TNNI1 (troponin I1, slow skeletal type)

Gene

• Entrez ID: 7135
• Gene name: Troponin I1, slow skeletal type
• Gene symbol: TNNI1
• Synonyms (NCBI Gene): SSTNI, TNN1
• Chromosome: 1
• Chromosome location: 1q32.1
• Summary: Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin c

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016700	hsa-miR-335-5p	Microarray	18185580
MIRT020440	hsa-miR-106b-5p	Microarray	17242205
MIRT021876	hsa-miR-128-3p	Microarray	17612493
MIRT1444029	hsa-miR-1228	CLIP-seq
MIRT1444030	hsa-miR-1253	CLIP-seq
MIRT1444031	hsa-miR-1262	CLIP-seq
MIRT1444032	hsa-miR-127-5p	CLIP-seq
MIRT1444033	hsa-miR-1276	CLIP-seq
MIRT1444034	hsa-miR-1291	CLIP-seq
MIRT1444035	hsa-miR-1302	CLIP-seq
MIRT1444036	hsa-miR-146b-3p	CLIP-seq
MIRT1444037	hsa-miR-1915	CLIP-seq
MIRT1444038	hsa-miR-2355-5p	CLIP-seq
MIRT1444039	hsa-miR-2467-3p	CLIP-seq
MIRT1444040	hsa-miR-296-5p	CLIP-seq
MIRT1444041	hsa-miR-31	CLIP-seq
MIRT1444042	hsa-miR-3122	CLIP-seq
MIRT1444043	hsa-miR-3140-5p	CLIP-seq
MIRT1444044	hsa-miR-3158-5p	CLIP-seq
MIRT1444045	hsa-miR-3173-5p	CLIP-seq
MIRT1444046	hsa-miR-3183	CLIP-seq
MIRT1444047	hsa-miR-3192	CLIP-seq
MIRT1444048	hsa-miR-326	CLIP-seq
MIRT1444049	hsa-miR-330-5p	CLIP-seq
MIRT1444050	hsa-miR-342-3p	CLIP-seq
MIRT1444051	hsa-miR-342-5p	CLIP-seq
MIRT1444052	hsa-miR-3646	CLIP-seq
MIRT1444053	hsa-miR-3661	CLIP-seq
MIRT1444054	hsa-miR-3664-3p	CLIP-seq
MIRT1444055	hsa-miR-3678-3p	CLIP-seq
MIRT1444056	hsa-miR-3679-3p	CLIP-seq
MIRT1444057	hsa-miR-3913-5p	CLIP-seq
MIRT1444058	hsa-miR-3925-3p	CLIP-seq
MIRT1444059	hsa-miR-4267	CLIP-seq
MIRT1444060	hsa-miR-4286	CLIP-seq
MIRT1444061	hsa-miR-4298	CLIP-seq
MIRT1444062	hsa-miR-4314	CLIP-seq
MIRT1444063	hsa-miR-4321	CLIP-seq
MIRT1444064	hsa-miR-4324	CLIP-seq
MIRT1444065	hsa-miR-4328	CLIP-seq
MIRT1444066	hsa-miR-4433	CLIP-seq
MIRT1444067	hsa-miR-4434	CLIP-seq
MIRT1444068	hsa-miR-4446-5p	CLIP-seq
MIRT1444069	hsa-miR-4455	CLIP-seq
MIRT1444070	hsa-miR-4474-5p	CLIP-seq
MIRT1444071	hsa-miR-4516	CLIP-seq
MIRT1444072	hsa-miR-4640-5p	CLIP-seq
MIRT1444073	hsa-miR-4646-5p	CLIP-seq
MIRT1444074	hsa-miR-4664-5p	CLIP-seq
MIRT1444075	hsa-miR-4676-5p	CLIP-seq
MIRT1444076	hsa-miR-4685-5p	CLIP-seq
MIRT1444077	hsa-miR-4701-3p	CLIP-seq
MIRT1444078	hsa-miR-4718	CLIP-seq
MIRT1444079	hsa-miR-4723-3p	CLIP-seq
MIRT1444080	hsa-miR-4726-5p	CLIP-seq
MIRT1444081	hsa-miR-4742-5p	CLIP-seq
MIRT1444082	hsa-miR-4755-3p	CLIP-seq
MIRT1444083	hsa-miR-4764-5p	CLIP-seq
MIRT1444084	hsa-miR-4768-3p	CLIP-seq
MIRT1444085	hsa-miR-4779	CLIP-seq
MIRT1444086	hsa-miR-4781-5p	CLIP-seq
MIRT1444087	hsa-miR-508-5p	CLIP-seq
MIRT1444088	hsa-miR-510	CLIP-seq
MIRT1444089	hsa-miR-512-5p	CLIP-seq
MIRT1444090	hsa-miR-550a	CLIP-seq
MIRT1444091	hsa-miR-554	CLIP-seq
MIRT1444092	hsa-miR-564	CLIP-seq
MIRT1444093	hsa-miR-575	CLIP-seq
MIRT1444094	hsa-miR-580	CLIP-seq
MIRT1444095	hsa-miR-631	CLIP-seq
MIRT1444096	hsa-miR-642b	CLIP-seq
MIRT1444097	hsa-miR-661	CLIP-seq
MIRT1444098	hsa-miR-759	CLIP-seq
MIRT1444099	hsa-miR-760	CLIP-seq
MIRT1444100	hsa-miR-765	CLIP-seq
MIRT1444101	hsa-miR-766	CLIP-seq
MIRT1444102	hsa-miR-874	CLIP-seq
MIRT1555089	hsa-miR-2278	CLIP-seq
MIRT2132919	hsa-miR-122	CLIP-seq
MIRT2132920	hsa-miR-1304	CLIP-seq
MIRT2132921	hsa-miR-219-1-3p	CLIP-seq
MIRT2132922	hsa-miR-27a	CLIP-seq
MIRT2132923	hsa-miR-27b	CLIP-seq
MIRT2132924	hsa-miR-296-3p	CLIP-seq
MIRT2132925	hsa-miR-298	CLIP-seq
MIRT1444042	hsa-miR-3122	CLIP-seq
MIRT2132926	hsa-miR-3160-3p	CLIP-seq
MIRT2132927	hsa-miR-3170	CLIP-seq
MIRT2132928	hsa-miR-3176	CLIP-seq
MIRT2132929	hsa-miR-3179	CLIP-seq
MIRT1444051	hsa-miR-342-5p	CLIP-seq
MIRT2132930	hsa-miR-3611	CLIP-seq
MIRT1444057	hsa-miR-3913-5p	CLIP-seq
MIRT2132931	hsa-miR-3922-3p	CLIP-seq
MIRT2132932	hsa-miR-3977	CLIP-seq
MIRT2132933	hsa-miR-4259	CLIP-seq
MIRT2132934	hsa-miR-4279	CLIP-seq
MIRT2132935	hsa-miR-4292	CLIP-seq
MIRT2132936	hsa-miR-4293	CLIP-seq
MIRT2132937	hsa-miR-4308	CLIP-seq
MIRT1444063	hsa-miR-4321	CLIP-seq
MIRT1444066	hsa-miR-4433	CLIP-seq
MIRT2132938	hsa-miR-4436b-5p	CLIP-seq
MIRT1444069	hsa-miR-4455	CLIP-seq
MIRT2132939	hsa-miR-4487	CLIP-seq
MIRT2132940	hsa-miR-4514	CLIP-seq
MIRT2132941	hsa-miR-4640-3p	CLIP-seq
MIRT2132942	hsa-miR-4651	CLIP-seq
MIRT2132943	hsa-miR-4663	CLIP-seq
MIRT1444074	hsa-miR-4664-5p	CLIP-seq
MIRT2132944	hsa-miR-4667-3p	CLIP-seq
MIRT1444075	hsa-miR-4676-5p	CLIP-seq
MIRT2132945	hsa-miR-4682	CLIP-seq
MIRT2132946	hsa-miR-4691-5p	CLIP-seq
MIRT2132947	hsa-miR-4692	CLIP-seq
MIRT1444082	hsa-miR-4755-3p	CLIP-seq
MIRT2132948	hsa-miR-4765	CLIP-seq
MIRT1444084	hsa-miR-4768-3p	CLIP-seq
MIRT1444086	hsa-miR-4781-5p	CLIP-seq
MIRT2132949	hsa-miR-4786-5p	CLIP-seq
MIRT2132950	hsa-miR-509-3p	CLIP-seq
MIRT2132951	hsa-miR-513a-5p	CLIP-seq
MIRT2132952	hsa-miR-541	CLIP-seq
MIRT2132953	hsa-miR-558	CLIP-seq
MIRT1444092	hsa-miR-564	CLIP-seq
MIRT2132954	hsa-miR-571	CLIP-seq
MIRT2132955	hsa-miR-574-5p	CLIP-seq
MIRT1444093	hsa-miR-575	CLIP-seq
MIRT2132956	hsa-miR-593	CLIP-seq
MIRT2132957	hsa-miR-608	CLIP-seq
MIRT2132958	hsa-miR-654-5p	CLIP-seq
MIRT2353984	hsa-miR-10a	CLIP-seq
MIRT2353985	hsa-miR-10b	CLIP-seq
MIRT2353986	hsa-miR-1207-3p	CLIP-seq
MIRT2353987	hsa-miR-1224-3p	CLIP-seq
MIRT2353988	hsa-miR-1225-5p	CLIP-seq
MIRT1444029	hsa-miR-1228	CLIP-seq
MIRT1444030	hsa-miR-1253	CLIP-seq
MIRT1444031	hsa-miR-1262	CLIP-seq
MIRT2353989	hsa-miR-1270	CLIP-seq
MIRT1444032	hsa-miR-127-5p	CLIP-seq
MIRT1444036	hsa-miR-146b-3p	CLIP-seq
MIRT2353990	hsa-miR-199a-3p	CLIP-seq
MIRT2353991	hsa-miR-199b-3p	CLIP-seq
MIRT2353992	hsa-miR-2110	CLIP-seq
MIRT1444038	hsa-miR-2355-5p	CLIP-seq
MIRT2132922	hsa-miR-27a	CLIP-seq
MIRT2132923	hsa-miR-27b	CLIP-seq
MIRT2132924	hsa-miR-296-3p	CLIP-seq
MIRT1444040	hsa-miR-296-5p	CLIP-seq
MIRT1444042	hsa-miR-3122	CLIP-seq
MIRT2353993	hsa-miR-3126-5p	CLIP-seq
MIRT2353994	hsa-miR-3129-5p	CLIP-seq
MIRT2353995	hsa-miR-3144-5p	CLIP-seq
MIRT2353996	hsa-miR-3191	CLIP-seq
MIRT1444047	hsa-miR-3192	CLIP-seq
MIRT2132930	hsa-miR-3611	CLIP-seq
MIRT2353997	hsa-miR-3612	CLIP-seq
MIRT2353998	hsa-miR-361-3p	CLIP-seq
MIRT2353999	hsa-miR-3620	CLIP-seq
MIRT1444054	hsa-miR-3664-3p	CLIP-seq
MIRT1444057	hsa-miR-3913-5p	CLIP-seq
MIRT2354000	hsa-miR-3923	CLIP-seq
MIRT2132934	hsa-miR-4279	CLIP-seq
MIRT1444062	hsa-miR-4314	CLIP-seq
MIRT1444063	hsa-miR-4321	CLIP-seq
MIRT1444066	hsa-miR-4433	CLIP-seq
MIRT1444069	hsa-miR-4455	CLIP-seq
MIRT2354001	hsa-miR-448	CLIP-seq
MIRT2132940	hsa-miR-4514	CLIP-seq
MIRT2354002	hsa-miR-4530	CLIP-seq
MIRT1444073	hsa-miR-4646-5p	CLIP-seq
MIRT2354003	hsa-miR-4652-5p	CLIP-seq
MIRT2132943	hsa-miR-4663	CLIP-seq
MIRT2354004	hsa-miR-4690-3p	CLIP-seq
MIRT2132947	hsa-miR-4692	CLIP-seq
MIRT1444077	hsa-miR-4701-3p	CLIP-seq
MIRT2354005	hsa-miR-4722-5p	CLIP-seq
MIRT2354006	hsa-miR-4726-3p	CLIP-seq
MIRT2354007	hsa-miR-4758-3p	CLIP-seq
MIRT1444084	hsa-miR-4768-3p	CLIP-seq
MIRT2354008	hsa-miR-4769-3p	CLIP-seq
MIRT1444086	hsa-miR-4781-5p	CLIP-seq
MIRT2354009	hsa-miR-4793-3p	CLIP-seq
MIRT2354010	hsa-miR-4797-3p	CLIP-seq
MIRT1444087	hsa-miR-508-5p	CLIP-seq
MIRT1444088	hsa-miR-510	CLIP-seq
MIRT1444089	hsa-miR-512-5p	CLIP-seq
MIRT2354011	hsa-miR-548c-3p	CLIP-seq
MIRT2132956	hsa-miR-593	CLIP-seq
MIRT2354012	hsa-miR-620	CLIP-seq
MIRT2354013	hsa-miR-635	CLIP-seq
MIRT1444096	hsa-miR-642b	CLIP-seq
MIRT2354014	hsa-miR-650	CLIP-seq
MIRT1444097	hsa-miR-661	CLIP-seq
MIRT2354015	hsa-miR-665	CLIP-seq
MIRT2354016	hsa-miR-764	CLIP-seq
MIRT1444101	hsa-miR-766	CLIP-seq
MIRT2354017	hsa-miR-936	CLIP-seq
MIRT1444031	hsa-miR-1262	CLIP-seq
MIRT1444032	hsa-miR-127-5p	CLIP-seq
MIRT2353995	hsa-miR-3144-5p	CLIP-seq
MIRT1444047	hsa-miR-3192	CLIP-seq
MIRT2396151	hsa-miR-3938	CLIP-seq
MIRT2132935	hsa-miR-4292	CLIP-seq
MIRT2132937	hsa-miR-4308	CLIP-seq
MIRT1444066	hsa-miR-4433	CLIP-seq
MIRT2132940	hsa-miR-4514	CLIP-seq
MIRT1444073	hsa-miR-4646-5p	CLIP-seq
MIRT2132947	hsa-miR-4692	CLIP-seq
MIRT1444077	hsa-miR-4701-3p	CLIP-seq
MIRT2354005	hsa-miR-4722-5p	CLIP-seq
MIRT1444084	hsa-miR-4768-3p	CLIP-seq
MIRT2396152	hsa-miR-670	CLIP-seq
MIRT1444100	hsa-miR-765	CLIP-seq
MIRT2353984	hsa-miR-10a	CLIP-seq
MIRT2353985	hsa-miR-10b	CLIP-seq
MIRT2353987	hsa-miR-1224-3p	CLIP-seq
MIRT2462106	hsa-miR-1292	CLIP-seq
MIRT2462107	hsa-miR-193a-5p	CLIP-seq
MIRT1444047	hsa-miR-3192	CLIP-seq
MIRT2462108	hsa-miR-339-5p	CLIP-seq
MIRT1444062	hsa-miR-4314	CLIP-seq
MIRT1444063	hsa-miR-4321	CLIP-seq
MIRT2462109	hsa-miR-4421	CLIP-seq
MIRT1444069	hsa-miR-4455	CLIP-seq
MIRT2462110	hsa-miR-4471	CLIP-seq
MIRT2462111	hsa-miR-4475	CLIP-seq
MIRT1444073	hsa-miR-4646-5p	CLIP-seq
MIRT2462112	hsa-miR-4684-5p	CLIP-seq
MIRT2354006	hsa-miR-4726-3p	CLIP-seq
MIRT2354007	hsa-miR-4758-3p	CLIP-seq
MIRT1444086	hsa-miR-4781-5p	CLIP-seq
MIRT2354011	hsa-miR-548c-3p	CLIP-seq
MIRT2132956	hsa-miR-593	CLIP-seq
MIRT2353984	hsa-miR-10a	CLIP-seq
MIRT2353985	hsa-miR-10b	CLIP-seq
MIRT1444029	hsa-miR-1228	CLIP-seq
MIRT1444042	hsa-miR-3122	CLIP-seq
MIRT2648100	hsa-miR-3148	CLIP-seq
MIRT2462108	hsa-miR-339-5p	CLIP-seq
MIRT2648101	hsa-miR-3613-3p	CLIP-seq
MIRT2648102	hsa-miR-371-5p	CLIP-seq
MIRT2648103	hsa-miR-371b-5p	CLIP-seq
MIRT1444057	hsa-miR-3913-5p	CLIP-seq
MIRT2462109	hsa-miR-4421	CLIP-seq
MIRT2462112	hsa-miR-4684-5p	CLIP-seq
MIRT2132952	hsa-miR-541	CLIP-seq
MIRT2354011	hsa-miR-548c-3p	CLIP-seq
MIRT2132956	hsa-miR-593	CLIP-seq
MIRT2132958	hsa-miR-654-5p	CLIP-seq
MIRT1444029	hsa-miR-1228	CLIP-seq
MIRT1444042	hsa-miR-3122	CLIP-seq
MIRT1444057	hsa-miR-3913-5p	CLIP-seq
MIRT2132952	hsa-miR-541	CLIP-seq
MIRT2132958	hsa-miR-654-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003009	Process	Skeletal muscle contraction	IBA
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	21988832, 25416956, 32296183
GO:0005829	Component	Cytosol	TAS
GO:0005861	Component	Troponin complex	IBA
GO:0005861	Component	Troponin complex	IEA
GO:0006942	Process	Regulation of striated muscle contraction	NAS	2365354
GO:0014883	Process	Transition between fast and slow fiber	IEA
GO:0055010	Process	Ventricular cardiac muscle tissue morphogenesis	IEA
GO:0060048	Process	Cardiac muscle contraction	IBA

Other IDs

• MIM: 191042
• HGNC: 11945
• e!Ensembl: ENSG00000159173

Protein

• UniProt ID: P19237
• Protein name: Troponin I, slow skeletal muscle (Troponin I, slow-twitch isoform)
• Protein function: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00992	Troponin	15 → 146	Troponin	Family

• Tissue specificity: TISSUE SPECIFICITY: Highest levels observed in human skeletal muscle (e.g. gastrocnemious muscle), differentiated cultures of primary human muscle cells and rhabdomyosarcoma cells cultured in low serum medium. Expressed in C2 muscle cell myoblasts and myo
• Sequence:

  MPEVERKPKITASRKLLLKSLMLAKAKECWEQEHEEREAEKVRYLAERIPTLQTRGLSLS
  ALQDLCRELHAKVEVVDEERYDIEAKCLHNTREIKDLKLKVMDLRGKFKRPPLRRVRVSA
  DAMLRALLGSKHKVSMDLRANLKSVKKEDTEKERPVEVGDWRKNVEAMSGMEGRKKMFDA
  AKSPTSQ

• Sequence length: 187

Pathways

KEGG:

Motor proteins
Cytoskeleton in muscle cells

Reactome:

Striated Muscle Contraction

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ARTHROGRYPOSIS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TNNI1-related congenital myopathy	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute Coronary Syndrome	Coronary Syndrome	LHGDN	16236952		★☆☆☆☆ Found in Text Mining only
Coronary Stenosis	Coronary Stenosis	LHGDN	16358990		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	27437768		★☆☆☆☆ Found in Text Mining only
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation	BEFREE	15289369		★☆☆☆☆ Found in Text Mining only