TLR5 (toll like receptor 5)

Gene

• Entrez ID: 7100
• Gene name: Toll like receptor 5
• Gene symbol: TLR5
• Synonyms (NCBI Gene): MELIOS, SLE1, SLEB1, TIL3
• Chromosome: 1
• Chromosome location: 1q41
• Summary: This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are express

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs2072493	T>A,C	Risk-factor	Coding sequence variant, missense variant
rs5744168	G>A	Risk-factor, protective	Coding sequence variant, stop gained

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT451800	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT451799	hsa-miR-3185	PAR-CLIP	23592263
MIRT451798	hsa-miR-4645-3p	PAR-CLIP	23592263
MIRT451797	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT451796	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT451795	hsa-miR-1914-3p	PAR-CLIP	23592263
MIRT451794	hsa-miR-5194	PAR-CLIP	23592263
MIRT451793	hsa-miR-6738-5p	PAR-CLIP	23592263
MIRT451792	hsa-miR-4271	PAR-CLIP	23592263
MIRT451791	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT451789	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT451790	hsa-miR-542-3p	PAR-CLIP	23592263
MIRT451788	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT451800	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT451799	hsa-miR-3185	PAR-CLIP	23592263
MIRT451798	hsa-miR-4645-3p	PAR-CLIP	23592263
MIRT451797	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT451796	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT451795	hsa-miR-1914-3p	PAR-CLIP	23592263
MIRT451794	hsa-miR-5194	PAR-CLIP	23592263
MIRT451793	hsa-miR-6738-5p	PAR-CLIP	23592263
MIRT451792	hsa-miR-4271	PAR-CLIP	23592263
MIRT451791	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT451789	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT451790	hsa-miR-542-3p	PAR-CLIP	23592263
MIRT451788	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT755873	hsa-miR-27a-3p	Luciferase reporter assay, Western blotting, qRT-PCR, RNA pull down assay	34539823
MIRT1426957	hsa-miR-103a	CLIP-seq
MIRT1426958	hsa-miR-107	CLIP-seq
MIRT1426959	hsa-miR-19a	CLIP-seq
MIRT1426960	hsa-miR-19b	CLIP-seq
MIRT1426961	hsa-miR-2116	CLIP-seq
MIRT1426962	hsa-miR-3607-5p	CLIP-seq
MIRT1426963	hsa-miR-3658	CLIP-seq
MIRT1426964	hsa-miR-3714	CLIP-seq
MIRT1426965	hsa-miR-376c	CLIP-seq
MIRT1426966	hsa-miR-4484	CLIP-seq
MIRT1426967	hsa-miR-4662a-3p	CLIP-seq
MIRT1426968	hsa-miR-4677-5p	CLIP-seq
MIRT1426969	hsa-miR-4716-5p	CLIP-seq
MIRT1426970	hsa-miR-4729	CLIP-seq
MIRT1426971	hsa-miR-4766-5p	CLIP-seq
MIRT1426972	hsa-miR-518a-5p	CLIP-seq
MIRT1426973	hsa-miR-527	CLIP-seq
MIRT1426974	hsa-miR-548an	CLIP-seq
MIRT1426975	hsa-miR-577	CLIP-seq
MIRT1426976	hsa-miR-579	CLIP-seq
MIRT2127900	hsa-miR-3174	CLIP-seq
MIRT2127901	hsa-miR-3606	CLIP-seq
MIRT2127902	hsa-miR-3689d	CLIP-seq
MIRT2127903	hsa-miR-376a	CLIP-seq
MIRT2127904	hsa-miR-376b	CLIP-seq
MIRT2127905	hsa-miR-4443	CLIP-seq
MIRT2127906	hsa-miR-548p	CLIP-seq
MIRT2127907	hsa-miR-587	CLIP-seq
MIRT2127908	hsa-miR-921	CLIP-seq
MIRT2349555	hsa-miR-425	CLIP-seq
MIRT2395857	hsa-miR-1253	CLIP-seq
MIRT2395858	hsa-miR-3156-5p	CLIP-seq
MIRT2395859	hsa-miR-3200-5p	CLIP-seq
MIRT2395860	hsa-miR-4251	CLIP-seq
MIRT2395861	hsa-miR-4329	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002224	Process	Toll-like receptor signaling pathway	IBA
GO:0002224	Process	Toll-like receptor signaling pathway	IEA
GO:0002376	Process	Immune system process	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0005149	Function	Interleukin-1 receptor binding	IPI	12925853
GO:0005515	Function	Protein binding	IPI	30158114
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	24778236
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006954	Process	Inflammatory response	IBA
GO:0006954	Process	Inflammatory response	IEA
GO:0006955	Process	Immune response	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0008584	Process	Male gonad development	IEA
GO:0016020	Component	Membrane	IEA
GO:0032757	Process	Positive regulation of interleukin-8 production	IDA	17128265
GO:0034146	Process	Toll-like receptor 5 signaling pathway	IDA	16751103
GO:0034146	Process	Toll-like receptor 5 signaling pathway	IDA	14625549, 17128265
GO:0038023	Function	Signaling receptor activity	IBA
GO:0038187	Function	Pattern recognition receptor activity	IDA	14625549, 17128265
GO:0045087	Process	Innate immune response	IEA
GO:0045429	Process	Positive regulation of nitric oxide biosynthetic process	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA
GO:0071260	Process	Cellular response to mechanical stimulus	IEP	19593445

Other IDs

• MIM: 603031
• HGNC: 11851
• e!Ensembl: ENSG00000187554

Protein

• UniProt ID: O60602
• Protein name: Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3)
• Protein function: Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781). Recognizes small molecular motifs named pathogen-associated molec
• PDB: 3J0A, 8AR2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	79 → 131	Leucine rich repeat	Repeat
  PF13855	LRR_8	288 → 348	Leucine rich repeat	Repeat
  PF13855	LRR_8	491 → 538	Leucine rich repeat	Repeat
  PF01582	TIR	692 → 858	TIR domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed on the basolateral surface of intestinal epithelia (PubMed:11489966). Expressed also in other cells such as lung epithelial cells (PubMed:11489966, PubMed:18490781). {ECO:0000269|PubMed:11489966, ECO:0000269|PubMed:184
• Sequence:

  MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
  VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
  LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
  QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
  DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
  FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
  KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
  INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
  GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
  LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT
  IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
  TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
  DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
  SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDFQDVGWFLHKLSQQILKKE
  KEKKKDNNIPLQTVATIS

• Sequence length: 858

Pathways

KEGG:

Toll-like receptor signaling pathway
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Legionellosis
Inflammatory bowel disease

Reactome:

Toll Like Receptor 5 (TLR5) Cascade
MyD88 deficiency (TLR5)
IRAK4 deficiency (TLR5)
MyD88 cascade initiated on plasma membrane

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CYSTIC FIBROSIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CYSTITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign; Likely benign; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERAMMONEMIA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Legionnaire disease, susceptibility to	protective; risk factor; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUPUS ERYTHEMATOSUS, SYSTEMIC	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melioidosis, resistance to	protective; risk factor	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Systemic lupus erythematosus, resistance to, 1	protective; risk factor	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 1	—	ClinGen, ClinVar, GenCC	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TLR5-related disorder	Benign; risk factor; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma	Adenocarcinoma	BEFREE	25797291		★☆☆☆☆ Found in Text Mining only
Aicardi Syndrome	Aicardi syndrome	Pubtator	26888781	Associate	★☆☆☆☆ Found in Text Mining only
Allergic rhinitis (disorder)	Allergic rhinitis	BEFREE	28228119		★☆☆☆☆ Found in Text Mining only
Allergic sensitization	Allergic Sensitization	BEFREE	30991709		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	17652175	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Amyloidosis	Amyloidosis	BEFREE	30158114		★☆☆☆☆ Found in Text Mining only
Ankylosing spondylitis	Ankylosing Spondylitis	BEFREE	20952467		★☆☆☆☆ Found in Text Mining only
Appendicitis	Appendicitis	Pubtator	24336024	Associate	★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	27146088, 28202909, 31292433		★☆☆☆☆ Found in Text Mining only
Arthritis	Arthritis	BEFREE	22661088, 27094092		★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	21179534, 22661088, 26440629, 31376255, 33482886, 37796367	Associate	★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	31396542	Stimulate	★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	19067129		★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	29486764	Associate	★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	Pubtator	29912993	Associate	★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	27146088, 28202909, 31292433		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	37339167	Associate	★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	11489951, 26606525, 28424695		★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune disease	Pubtator	18796002	Associate	★☆☆☆☆ Found in Text Mining only
Behcet Syndrome	Behcet disease	Pubtator	32756992	Associate	★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	BEFREE	26795430		★☆☆☆☆ Found in Text Mining only
Brachydactyly Type D	Brachydactyly	Pubtator	28504607	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	21427357, 25533336, 29179462, 31789409		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	24466264	Associate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	31789409	Inhibit	★☆☆☆☆ Found in Text Mining only
Bronchiectasis	Bronchiectasis	Pubtator	18684966	Stimulate	★☆☆☆☆ Found in Text Mining only
Bronchopulmonary Dysplasia	Bronchopulmonary Dysplasia	BEFREE	22058078, 27457283		★☆☆☆☆ Found in Text Mining only
Cancer Pain	Cancer	Pubtator	30610800	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	28404962	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Adenoid Cystic	Adenoid cystic carcinoma	Pubtator	26888781	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	22938463		★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	31238894	Associate	★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Cerebral Infarction	BEFREE	28912644		★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	27262705		★☆☆☆☆ Found in Text Mining only
Chorioretinitis	Chorioretinitis	BEFREE	20140383		★☆☆☆☆ Found in Text Mining only
Chronic granulomatous disease	Granulomatous Disease	BEFREE	18155283		★☆☆☆☆ Found in Text Mining only
Chronic otitis media	Otitis media	BEFREE	24882571		★☆☆☆☆ Found in Text Mining only
Chronic Periodontitis	Periodontitis	Pubtator	15664906	Associate	★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	19774646, 22863420, 31581570		★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	22185629, 25789623, 26698117, 32322884	Associate	★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	35546982	Inhibit	★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	18538140		★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	BEFREE	18538140		★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	LHGDN	18538140		★☆☆☆☆ Found in Text Mining only
Colonic Polyps	Colonic polyps	Pubtator	33255933	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	24154872		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	36649244	Associate	★☆☆☆☆ Found in Text Mining only
Complete atrioventricular block	Complete Atrioventricular Block	BEFREE	28543911, 29276096		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	39614436	Associate	★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	16439468, 19774646, 22275320, 22341723, 23593463, 26698117, 28139755, 28146004, 28827825		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	16439468, 18796002, 22275320, 23593463, 24901824, 26698117	Associate	★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	LHGDN	16897777		★☆☆☆☆ Found in Text Mining only
Cystic Disease Of Lung	Cystic lung disease	Pubtator	18684966	Associate	★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic Fibrosis	LHGDN	18490781, 18684966		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cystic Fibrosis	Cystic Fibrosis	BEFREE	18684966, 21068401, 23994582		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cystic Fibrosis	Cystic fibrosis	Pubtator	18684966	Stimulate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cystic Fibrosis	Cystic fibrosis	Pubtator	21068401	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cystic Fibrosis	Cystic fibrosis	Pubtator	24098711	Inhibit	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cystitis	Cystitis	Pubtator	19543401	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cystitis	Cystitis	BEFREE	27651177		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Degenerative polyarthritis	Arthritis	BEFREE	22661088		★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	30726515		★☆☆☆☆ Found in Text Mining only
Dermatitis Atopic	Atopic dermatitis	Pubtator	22710427	Associate	★☆☆☆☆ Found in Text Mining only
Dermatitis, Atopic	Dermatitis	BEFREE	21112617		★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	23455496		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	23455496		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	23455496		★☆☆☆☆ Found in Text Mining only
Diabetic Neuropathies	Diabetic Nephropathy	BEFREE	26479925		★☆☆☆☆ Found in Text Mining only
Duodenal Ulcer	Duodenal Ulcer	BEFREE	18809506, 25995217		★☆☆☆☆ Found in Text Mining only
Duodenal Ulcer	Duodenal ulcer	Pubtator	25995217	Associate	★☆☆☆☆ Found in Text Mining only
Dysentery	Dysentery	Pubtator	30323026	Associate	★☆☆☆☆ Found in Text Mining only
Eczema	Eczema	BEFREE	21112617		★☆☆☆☆ Found in Text Mining only
Glomerulonephritis	Glomerulonephritis	BEFREE	27992697		★☆☆☆☆ Found in Text Mining only
Glomerulonephritis IGA	Iga nephropathy	Pubtator	27818460	Associate	★☆☆☆☆ Found in Text Mining only
Graft vs Host Disease	Graft-versus-host disease	Pubtator	22703024, 23022388	Associate	★☆☆☆☆ Found in Text Mining only
Graft vs Host Disease	Graft-versus-host disease	Pubtator	24184334	Stimulate	★☆☆☆☆ Found in Text Mining only
Graft-vs-Host Disease	Graft-Vs-Host Disease	BEFREE	22703024, 24184334, 31057554		★☆☆☆☆ Found in Text Mining only
Granulomatous Disease Chronic	Granulomatous disease	Pubtator	14688376	Associate	★☆☆☆☆ Found in Text Mining only
Graves Disease	Graves Disease	BEFREE	24830583		★☆☆☆☆ Found in Text Mining only
Ileitis	Ileitis	BEFREE	28146004		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	16010583, 16439468, 20161736, 21203467, 22279566, 28139755, 31796949		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	24901824, 36847442	Associate	★☆☆☆☆ Found in Text Mining only
Intestinal Neoplasms	Intestinal neoplasm	Pubtator	31467388	Associate	★☆☆☆☆ Found in Text Mining only
Irritable Bowel Syndrome	Irritable Bowel Syndrome	BEFREE	28246611, 30347939		★☆☆☆☆ Found in Text Mining only
Irritable Bowel Syndrome	Irritable bowel syndrome	Pubtator	28246611	Stimulate	★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	27262705		★☆☆☆☆ Found in Text Mining only
Keratitis Ichthyosis Deafness Syndrome	Keratitis ichthyosis deafness syndrome	Pubtator	30150638	Associate	★☆☆☆☆ Found in Text Mining only
Laryngeal Neoplasms	Laryngeal neoplasm	Pubtator	21478107	Associate	★☆☆☆☆ Found in Text Mining only
Legionnaires` Disease	Legionnaires` Disease	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid	Myeloid leukemia	Pubtator	29651431	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	29651431	Associate	★☆☆☆☆ Found in Text Mining only
Libman-Sacks Disease	Nonbacterial verrucal endocardiosis	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	28543911		★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver Cirrhosis	BEFREE	28543911		★☆☆☆☆ Found in Text Mining only
Lung diseases	Lung Diseases	BEFREE	18684966		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus	Lupus Erythematosus	BEFREE	11489951, 17712995, 23150717, 23280626, 27992697, 28166678, 28219887, 30174216		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	16027372, 19843090, 35603218	Associate	★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	31396542	Stimulate	★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Discoid	Lupus Erythematosus	BEFREE	11489951, 17712995, 23150717, 23280626, 27992697, 28166678, 28219887, 30174216		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	11489951, 16027372, 17516623, 17712995, 19473567, 20952467, 22325161, 23150717, 23280626, 26762473, 27992697, 28166678, 28219887, 28763101, 30174216, 31691269, 31781106		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lupus Erythematosus, Systemic	Lupus Erythematosus	LHGDN	16027372, 17516623		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lupus Erythematosus, Systemic	Lupus Erythematosus	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lupus Nephritis	Lupus Nephritis	BEFREE	22180614, 28763101		★☆☆☆☆ Found in Text Mining only
Lupus Nephritis	Lupus nephritis	Pubtator	28763101	Associate	★☆☆☆☆ Found in Text Mining only
Lupus Nephritis	Lupus nephritis	Pubtator	40011954	Stimulate	★☆☆☆☆ Found in Text Mining only
Lupus Vulgaris	Lupus Vulgaris	BEFREE	11489951, 17712995, 23150717, 23280626, 27992697, 28166678, 28219887, 30174216		★☆☆☆☆ Found in Text Mining only
Lymphoma Follicular	Lymphoma	Pubtator	24771328	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	21427357, 25533336, 29179462, 31789409		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	22938463		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CTD_human_DG	16284379		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	21455558, 21994405, 28404962, 31083432, 31467388		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	23831323, 25533336, 29179462, 31467388		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	18538140		★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	30726515		★☆☆☆☆ Found in Text Mining only
Mental disorders	Mental Disorders	BEFREE	30726515		★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome X	Metabolic Syndrome	BEFREE	27094092, 29617463		★☆☆☆☆ Found in Text Mining only
Mucocutaneous Lymph Node Syndrome	Kawasaki disease	Pubtator	34290221	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	23593278	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple sclerosis	Pubtator	19664140	Associate	★☆☆☆☆ Found in Text Mining only
Myocarditis	Myocarditis	BEFREE	20856884		★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	31238894		★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	31238894	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	18538140, 22938463, 24549739, 25533336, 25862837, 28179508, 28323577, 29523766, 31238894, 31576678		★☆☆☆☆ Found in Text Mining only
Nephritis	Nephritis	BEFREE	19473567		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	24549739		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	20535027, 23455496, 25611816		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	25394788, 25611816, 33487124	Associate	★☆☆☆☆ Found in Text Mining only
Optic Neuritis	Optic neuritis	Pubtator	36969199	Associate	★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	22661088	Associate	★☆☆☆☆ Found in Text Mining only
Otitis Media	Otitis media	BEFREE	24882571		★☆☆☆☆ Found in Text Mining only
Peptic Ulcer	Peptic ulcer disease	Pubtator	34420402	Associate	★☆☆☆☆ Found in Text Mining only
Prostatic Intraepithelial Neoplasias	Prostatic Neoplasms	BEFREE	25797291		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	CTD_human_DG	16284379		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Proteinuria	Proteinuria	Pubtator	27818460	Associate	★☆☆☆☆ Found in Text Mining only
Pulmonary Cystic Fibrosis	Pulmonary Cystic Fibrosis	BEFREE	18684966		★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	22855713	Inhibit	★☆☆☆☆ Found in Text Mining only
Pyelonephritis	Pyelonephritis	BEFREE	19543401		★☆☆☆☆ Found in Text Mining only
Recurrent aphthous ulcer	Aphthous Ulcer	BEFREE	21554403		★☆☆☆☆ Found in Text Mining only
Recurrent cystitis	Cystitis	BEFREE	19543401		★☆☆☆☆ Found in Text Mining only
Respiratory Tract Infections	Respiratory system infectious disease	Pubtator	29486764	Associate	★☆☆☆☆ Found in Text Mining only
Rheumatic Heart Disease	Rheumatic Heart Disease	BEFREE	19616328, 30929974		★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	21179534, 21324962, 22661088, 26440629, 27988432, 28827825, 30412746		★☆☆☆☆ Found in Text Mining only
Rhinitis Allergic	Rhinitis	Pubtator	28228119	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	28646138		★☆☆☆☆ Found in Text Mining only
Scleroderma Systemic	Systemic sclerosis	Pubtator	31396542	Associate	★☆☆☆☆ Found in Text Mining only
Sepsis	Sepsis	Pubtator	27056672	Inhibit	★☆☆☆☆ Found in Text Mining only
Sepsis	Sepsis	Pubtator	37261353	Associate	★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	20463618, 30944018		★☆☆☆☆ Found in Text Mining only
Sezary Syndrome	Sezary syndrome	Pubtator	21951393	Stimulate	★☆☆☆☆ Found in Text Mining only
Sjogren's Syndrome	Sjogren syndrome	Pubtator	27943374	Inhibit	★☆☆☆☆ Found in Text Mining only
SPHEROCYTOSIS, TYPE 1 (disorder)	Spherocytosis	BEFREE	29053741		★☆☆☆☆ Found in Text Mining only
Spondylitis Ankylosing	Ankylosing spondylitis	Pubtator	20952467	Stimulate	★☆☆☆☆ Found in Text Mining only
Sporadic Breast Carcinoma	Breast Carcinoma	BEFREE	29179462		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	19740321, 23287987, 25941114, 28856441, 30794027	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of oropharynx	Oropharyngeal carcinoma	BEFREE	25941114, 29930251, 30794027		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of tongue	Tongue carcinoma	BEFREE	29246940, 30794027		★☆☆☆☆ Found in Text Mining only
Stickler syndrome type 1	Stickler syndrome	Pubtator	22306269	Stimulate	★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	21455558, 21994405, 28404962, 31083432, 31467388		★☆☆☆☆ Found in Text Mining only
Stomach Diseases	Stomach disease	Pubtator	21455638	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	28404962, 31467388	Associate	★☆☆☆☆ Found in Text Mining only
Synovitis	Synovitis	Pubtator	33377396	Associate	★☆☆☆☆ Found in Text Mining only
Systemic Scleroderma	Scleroderma	BEFREE	24959869		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	31576678		★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	16439468, 20083854, 22341723, 26698117, 28139755, 29669309		★☆☆☆☆ Found in Text Mining only
Uterine Cervical Dysplasia	Uterine disease	Pubtator	17587322	Associate	★☆☆☆☆ Found in Text Mining only
Vasculitis	Vasculitis	LHGDN	19150884		★☆☆☆☆ Found in Text Mining only
von Willebrand Disease	von Willebrand disorder	BEFREE	30111575, 30642920		★☆☆☆☆ Found in Text Mining only