Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7083
Gene name	Thymidine kinase 1
Gene symbol	TK1
Synonyms (NCBI Gene)	TK2
Chromosome	17
Chromosome location	17q25.3
Summary	The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encod

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016357	hsa-miR-193b-3p	Microarray	20304954
MIRT029423	hsa-miR-26b-5p	Microarray	19088304
MIRT048356	hsa-miR-103a-3p	CLASH	23622248
MIRT038616	hsa-miR-186-3p	CLASH	23622248
MIRT723919	hsa-miR-4639-3p	HITS-CLIP	19536157
MIRT723918	hsa-miR-6777-3p	HITS-CLIP	19536157
MIRT723917	hsa-miR-3924	HITS-CLIP	19536157
MIRT723916	hsa-miR-675-3p	HITS-CLIP	19536157
MIRT695302	hsa-miR-497-3p	HITS-CLIP	23313552
MIRT695301	hsa-miR-590-3p	HITS-CLIP	23313552
MIRT695300	hsa-miR-4724-5p	HITS-CLIP	23313552
MIRT695299	hsa-miR-105-5p	HITS-CLIP	23313552
MIRT695298	hsa-miR-7853-5p	HITS-CLIP	23313552
MIRT695297	hsa-miR-181d-3p	HITS-CLIP	23313552
MIRT695296	hsa-miR-181a-2-3p	HITS-CLIP	23313552
MIRT695295	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT695294	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT048356	hsa-miR-103a-3p	HITS-CLIP	23313552
MIRT695293	hsa-miR-107	HITS-CLIP	23313552
MIRT695292	hsa-miR-4775	HITS-CLIP	23313552
MIRT695291	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT695290	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT695289	hsa-miR-6833-5p	HITS-CLIP	23313552
MIRT695288	hsa-miR-4752	HITS-CLIP	23313552
MIRT695287	hsa-miR-2113	HITS-CLIP	23313552
MIRT695286	hsa-miR-5010-3p	HITS-CLIP	23313552
MIRT695285	hsa-miR-4799-5p	HITS-CLIP	23313552
MIRT723919	hsa-miR-4639-3p	HITS-CLIP	19536157
MIRT723918	hsa-miR-6777-3p	HITS-CLIP	19536157
MIRT723917	hsa-miR-3924	HITS-CLIP	19536157
MIRT723916	hsa-miR-675-3p	HITS-CLIP	19536157
MIRT695302	hsa-miR-497-3p	HITS-CLIP	23313552
MIRT695301	hsa-miR-590-3p	HITS-CLIP	23313552
MIRT695300	hsa-miR-4724-5p	HITS-CLIP	23313552
MIRT695299	hsa-miR-105-5p	HITS-CLIP	23313552
MIRT695298	hsa-miR-7853-5p	HITS-CLIP	23313552
MIRT695297	hsa-miR-181d-3p	HITS-CLIP	23313552
MIRT695296	hsa-miR-181a-2-3p	HITS-CLIP	23313552
MIRT695295	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT695294	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT048356	hsa-miR-103a-3p	HITS-CLIP	23313552
MIRT695293	hsa-miR-107	HITS-CLIP	23313552
MIRT695292	hsa-miR-4775	HITS-CLIP	23313552
MIRT695291	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT695290	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT695289	hsa-miR-6833-5p	HITS-CLIP	23313552
MIRT695288	hsa-miR-4752	HITS-CLIP	23313552
MIRT695287	hsa-miR-2113	HITS-CLIP	23313552
MIRT695286	hsa-miR-5010-3p	HITS-CLIP	23313552
MIRT695285	hsa-miR-4799-5p	HITS-CLIP	23313552
MIRT1425858	hsa-let-7a	CLIP-seq
MIRT1425859	hsa-let-7b	CLIP-seq
MIRT1425860	hsa-let-7c	CLIP-seq
MIRT1425861	hsa-let-7d	CLIP-seq
MIRT1425862	hsa-let-7e	CLIP-seq
MIRT1425863	hsa-let-7f	CLIP-seq
MIRT1425864	hsa-let-7g	CLIP-seq
MIRT1425865	hsa-let-7i	CLIP-seq
MIRT1425866	hsa-miR-1225-3p	CLIP-seq
MIRT1425867	hsa-miR-1226	CLIP-seq
MIRT1425868	hsa-miR-1233	CLIP-seq
MIRT1425869	hsa-miR-18a	CLIP-seq
MIRT1425870	hsa-miR-18b	CLIP-seq
MIRT1425871	hsa-miR-1914	CLIP-seq
MIRT1425872	hsa-miR-1915	CLIP-seq
MIRT1425873	hsa-miR-214	CLIP-seq
MIRT1425874	hsa-miR-2467-3p	CLIP-seq
MIRT1425875	hsa-miR-2964a-5p	CLIP-seq
MIRT1425876	hsa-miR-3120-3p	CLIP-seq
MIRT1425877	hsa-miR-3151	CLIP-seq
MIRT1425878	hsa-miR-3158-3p	CLIP-seq
MIRT1425879	hsa-miR-3185	CLIP-seq
MIRT1425880	hsa-miR-3190	CLIP-seq
MIRT1425881	hsa-miR-3202	CLIP-seq
MIRT1425882	hsa-miR-3619-5p	CLIP-seq
MIRT1425883	hsa-miR-3929	CLIP-seq
MIRT1425884	hsa-miR-421	CLIP-seq
MIRT1425885	hsa-miR-4257	CLIP-seq
MIRT1425886	hsa-miR-4261	CLIP-seq
MIRT1425887	hsa-miR-4265	CLIP-seq
MIRT1425888	hsa-miR-4270	CLIP-seq
MIRT1425889	hsa-miR-4271	CLIP-seq
MIRT1425890	hsa-miR-4283	CLIP-seq
MIRT1425891	hsa-miR-4290	CLIP-seq
MIRT1425892	hsa-miR-4291	CLIP-seq
MIRT1425893	hsa-miR-4296	CLIP-seq
MIRT1425894	hsa-miR-4302	CLIP-seq
MIRT1425895	hsa-miR-4322	CLIP-seq
MIRT1425896	hsa-miR-4326	CLIP-seq
MIRT1425897	hsa-miR-4417	CLIP-seq
MIRT1425898	hsa-miR-4419b	CLIP-seq
MIRT1425899	hsa-miR-4428	CLIP-seq
MIRT1425900	hsa-miR-4438	CLIP-seq
MIRT1425901	hsa-miR-4441	CLIP-seq
MIRT1425902	hsa-miR-4458	CLIP-seq
MIRT1425903	hsa-miR-4476	CLIP-seq
MIRT1425904	hsa-miR-4478	CLIP-seq
MIRT1425905	hsa-miR-4489	CLIP-seq
MIRT1425906	hsa-miR-4493	CLIP-seq
MIRT1425907	hsa-miR-4500	CLIP-seq
MIRT1425908	hsa-miR-4519	CLIP-seq
MIRT1425909	hsa-miR-4530	CLIP-seq
MIRT1425910	hsa-miR-4640-5p	CLIP-seq
MIRT1425911	hsa-miR-4690-5p	CLIP-seq
MIRT1425912	hsa-miR-4691-3p	CLIP-seq
MIRT1425913	hsa-miR-4709-5p	CLIP-seq
MIRT1425914	hsa-miR-4725-3p	CLIP-seq
MIRT1425915	hsa-miR-4725-5p	CLIP-seq
MIRT1425916	hsa-miR-4726-3p	CLIP-seq
MIRT1425917	hsa-miR-4726-5p	CLIP-seq
MIRT1425918	hsa-miR-4733-3p	CLIP-seq
MIRT1425919	hsa-miR-4735-3p	CLIP-seq
MIRT1425920	hsa-miR-4753-5p	CLIP-seq
MIRT1425921	hsa-miR-4761-5p	CLIP-seq
MIRT1425922	hsa-miR-4773	CLIP-seq
MIRT1425923	hsa-miR-4800-5p	CLIP-seq
MIRT1425924	hsa-miR-486-3p	CLIP-seq
MIRT1425925	hsa-miR-504	CLIP-seq
MIRT1425926	hsa-miR-505	CLIP-seq
MIRT1425927	hsa-miR-512-5p	CLIP-seq
MIRT1425928	hsa-miR-548v	CLIP-seq
MIRT1425929	hsa-miR-646	CLIP-seq
MIRT1425930	hsa-miR-711	CLIP-seq
MIRT1425931	hsa-miR-760	CLIP-seq
MIRT1425932	hsa-miR-761	CLIP-seq
MIRT1425933	hsa-miR-922	CLIP-seq
MIRT1425934	hsa-miR-98	CLIP-seq
MIRT1425858	hsa-let-7a	CLIP-seq
MIRT1425859	hsa-let-7b	CLIP-seq
MIRT1425860	hsa-let-7c	CLIP-seq
MIRT1425861	hsa-let-7d	CLIP-seq
MIRT1425862	hsa-let-7e	CLIP-seq
MIRT1425863	hsa-let-7f	CLIP-seq
MIRT1425864	hsa-let-7g	CLIP-seq
MIRT1425865	hsa-let-7i	CLIP-seq
MIRT2127628	hsa-miR-103a	CLIP-seq
MIRT2127629	hsa-miR-1207-5p	CLIP-seq
MIRT2127630	hsa-miR-122	CLIP-seq
MIRT1425866	hsa-miR-1225-3p	CLIP-seq
MIRT1425867	hsa-miR-1226	CLIP-seq
MIRT1425868	hsa-miR-1233	CLIP-seq
MIRT2127631	hsa-miR-1266	CLIP-seq
MIRT2127632	hsa-miR-1285	CLIP-seq
MIRT1425871	hsa-miR-1914	CLIP-seq
MIRT1425872	hsa-miR-1915	CLIP-seq
MIRT1425873	hsa-miR-214	CLIP-seq
MIRT1425874	hsa-miR-2467-3p	CLIP-seq
MIRT1425875	hsa-miR-2964a-5p	CLIP-seq
MIRT1425877	hsa-miR-3151	CLIP-seq
MIRT1425878	hsa-miR-3158-3p	CLIP-seq
MIRT1425879	hsa-miR-3185	CLIP-seq
MIRT2127633	hsa-miR-3187-5p	CLIP-seq
MIRT1425881	hsa-miR-3202	CLIP-seq
MIRT2127634	hsa-miR-34a	CLIP-seq
MIRT2127635	hsa-miR-34c-5p	CLIP-seq
MIRT1425882	hsa-miR-3619-5p	CLIP-seq
MIRT2127636	hsa-miR-3652	CLIP-seq
MIRT2127637	hsa-miR-3690	CLIP-seq
MIRT1425883	hsa-miR-3929	CLIP-seq
MIRT1425884	hsa-miR-421	CLIP-seq
MIRT2127638	hsa-miR-4254	CLIP-seq
MIRT1425885	hsa-miR-4257	CLIP-seq
MIRT1425887	hsa-miR-4265	CLIP-seq
MIRT1425888	hsa-miR-4270	CLIP-seq
MIRT1425889	hsa-miR-4271	CLIP-seq
MIRT1425890	hsa-miR-4283	CLIP-seq
MIRT1425892	hsa-miR-4291	CLIP-seq
MIRT1425893	hsa-miR-4296	CLIP-seq
MIRT2127639	hsa-miR-4300	CLIP-seq
MIRT1425894	hsa-miR-4302	CLIP-seq
MIRT1425895	hsa-miR-4322	CLIP-seq
MIRT1425896	hsa-miR-4326	CLIP-seq
MIRT1425897	hsa-miR-4417	CLIP-seq
MIRT1425898	hsa-miR-4419b	CLIP-seq
MIRT1425899	hsa-miR-4428	CLIP-seq
MIRT2127640	hsa-miR-4430	CLIP-seq
MIRT1425900	hsa-miR-4438	CLIP-seq
MIRT1425901	hsa-miR-4441	CLIP-seq
MIRT1425902	hsa-miR-4458	CLIP-seq
MIRT1425903	hsa-miR-4476	CLIP-seq
MIRT1425904	hsa-miR-4478	CLIP-seq
MIRT1425905	hsa-miR-4489	CLIP-seq
MIRT2127641	hsa-miR-4496	CLIP-seq
MIRT2127642	hsa-miR-449a	CLIP-seq
MIRT2127643	hsa-miR-449b	CLIP-seq
MIRT1425907	hsa-miR-4500	CLIP-seq
MIRT2127644	hsa-miR-4505	CLIP-seq
MIRT2127645	hsa-miR-4514	CLIP-seq
MIRT2127646	hsa-miR-4518	CLIP-seq
MIRT1425908	hsa-miR-4519	CLIP-seq
MIRT2127647	hsa-miR-4529-5p	CLIP-seq
MIRT1425910	hsa-miR-4640-5p	CLIP-seq
MIRT2127648	hsa-miR-4645-5p	CLIP-seq
MIRT2127649	hsa-miR-4673	CLIP-seq
MIRT1425911	hsa-miR-4690-5p	CLIP-seq
MIRT2127650	hsa-miR-4692	CLIP-seq
MIRT1425913	hsa-miR-4709-5p	CLIP-seq
MIRT2127651	hsa-miR-4712-5p	CLIP-seq
MIRT2127652	hsa-miR-4715-3p	CLIP-seq
MIRT1425914	hsa-miR-4725-3p	CLIP-seq
MIRT1425916	hsa-miR-4726-3p	CLIP-seq
MIRT1425917	hsa-miR-4726-5p	CLIP-seq
MIRT2127653	hsa-miR-4728-5p	CLIP-seq
MIRT1425918	hsa-miR-4733-3p	CLIP-seq
MIRT2127654	hsa-miR-4763-3p	CLIP-seq
MIRT1425922	hsa-miR-4773	CLIP-seq
MIRT1425926	hsa-miR-505	CLIP-seq
MIRT1425927	hsa-miR-512-5p	CLIP-seq
MIRT2127655	hsa-miR-612	CLIP-seq
MIRT2127656	hsa-miR-617	CLIP-seq
MIRT1425931	hsa-miR-760	CLIP-seq
MIRT1425932	hsa-miR-761	CLIP-seq
MIRT2127657	hsa-miR-770-5p	CLIP-seq
MIRT2127658	hsa-miR-885-3p	CLIP-seq
MIRT2127659	hsa-miR-920	CLIP-seq
MIRT1425933	hsa-miR-922	CLIP-seq
MIRT1425934	hsa-miR-98	CLIP-seq
MIRT1425858	hsa-let-7a	CLIP-seq
MIRT1425859	hsa-let-7b	CLIP-seq
MIRT1425860	hsa-let-7c	CLIP-seq
MIRT1425861	hsa-let-7d	CLIP-seq
MIRT1425862	hsa-let-7e	CLIP-seq
MIRT1425863	hsa-let-7f	CLIP-seq
MIRT1425864	hsa-let-7g	CLIP-seq
MIRT1425865	hsa-let-7i	CLIP-seq
MIRT2127630	hsa-miR-122	CLIP-seq
MIRT1425866	hsa-miR-1225-3p	CLIP-seq
MIRT1425867	hsa-miR-1226	CLIP-seq
MIRT2349358	hsa-miR-1227	CLIP-seq
MIRT1425868	hsa-miR-1233	CLIP-seq
MIRT1425869	hsa-miR-18a	CLIP-seq
MIRT1425870	hsa-miR-18b	CLIP-seq
MIRT1425871	hsa-miR-1914	CLIP-seq
MIRT1425872	hsa-miR-1915	CLIP-seq
MIRT2349359	hsa-miR-1972	CLIP-seq
MIRT1425873	hsa-miR-214	CLIP-seq
MIRT1425874	hsa-miR-2467-3p	CLIP-seq
MIRT1425875	hsa-miR-2964a-5p	CLIP-seq
MIRT1425876	hsa-miR-3120-3p	CLIP-seq
MIRT1425877	hsa-miR-3151	CLIP-seq
MIRT1425878	hsa-miR-3158-3p	CLIP-seq
MIRT1425879	hsa-miR-3185	CLIP-seq
MIRT1425880	hsa-miR-3190	CLIP-seq
MIRT1425881	hsa-miR-3202	CLIP-seq
MIRT1425882	hsa-miR-3619-5p	CLIP-seq
MIRT1425883	hsa-miR-3929	CLIP-seq
MIRT1425885	hsa-miR-4257	CLIP-seq
MIRT1425886	hsa-miR-4261	CLIP-seq
MIRT1425887	hsa-miR-4265	CLIP-seq
MIRT1425888	hsa-miR-4270	CLIP-seq
MIRT1425889	hsa-miR-4271	CLIP-seq
MIRT1425891	hsa-miR-4290	CLIP-seq
MIRT1425892	hsa-miR-4291	CLIP-seq
MIRT1425893	hsa-miR-4296	CLIP-seq
MIRT1425894	hsa-miR-4302	CLIP-seq
MIRT1425895	hsa-miR-4322	CLIP-seq
MIRT1425897	hsa-miR-4417	CLIP-seq
MIRT1425898	hsa-miR-4419b	CLIP-seq
MIRT1425899	hsa-miR-4428	CLIP-seq
MIRT1425900	hsa-miR-4438	CLIP-seq
MIRT1425901	hsa-miR-4441	CLIP-seq
MIRT1425902	hsa-miR-4458	CLIP-seq
MIRT1425903	hsa-miR-4476	CLIP-seq
MIRT1425904	hsa-miR-4478	CLIP-seq
MIRT1425906	hsa-miR-4493	CLIP-seq
MIRT1425907	hsa-miR-4500	CLIP-seq
MIRT1425908	hsa-miR-4519	CLIP-seq
MIRT1425909	hsa-miR-4530	CLIP-seq
MIRT1425910	hsa-miR-4640-5p	CLIP-seq
MIRT1425911	hsa-miR-4690-5p	CLIP-seq
MIRT1425912	hsa-miR-4691-3p	CLIP-seq
MIRT2349360	hsa-miR-4717-5p	CLIP-seq
MIRT1425914	hsa-miR-4725-3p	CLIP-seq
MIRT1425915	hsa-miR-4725-5p	CLIP-seq
MIRT1425916	hsa-miR-4726-3p	CLIP-seq
MIRT1425917	hsa-miR-4726-5p	CLIP-seq
MIRT1425918	hsa-miR-4733-3p	CLIP-seq
MIRT1425919	hsa-miR-4735-3p	CLIP-seq
MIRT1425920	hsa-miR-4753-5p	CLIP-seq
MIRT1425921	hsa-miR-4761-5p	CLIP-seq
MIRT1425922	hsa-miR-4773	CLIP-seq
MIRT1425923	hsa-miR-4800-5p	CLIP-seq
MIRT1425924	hsa-miR-486-3p	CLIP-seq
MIRT1425925	hsa-miR-504	CLIP-seq
MIRT1425927	hsa-miR-512-5p	CLIP-seq
MIRT1425928	hsa-miR-548v	CLIP-seq
MIRT2349361	hsa-miR-574-5p	CLIP-seq
MIRT1425929	hsa-miR-646	CLIP-seq
MIRT2349362	hsa-miR-648	CLIP-seq
MIRT1425930	hsa-miR-711	CLIP-seq
MIRT1425932	hsa-miR-761	CLIP-seq
MIRT1425933	hsa-miR-922	CLIP-seq
MIRT1425934	hsa-miR-98	CLIP-seq
MIRT1425872	hsa-miR-1915	CLIP-seq
MIRT1425875	hsa-miR-2964a-5p	CLIP-seq
MIRT1425879	hsa-miR-3185	CLIP-seq
MIRT1425883	hsa-miR-3929	CLIP-seq
MIRT1425888	hsa-miR-4270	CLIP-seq
MIRT2127639	hsa-miR-4300	CLIP-seq
MIRT1425894	hsa-miR-4302	CLIP-seq
MIRT1425898	hsa-miR-4419b	CLIP-seq
MIRT1425900	hsa-miR-4438	CLIP-seq
MIRT1425901	hsa-miR-4441	CLIP-seq
MIRT1425904	hsa-miR-4478	CLIP-seq
MIRT2127648	hsa-miR-4645-5p	CLIP-seq
MIRT2127649	hsa-miR-4673	CLIP-seq
MIRT1425911	hsa-miR-4690-5p	CLIP-seq
MIRT1425916	hsa-miR-4726-3p	CLIP-seq
MIRT2127653	hsa-miR-4728-5p	CLIP-seq
MIRT1425922	hsa-miR-4773	CLIP-seq
MIRT1425926	hsa-miR-505	CLIP-seq
MIRT2127659	hsa-miR-920	CLIP-seq
MIRT1425869	hsa-miR-18a	CLIP-seq
MIRT1425870	hsa-miR-18b	CLIP-seq
MIRT1425900	hsa-miR-4438	CLIP-seq
MIRT1425919	hsa-miR-4735-3p	CLIP-seq

Show/Hide all (5)

Transcription factor	Regulation	Reference
MYB	Activation	1944282
POU2AF1	Activation	15831936
POU2F1	Activation	15831936
POU2F2	Activation	15831936
SP1	Activation	10502302

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004797	Function	Thymidine kinase activity	IBA
GO:0004797	Function	Thymidine kinase activity	IDA	14697231, 22385435
GO:0004797	Function	Thymidine kinase activity	IEA
GO:0004797	Function	Thymidine kinase activity	TAS	3335503
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	3335503
GO:0008270	Function	Zinc ion binding	IDA	17407781
GO:0009157	Process	Deoxyribonucleoside monophosphate biosynthetic process	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0042802	Function	Identical protein binding	IPI	21900206, 22385435
GO:0046104	Process	Thymidine metabolic process	IBA
GO:0046104	Process	Thymidine metabolic process	IDA	22385435
GO:0046105	Process	Thymidine biosynthetic process	IDA	14697231
GO:0046872	Function	Metal ion binding	IEA
GO:0051289	Process	Protein homotetramerization	IDA	14697231
GO:0051289	Process	Protein homotetramerization	IPI	17407781
GO:0071897	Process	DNA biosynthetic process	IEA
GO:1904860	Process	DNA synthesis involved in mitotic DNA replication	IDA	14697231

MIM	HGNC	e!Ensembl
188300	11830	ENSG00000167900

P04183

Protein name

Thymidine kinase, cytosolic (EC 2.7.1.21)

Protein function

Cell-cycle-regulated enzyme of importance in nucleotide metabolism (PubMed:9575153). Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate (PubMed:22385435). Transcriptional regulation limits

PDB

1W4R , 1XBT , 2ORV , 2WVJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00265	TK	19 → 189	Thymidine kinase	Family

Sequence

MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTR
YSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVI
VAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADK
YHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN

Sequence length

234

Interactions

View interactions

	KEGG		Reactome
	Pyrimidine metabolism Drug metabolism - other enzymes Metabolic pathways Nucleotide metabolism		Pyrimidine salvage

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CARCINOMA, HEPATOCELLULAR	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER NEOPLASMS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (88)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma	Adenocarcinoma	BEFREE	15809747		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	CTD_human_DG	27602772		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	31589613		★★★★★ ★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	29266545		★★★★★ ★☆☆☆☆ Found in Text Mining only
Aortic Aneurysm, Abdominal	Aortic Aneurysm	BEFREE	31741324		★★★★★ ★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	20716805		★★★★★ ★☆☆☆☆ Found in Text Mining only
Blood Coagulation Disorders	Blood coagulation disorder	Pubtator	40629026	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain Neoplasms	BEFREE	8527482		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	23966579, 30520339, 31601121		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	12699056, 27527857, 28349820, 29162134, 38033034	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	21178264	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	28412734	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	32513905, 38033034	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	28817340, 29247745, 31589613		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	19957115	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	29131263		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Dilated	Dilated cardiomyopathy	Pubtator	23695888	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	19629630, 20716805, 7967713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	12699056, 29483954, 29866926, 30214377, 30317880		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	CTD_human_DG	15814641		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	LHGDN	12699056		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	12699056, 30172759	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal Neoplasms	Colorectal Neoplasms	CTD_human_DG	15814641		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Craniofacial Dysostosis	Craniofacial Dysostosis	BEFREE	23913723		★★★★★ ★☆☆☆☆ Found in Text Mining only
Craniofacial dysostosis type 1	Craniofacial Dysostosis	BEFREE	23913723		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	35650387	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	16126870	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Frontotemporal Dementia	Frontotemporal dementia	Pubtator	30172759, 31619711	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gallbladder Neoplasms	Gallbladder neoplasm	Pubtator	25970782	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastrointestinal Neoplasms	Gastrointestinal neoplasm	Pubtator	27625087	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastrointestinal Stromal Tumors	Gastrointestinal stromal tumor	BEFREE	11984533		★★★★★ ★☆☆☆☆ Found in Text Mining only
Germ cell tumor	Tumor	BEFREE	11984533		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	20154339		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	20154339		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hashimoto Disease	Hashimoto Disease	BEFREE	12761888		★★★★★ ★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	32083704	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic Neoplasms	BEFREE	22516918, 30039979		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Hereditary breast and ovarian cancer syndrome	Pubtator	12699056	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hydatidiform Mole	Hydatidiform Mole	BEFREE	15361213		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hydatidiform Mole	Hydatidiform mole	Pubtator	15361213	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Idiopathic pulmonary hypertension	Pulmonary Hypertension	BEFREE	30354494		★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	30520339		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	9324277		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	28284560		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	25881156		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Diseases	Lung disease	Pubtator	21764789	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	11384664		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	LHGDN	15809747		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	21764789, 24859971, 32638267	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	34813778	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	22516918		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Glioma	Glioma	BEFREE	20154339		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	23966579, 30520339, 31601121		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of gastrointestinal tract	Malignant gastrointestinal tract tumors	BEFREE	21423062, 27625087		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	28817340, 29247745, 31589613		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	29131263		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	12192562, 29266545		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	30889628		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	29483954		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	12699056, 15809747, 21423062, 21737633, 25964590, 29247745, 29266545, 29483954, 30214377, 30792612, 30900869, 31138881		★★★★★ ★☆☆☆☆ Found in Text Mining only
Medullary carcinoma of thyroid	Megalencephaly, Polymicrogyria, Polydactyly, Hydrocephalus Syndrome	BEFREE	15978330		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	24941944	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mouth Neoplasms	Mouth neoplasm	Pubtator	32083704	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	9324277		★★★★★ ★☆☆☆☆ Found in Text Mining only
MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA	Myeloproliferative Disorder with Eosinophilia	BEFREE	30985967		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	12699056, 15809747, 16982761, 19654105, 20154339, 20723540, 23554961, 27324368, 27647762, 28093273, 29162134, 29247745, 29483954, 29662653, 30039191 View all (5 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	15809747, 19654105		★★★★★ ★☆☆☆☆ Found in Text Mining only
Oestrogen receptor positive breast cancer	Oestrogen Receptor Positive Breast Cancer	BEFREE	29162134		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	LHGDN	11992400		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	29131263		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	28651488	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	34813778	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Serous Adenocarcinoma	Ovarian serous adenocarcinoma	BEFREE	28651488		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	12192562, 29266545		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Ductal Adenocarcinoma	Pancreatic adenocarcinoma	BEFREE	29266545		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	23934415, 40155654	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatitis, Chronic	Pancreatitis	BEFREE	12192562		★★★★★ ★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	15978330		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pleural effusion disorder	Pleural effusion	BEFREE	30985967		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	30333882, 30889628		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	25990700, 31306099	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Secondary malignant neoplasm of colon and/or rectum	Colorectal Neoplasms	BEFREE	30172759		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	15809747		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of lung	Lung carcinoma	BEFREE	29247745		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	29483954		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	37767092	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	23693054, 33302814	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Visceral myopathy familial external ophthalmoplegia	Visceral neuropathy	Pubtator	34070501	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

TK1 (thymidine kinase 1)