Gene Gene information from NCBI Gene database.
Entrez ID 7098
Gene name Toll like receptor 3
Gene symbol TLR3
Synonyms (NCBI Gene)
CD283IIAE2IMD83
Chromosome 4
Chromosome location 4q35.1
Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and func
SNPs SNP information provided by dbSNP.
7
SNP ID Visualize variation Clinical significance Consequence
rs35311343 C>G Likely-benign, risk-factor Missense variant, coding sequence variant
rs121434431 C>T Risk-factor, uncertain-significance Missense variant, coding sequence variant
rs199768900 G>A Risk-factor Coding sequence variant, missense variant
rs768091235 T>C Risk-factor Coding sequence variant, missense variant
rs1244010954 G>A,T Risk-factor Missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
30
miRTarBase ID miRNA Experiments Reference
MIRT022528 hsa-miR-124-3p Microarray 18668037
MIRT438603 hsa-miR-758-3p Luciferase reporter assayWestern blotqRT-PCR 25008898
MIRT438603 hsa-miR-758-3p Luciferase reporter assayWestern blotqRT-PCR 25008898
MIRT564104 hsa-miR-548e-5p PAR-CLIP 20371350
MIRT564103 hsa-miR-3662 PAR-CLIP 20371350
Transcription factors Transcription factors information provided by TRRUST V2 database.
8
Transcription factor Regulation Reference
E2F1 Repression 22310660
IRF3 Unknown 22208359
IRF8 Repression 21220691
NFKB1 Activation 20658750
NFKB1 Repression 16423052
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
116
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane TAS
GO:0000165 Process MAPK cascade IEA
GO:0001774 Process Microglial cell activation IEA
GO:0002224 Process Toll-like receptor signaling pathway IDA 12471095
GO:0002224 Process Toll-like receptor signaling pathway IDA 18172197
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603029 11849 ENSG00000164342
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O15455
Protein name Toll-like receptor 3 (CD antigen CD283)
Protein function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by
PDB 1ZIW , 2A0Z , 2MK9 , 2MKA , 3ULU , 3ULV , 5GS0 , 7C76 , 7WV3 , 7WV4 , 7WV5 , 7WVE , 7WVF , 7WVJ , 8AR1 , 8YHT , 8YHU , 9LSH , 9LSI , 9LSJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13855 LRR_8 51 111 Leucine rich repeat Repeat
PF13516 LRR_6 195 210 Leucine Rich repeat Repeat
PF13855 LRR_8 248 302 Leucine rich repeat Repeat
PF13855 LRR_8 274 332 Leucine rich repeat Repeat
PF13855 LRR_8 562 620 Leucine rich repeat Repeat
PF13855 LRR_8 586 647 Leucine rich repeat Repeat
PF17968 Tlr3_TMD 698 730 Toll-like receptor 3 trans-membrane domain Domain
PF01582 TIR 755 897 TIR domain Family
Tissue specificity TISSUE SPECIFICITY: Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most st
Sequence
MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTH
NQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNEL
SQLSDKTFA
FCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSN
NKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEK
LCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQL
EY
FFLEYNNIQHLFSHSLHGLFNVRYLNLKRS
FTKQSISLASLPKIDDFSFQWLKCLEHL
NMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKIS
KIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVP
SLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHN
NLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNT
LPASVFNNQVSLKSLNLQKN
LITSVEKKVFGPAFRNLTELDMRFNPF
DCTCESIAWFVNW
INETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIV
LLIHFEGWRI
SFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKE
DQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAI
EQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVAL
GSK
NSVH
Sequence length 904
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Necroptosis
Toll-like receptor signaling pathway
Hepatitis C
Hepatitis B
Influenza A
Human papillomavirus infection
Kaposi sarcoma-associated herpesvirus infection
Herpes simplex virus 1 infection
Coronavirus disease - COVID-19
  Trafficking and processing of endosomal TLR
Toll Like Receptor 3 (TLR3) Cascade
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
TLR3 deficiency - HSE
UNC93B1 deficiency - HSE
TICAM1 deficiency - HSE
TRAF3 deficiency - HSE
TLR3-mediated TICAM1-dependent programmed cell death
TICAM1-dependent activation of IRF3/IRF7
TICAM1,TRAF6-dependent induction of TAK1 complex
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
24
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTHMA Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTOIMMUNE THYROID DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BASAL CELL CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cervical cancer Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute pancreatitis Pancreatitis BEFREE 30583980, 31130960
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 19609015
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 21960283
★☆☆☆☆
Found in Text Mining only
Adrenoleukodystrophy Adrenoleukodystrophy BEFREE 31849082
★☆☆☆☆
Found in Text Mining only
Adult type dermatomyositis Dermatomyositis BEFREE 20309865, 25365350
★☆☆☆☆
Found in Text Mining only
Age related macular degeneration Age-related macular degeneration BEFREE 18385087, 18753640, 19628747, 21079408, 23946637, 24682730, 26796995, 31809875
★☆☆☆☆
Found in Text Mining only
Age related macular degeneration Age-related macular degeneration LHGDN 18753640
★☆☆☆☆
Found in Text Mining only
Allergic rhinitis (disorder) Allergic rhinitis BEFREE 19752565, 27667736, 29398117
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 17652175 Associate
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 30076830 Stimulate
★☆☆☆☆
Found in Text Mining only