TOP1 (DNA topoisomerase I)

Gene

• Entrez ID: 7150
• Gene name: DNA topoisomerase I
• Gene symbol: TOP1
• Synonyms (NCBI Gene): TOPI
• Chromosome: 20
• Chromosome location: 20q12
• Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one a

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024385	hsa-miR-215-5p	Microarray	19074876
MIRT026200	hsa-miR-192-5p	Microarray	19074876
MIRT028857	hsa-miR-26b-5p	Microarray	19088304
MIRT030382	hsa-miR-24-3p	qRT-PCR;Microarray	19748357
MIRT044929	hsa-miR-186-5p	CLASH	23622248
MIRT042230	hsa-miR-484	CLASH	23622248
MIRT437443	hsa-miR-23a-3p	Luciferase reporter assay, qRT-PCR, Western blot	24103454
MIRT437443	hsa-miR-23a-3p	Luciferase reporter assay, qRT-PCR, Western blot	24103454
MIRT437443	hsa-miR-23a-3p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	23158364
MIRT437443	hsa-miR-23a-3p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	23158364
MIRT153406	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT153406	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT733642	hsa-miR-382-5p	qRT-PCR, Western blotting	34002668
MIRT755616	mmu-miR-92a-3p	qRT-PCR, in vitro cullelar assays, CLIP-seq	37094168
MIRT1447045	hsa-miR-101	CLIP-seq
MIRT1447046	hsa-miR-1197	CLIP-seq
MIRT1447047	hsa-miR-1208	CLIP-seq
MIRT1447048	hsa-miR-1224-5p	CLIP-seq
MIRT1447049	hsa-miR-1238	CLIP-seq
MIRT1447050	hsa-miR-1249	CLIP-seq
MIRT1447051	hsa-miR-1254	CLIP-seq
MIRT1447052	hsa-miR-129-5p	CLIP-seq
MIRT1447053	hsa-miR-1297	CLIP-seq
MIRT1447054	hsa-miR-1323	CLIP-seq
MIRT1447055	hsa-miR-139-5p	CLIP-seq
MIRT1447056	hsa-miR-141	CLIP-seq
MIRT1447057	hsa-miR-144	CLIP-seq
MIRT1447058	hsa-miR-149	CLIP-seq
MIRT1447059	hsa-miR-153	CLIP-seq
MIRT1447060	hsa-miR-192	CLIP-seq
MIRT1447061	hsa-miR-200a	CLIP-seq
MIRT1447062	hsa-miR-205	CLIP-seq
MIRT1447063	hsa-miR-2053	CLIP-seq
MIRT1447064	hsa-miR-208a	CLIP-seq
MIRT1447065	hsa-miR-208b	CLIP-seq
MIRT1447066	hsa-miR-215	CLIP-seq
MIRT1447067	hsa-miR-23a	CLIP-seq
MIRT1447068	hsa-miR-23b	CLIP-seq
MIRT1447069	hsa-miR-23c	CLIP-seq
MIRT1447070	hsa-miR-24	CLIP-seq
MIRT1447071	hsa-miR-2467-5p	CLIP-seq
MIRT1447072	hsa-miR-26a	CLIP-seq
MIRT1447073	hsa-miR-26b	CLIP-seq
MIRT1447074	hsa-miR-27a	CLIP-seq
MIRT1447075	hsa-miR-27b	CLIP-seq
MIRT1447076	hsa-miR-296-3p	CLIP-seq
MIRT1447077	hsa-miR-300	CLIP-seq
MIRT1447078	hsa-miR-3116	CLIP-seq
MIRT1447079	hsa-miR-3121-3p	CLIP-seq
MIRT1447080	hsa-miR-3123	CLIP-seq
MIRT1447081	hsa-miR-3124-3p	CLIP-seq
MIRT1447082	hsa-miR-3140-3p	CLIP-seq
MIRT1447083	hsa-miR-3152-5p	CLIP-seq
MIRT1447084	hsa-miR-3153	CLIP-seq
MIRT1447085	hsa-miR-3163	CLIP-seq
MIRT1447086	hsa-miR-3183	CLIP-seq
MIRT1447087	hsa-miR-3188	CLIP-seq
MIRT1447088	hsa-miR-3200-5p	CLIP-seq
MIRT1447089	hsa-miR-3201	CLIP-seq
MIRT1447090	hsa-miR-338-5p	CLIP-seq
MIRT1447091	hsa-miR-3529	CLIP-seq
MIRT1447092	hsa-miR-3610	CLIP-seq
MIRT1447093	hsa-miR-3613-3p	CLIP-seq
MIRT1447094	hsa-miR-361-3p	CLIP-seq
MIRT1447095	hsa-miR-3616-3p	CLIP-seq
MIRT1447096	hsa-miR-3619-3p	CLIP-seq
MIRT1447097	hsa-miR-3622a-5p	CLIP-seq
MIRT1447098	hsa-miR-362-5p	CLIP-seq
MIRT1447099	hsa-miR-3647-3p	CLIP-seq
MIRT1447100	hsa-miR-3661	CLIP-seq
MIRT1447101	hsa-miR-3672	CLIP-seq
MIRT1447102	hsa-miR-369-3p	CLIP-seq
MIRT1447103	hsa-miR-374a	CLIP-seq
MIRT1447104	hsa-miR-374b	CLIP-seq
MIRT1447105	hsa-miR-379	CLIP-seq
MIRT1447106	hsa-miR-381	CLIP-seq
MIRT1447107	hsa-miR-382	CLIP-seq
MIRT1447108	hsa-miR-3915	CLIP-seq
MIRT1447109	hsa-miR-3920	CLIP-seq
MIRT1447110	hsa-miR-3925-3p	CLIP-seq
MIRT1447111	hsa-miR-3928	CLIP-seq
MIRT1447112	hsa-miR-3934	CLIP-seq
MIRT1447113	hsa-miR-3975	CLIP-seq
MIRT1447114	hsa-miR-3977	CLIP-seq
MIRT1447115	hsa-miR-412	CLIP-seq
MIRT1447116	hsa-miR-4269	CLIP-seq
MIRT1447117	hsa-miR-4282	CLIP-seq
MIRT1447118	hsa-miR-4284	CLIP-seq
MIRT1447119	hsa-miR-4287	CLIP-seq
MIRT1447120	hsa-miR-4316	CLIP-seq
MIRT1447121	hsa-miR-4326	CLIP-seq
MIRT1447122	hsa-miR-4328	CLIP-seq
MIRT1447123	hsa-miR-433	CLIP-seq
MIRT1447124	hsa-miR-4420	CLIP-seq
MIRT1447125	hsa-miR-4431	CLIP-seq
MIRT1447126	hsa-miR-4432	CLIP-seq
MIRT1447127	hsa-miR-4436b-5p	CLIP-seq
MIRT1447128	hsa-miR-4446-5p	CLIP-seq
MIRT1447129	hsa-miR-4451	CLIP-seq
MIRT1447130	hsa-miR-4463	CLIP-seq
MIRT1447131	hsa-miR-4465	CLIP-seq
MIRT1447132	hsa-miR-4469	CLIP-seq
MIRT1447133	hsa-miR-448	CLIP-seq
MIRT1447134	hsa-miR-4520b-3p	CLIP-seq
MIRT1447135	hsa-miR-4528	CLIP-seq
MIRT1447136	hsa-miR-4529-3p	CLIP-seq
MIRT1447137	hsa-miR-4535	CLIP-seq
MIRT1447138	hsa-miR-4539	CLIP-seq
MIRT1447139	hsa-miR-4645-5p	CLIP-seq
MIRT1447140	hsa-miR-4650-3p	CLIP-seq
MIRT1447141	hsa-miR-4652-3p	CLIP-seq
MIRT1447142	hsa-miR-4666-3p	CLIP-seq
MIRT1447143	hsa-miR-4668-3p	CLIP-seq
MIRT1447144	hsa-miR-4668-5p	CLIP-seq
MIRT1447145	hsa-miR-4673	CLIP-seq
MIRT1447146	hsa-miR-4677-3p	CLIP-seq
MIRT1447147	hsa-miR-4679	CLIP-seq
MIRT1447148	hsa-miR-4680-5p	CLIP-seq
MIRT1447149	hsa-miR-4685-3p	CLIP-seq
MIRT1447150	hsa-miR-4689	CLIP-seq
MIRT1447151	hsa-miR-4704-3p	CLIP-seq
MIRT1447152	hsa-miR-4723-3p	CLIP-seq
MIRT1447153	hsa-miR-4738-3p	CLIP-seq
MIRT1447154	hsa-miR-4760-3p	CLIP-seq
MIRT1447155	hsa-miR-4760-5p	CLIP-seq
MIRT1447156	hsa-miR-4766-5p	CLIP-seq
MIRT1447157	hsa-miR-4774-3p	CLIP-seq
MIRT1447158	hsa-miR-4776-5p	CLIP-seq
MIRT1447159	hsa-miR-4789-5p	CLIP-seq
MIRT1447160	hsa-miR-4791	CLIP-seq
MIRT1447161	hsa-miR-485-3p	CLIP-seq
MIRT1447162	hsa-miR-485-5p	CLIP-seq
MIRT1447163	hsa-miR-487a	CLIP-seq
MIRT1447164	hsa-miR-494	CLIP-seq
MIRT1447165	hsa-miR-498	CLIP-seq
MIRT1447166	hsa-miR-499-5p	CLIP-seq
MIRT1447167	hsa-miR-500b	CLIP-seq
MIRT1447168	hsa-miR-501-5p	CLIP-seq
MIRT1447169	hsa-miR-513a-5p	CLIP-seq
MIRT1447170	hsa-miR-522	CLIP-seq
MIRT1447171	hsa-miR-526b	CLIP-seq
MIRT1447172	hsa-miR-548o	CLIP-seq
MIRT1447173	hsa-miR-548p	CLIP-seq
MIRT1447174	hsa-miR-549	CLIP-seq
MIRT1447175	hsa-miR-552	CLIP-seq
MIRT1447176	hsa-miR-582-5p	CLIP-seq
MIRT1447177	hsa-miR-629	CLIP-seq
MIRT1447178	hsa-miR-631	CLIP-seq
MIRT1447179	hsa-miR-640	CLIP-seq
MIRT1447180	hsa-miR-661	CLIP-seq
MIRT1447181	hsa-miR-764	CLIP-seq
MIRT1447182	hsa-miR-766	CLIP-seq
MIRT1447183	hsa-miR-873	CLIP-seq
MIRT1447184	hsa-miR-885-5p	CLIP-seq
MIRT1447185	hsa-miR-889	CLIP-seq
MIRT1447186	hsa-miR-892b	CLIP-seq
MIRT1447102	hsa-miR-369-3p	CLIP-seq
MIRT1447103	hsa-miR-374a	CLIP-seq
MIRT1447104	hsa-miR-374b	CLIP-seq
MIRT1447110	hsa-miR-3925-3p	CLIP-seq
MIRT1447119	hsa-miR-4287	CLIP-seq
MIRT1447132	hsa-miR-4469	CLIP-seq
MIRT1447149	hsa-miR-4685-3p	CLIP-seq
MIRT1447182	hsa-miR-766	CLIP-seq
MIRT1447185	hsa-miR-889	CLIP-seq
MIRT1447048	hsa-miR-1224-5p	CLIP-seq
MIRT1447050	hsa-miR-1249	CLIP-seq
MIRT1447051	hsa-miR-1254	CLIP-seq
MIRT1447052	hsa-miR-129-5p	CLIP-seq
MIRT1447053	hsa-miR-1297	CLIP-seq
MIRT1447055	hsa-miR-139-5p	CLIP-seq
MIRT2133684	hsa-miR-1470	CLIP-seq
MIRT1447062	hsa-miR-205	CLIP-seq
MIRT1447063	hsa-miR-2053	CLIP-seq
MIRT1447064	hsa-miR-208a	CLIP-seq
MIRT1447065	hsa-miR-208b	CLIP-seq
MIRT1447070	hsa-miR-24	CLIP-seq
MIRT1447071	hsa-miR-2467-5p	CLIP-seq
MIRT1447072	hsa-miR-26a	CLIP-seq
MIRT1447073	hsa-miR-26b	CLIP-seq
MIRT2133685	hsa-miR-299-3p	CLIP-seq
MIRT1447078	hsa-miR-3116	CLIP-seq
MIRT1447079	hsa-miR-3121-3p	CLIP-seq
MIRT2133686	hsa-miR-3130-3p	CLIP-seq
MIRT1447082	hsa-miR-3140-3p	CLIP-seq
MIRT1447083	hsa-miR-3152-5p	CLIP-seq
MIRT1447084	hsa-miR-3153	CLIP-seq
MIRT1447086	hsa-miR-3183	CLIP-seq
MIRT1447087	hsa-miR-3188	CLIP-seq
MIRT1447091	hsa-miR-3529	CLIP-seq
MIRT1447094	hsa-miR-361-3p	CLIP-seq
MIRT1447095	hsa-miR-3616-3p	CLIP-seq
MIRT1447096	hsa-miR-3619-3p	CLIP-seq
MIRT1447097	hsa-miR-3622a-5p	CLIP-seq
MIRT1447098	hsa-miR-362-5p	CLIP-seq
MIRT1447099	hsa-miR-3647-3p	CLIP-seq
MIRT1447102	hsa-miR-369-3p	CLIP-seq
MIRT1447103	hsa-miR-374a	CLIP-seq
MIRT1447104	hsa-miR-374b	CLIP-seq
MIRT1447105	hsa-miR-379	CLIP-seq
MIRT1447108	hsa-miR-3915	CLIP-seq
MIRT1447109	hsa-miR-3920	CLIP-seq
MIRT1447110	hsa-miR-3925-3p	CLIP-seq
MIRT1447111	hsa-miR-3928	CLIP-seq
MIRT1447112	hsa-miR-3934	CLIP-seq
MIRT1447113	hsa-miR-3975	CLIP-seq
MIRT2133687	hsa-miR-3976	CLIP-seq
MIRT1447114	hsa-miR-3977	CLIP-seq
MIRT1447116	hsa-miR-4269	CLIP-seq
MIRT1447119	hsa-miR-4287	CLIP-seq
MIRT2133688	hsa-miR-4307	CLIP-seq
MIRT1447120	hsa-miR-4316	CLIP-seq
MIRT1447122	hsa-miR-4328	CLIP-seq
MIRT1447123	hsa-miR-433	CLIP-seq
MIRT1447124	hsa-miR-4420	CLIP-seq
MIRT1447126	hsa-miR-4432	CLIP-seq
MIRT1447128	hsa-miR-4446-5p	CLIP-seq
MIRT1447129	hsa-miR-4451	CLIP-seq
MIRT1447131	hsa-miR-4465	CLIP-seq
MIRT1447132	hsa-miR-4469	CLIP-seq
MIRT1447134	hsa-miR-4520b-3p	CLIP-seq
MIRT2133689	hsa-miR-4522	CLIP-seq
MIRT1447135	hsa-miR-4528	CLIP-seq
MIRT1447136	hsa-miR-4529-3p	CLIP-seq
MIRT1447137	hsa-miR-4535	CLIP-seq
MIRT1447139	hsa-miR-4645-5p	CLIP-seq
MIRT2133690	hsa-miR-4648	CLIP-seq
MIRT1447140	hsa-miR-4650-3p	CLIP-seq
MIRT1447141	hsa-miR-4652-3p	CLIP-seq
MIRT2133691	hsa-miR-4654	CLIP-seq
MIRT2133692	hsa-miR-4667-3p	CLIP-seq
MIRT1447144	hsa-miR-4668-5p	CLIP-seq
MIRT1447145	hsa-miR-4673	CLIP-seq
MIRT1447146	hsa-miR-4677-3p	CLIP-seq
MIRT1447147	hsa-miR-4679	CLIP-seq
MIRT1447149	hsa-miR-4685-3p	CLIP-seq
MIRT1447150	hsa-miR-4689	CLIP-seq
MIRT2133693	hsa-miR-4693-3p	CLIP-seq
MIRT2133694	hsa-miR-4694-3p	CLIP-seq
MIRT1447151	hsa-miR-4704-3p	CLIP-seq
MIRT1447152	hsa-miR-4723-3p	CLIP-seq
MIRT1447154	hsa-miR-4760-3p	CLIP-seq
MIRT1447155	hsa-miR-4760-5p	CLIP-seq
MIRT2133695	hsa-miR-4769-5p	CLIP-seq
MIRT1447157	hsa-miR-4774-3p	CLIP-seq
MIRT1447158	hsa-miR-4776-5p	CLIP-seq
MIRT2133696	hsa-miR-4793-3p	CLIP-seq
MIRT1447162	hsa-miR-485-5p	CLIP-seq
MIRT1447164	hsa-miR-494	CLIP-seq
MIRT1447166	hsa-miR-499-5p	CLIP-seq
MIRT1447167	hsa-miR-500b	CLIP-seq
MIRT1447168	hsa-miR-501-5p	CLIP-seq
MIRT1447170	hsa-miR-522	CLIP-seq
MIRT2133697	hsa-miR-548c-3p	CLIP-seq
MIRT1447175	hsa-miR-552	CLIP-seq
MIRT2133698	hsa-miR-576-3p	CLIP-seq
MIRT1447176	hsa-miR-582-5p	CLIP-seq
MIRT2133699	hsa-miR-603	CLIP-seq
MIRT1447179	hsa-miR-640	CLIP-seq
MIRT1447180	hsa-miR-661	CLIP-seq
MIRT1447182	hsa-miR-766	CLIP-seq
MIRT1447183	hsa-miR-873	CLIP-seq
MIRT1447185	hsa-miR-889	CLIP-seq
MIRT1447053	hsa-miR-1297	CLIP-seq
MIRT1447054	hsa-miR-1323	CLIP-seq
MIRT1447058	hsa-miR-149	CLIP-seq
MIRT1447064	hsa-miR-208a	CLIP-seq
MIRT1447065	hsa-miR-208b	CLIP-seq
MIRT1447070	hsa-miR-24	CLIP-seq
MIRT1447072	hsa-miR-26a	CLIP-seq
MIRT1447073	hsa-miR-26b	CLIP-seq
MIRT1447082	hsa-miR-3140-3p	CLIP-seq
MIRT1447086	hsa-miR-3183	CLIP-seq
MIRT1447094	hsa-miR-361-3p	CLIP-seq
MIRT1447099	hsa-miR-3647-3p	CLIP-seq
MIRT1447102	hsa-miR-369-3p	CLIP-seq
MIRT1447103	hsa-miR-374a	CLIP-seq
MIRT1447104	hsa-miR-374b	CLIP-seq
MIRT1447109	hsa-miR-3920	CLIP-seq
MIRT1447110	hsa-miR-3925-3p	CLIP-seq
MIRT1447112	hsa-miR-3934	CLIP-seq
MIRT1447114	hsa-miR-3977	CLIP-seq
MIRT1447115	hsa-miR-412	CLIP-seq
MIRT1447116	hsa-miR-4269	CLIP-seq
MIRT1447118	hsa-miR-4284	CLIP-seq
MIRT1447119	hsa-miR-4287	CLIP-seq
MIRT1447124	hsa-miR-4420	CLIP-seq
MIRT1447126	hsa-miR-4432	CLIP-seq
MIRT1447131	hsa-miR-4465	CLIP-seq
MIRT1447132	hsa-miR-4469	CLIP-seq
MIRT1447139	hsa-miR-4645-5p	CLIP-seq
MIRT1447141	hsa-miR-4652-3p	CLIP-seq
MIRT1447145	hsa-miR-4673	CLIP-seq
MIRT1447146	hsa-miR-4677-3p	CLIP-seq
MIRT1447147	hsa-miR-4679	CLIP-seq
MIRT1447149	hsa-miR-4685-3p	CLIP-seq
MIRT1447151	hsa-miR-4704-3p	CLIP-seq
MIRT1447152	hsa-miR-4723-3p	CLIP-seq
MIRT2354861	hsa-miR-4781-3p	CLIP-seq
MIRT1447161	hsa-miR-485-3p	CLIP-seq
MIRT1447163	hsa-miR-487a	CLIP-seq
MIRT1447166	hsa-miR-499-5p	CLIP-seq
MIRT1447170	hsa-miR-522	CLIP-seq
MIRT1447172	hsa-miR-548o	CLIP-seq
MIRT1447175	hsa-miR-552	CLIP-seq
MIRT2133699	hsa-miR-603	CLIP-seq
MIRT1447179	hsa-miR-640	CLIP-seq
MIRT1447182	hsa-miR-766	CLIP-seq
MIRT1447185	hsa-miR-889	CLIP-seq
MIRT1447186	hsa-miR-892b	CLIP-seq
MIRT1447053	hsa-miR-1297	CLIP-seq
MIRT1447072	hsa-miR-26a	CLIP-seq
MIRT1447073	hsa-miR-26b	CLIP-seq
MIRT2434290	hsa-miR-3129-3p	CLIP-seq
MIRT1447084	hsa-miR-3153	CLIP-seq
MIRT1447099	hsa-miR-3647-3p	CLIP-seq
MIRT1447114	hsa-miR-3977	CLIP-seq
MIRT1447131	hsa-miR-4465	CLIP-seq
MIRT1447144	hsa-miR-4668-5p	CLIP-seq
MIRT1447170	hsa-miR-522	CLIP-seq
MIRT2434291	hsa-miR-548a-3p	CLIP-seq
MIRT2434292	hsa-miR-548e	CLIP-seq
MIRT2434293	hsa-miR-548f	CLIP-seq
MIRT1447070	hsa-miR-24	CLIP-seq
MIRT2441478	hsa-miR-3157-3p	CLIP-seq
MIRT1447099	hsa-miR-3647-3p	CLIP-seq
MIRT1447102	hsa-miR-369-3p	CLIP-seq
MIRT1447103	hsa-miR-374a	CLIP-seq
MIRT1447104	hsa-miR-374b	CLIP-seq
MIRT1447110	hsa-miR-3925-3p	CLIP-seq
MIRT1447118	hsa-miR-4284	CLIP-seq
MIRT1447119	hsa-miR-4287	CLIP-seq
MIRT2441479	hsa-miR-4290	CLIP-seq
MIRT1447127	hsa-miR-4436b-5p	CLIP-seq
MIRT1447132	hsa-miR-4469	CLIP-seq
MIRT2441480	hsa-miR-4635	CLIP-seq
MIRT1447149	hsa-miR-4685-3p	CLIP-seq
MIRT2354861	hsa-miR-4781-3p	CLIP-seq
MIRT2441481	hsa-miR-548ac	CLIP-seq
MIRT2441482	hsa-miR-548ae	CLIP-seq
MIRT2441483	hsa-miR-548aj	CLIP-seq
MIRT2441484	hsa-miR-548am	CLIP-seq
MIRT2441485	hsa-miR-548d-3p	CLIP-seq
MIRT2441486	hsa-miR-548x	CLIP-seq
MIRT2441487	hsa-miR-548z	CLIP-seq
MIRT1447182	hsa-miR-766	CLIP-seq
MIRT2441488	hsa-miR-874	CLIP-seq
MIRT1447185	hsa-miR-889	CLIP-seq
MIRT2466256	hsa-miR-4670-3p	CLIP-seq
MIRT1447046	hsa-miR-1197	CLIP-seq
MIRT2648610	hsa-miR-1200	CLIP-seq
MIRT1447052	hsa-miR-129-5p	CLIP-seq
MIRT1447053	hsa-miR-1297	CLIP-seq
MIRT1447054	hsa-miR-1323	CLIP-seq
MIRT1447058	hsa-miR-149	CLIP-seq
MIRT2648611	hsa-miR-185	CLIP-seq
MIRT2648612	hsa-miR-203	CLIP-seq
MIRT1447063	hsa-miR-2053	CLIP-seq
MIRT1447064	hsa-miR-208a	CLIP-seq
MIRT1447065	hsa-miR-208b	CLIP-seq
MIRT1447067	hsa-miR-23a	CLIP-seq
MIRT1447068	hsa-miR-23b	CLIP-seq
MIRT1447069	hsa-miR-23c	CLIP-seq
MIRT1447070	hsa-miR-24	CLIP-seq
MIRT1447071	hsa-miR-2467-5p	CLIP-seq
MIRT1447072	hsa-miR-26a	CLIP-seq
MIRT1447073	hsa-miR-26b	CLIP-seq
MIRT1447076	hsa-miR-296-3p	CLIP-seq
MIRT1447077	hsa-miR-300	CLIP-seq
MIRT2434290	hsa-miR-3129-3p	CLIP-seq
MIRT2648613	hsa-miR-3134	CLIP-seq
MIRT2648614	hsa-miR-3140-5p	CLIP-seq
MIRT2441478	hsa-miR-3157-3p	CLIP-seq
MIRT1447085	hsa-miR-3163	CLIP-seq
MIRT1447086	hsa-miR-3183	CLIP-seq
MIRT1447087	hsa-miR-3188	CLIP-seq
MIRT1447088	hsa-miR-3200-5p	CLIP-seq
MIRT1447089	hsa-miR-3201	CLIP-seq
MIRT2648615	hsa-miR-3202	CLIP-seq
MIRT1447090	hsa-miR-338-5p	CLIP-seq
MIRT1447093	hsa-miR-3613-3p	CLIP-seq
MIRT1447094	hsa-miR-361-3p	CLIP-seq
MIRT1447095	hsa-miR-3616-3p	CLIP-seq
MIRT1447097	hsa-miR-3622a-5p	CLIP-seq
MIRT1447099	hsa-miR-3647-3p	CLIP-seq
MIRT1447102	hsa-miR-369-3p	CLIP-seq
MIRT1447103	hsa-miR-374a	CLIP-seq
MIRT1447104	hsa-miR-374b	CLIP-seq
MIRT2648616	hsa-miR-375	CLIP-seq
MIRT1447106	hsa-miR-381	CLIP-seq
MIRT1447107	hsa-miR-382	CLIP-seq
MIRT1447110	hsa-miR-3925-3p	CLIP-seq
MIRT1447113	hsa-miR-3975	CLIP-seq
MIRT1447115	hsa-miR-412	CLIP-seq
MIRT1447116	hsa-miR-4269	CLIP-seq
MIRT2648617	hsa-miR-4273	CLIP-seq
MIRT1447117	hsa-miR-4282	CLIP-seq
MIRT1447118	hsa-miR-4284	CLIP-seq
MIRT1447119	hsa-miR-4287	CLIP-seq
MIRT2441479	hsa-miR-4290	CLIP-seq
MIRT2648618	hsa-miR-4306	CLIP-seq
MIRT1447120	hsa-miR-4316	CLIP-seq
MIRT2648619	hsa-miR-4426	CLIP-seq
MIRT1447125	hsa-miR-4431	CLIP-seq
MIRT1447126	hsa-miR-4432	CLIP-seq
MIRT1447127	hsa-miR-4436b-5p	CLIP-seq
MIRT1447131	hsa-miR-4465	CLIP-seq
MIRT1447132	hsa-miR-4469	CLIP-seq
MIRT2441480	hsa-miR-4635	CLIP-seq
MIRT2648620	hsa-miR-4644	CLIP-seq
MIRT1447139	hsa-miR-4645-5p	CLIP-seq
MIRT2648621	hsa-miR-4647	CLIP-seq
MIRT2648622	hsa-miR-4662b	CLIP-seq
MIRT1447142	hsa-miR-4666-3p	CLIP-seq
MIRT1447143	hsa-miR-4668-3p	CLIP-seq
MIRT1447145	hsa-miR-4673	CLIP-seq
MIRT2648623	hsa-miR-4677-5p	CLIP-seq
MIRT1447149	hsa-miR-4685-3p	CLIP-seq
MIRT1447152	hsa-miR-4723-3p	CLIP-seq
MIRT1447153	hsa-miR-4738-3p	CLIP-seq
MIRT2648624	hsa-miR-4747-5p	CLIP-seq
MIRT1447156	hsa-miR-4766-5p	CLIP-seq
MIRT2648625	hsa-miR-4775	CLIP-seq
MIRT2354861	hsa-miR-4781-3p	CLIP-seq
MIRT1447159	hsa-miR-4789-5p	CLIP-seq
MIRT1447160	hsa-miR-4791	CLIP-seq
MIRT1447161	hsa-miR-485-3p	CLIP-seq
MIRT1447162	hsa-miR-485-5p	CLIP-seq
MIRT1447163	hsa-miR-487a	CLIP-seq
MIRT1447165	hsa-miR-498	CLIP-seq
MIRT1447166	hsa-miR-499-5p	CLIP-seq
MIRT2434291	hsa-miR-548a-3p	CLIP-seq
MIRT2441481	hsa-miR-548ac	CLIP-seq
MIRT2441482	hsa-miR-548ae	CLIP-seq
MIRT2441483	hsa-miR-548aj	CLIP-seq
MIRT2441484	hsa-miR-548am	CLIP-seq
MIRT2441485	hsa-miR-548d-3p	CLIP-seq
MIRT2434292	hsa-miR-548e	CLIP-seq
MIRT2434293	hsa-miR-548f	CLIP-seq
MIRT1447172	hsa-miR-548o	CLIP-seq
MIRT1447173	hsa-miR-548p	CLIP-seq
MIRT2441486	hsa-miR-548x	CLIP-seq
MIRT2441487	hsa-miR-548z	CLIP-seq
MIRT1447174	hsa-miR-549	CLIP-seq
MIRT1447175	hsa-miR-552	CLIP-seq
MIRT2648626	hsa-miR-590-3p	CLIP-seq
MIRT1447177	hsa-miR-629	CLIP-seq
MIRT2648627	hsa-miR-651	CLIP-seq
MIRT1447181	hsa-miR-764	CLIP-seq
MIRT1447182	hsa-miR-766	CLIP-seq
MIRT2441488	hsa-miR-874	CLIP-seq
MIRT1447185	hsa-miR-889	CLIP-seq
MIRT1447186	hsa-miR-892b	CLIP-seq
MIRT1447046	hsa-miR-1197	CLIP-seq
MIRT2648610	hsa-miR-1200	CLIP-seq
MIRT1447052	hsa-miR-129-5p	CLIP-seq
MIRT1447053	hsa-miR-1297	CLIP-seq
MIRT1447054	hsa-miR-1323	CLIP-seq
MIRT2648611	hsa-miR-185	CLIP-seq
MIRT2648612	hsa-miR-203	CLIP-seq
MIRT1447063	hsa-miR-2053	CLIP-seq
MIRT1447064	hsa-miR-208a	CLIP-seq
MIRT1447065	hsa-miR-208b	CLIP-seq
MIRT1447067	hsa-miR-23a	CLIP-seq
MIRT1447068	hsa-miR-23b	CLIP-seq
MIRT1447069	hsa-miR-23c	CLIP-seq
MIRT1447070	hsa-miR-24	CLIP-seq
MIRT1447071	hsa-miR-2467-5p	CLIP-seq
MIRT1447072	hsa-miR-26a	CLIP-seq
MIRT1447073	hsa-miR-26b	CLIP-seq
MIRT1447076	hsa-miR-296-3p	CLIP-seq
MIRT1447077	hsa-miR-300	CLIP-seq
MIRT2434290	hsa-miR-3129-3p	CLIP-seq
MIRT2648613	hsa-miR-3134	CLIP-seq
MIRT1447082	hsa-miR-3140-3p	CLIP-seq
MIRT2648614	hsa-miR-3140-5p	CLIP-seq
MIRT2441478	hsa-miR-3157-3p	CLIP-seq
MIRT1447085	hsa-miR-3163	CLIP-seq
MIRT1447086	hsa-miR-3183	CLIP-seq
MIRT1447087	hsa-miR-3188	CLIP-seq
MIRT1447088	hsa-miR-3200-5p	CLIP-seq
MIRT1447089	hsa-miR-3201	CLIP-seq
MIRT2648615	hsa-miR-3202	CLIP-seq
MIRT1447090	hsa-miR-338-5p	CLIP-seq
MIRT1447093	hsa-miR-3613-3p	CLIP-seq
MIRT1447094	hsa-miR-361-3p	CLIP-seq
MIRT1447095	hsa-miR-3616-3p	CLIP-seq
MIRT1447097	hsa-miR-3622a-5p	CLIP-seq
MIRT1447099	hsa-miR-3647-3p	CLIP-seq
MIRT1447102	hsa-miR-369-3p	CLIP-seq
MIRT1447103	hsa-miR-374a	CLIP-seq
MIRT1447104	hsa-miR-374b	CLIP-seq
MIRT2648616	hsa-miR-375	CLIP-seq
MIRT1447106	hsa-miR-381	CLIP-seq
MIRT1447107	hsa-miR-382	CLIP-seq
MIRT1447110	hsa-miR-3925-3p	CLIP-seq
MIRT1447113	hsa-miR-3975	CLIP-seq
MIRT1447115	hsa-miR-412	CLIP-seq
MIRT1447116	hsa-miR-4269	CLIP-seq
MIRT2648617	hsa-miR-4273	CLIP-seq
MIRT1447117	hsa-miR-4282	CLIP-seq
MIRT1447118	hsa-miR-4284	CLIP-seq
MIRT1447119	hsa-miR-4287	CLIP-seq
MIRT2441479	hsa-miR-4290	CLIP-seq
MIRT2648618	hsa-miR-4306	CLIP-seq
MIRT1447120	hsa-miR-4316	CLIP-seq
MIRT2648619	hsa-miR-4426	CLIP-seq
MIRT1447125	hsa-miR-4431	CLIP-seq
MIRT1447126	hsa-miR-4432	CLIP-seq
MIRT1447127	hsa-miR-4436b-5p	CLIP-seq
MIRT1447131	hsa-miR-4465	CLIP-seq
MIRT1447132	hsa-miR-4469	CLIP-seq
MIRT2441480	hsa-miR-4635	CLIP-seq
MIRT2648620	hsa-miR-4644	CLIP-seq
MIRT1447139	hsa-miR-4645-5p	CLIP-seq
MIRT2648621	hsa-miR-4647	CLIP-seq
MIRT2648622	hsa-miR-4662b	CLIP-seq
MIRT1447142	hsa-miR-4666-3p	CLIP-seq
MIRT1447143	hsa-miR-4668-3p	CLIP-seq
MIRT1447145	hsa-miR-4673	CLIP-seq
MIRT2648623	hsa-miR-4677-5p	CLIP-seq
MIRT1447149	hsa-miR-4685-3p	CLIP-seq
MIRT1447152	hsa-miR-4723-3p	CLIP-seq
MIRT1447153	hsa-miR-4738-3p	CLIP-seq
MIRT2648624	hsa-miR-4747-5p	CLIP-seq
MIRT1447156	hsa-miR-4766-5p	CLIP-seq
MIRT2648625	hsa-miR-4775	CLIP-seq
MIRT2354861	hsa-miR-4781-3p	CLIP-seq
MIRT1447159	hsa-miR-4789-5p	CLIP-seq
MIRT1447160	hsa-miR-4791	CLIP-seq
MIRT1447161	hsa-miR-485-3p	CLIP-seq
MIRT1447162	hsa-miR-485-5p	CLIP-seq
MIRT1447163	hsa-miR-487a	CLIP-seq
MIRT1447165	hsa-miR-498	CLIP-seq
MIRT1447166	hsa-miR-499-5p	CLIP-seq
MIRT2434291	hsa-miR-548a-3p	CLIP-seq
MIRT2441481	hsa-miR-548ac	CLIP-seq
MIRT2441482	hsa-miR-548ae	CLIP-seq
MIRT2441483	hsa-miR-548aj	CLIP-seq
MIRT2441484	hsa-miR-548am	CLIP-seq
MIRT2441485	hsa-miR-548d-3p	CLIP-seq
MIRT2434292	hsa-miR-548e	CLIP-seq
MIRT2434293	hsa-miR-548f	CLIP-seq
MIRT1447172	hsa-miR-548o	CLIP-seq
MIRT1447173	hsa-miR-548p	CLIP-seq
MIRT2441486	hsa-miR-548x	CLIP-seq
MIRT2441487	hsa-miR-548z	CLIP-seq
MIRT1447174	hsa-miR-549	CLIP-seq
MIRT1447175	hsa-miR-552	CLIP-seq
MIRT2648626	hsa-miR-590-3p	CLIP-seq
MIRT1447177	hsa-miR-629	CLIP-seq
MIRT1447181	hsa-miR-764	CLIP-seq
MIRT1447182	hsa-miR-766	CLIP-seq
MIRT2441488	hsa-miR-874	CLIP-seq
MIRT1447185	hsa-miR-889	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CEBPB	Unknown	8524227

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000228	Component	Nuclear chromosome	IDA	9049244
GO:0000932	Component	P-body	IDA	12878161
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	22904072
GO:0001650	Component	Fibrillar center	IDA
GO:0001650	Component	Fibrillar center	IEA
GO:0001651	Component	Dense fibrillar component	IEA
GO:0001673	Component	Male germ cell nucleus	IEA
GO:0003677	Function	DNA binding	EXP	11283003
GO:0003677	Function	DNA binding	IDA	17355975
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	IMP	10497031
GO:0003682	Function	Chromatin binding	IDA	9049244
GO:0003690	Function	Double-stranded DNA binding	IMP	8631794
GO:0003697	Function	Single-stranded DNA binding	IMP	8631794
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003916	Function	DNA topoisomerase activity	IEA
GO:0003917	Function	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IBA
GO:0003917	Function	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IDA	14594810
GO:0003917	Function	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IEA
GO:0003917	Function	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IMP	8567649, 8631793, 8631794, 9611241, 14654701, 17355975
GO:0004674	Function	Protein serine/threonine kinase activity	IMP	9611241
GO:0005515	Function	Protein binding	IPI	8567649, 10352183, 12878161, 15448168, 17234752, 17314511, 20195357, 23213405, 26030138, 29248492, 34591642
GO:0005524	Function	ATP binding	IMP	8631793, 9611241
GO:0005634	Component	Nucleus	HDA	16791210
GO:0005634	Component	Nucleus	IDA	9049244, 11016921
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	9049244
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	IMP	14654701
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	9049244
GO:0005730	Component	Nucleolus	IEA
GO:0005730	Component	Nucleolus	IMP	14654701
GO:0005737	Component	Cytoplasm	IEA
GO:0006260	Process	DNA replication	IBA
GO:0006260	Process	DNA replication	IEA
GO:0006265	Process	DNA topological change	IBA
GO:0006265	Process	DNA topological change	IDA	14594810
GO:0006265	Process	DNA topological change	IEA
GO:0006265	Process	DNA topological change	IEA
GO:0006265	Process	DNA topological change	IMP	8567649, 8631793, 8631794, 9611241, 14654701
GO:0006338	Process	Chromatin remodeling	IMP	22904072
GO:0007059	Process	Chromosome segregation	IBA
GO:0007623	Process	Circadian rhythm	IEP	22904072
GO:0008301	Function	DNA binding, bending	EXP	11283003
GO:0009266	Process	Response to temperature stimulus	IEA
GO:0009303	Process	RRNA transcription	IEA
GO:0009410	Process	Response to xenobiotic stimulus	IEP	16127745
GO:0010332	Process	Response to gamma radiation	IEA
GO:0012501	Process	Programmed cell death	NAS	17172417
GO:0016853	Function	Isomerase activity	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	IMP	9611241
GO:0019904	Function	Protein domain specific binding	IPI	9611241
GO:0031100	Process	Animal organ regeneration	IEA
GO:0031490	Function	Chromatin DNA binding	IEA
GO:0032922	Process	Circadian regulation of gene expression	IMP	22904072
GO:0032993	Component	Protein-DNA complex	IMP	10497031
GO:0040016	Process	Embryonic cleavage	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0048511	Process	Rhythmic process	IEA
GO:0051591	Process	Response to cAMP	IEA
GO:0071373	Process	Cellular response to luteinizing hormone stimulus	IEA
GO:0097100	Function	Supercoiled DNA binding	IMP	8631793, 9611241, 14654701

Other IDs

• MIM: 126420
• HGNC: 11986
• e!Ensembl: ENSG00000198900

Protein

• UniProt ID: P11387
• Protein name: DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
• Protein function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a targ
• PDB: 1A31, 1A35, 1A36, 1EJ9, 1K4S, 1K4T, 1LPQ, 1NH3, 1R49, 1RR8, 1RRJ, 1SC7, 1SEU, 1T8I, 1TL8
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02919	Topoisom_I_N	215 → 429	Eukaryotic DNA topoisomerase I, DNA binding fragment	Family
  PF01028	Topoisom_I	432 → 665	Eukaryotic DNA topoisomerase I, catalytic core	Domain
  PF14370	Topo_C_assoc	695 → 765	C-terminal topoisomerase domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Endothelial cells. {ECO:0000269|PubMed:19168442}.
• Sequence:

  MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKK
  HKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEP
  EDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKD
  KDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKF
  YYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKC
  DFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGL
  FRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENI
  QGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALY
  FIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNK
  VPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQ
  QLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLAD
  ARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSK
  LNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF

• Sequence length: 765

Pathways

Reactome:

SUMOylation of DNA replication proteins

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
DNA topoisomerase I, camptothecin-resistant	Pathogenic	rs121434562	RCV000018262	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Autism spectrum disorder	association	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CATARACT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TOP1-related disorder	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute monocytic leukemia	Monocytic Leukemia	BEFREE	12645654		★☆☆☆☆ Found in Text Mining only
Adult Medulloblastoma	Medulloblastoma	BEFREE	29869738		★☆☆☆☆ Found in Text Mining only
Anemia	Anemia	BEFREE	15100157		★☆☆☆☆ Found in Text Mining only
Angelman Syndrome	Angelman Syndrome	BEFREE	30140420		★☆☆☆☆ Found in Text Mining only
Ataxia Telangiectasia	Ataxia telangiectasia	Pubtator	23626666, 30679601	Associate	★☆☆☆☆ Found in Text Mining only
Ataxia Telangiectasia	Ataxia Telangiectasia	BEFREE	24793032		★☆☆☆☆ Found in Text Mining only
Ataxia Telangiectasia	Ataxia telangiectasia	Pubtator	25032865	Stimulate	★☆☆☆☆ Found in Text Mining only
ATAXIA, EARLY-ONSET, WITH OCULOMOTOR APRAXIA AND HYPOALBUMINEMIA	Ataxia-oculomotor apraxia	BEFREE	15719174		★☆☆☆☆ Found in Text Mining only
Ataxia, Spinocerebellar	Spinocerebellar Ataxia	BEFREE	24793032		★☆☆☆☆ Found in Text Mining only
Ataxias, Hereditary	Ataxia	BEFREE	29177742		★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	23995680		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autoimmune Diseases	Autoimmune Diseases	BEFREE	2479024		★☆☆☆☆ Found in Text Mining only
Behavior Disorders	Behavior Disorders	BEFREE	28850114		★☆☆☆☆ Found in Text Mining only
Benign Neoplasm	Benign Neoplasm	CTD_human_DG	11598410		★☆☆☆☆ Found in Text Mining only
Benign Neoplasm	Benign Neoplasm	BEFREE	1682037		★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	23365634		★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain Neoplasms	BEFREE	10982004		★☆☆☆☆ Found in Text Mining only
Breast adenocarcinoma	Breast Adenocarcinoma	BEFREE	29208488		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	11479235, 17875716, 20817775, 27566577, 28360015, 31059050, 31783818, 9499438		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	12833450, 20215517, 25885574, 31783818, 33144457, 37913680	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	23365634		★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	11844605, 28477120, 9045964		★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	27315793	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	33062672	Associate	★☆☆☆☆ Found in Text Mining only
Carcinosarcoma	Carcinosarcoma	LHGDN	17490723		★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	40102901	Associate	★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	31242600		★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	31242600		★☆☆☆☆ Found in Text Mining only
Childhood Medulloblastoma	Medulloblastoma	BEFREE	29869738		★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	20817775, 23653048, 23836376, 26542057, 27029323		★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	9321666	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	10732766, 22171973, 23110915, 23577133, 23653048, 25522766, 25777966, 26676887, 28180300, 30983992		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	16127745, 19584232, 20164542, 21636699, 23110915, 23577133, 23836376, 25777966, 25885574, 27029323, 28077117, 35053185, 37353483	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	LHGDN	18855534		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	BEFREE	28337384		★☆☆☆☆ Found in Text Mining only
Crisponi syndrome	Crisponi syndrome	Pubtator	21628532	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	33083497	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	31342163		★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	25931012		★☆☆☆☆ Found in Text Mining only
Diffuse Scleroderma	Scleroderma	BEFREE	2479024		★☆☆☆☆ Found in Text Mining only
Emphysema	Emphysema	Pubtator	31383554	Associate	★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	31817790		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	31817790		★☆☆☆☆ Found in Text Mining only
Fanconi Anemia	Fanconi anemia	Pubtator	21478670, 24130054	Associate	★☆☆☆☆ Found in Text Mining only
Fanconi Anemia	Fanconi Anemia	BEFREE	6096255		★☆☆☆☆ Found in Text Mining only
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)	Anemia	BEFREE	6096255		★☆☆☆☆ Found in Text Mining only
Fibrosarcoma	Fibrosarcoma	BEFREE	9495454		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	14961077, 17127074, 17984197, 28963609, 31547492		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	LHGDN	14961077		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	14961077, 17127074, 17984197, 28963609, 31547492		★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic Neoplasms	BEFREE	12461755		★☆☆☆☆ Found in Text Mining only
Hepatitis C	Hepatitis c	Pubtator	36405960	Associate	★☆☆☆☆ Found in Text Mining only
Hepatoblastoma	Hepatoblastoma	BEFREE	29414822		★☆☆☆☆ Found in Text Mining only
IGA Glomerulonephritis	Glomerulonephritis	BEFREE	31551340		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	28850114		★☆☆☆☆ Found in Text Mining only
Kidney Neoplasms	Kidney neoplasm	Pubtator	19584232	Inhibit	★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	11118036, 15100157, 16939812, 29748210, 31775111, 8938793, 9408961		★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	23085462	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	29781401	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	11979559, 15036893		★☆☆☆☆ Found in Text Mining only
Leukopenia	Leukopenia	BEFREE	18347181		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	27639803		★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	CTD_human_DG	30132517		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung Neoplasms	Lung Neoplasms	LHGDN	11844605		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	28355294	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	35794238	Inhibit	★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	29156741		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	30983992		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	11479235, 27566577, 28360015, 31059050, 31783818, 9499438		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	31817790		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	30132517		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	CTD_human_DG	30132517		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	11844605, 9045964		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	9497914		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	25615400		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	11280753		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	23365634		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	CTD_human_DG	11598410		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	11877436, 15132777, 15157660, 16467868, 22797812, 23006513, 23169295, 25036042, 26287259, 27138759, 27825117, 28974621, 29267866, 29312794, 30148840, 30867893, 31409613, 8383888		★☆☆☆☆ Found in Text Mining only
Malignant Peripheral Nerve Sheath Tumor	Malignant Peripheral Nerve Sheath Tumor	BEFREE	31444410		★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	31242600		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	23653048, 23836376, 26542057, 27029323		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	12833450		★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Medulloblastoma	BEFREE	29869738		★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Medulloblastoma	Pubtator	29869738	Associate	★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	20465595, 21809047		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	33631697, 34560251	Associate	★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	Pubtator	37916443	Associate	★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	31383554	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	9408961		★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Myelodysplastic syndrome	Pubtator	10556215	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	CTD_human_DG	11598410		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	16990856, 20465595, 22171973, 23006513, 23110915, 23347980, 23432590, 23577133, 24256029, 25615400, 25777966, 28337384, 29170084, 29252124, 29869738, 30061364, 31196001, 31242600		★☆☆☆☆ Found in Text Mining only
Nerve Sheath Tumors	Nerve Sheath Tumors	BEFREE	31444410		★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	30456874, 30555231		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	16501609		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	34465595	Associate	★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	25032865, 26578593, 30679601	Associate	★☆☆☆☆ Found in Text Mining only
Neurofibromatosis 1	Neurofibromatosis	BEFREE	31444410		★☆☆☆☆ Found in Text Mining only
Neutropenia	Neutropenia	BEFREE	18347181		★☆☆☆☆ Found in Text Mining only
Neutropenia	Neutropenia	Pubtator	19604089	Associate	★☆☆☆☆ Found in Text Mining only
Nevus comedonicus	Nevus comedonicus	BEFREE	30132517		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	11844605, 17118488, 28355294, 29453962, 9119744		★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	32788627	Associate	★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	LHGDN	17976381		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	35197484	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	25615400		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasm	Pancreatic Neoplasm	BEFREE	1315526		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	37831776	Associate	★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	BEFREE	22052386		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	11118036, 11280753		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	LHGDN	18089815		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	35349486	Associate	★☆☆☆☆ Found in Text Mining only
Pulmonary Fibrosis	Pulmonary Fibrosis	BEFREE	20508030, 28365359, 29307688		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	28850114		★☆☆☆☆ Found in Text Mining only
Secondary malignant neoplasm of colon and/or rectum	Colorectal Neoplasms	BEFREE	22171973, 23110915, 24256029, 28077117		★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	30691855		★☆☆☆☆ Found in Text Mining only
Small cell carcinoma of lung	Lung carcinoma	BEFREE	24327519		★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	22344449, 33848478, 35794238, 35957613	Associate	★☆☆☆☆ Found in Text Mining only
Spinocerebellar ataxia autosomal recessive with axonal neuropathy	Spinocerebellar ataxia	Pubtator	26578593	Associate	★☆☆☆☆ Found in Text Mining only
SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE, WITH AXONAL NEUROPATHY	Spinocerebellar Ataxia, WITH AXONAL NEUROPATHY	BEFREE	16935573		★☆☆☆☆ Found in Text Mining only
Squamous Cell Neoplasms	Neoplasm	LHGDN	11749700		★☆☆☆☆ Found in Text Mining only
Systemic Scleroderma	Scleroderma	BEFREE	10088769, 10366110, 11739535, 19950302, 2479024, 28365359, 29193892, 29307688, 7692859		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	27107440, 32075943	Associate	★☆☆☆☆ Found in Text Mining only
Turcot syndrome	Turcot syndrome	Pubtator	25777966	Associate	★☆☆☆☆ Found in Text Mining only