Gene Gene information from NCBI Gene database.
Entrez ID 7077
Gene name TIMP metallopeptidase inhibitor 2
Gene symbol TIMP2
Synonyms (NCBI Gene)
CSC-21KDDC8
Chromosome 17
Chromosome location 17q25.3
Summary This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role a
miRNA miRNA information provided by mirtarbase database.
938
miRTarBase ID miRNA Experiments Reference
MIRT006198 hsa-miR-519d-3p Luciferase reporter assayWestern blot 22262409
MIRT006198 hsa-miR-519d-3p Luciferase reporter assayWestern blot 22262409
MIRT006198 hsa-miR-519d-3p Luciferase reporter assayWestern blot 22262409
MIRT006639 hsa-miR-519c-3p Luciferase reporter assayqRT-PCRWestern blot 22262409
MIRT006769 hsa-miR-200c-3p Luciferase reporter assay 22685266
Transcription factors Transcription factors information provided by TRRUST V2 database.
8
Transcription factor Regulation Reference
ETV4 Unknown 8810321
HIF1A Activation 17332917
JUN Unknown 8810321
NR4A1 Activation 22551568
PTTG1 Repression 19351864
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
24
GO ID Ontology Definition Evidence Reference
GO:0002020 Function Protease binding IPI 9573338
GO:0004857 Function Enzyme inhibitor activity IEA
GO:0005515 Function Protein binding IPI 12032297, 24112707, 28514442, 32296183, 33961781
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
188825 11821 ENSG00000035862
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P16035
Protein name Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2)
Protein function Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
PDB 1BR9 , 1GXD , 2TMP , 4ILW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00965 TIMP 25 203 Tissue inhibitor of metalloproteinase Domain
Sequence
Sequence length 220
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Activation of Matrix Metalloproteinases
Neutrophil degranulation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
22
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CALCINOSIS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHOLESTASIS, EXTRAHEPATIC CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acne Acne BEFREE 31032338
★☆☆☆☆
Found in Text Mining only
Acne Vulgaris Acne BEFREE 31032338
★☆☆☆☆
Found in Text Mining only
Acute Coronary Syndrome Coronary Syndrome LHGDN 17706812
★☆☆☆☆
Found in Text Mining only
Acute Coronary Syndrome Coronary Syndrome BEFREE 23793312
★☆☆☆☆
Found in Text Mining only
Acute leukemia Leukemia BEFREE 23472970
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 17350093
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 10995877, 21337552, 22292754, 8269281
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 22735808, 31002360
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma, Endometrioid Endometrial Cancer BEFREE 24344400
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 26071077, 8269281
★☆☆☆☆
Found in Text Mining only