Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7111
Gene name	Tropomodulin 1
Gene symbol	TMOD1
Synonyms (NCBI Gene)	D9S57EETMODTMOD
Chromosome	9
Chromosome location	9q22.33
Summary	This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby in

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miRTarBase ID	miRNA	Experiments	Reference
MIRT439420	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT439421	hsa-miR-1185-1-3p	HITS-CLIP	24374217
MIRT439419	hsa-miR-544a	HITS-CLIP	24374217
MIRT439418	hsa-miR-412-3p	HITS-CLIP	24374217
MIRT439420	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT439421	hsa-miR-1185-1-3p	HITS-CLIP	24374217
MIRT439419	hsa-miR-544a	HITS-CLIP	24374217
MIRT439418	hsa-miR-412-3p	HITS-CLIP	24374217
MIRT1440127	hsa-miR-488	CLIP-seq
MIRT1440128	hsa-miR-15a	CLIP-seq
MIRT1440129	hsa-miR-15b	CLIP-seq
MIRT1440130	hsa-miR-16	CLIP-seq
MIRT1440131	hsa-miR-195	CLIP-seq
MIRT1440132	hsa-miR-214	CLIP-seq
MIRT1440133	hsa-miR-2355-5p	CLIP-seq
MIRT1440134	hsa-miR-3160-5p	CLIP-seq
MIRT1440135	hsa-miR-3194-3p	CLIP-seq
MIRT1440136	hsa-miR-3619-5p	CLIP-seq
MIRT1440137	hsa-miR-3679-3p	CLIP-seq
MIRT1440138	hsa-miR-3974	CLIP-seq
MIRT1440139	hsa-miR-424	CLIP-seq
MIRT1440140	hsa-miR-4291	CLIP-seq
MIRT1440141	hsa-miR-497	CLIP-seq
MIRT1440142	hsa-miR-550b	CLIP-seq
MIRT1440143	hsa-miR-761	CLIP-seq
MIRT1440144	hsa-miR-922	CLIP-seq
MIRT1555004	hsa-miR-1202	CLIP-seq
MIRT1555005	hsa-miR-1237	CLIP-seq
MIRT1555006	hsa-miR-1245b-5p	CLIP-seq
MIRT1555007	hsa-miR-148a	CLIP-seq
MIRT1555008	hsa-miR-148b	CLIP-seq
MIRT1555009	hsa-miR-152	CLIP-seq
MIRT1555010	hsa-miR-3142	CLIP-seq
MIRT1555011	hsa-miR-3152-5p	CLIP-seq
MIRT1555012	hsa-miR-3194-5p	CLIP-seq
MIRT1555013	hsa-miR-338-3p	CLIP-seq
MIRT1555014	hsa-miR-3972	CLIP-seq
MIRT1555015	hsa-miR-412	CLIP-seq
MIRT1555016	hsa-miR-4297	CLIP-seq
MIRT1555017	hsa-miR-4310	CLIP-seq
MIRT1555018	hsa-miR-4650-5p	CLIP-seq
MIRT1555019	hsa-miR-4774-3p	CLIP-seq
MIRT1555020	hsa-miR-933	CLIP-seq
MIRT1555004	hsa-miR-1202	CLIP-seq
MIRT1555005	hsa-miR-1237	CLIP-seq
MIRT1555006	hsa-miR-1245b-5p	CLIP-seq
MIRT1555010	hsa-miR-3142	CLIP-seq
MIRT1555011	hsa-miR-3152-5p	CLIP-seq
MIRT1555012	hsa-miR-3194-5p	CLIP-seq
MIRT1555013	hsa-miR-338-3p	CLIP-seq
MIRT1555014	hsa-miR-3972	CLIP-seq
MIRT1555015	hsa-miR-412	CLIP-seq
MIRT1555016	hsa-miR-4297	CLIP-seq
MIRT1555017	hsa-miR-4310	CLIP-seq
MIRT1555018	hsa-miR-4650-5p	CLIP-seq
MIRT1555019	hsa-miR-4774-3p	CLIP-seq
MIRT1555020	hsa-miR-933	CLIP-seq
MIRT2131821	hsa-miR-124	CLIP-seq
MIRT2131822	hsa-miR-1256	CLIP-seq
MIRT2131823	hsa-miR-141	CLIP-seq
MIRT2131824	hsa-miR-200a	CLIP-seq
MIRT2131825	hsa-miR-4289	CLIP-seq
MIRT2131826	hsa-miR-4457	CLIP-seq
MIRT2131827	hsa-miR-4474-3p	CLIP-seq
MIRT2131828	hsa-miR-4536	CLIP-seq
MIRT2131829	hsa-miR-4761-3p	CLIP-seq
MIRT2131830	hsa-miR-4804-3p	CLIP-seq
MIRT2131831	hsa-miR-506	CLIP-seq
MIRT2131832	hsa-miR-548an	CLIP-seq
MIRT2131833	hsa-miR-656	CLIP-seq
MIRT1555015	hsa-miR-412	CLIP-seq
MIRT1555004	hsa-miR-1202	CLIP-seq
MIRT2461883	hsa-miR-1231	CLIP-seq
MIRT2131821	hsa-miR-124	CLIP-seq
MIRT2131822	hsa-miR-1256	CLIP-seq
MIRT2461884	hsa-miR-1287	CLIP-seq
MIRT2461885	hsa-miR-1293	CLIP-seq
MIRT2461886	hsa-miR-139-3p	CLIP-seq
MIRT2131823	hsa-miR-141	CLIP-seq
MIRT2461887	hsa-miR-153	CLIP-seq
MIRT2461888	hsa-miR-197	CLIP-seq
MIRT2461889	hsa-miR-199a-3p	CLIP-seq
MIRT2461890	hsa-miR-199b-3p	CLIP-seq
MIRT2131824	hsa-miR-200a	CLIP-seq
MIRT2461891	hsa-miR-200b	CLIP-seq
MIRT2461892	hsa-miR-200c	CLIP-seq
MIRT2461893	hsa-miR-203	CLIP-seq
MIRT2461894	hsa-miR-299-3p	CLIP-seq
MIRT2461895	hsa-miR-3065-3p	CLIP-seq
MIRT2461896	hsa-miR-3117-5p	CLIP-seq
MIRT2461897	hsa-miR-3120-5p	CLIP-seq
MIRT2461898	hsa-miR-3126-3p	CLIP-seq
MIRT2461899	hsa-miR-3129-5p	CLIP-seq
MIRT2461900	hsa-miR-3135b	CLIP-seq
MIRT2461901	hsa-miR-3167	CLIP-seq
MIRT2461902	hsa-miR-3170	CLIP-seq
MIRT2461903	hsa-miR-3176	CLIP-seq
MIRT2461904	hsa-miR-3184	CLIP-seq
MIRT2461905	hsa-miR-3187-3p	CLIP-seq
MIRT1555012	hsa-miR-3194-5p	CLIP-seq
MIRT2461906	hsa-miR-320e	CLIP-seq
MIRT2461907	hsa-miR-337-3p	CLIP-seq
MIRT1555013	hsa-miR-338-3p	CLIP-seq
MIRT2461908	hsa-miR-342-5p	CLIP-seq
MIRT2461909	hsa-miR-3610	CLIP-seq
MIRT2461910	hsa-miR-3685	CLIP-seq
MIRT2461911	hsa-miR-377	CLIP-seq
MIRT2461912	hsa-miR-384	CLIP-seq
MIRT2461913	hsa-miR-3922-3p	CLIP-seq
MIRT1555014	hsa-miR-3972	CLIP-seq
MIRT2461914	hsa-miR-423-5p	CLIP-seq
MIRT2461915	hsa-miR-4276	CLIP-seq
MIRT2131825	hsa-miR-4289	CLIP-seq
MIRT2461916	hsa-miR-429	CLIP-seq
MIRT2461917	hsa-miR-4302	CLIP-seq
MIRT2461918	hsa-miR-4303	CLIP-seq
MIRT2461919	hsa-miR-4305	CLIP-seq
MIRT2461920	hsa-miR-4318	CLIP-seq
MIRT2461921	hsa-miR-4328	CLIP-seq
MIRT2461922	hsa-miR-4435	CLIP-seq
MIRT2131826	hsa-miR-4457	CLIP-seq
MIRT2131827	hsa-miR-4474-3p	CLIP-seq
MIRT2461923	hsa-miR-448	CLIP-seq
MIRT2461924	hsa-miR-4483	CLIP-seq
MIRT2461925	hsa-miR-4491	CLIP-seq
MIRT2461926	hsa-miR-4530	CLIP-seq
MIRT2131828	hsa-miR-4536	CLIP-seq
MIRT2461927	hsa-miR-4640-5p	CLIP-seq
MIRT2461928	hsa-miR-4649-3p	CLIP-seq
MIRT2461929	hsa-miR-4651	CLIP-seq
MIRT2461930	hsa-miR-4653-3p	CLIP-seq
MIRT2461931	hsa-miR-4657	CLIP-seq
MIRT2461932	hsa-miR-4659a-5p	CLIP-seq
MIRT2461933	hsa-miR-4659b-5p	CLIP-seq
MIRT2461934	hsa-miR-4664-5p	CLIP-seq
MIRT2461935	hsa-miR-4668-5p	CLIP-seq
MIRT2461936	hsa-miR-4693-5p	CLIP-seq
MIRT2461937	hsa-miR-4701-5p	CLIP-seq
MIRT2461938	hsa-miR-4726-5p	CLIP-seq
MIRT2461939	hsa-miR-4733-5p	CLIP-seq
MIRT2461940	hsa-miR-4738-3p	CLIP-seq
MIRT2461941	hsa-miR-4760-5p	CLIP-seq
MIRT2131829	hsa-miR-4761-3p	CLIP-seq
MIRT2461942	hsa-miR-4769-3p	CLIP-seq
MIRT2461943	hsa-miR-4776-3p	CLIP-seq
MIRT2461944	hsa-miR-4789-3p	CLIP-seq
MIRT2461945	hsa-miR-4796-5p	CLIP-seq
MIRT2131830	hsa-miR-4804-3p	CLIP-seq
MIRT2461946	hsa-miR-502-5p	CLIP-seq
MIRT2131831	hsa-miR-506	CLIP-seq
MIRT2461947	hsa-miR-5096	CLIP-seq
MIRT2461948	hsa-miR-513a-3p	CLIP-seq
MIRT2461949	hsa-miR-516b	CLIP-seq
MIRT2461950	hsa-miR-544	CLIP-seq
MIRT2461951	hsa-miR-545	CLIP-seq
MIRT2131832	hsa-miR-548an	CLIP-seq
MIRT2461952	hsa-miR-548p	CLIP-seq
MIRT2461953	hsa-miR-548s	CLIP-seq
MIRT1440142	hsa-miR-550b	CLIP-seq
MIRT2461954	hsa-miR-561	CLIP-seq
MIRT2461955	hsa-miR-588	CLIP-seq
MIRT2461956	hsa-miR-604	CLIP-seq
MIRT2461957	hsa-miR-608	CLIP-seq
MIRT2461958	hsa-miR-619	CLIP-seq
MIRT2461959	hsa-miR-622	CLIP-seq
MIRT2461960	hsa-miR-634	CLIP-seq
MIRT2461961	hsa-miR-635	CLIP-seq
MIRT2461962	hsa-miR-642b	CLIP-seq
MIRT2461963	hsa-miR-647	CLIP-seq
MIRT2131833	hsa-miR-656	CLIP-seq
MIRT2461964	hsa-miR-663b	CLIP-seq
MIRT2461965	hsa-miR-876-3p	CLIP-seq
MIRT2461966	hsa-miR-876-5p	CLIP-seq
MIRT2461967	hsa-miR-885-5p	CLIP-seq
MIRT2461968	hsa-miR-936	CLIP-seq
MIRT1555004	hsa-miR-1202	CLIP-seq
MIRT2646717	hsa-miR-1227	CLIP-seq
MIRT2461883	hsa-miR-1231	CLIP-seq
MIRT2131821	hsa-miR-124	CLIP-seq
MIRT2131822	hsa-miR-1256	CLIP-seq
MIRT2461884	hsa-miR-1287	CLIP-seq
MIRT2461885	hsa-miR-1293	CLIP-seq
MIRT2461886	hsa-miR-139-3p	CLIP-seq
MIRT2131823	hsa-miR-141	CLIP-seq
MIRT2646718	hsa-miR-1539	CLIP-seq
MIRT2461888	hsa-miR-197	CLIP-seq
MIRT2646719	hsa-miR-199a-5p	CLIP-seq
MIRT2646720	hsa-miR-199b-5p	CLIP-seq
MIRT2131824	hsa-miR-200a	CLIP-seq
MIRT2461891	hsa-miR-200b	CLIP-seq
MIRT2461892	hsa-miR-200c	CLIP-seq
MIRT2461894	hsa-miR-299-3p	CLIP-seq
MIRT2461896	hsa-miR-3117-5p	CLIP-seq
MIRT2461897	hsa-miR-3120-5p	CLIP-seq
MIRT2461898	hsa-miR-3126-3p	CLIP-seq
MIRT2646721	hsa-miR-3128	CLIP-seq
MIRT2461900	hsa-miR-3135b	CLIP-seq
MIRT2461901	hsa-miR-3167	CLIP-seq
MIRT2461902	hsa-miR-3170	CLIP-seq
MIRT2461903	hsa-miR-3176	CLIP-seq
MIRT2646722	hsa-miR-3182	CLIP-seq
MIRT2461905	hsa-miR-3187-3p	CLIP-seq
MIRT2646723	hsa-miR-3188	CLIP-seq
MIRT2646724	hsa-miR-3193	CLIP-seq
MIRT1555012	hsa-miR-3194-5p	CLIP-seq
MIRT1555013	hsa-miR-338-3p	CLIP-seq
MIRT2461908	hsa-miR-342-5p	CLIP-seq
MIRT2461909	hsa-miR-3610	CLIP-seq
MIRT2461913	hsa-miR-3922-3p	CLIP-seq
MIRT1555014	hsa-miR-3972	CLIP-seq
MIRT1555015	hsa-miR-412	CLIP-seq
MIRT2461915	hsa-miR-4276	CLIP-seq
MIRT2131825	hsa-miR-4289	CLIP-seq
MIRT2461916	hsa-miR-429	CLIP-seq
MIRT2461917	hsa-miR-4302	CLIP-seq
MIRT2646725	hsa-miR-4311	CLIP-seq
MIRT2461920	hsa-miR-4318	CLIP-seq
MIRT2461922	hsa-miR-4435	CLIP-seq
MIRT2646726	hsa-miR-4438	CLIP-seq
MIRT2131826	hsa-miR-4457	CLIP-seq
MIRT2131827	hsa-miR-4474-3p	CLIP-seq
MIRT2461924	hsa-miR-4483	CLIP-seq
MIRT2461925	hsa-miR-4491	CLIP-seq
MIRT2461926	hsa-miR-4530	CLIP-seq
MIRT2131828	hsa-miR-4536	CLIP-seq
MIRT2461929	hsa-miR-4651	CLIP-seq
MIRT2461930	hsa-miR-4653-3p	CLIP-seq
MIRT2461931	hsa-miR-4657	CLIP-seq
MIRT2646727	hsa-miR-4659a-3p	CLIP-seq
MIRT2461932	hsa-miR-4659a-5p	CLIP-seq
MIRT2646728	hsa-miR-4659b-3p	CLIP-seq
MIRT2461933	hsa-miR-4659b-5p	CLIP-seq
MIRT2461934	hsa-miR-4664-5p	CLIP-seq
MIRT2461936	hsa-miR-4693-5p	CLIP-seq
MIRT2461937	hsa-miR-4701-5p	CLIP-seq
MIRT2646729	hsa-miR-4720-5p	CLIP-seq
MIRT2461939	hsa-miR-4733-5p	CLIP-seq
MIRT2646730	hsa-miR-4755-3p	CLIP-seq
MIRT2131829	hsa-miR-4761-3p	CLIP-seq
MIRT2461942	hsa-miR-4769-3p	CLIP-seq
MIRT2461943	hsa-miR-4776-3p	CLIP-seq
MIRT2646731	hsa-miR-4793-5p	CLIP-seq
MIRT2646732	hsa-miR-4799-3p	CLIP-seq
MIRT2131830	hsa-miR-4804-3p	CLIP-seq
MIRT2461946	hsa-miR-502-5p	CLIP-seq
MIRT2131831	hsa-miR-506	CLIP-seq
MIRT2646733	hsa-miR-5095	CLIP-seq
MIRT2461949	hsa-miR-516b	CLIP-seq
MIRT2131832	hsa-miR-548an	CLIP-seq
MIRT2461953	hsa-miR-548s	CLIP-seq
MIRT1440142	hsa-miR-550b	CLIP-seq
MIRT2461954	hsa-miR-561	CLIP-seq
MIRT2461955	hsa-miR-588	CLIP-seq
MIRT2461956	hsa-miR-604	CLIP-seq
MIRT2461957	hsa-miR-608	CLIP-seq
MIRT2461961	hsa-miR-635	CLIP-seq
MIRT2461962	hsa-miR-642b	CLIP-seq
MIRT2461963	hsa-miR-647	CLIP-seq
MIRT2646734	hsa-miR-648	CLIP-seq
MIRT2131833	hsa-miR-656	CLIP-seq
MIRT2646735	hsa-miR-658	CLIP-seq
MIRT2461964	hsa-miR-663b	CLIP-seq
MIRT2461965	hsa-miR-876-3p	CLIP-seq
MIRT2461966	hsa-miR-876-5p	CLIP-seq
MIRT2646736	hsa-miR-885-3p	CLIP-seq
MIRT2646737	hsa-miR-889	CLIP-seq
MIRT1555004	hsa-miR-1202	CLIP-seq
MIRT2646717	hsa-miR-1227	CLIP-seq
MIRT2461883	hsa-miR-1231	CLIP-seq
MIRT2131821	hsa-miR-124	CLIP-seq
MIRT2131822	hsa-miR-1256	CLIP-seq
MIRT2461884	hsa-miR-1287	CLIP-seq
MIRT2461885	hsa-miR-1293	CLIP-seq
MIRT2461886	hsa-miR-139-3p	CLIP-seq
MIRT2131823	hsa-miR-141	CLIP-seq
MIRT2646718	hsa-miR-1539	CLIP-seq
MIRT2461888	hsa-miR-197	CLIP-seq
MIRT2646719	hsa-miR-199a-5p	CLIP-seq
MIRT2646720	hsa-miR-199b-5p	CLIP-seq
MIRT2131824	hsa-miR-200a	CLIP-seq
MIRT2461891	hsa-miR-200b	CLIP-seq
MIRT2461892	hsa-miR-200c	CLIP-seq
MIRT2461894	hsa-miR-299-3p	CLIP-seq
MIRT2461896	hsa-miR-3117-5p	CLIP-seq
MIRT2461897	hsa-miR-3120-5p	CLIP-seq
MIRT2461898	hsa-miR-3126-3p	CLIP-seq
MIRT2461900	hsa-miR-3135b	CLIP-seq
MIRT2461901	hsa-miR-3167	CLIP-seq
MIRT2461902	hsa-miR-3170	CLIP-seq
MIRT2461903	hsa-miR-3176	CLIP-seq
MIRT2646722	hsa-miR-3182	CLIP-seq
MIRT2461905	hsa-miR-3187-3p	CLIP-seq
MIRT2646723	hsa-miR-3188	CLIP-seq
MIRT2646724	hsa-miR-3193	CLIP-seq
MIRT1555012	hsa-miR-3194-5p	CLIP-seq
MIRT1555013	hsa-miR-338-3p	CLIP-seq
MIRT2461908	hsa-miR-342-5p	CLIP-seq
MIRT2461909	hsa-miR-3610	CLIP-seq
MIRT2461913	hsa-miR-3922-3p	CLIP-seq
MIRT1555014	hsa-miR-3972	CLIP-seq
MIRT1555015	hsa-miR-412	CLIP-seq
MIRT2461915	hsa-miR-4276	CLIP-seq
MIRT2131825	hsa-miR-4289	CLIP-seq
MIRT2461916	hsa-miR-429	CLIP-seq
MIRT2461917	hsa-miR-4302	CLIP-seq
MIRT2461920	hsa-miR-4318	CLIP-seq
MIRT2461922	hsa-miR-4435	CLIP-seq
MIRT2131826	hsa-miR-4457	CLIP-seq
MIRT2131827	hsa-miR-4474-3p	CLIP-seq
MIRT2461924	hsa-miR-4483	CLIP-seq
MIRT2461925	hsa-miR-4491	CLIP-seq
MIRT2461926	hsa-miR-4530	CLIP-seq
MIRT2131828	hsa-miR-4536	CLIP-seq
MIRT2461929	hsa-miR-4651	CLIP-seq
MIRT2461930	hsa-miR-4653-3p	CLIP-seq
MIRT2461931	hsa-miR-4657	CLIP-seq
MIRT2646727	hsa-miR-4659a-3p	CLIP-seq
MIRT2461932	hsa-miR-4659a-5p	CLIP-seq
MIRT2646728	hsa-miR-4659b-3p	CLIP-seq
MIRT2461933	hsa-miR-4659b-5p	CLIP-seq
MIRT2461934	hsa-miR-4664-5p	CLIP-seq
MIRT2461936	hsa-miR-4693-5p	CLIP-seq
MIRT2461937	hsa-miR-4701-5p	CLIP-seq
MIRT2461939	hsa-miR-4733-5p	CLIP-seq
MIRT2646730	hsa-miR-4755-3p	CLIP-seq
MIRT2131829	hsa-miR-4761-3p	CLIP-seq
MIRT2461942	hsa-miR-4769-3p	CLIP-seq
MIRT2461943	hsa-miR-4776-3p	CLIP-seq
MIRT2646731	hsa-miR-4793-5p	CLIP-seq
MIRT2131830	hsa-miR-4804-3p	CLIP-seq
MIRT2461946	hsa-miR-502-5p	CLIP-seq
MIRT2131831	hsa-miR-506	CLIP-seq
MIRT2461949	hsa-miR-516b	CLIP-seq
MIRT2131832	hsa-miR-548an	CLIP-seq
MIRT2461953	hsa-miR-548s	CLIP-seq
MIRT1440142	hsa-miR-550b	CLIP-seq
MIRT2461954	hsa-miR-561	CLIP-seq
MIRT2461955	hsa-miR-588	CLIP-seq
MIRT2461956	hsa-miR-604	CLIP-seq
MIRT2461957	hsa-miR-608	CLIP-seq
MIRT2461961	hsa-miR-635	CLIP-seq
MIRT2461962	hsa-miR-642b	CLIP-seq
MIRT2461963	hsa-miR-647	CLIP-seq
MIRT2646734	hsa-miR-648	CLIP-seq
MIRT2131833	hsa-miR-656	CLIP-seq
MIRT2646735	hsa-miR-658	CLIP-seq
MIRT2461964	hsa-miR-663b	CLIP-seq
MIRT2461965	hsa-miR-876-3p	CLIP-seq
MIRT2461966	hsa-miR-876-5p	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IDA	26370058
GO:0003779	Function	Actin binding	IEA
GO:0005523	Function	Tropomyosin binding	IBA
GO:0005523	Function	Tropomyosin binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IBA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005865	Component	Striated muscle thin filament	IBA
GO:0005865	Component	Striated muscle thin filament	IDA	25250574, 38168645
GO:0005884	Component	Actin filament	IDA	26370058
GO:0006936	Process	Muscle contraction	IBA
GO:0006936	Process	Muscle contraction	IEA
GO:0007015	Process	Actin filament organization	IBA
GO:0008180	Component	COP9 signalosome	IDA	18850735
GO:0008344	Process	Adult locomotory behavior	IEA
GO:0016020	Component	Membrane	IEA
GO:0030016	Component	Myofibril	IBA
GO:0030016	Component	Myofibril	IDA	26370058
GO:0030016	Component	Myofibril	IEA
GO:0030017	Component	Sarcomere	IDA	26370058
GO:0030017	Component	Sarcomere	IEA
GO:0030239	Process	Myofibril assembly	IBA
GO:0030239	Process	Myofibril assembly	IEA
GO:0030863	Component	Cortical cytoskeleton	IEA
GO:0051694	Process	Pointed-end actin filament capping	IEA
GO:0070307	Process	Lens fiber cell development	IEA

MIM	HGNC	e!Ensembl
190930	11871	ENSG00000136842

P28289

Protein name

Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)

Protein function

Blocks the elongation and depolymerization of the actin filaments at the pointed end (PubMed:38168645). The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleto

PDB

4PKG , 4PKH , 4PKI , 4Z8G , 4Z94 , 8F8T

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03250	Tropomodulin	3 → 143	Tropomodulin	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in the erythrocyte, heart and skeletal muscle.

Sequence

MSYRRELEKYRDLDEDEILGALTEEELRTLENELDELDPDNALLPAGLRQKDQTTKAPTG
PFKREELLDHLEKQAKEFKDREDLVPYTGEKRGKVWVPKQKPLDPVLESVTLEPELEEAL
ANASDAELCDIAAILGMHTLMSNQQYYQALSSSSIMNKEGLNSVIKPTQYKPVPDEEPNS
TDVEETLERIKNNDPKLEEVNLNNIRNIPIPTLKAYAEALKENSYVKKFSIVGTRSNDPV
AYALAEMLKENKVLKTLNVESNFISGAGILRLVEALPYNTSLVEMKIDNQSQPLGNKVEM
EIVSMLEKNATLLKFGYHFTQQGPRLRASNAMMNNNDLVRKRRLADLTGPIIPKCRSGV

Sequence length

359

Interactions

View interactions

	KEGG		Reactome
	Cytoskeleton in muscle cells		Striated Muscle Contraction

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (11)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BARRETT'S ESOPHAGUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRAIN ANEURYSM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHY, DILATED	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DILATED CARDIOMYOPATHY	—	ClinGen, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL ADENOCARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Idiopathic cardiomyopathy	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CYSTS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PRIMARY CARDIOMYOPATHY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (28)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma Of Esophagus	Esophageal Cancer	BEFREE	27527254		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma Of Esophagus	Esophageal Cancer	GWASCAT_DG	27527254		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	31333911		★★★★★ ★☆☆☆☆ Found in Text Mining only
Barrett Esophagus	Barrett esophagus	GWASCAT_DG	27527254		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	25398440		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	Pubtator	38168645	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Restrictive	Restrictive cardiomyopathy	Pubtator	38168645	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathy, Familial Idiopathic	Cardiomyopathy	BEFREE	26873245		★★★★★ ★☆☆☆☆ Found in Text Mining only
Corpus Luteum Cyst	Corpus Luteum Cyst	CTD_human_DG	21239663		★★★★★ ★☆☆☆☆ Found in Text Mining only
familial dilated cardiomyopathy	Dilated cardiomyopathy	Pubtator	26873245	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intracranial Aneurysm	Intracranial Aneurysm	GWASCAT_DG	30823506		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ki-1+ Anaplastic Large Cell Lymphoma	Anaplastic Lymphoma	BEFREE	22740451		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lip and Oral Cavity Carcinoma	Lip and Oral Cavity Carcinoma	BEFREE	26718916		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	25398440		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of mouth	Malignant neoplasm of mouth	BEFREE	26718916		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CTD_human_DG	17199135		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31364131		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopathies Nemaline	Nemaline myopathy	Pubtator	11964245, 37956287	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myotonia Congenita	Myotonia congenita	Pubtator	30768849	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	14741341, 25398440		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	29930753		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Cysts	Ovarian Cysts	CTD_human_DG	21239663		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Peripheral T-Cell Lymphoma	T-Cell Lymphoma	BEFREE	22740451		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	CTD_human_DG	17199135		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	28025995	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	36316666	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	25398440		★★★★★ ★☆☆☆☆ Found in Text Mining only

TMOD1 (tropomodulin 1)