
MIRT2134442	hsa-miR-371b-5p	CLIP-seq
MIRT1449881	hsa-miR-3913-5p	CLIP-seq
MIRT2462212	hsa-miR-411	CLIP-seq
MIRT1449883	hsa-miR-421	CLIP-seq
MIRT1449884	hsa-miR-4257	CLIP-seq
MIRT2134445	hsa-miR-4269	CLIP-seq
MIRT2649303	hsa-miR-4274	CLIP-seq
MIRT2649304	hsa-miR-4291	CLIP-seq
MIRT1449885	hsa-miR-4293	CLIP-seq
MIRT1449886	hsa-miR-4325	CLIP-seq
MIRT1449888	hsa-miR-4421	CLIP-seq
MIRT1449889	hsa-miR-4433	CLIP-seq
MIRT1449890	hsa-miR-4459	CLIP-seq
MIRT2134447	hsa-miR-4486	CLIP-seq
MIRT1449892	hsa-miR-4487	CLIP-seq
MIRT2649306	hsa-miR-4672	CLIP-seq
MIRT2462215	hsa-miR-4684-5p	CLIP-seq
MIRT2134451	hsa-miR-4715-3p	CLIP-seq
MIRT1449894	hsa-miR-4722-5p	CLIP-seq
MIRT2649307	hsa-miR-4726-3p	CLIP-seq
MIRT1449896	hsa-miR-4728-5p	CLIP-seq
MIRT2134452	hsa-miR-4735-5p	CLIP-seq
MIRT2649308	hsa-miR-4758-3p	CLIP-seq
MIRT1449897	hsa-miR-4768-3p	CLIP-seq
MIRT2134454	hsa-miR-4775	CLIP-seq
MIRT2134455	hsa-miR-4794	CLIP-seq
MIRT1449899	hsa-miR-4799-5p	CLIP-seq
MIRT2462217	hsa-miR-483-5p	CLIP-seq
MIRT1449901	hsa-miR-490-3p	CLIP-seq
MIRT1449903	hsa-miR-508-5p	CLIP-seq
MIRT1449906	hsa-miR-544b	CLIP-seq
MIRT2462218	hsa-miR-548c-3p	CLIP-seq
MIRT1449908	hsa-miR-558	CLIP-seq
MIRT2134459	hsa-miR-585	CLIP-seq
MIRT2462219	hsa-miR-590-3p	CLIP-seq
MIRT2462220	hsa-miR-593	CLIP-seq
MIRT1449909	hsa-miR-650	CLIP-seq
MIRT1449910	hsa-miR-708	CLIP-seq
MIRT2649310	hsa-miR-761	CLIP-seq
MIRT2649311	hsa-miR-922	CLIP-seq
MIRT1449913	hsa-miR-92a	CLIP-seq
MIRT1449914	hsa-miR-92b	CLIP-seq
MIRT1449915	hsa-miR-940	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
SP1	Unknown	20350137
SP3	Unknown	20350137

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	8316220
GO:0006805	Process	Xenobiotic metabolic process	IDA	657528, 18484748
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0008119	Function	Thiopurine S-methyltransferase activity	IBA
GO:0008119	Function	Thiopurine S-methyltransferase activity	IDA	657528, 18484748
GO:0008119	Function	Thiopurine S-methyltransferase activity	IEA
GO:0008119	Function	Thiopurine S-methyltransferase activity	TAS	8316220
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008757	Function	S-adenosylmethionine-dependent methyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0032259	Process	Methylation	IEA
GO:0032259	Process	Methylation	TAS
GO:0042178	Process	Xenobiotic catabolic process	TAS
GO:1904047	Function	S-adenosyl-L-methionine binding	IDA	657528, 18484748

MIM	HGNC	e!Ensembl
187680	12014	ENSG00000137364

P51580

Protein name

Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase)

Protein function

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed

PDB

2BZG , 2H11

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05724	TPMT	24 → 245	Thiopurine S-methyltransferase (TPMT)	Family

Sequence

MDGTRTSLDIEEYSDTEVQKNQVLTLEEWQDKWVNGKTAFHQEQGHQLLKKHLDTFLKGK
SGLRVFFPLCGKAVEMKWFADRGHSVVGVEISELGIQEFFTEQNLSYSEEPITEIPGTKV
FKSSSGNISLYCCSIFDLPRTNIGKFDMIWDRGALVAINPGDRKCYADTMFSLLGKKFQY
LLCVLSYDPTKHPGPPFYVPHAEIERLFGKICNIRCLEKVDAFEERHKSWGIDCLFEKLY
LLTEK

Sequence length

245

Interactions

View interactions

	KEGG		Reactome
	Drug metabolism - other enzymes		Methylation Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTISM SPECTRUM DISORDER	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Azathioprine response	drug response; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Chronic lymphocytic leukemia/small lymphocytic lymphoma	drug response	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUTROPENIA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thiopurine response	drug response	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
THIOPURINE S METHYLTRANFERASE DEFICIENCY	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thiopurine S-methyltransferase deficiency	drug response; Benign; Likely benign; other; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TPMT-related disorder	drug response; Likely benign; Benign; other	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (91)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
6 alpha mercaptopurine sensitivity	6 Alpha Mercaptopurine Sensitivity	CTD_human_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute leukemia	Leukemia	BEFREE	12142782, 23407052, 25347948, 9763570		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	10354134, 10376773, 10491537, 11681411, 12021625, 12142782, 15737567, 15784872, 16886902, 16966276, 17015055, 17617792, 18021342, 18385010, 18662289 View all (40 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute Promyelocytic Leukemia	Promyelocytic Leukemia	BEFREE	25791511		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	11681411, 15784872, 16886902, 16966276, 18385010, 18685564, 18987654, 19034904, 20021291, 20153897, 21344614, 21400026, 22009189, 22838948, 22846425 View all (13 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Agranulocytosis	Agranulocytosis	BEFREE	10798786, 19214663		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alopecia	Alopecia	BEFREE	24322830		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia	Anemia	BEFREE	20595409		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia Iron Deficiency	Iron deficiency anemia	Pubtator	24385893	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	30055072		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthralgia	Arthralgia	Pubtator	21961091	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Chronic Hepatitis	Autoimmune hepatitis	BEFREE	12217596, 16876902, 17241387, 31024313		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune disease	Pubtator	15802809, 23377985, 26213853	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	19473575, 23377985, 23398787, 26633017, 27665263, 28507448, 29264794, 30214603, 30451390		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bone Marrow Diseases	Bone marrow diseases	Pubtator	23962279	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain Neoplasms	BEFREE	10764140, 19535798		★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain neoplasms	Pubtator	19535798	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	30055072	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Celiac Disease	Celiac disease	BEFREE	31640999		★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	10764140, 11681411, 12142782, 15784872, 16886902, 16966276, 17164697, 17617792, 18385010, 18685564, 18987654, 19034904, 19535798, 20021291, 20153897 View all (26 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cirrhosis	Cirrhosis	BEFREE	31024313		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	27703193, 29491687, 30452647	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	8316220		★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	10833476, 12192200, 12492733, 14531535, 16181376, 16431304, 17304143, 19356188, 22741564, 23553048, 27604507, 29206869		★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	27703193, 29206869, 29491687, 32372428	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cyclic neutropenia	Cyclic neutropenia	Pubtator	10628931, 15349717, 28914446, 34425754	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatologic disorders	Dermatologic Disorders	BEFREE	19663853		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	24385893	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diffuse alveolar hemorrhage	Diffuse alveolar hemorrhage	BEFREE	17978158		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dihydropyrimidine Dehydrogenase Deficiency	Dihydropyrimidine dehydrogenase deficiency	Pubtator	32973300	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastrointestinal Diseases	Gastrointestinal disease	Pubtator	22846425	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hamartoma Syndrome, Multiple	Hamartoma	BEFREE	10833476, 27082580		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hearing Loss	Hearing loss	Pubtator	23588304	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Diseases	Hematologic disease	Pubtator	10354134, 25441457, 32611418, 33958640, 36707393, 9384462	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic Neoplasms	BEFREE	19034904, 24643197		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic neoplasm	Pubtator	19034904, 8644731	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematological Disease	Hematological Disease	BEFREE	27665263		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemoglobin H Disease	Hemoglobin H Disease	BEFREE	28296824		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemorrhage	Hemorrhage	Pubtator	17978158	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatic Veno Occlusive Disease	Hepatic veno occlusive disease	Pubtator	33714975	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatic Veno-Occlusive Disease	Hepatic veno-occlusive disease-immunodeficiency syndrome	BEFREE	17015055, 24737678		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatitis Autoimmune	Autoimmune hepatitis	Pubtator	33846471	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Pulmonary Fibrosis	BEFREE	20066544		★★★★★ ★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune system disease	Pubtator	23407052	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune System Diseases	BEFREE	29327413, 31651720		★★★★★ ★☆☆☆☆ Found in Text Mining only
Immunologic Deficiency Syndromes	Immunologic Deficiency Syndromes	BEFREE	28961694		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	10461478, 12021625, 12172211, 12269967, 12940924, 14656901, 15352906, 16202677, 16431304, 16543290, 16611274, 16773681, 16918876, 16961737, 17065060 View all (41 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	16543290, 18482735, 18827410, 23407052, 24142665, 24696613, 25048487, 26213853, 27307154, 28843236, 28914446, 29491687, 30698675, 34521801, 36344599	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	LHGDN	16773681, 17065060, 18600549		★★★★★ ★☆☆☆☆ Found in Text Mining only
Irritable Bowel Syndrome	Irritable Bowel Syndrome	BEFREE	21723857, 28081040, 30451123		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	15802809, 18482735, 27564568, 30325120, 36344599, 7703493, 9763570	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	22846425, 23398787, 23962279, 27307154, 27564568, 31651720, 3467886		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	19535798, 23407052, 30325120, 9763570	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	10764140, 19535798, 25000470, 30214603, 9763570		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukopenia	Leukopenia	BEFREE	12192200, 15167634, 15352906, 16044099, 16166171, 16175140, 16272700, 16431304, 16898847, 17164697, 18601797, 18662289, 19682195, 20066544, 20136357 View all (29 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukopenia	Leukopenia	CTD_human_DG	18662289, 22535280, 25108385		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver Cirrhosis	BEFREE	31024313		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	16272700	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	10461478, 16272700, 16396707, 18250137, 24322830, 29264794, 29441893		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoid leukemia	Lymphoid leukemia	BEFREE	11681411		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	10679940, 14576848, 16143001, 16815558, 19034904, 19535798, 23820299, 25000470, 25551397, 27577869, 30055072, 30328952		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	CGI_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	16459728		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	LHGDN	16459728		★★★★★ ★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	25000470		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuromyelitis Optica	Neuromyelitis Optica	BEFREE	29191122		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neutropenia	Neutropenia	BEFREE	16898847, 18601797, 18662289, 21692613, 31635813		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neutropenia	Neutropenia	Pubtator	17617792, 20037211, 25347948, 32611418	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neutropenia	Neutropenia	CTD_human_DG	18662289		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Oral Ulcer	Oral Ulcer	BEFREE	30002211		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatitis	Pancreatitis	BEFREE	20593505, 25799415		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancytopenia	Pancytopenia	BEFREE	12172211, 25791511, 30002211, 31464791, 9336428		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	10491537, 11681411, 12021625, 12142782, 16886902, 17015055, 17617792, 19057372, 19663675, 20153897, 21319286, 21344614, 21400026, 22009189, 23065291 View all (9 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	LHGDN	12142782, 15784872, 17617792, 19057372		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	GWASCAT_DG	27564568, 30201983		★★★★★ ★☆☆☆☆ Found in Text Mining only
Primary biliary cirrhosis	Biliary Cirrhosis	BEFREE	17241387		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	12509611, 16438485, 23398787, 29264794		★★★★★ ★☆☆☆☆ Found in Text Mining only
Scleroderma Systemic	Systemic sclerosis	Pubtator	37239884	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sepsis	Sepsis	Pubtator	19223932	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Spondylarthritis	Spondyloarthritis	BEFREE	9336428		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	35421138	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thiopurine S methyltranferase deficiency	Thiopurine Methyltransferase Deficiency	BEFREE	10764140, 10833476, 11304783, 12172211, 14967158, 16724002, 16898847, 16954954, 17241387, 19034904, 22972540, 23962279, 27307154, 29425801, 31464791		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thiopurine S methyltranferase deficiency	Thiopurine s-methyltransferase deficiency	Pubtator	10997970, 23252704, 27307154, 30806694, 32973300, 8644731	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thiopurine S methyltranferase deficiency	Thiopurine s-methyltransferase deficiency	Pubtator	19034904	Stimulate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thiopurine S methyltranferase deficiency	Thiopurine s-methyltransferase deficiency	Pubtator	23252704, 27307154, 7703493	Inhibit	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thiopurine S methyltranferase deficiency	Thiopurine Methyltransferase Deficiency	GENOMICS_ENGLAND_DG	27604308		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thiopurine S methyltranferase deficiency	Thiopurine Methyltransferase Deficiency	CTD_human_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thrombocytopenia	Thrombocytopenia	Pubtator	25347948	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	11007234, 16431304, 22147254, 27703193, 30452647, 30551694		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uremia	Uremia	BEFREE	11417444		★★★★★ ★☆☆☆☆ Found in Text Mining only
Vasculitis	Vasculitis	BEFREE	29630648		★★★★★ ★☆☆☆☆ Found in Text Mining only

TPMT (thiopurine S-methyltransferase)